Mechanism of gene transfection by polyamidoamine (PAMAM) dendrimers modified with ornithine residues

Journal of Drug Targeting

Volumn 19, Issue 9, 2011, Pages 770-780

  Kumar, Ajay ^a   Yellepeddi, Venkata K ^a   Vangara, Kiran K ^a   Strychar, Kevin B ^b   Palakurthi, Srinath ^a  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^b TEXAS A AND M UNIVERSITY CORPUS CHRISTI   (United States)

Author keywords

Dendriplexes; Endocytosis; Ornithine conjugated PAMAM dendrimers (PAMAM ORN); Poly(amido)amine (PAMAM) dendrimers; Polyamine transport system (PAT); Transfection efficiency

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; DENDRIMER; ORNITHINE DERIVATIVE; PARAQUAT; POLYAMIDOAMINE; POLYAMINE;

ARTICLE; CELL STRAIN HEK293; COMPARATIVE STUDY; CONJUGATION; CONTROLLED STUDY; CYTOTOXICITY; ENDOCYTOSIS; FLUORESCENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTERNALIZATION; PRIORITY JOURNAL; SYNTHESIS; ZETA POTENTIAL;

BIOLOGICAL TRANSPORT; CELL LINE; DENDRIMERS; DNA; ENDOCYTOSIS; FLUORESCENCE; HEK293 CELLS; HUMANS; NYLONS; ORNITHINE; PARAQUAT; POLYAMINES; TRANSFECTION;

EID: 80054692265     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.3109/1061186X.2011.568061     Document Type: Article

References (48)

1. Ahmed OA, Pourzand C, Blagbrough IS. (2006). Varying the unsaturation in N4,N9-dioctadecanoyl spermines: nonviral lipopolyamine vectors for more efficient plasmid DNA formulation. Pharm Res, 23, 31-40 (Pubitemid 43214658)
2. Bielinska A, Kukowska-Latallo JF, Johnson J, Tomalia DA, Baker JR Jr. (1996). Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using starburst PAMAM dendrimers. Nucleic Acids Res, 24, 2176-2182 (Pubitemid 26174562)
3. Bergeron RJ, Feng Y, Weimar WR, McManis JS, Dimova H, Porter C, Raisler B, Phanstiel O. (1997). A comparison of structure-activity relationships between spermidine and spermine analogue antineoplastics. J Med Chem, 40, 1475-1494 (Pubitemid 27200764)
4. Bloomfield VA. (1997). DNA condensation by multivalent cations. Biopolymers, 44, 269-282
5. Braun CS, Vetro JA, Tomalia DA, Koe GS, Koe JG, Middaugh CR. (2005). Structure/function relationships of polyamidoamine/DNA dendrimers as gene delivery vehicles. J Pharm Sci, 94, 423-436 (Pubitemid 40293337)
6. Brazeau GA, Attia S, Poxon S, Hughes JA. (1998). In vitro myotoxicity of selected cationic macromolecules used in non-viral gene delivery. Pharm Res, 15, 680-684 (Pubitemid 28275642)
7. Breunig M, Lungwitz U, Liebl R, Fontanari C, Klar J, Kurtz A, Blunk T, Goepferich A. (2005). Gene delivery with low molecular weight linear polyethylenimines. J Gene Med, 7, 1287-1298 (Pubitemid 41555435)
8. Casero RA Jr, Marton LJ. (2007). Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases. Nat Rev Drug Discov, 6, 373-390 (Pubitemid 46705201)
9. Choi JS, Nam K, Park JY, Kim JB, Lee JK, Park JS. (2004). Enhanced transfection efficiency of PAMAM dendrimer by surface modification with L-arginine. J Control Release, 99, 445-456 (Pubitemid 39296913)
10. Criss WE. (2003). A review of polyamines and cancer. Turk J Med Sci, 33, 195-205 (Pubitemid 37013752)
11. Cullis PM, Green RE, Merson-Davies L, Travis N. (1999). Probing the mechanism of transport and compartmentalisation of polyamines in mammalian cells. Chem Biol, 6, 717-729 (Pubitemid 29485534)
12. DAgostino L, di Pietro M, Di Luccia A. (2006). Nuclear aggregates of polyamines. IUBMB Life, 58, 75-82
13. Dufs C, Uchegbu IF, Schtzlein AG. (2005). Dendrimers in gene delivery. Adv Drug Deliv Rev, 57, 2177-2202 (Pubitemid 41759392)
14. Duncan R, Izzo L. (2005). Dendrimer biocompatibility and toxicity. Adv Drug Deliv Rev, 57, 2215-2237 (Pubitemid 41759394)
15. Ewert KK, Evans HM, Zidovska A, Bouxsein NF, Ahmad A, Safinya CR. (2006). A columnar phase of dendritic lipid-based cationic liposome-DNA complexes for gene delivery: hexagonally ordered cylindrical micelles embedded in a DNA honeycomb lattice. J Am Chem Soc, 128, 3998-4006
16. Fang Y, Hoh JH. (1998). Early intermediates in spermidine-induced DNA condensation on the surface of mica. J Am Chem Soc, 120, 8903-8909 (Pubitemid 28449167)
17. Fischer D, Li Y, Ahlemeyer B, Krieglstein J, Kissel T. (2003). In vitro cytotoxicity testing of polycations: Influence of polymer structure on cell viability and hemolysis. Biomaterials, 24, 1121-1131 (Pubitemid 36069121)
18. Futaki S. (2002). Arginine-rich peptides: potential for intracellular delivery of macromolecules and the mystery of the translocation mechanisms. Int J Pharm, 245, 1-7 (Pubitemid 35299886)
19. Gao X, Huang L. (1996). Potentiation of cationic liposome-mediated gene delivery by polycations. Biochemistry, 35, 1027-1036 (Pubitemid 26034590)
20. Gardner RA, Delcros JG, Konate F, Breitbeil F 3rd, Martin B, Sigman M, Huang M, Phanstiel O 4th. (2004). N1-substituent effects in the selective delivery of polyamine conjugates into cells containing active polyamine transporters. J Med Chem, 47, 6055-6069 (Pubitemid 39507347)
21. Geall AJ, Blagbrough IS. (2000). Rapid and sensitive ethidium bromide fluorescence quenching assay of polyamine conjugate-DNA interactions for the analysis of lipoplex formation in gene therapy. J Pharm Biomed Anal, 22, 849-859 (Pubitemid 30193315)
22. Golan R, Pietrasanta LI, Hsieh W, Hansma HG. (1999). DNA toroids: stages in condensation. Biochemistry, 38, 14069-14076 (Pubitemid 29504239)
23. Henry, CM. (2003). Breaching barriers. Chemical & Engineering News, 81, 35-43
24. Hung CF, Hwang TL, Chang CC, Fang JY. (2005). Physicochemical characterization and gene transfection efficiency of lipid emulsions with various co-emulsifiers. Int J Pharm, 289, 197-208
25. Hussain M, Shchepinov M, Sohail M, Benter IF, Hollins AJ, Southern EM, Akhtar S. (2004). A novel anionic dendrimer for improved cellular delivery of antisense oligonucleotides. J Control Release, 99, 139-155 (Pubitemid 39165740)
26. Kang H, DeLong R, Fisher MH, Juliano RL. (2005). Tat-conjugated PAMAM dendrimers as delivery agents for antisense and siRNA oligonucleotides. Pharm Res, 22, 2099-2106 (Pubitemid 41821589)
27. Kaur N, Delcros JG, Imran J, Khaled A, Chehtane M, Tschammer N, Martin B, Phanstiel O 4th. (2008). A comparison of chloroambuciland xylene-containing polyamines leads to improved ligands for accessing the polyamine transport system. J Med Chem, 51, 1393-1401 (Pubitemid 351480400)
28. Kitchens KM, Kolhatkar RB, Swaan PW, Ghandehari H. (2008). Endocytosis inhibitors prevent poly(amidoamine) dendrimer internalization and permeability across Caco-2 cells. Mol Pharm, 5, 364-369 (Pubitemid 351579139)
29. Kono K, Akiyama H, Takahashi T, Takagishi T, Harada A. (2005). Transfection activity of dendrimers having hydrophobic amino acid residues in the periphery. Bioconjug Chem, 16, 208-214 (Pubitemid 40129695)
30. Koppu S, Oh YJ, Edrada-Ebel R, Blatchford DR, Tetley L, Tate RJ, Dufs C. (2010). Tumor regression after systemic administration of a novel tumor-targeted gene delivery system carrying a therapeutic plasmid DNA. J Control Release, 143, 215-221
31. Kramer DL, Miller JT, Bergeron RJ, Khomutov R, Khomutov A, Porter CW. (1993). Regulation of polyamine transport by polyamines and polyamine analogs. J Cell Physiol, 155, 399-407 (Pubitemid 23134879)
32. Kumar A, Yellepeddi VK, Davies GE, Strychar KB, Palakurthi S. (2010). Enhanced gene transfection efficiency by polyamidoamine (PAMAM) dendrimers modified with ornithine residues. Int J Pharm, 392, 294-303
33. Li J, Menzel C, Meier D, Zhang C, Dübel S, Jostock T. (2007). A comparative study of different vector designs for the mammalian expression of recombinant IgG antibodies. J Immunol Methods, 318, 113-124 (Pubitemid 46026813)
34. Mislick KA, Baldeschwieler JD. (1996). Evidence for the role of proteoglycans in cation-mediated gene transfer. Proc Natl Acad Sci USA, 93, 12349-12354 (Pubitemid 26367146)
35. Miyake M, Minami T, Hirota M, Toguchi H, Odomi M, Ogawara K, Higaki K, Kimura T. (2006). Novel oral formulation safely improving intestinal absorption of poorly absorbable drugs: utilization of polyamines and bile acids. J Control Release, 111, 27-34 (Pubitemid 43289991)
36. Srinath P, McQuarrie SA, Suresh MR. (2002). Comparative uptake of polyamines by prostate and non-prostate cancer cell lines. Nucl Med Biol, 29, 497-503 (Pubitemid 34597123)
37. Pegg AE. (1988). Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. Cancer Res, 48, 759-774 (Pubitemid 18061860)
38. Rejman J, Bragonzi A, Conese M. (2005). Role of clathrin- and caveolae-mediated endocytosis in gene transfer mediated by lipoand polyplexes. Mol Ther, 12, 468-474 (Pubitemid 41150132)
39. Satriano J, Isome M, Casero RA Jr, Thomson SC, Blantz RC. (2001). Polyamine transport system mediates agmatine transport in mammalian cells. Am J Physiol, Cell Physiol, 281, C329-C334
40. Sgouras D, Duncan R. (1990). Methods for the evaluation of biocompatibility of soluble synthetic polymers which have potential for biomedical use: use of the tetrazolium-based colorimetric assay (MTT) as a preliminary screen for the evaluation of in vitro cytotoxicity. J Mater Sci Med, 1, 67-78
41. Shao D, Xiao L, Ha HC, Casero RA Jr. (1996). Isolation of a polyamine transport deficient cell line from the human non-small cell lung carcinoma line NCI H157. J Cell Physiol, 166, 43-48 (Pubitemid 26017777)
42. Shen Z, Li Y, Kohama K, Oneill B, Bi J. (2010). Improved drug targeting of cancer cells by utilizing actively targetable folic acid-conjugated albumin nanospheres. Pharmacol Res, in press
43. Soulet D, Gagnon B, Rivest S, Audette M, Poulin R. (2004). A fluorescent probe of polyamine transport accumulates into intracellular acidic vesicles via a two-step mechanism. J Biol Chem, 279, 49355-49366 (Pubitemid 39642166)
44. Tsen C, Iltis M, Kaur N, Bayer C, Delcros JG, von Kalm L, Phanstiel O 4th. (2008). A Drosophila model to identify polyamine-drug conjugates that target the polyamine transporter in an intact epithelium. J Med Chem, 51, 324-330
45. Tung CH, Weissleder R. (2003). Arginine containing peptides as delivery vectors. Adv Drug Deliv Rev, 55, 281-294 (Pubitemid 36135919)
46. Vijayanathan V, Thomas T, Shirahata A, Thomas TJ. (2001). DNA condensation by polyamines: a laser light scattering study of structural effects. Biochemistry, 40, 13644-13651 (Pubitemid 33130792)
47. Wang C, Delcros JG, Biggerstaff J, Phanstiel O 4th. (2003). Molecular requirements for targeting the \. Synthesis and biological evaluation of polyamine-anthracene conjugates. J Med Chem, 46, 2672-2682 (Pubitemid 36702536)
48. Wiethoff CM, Gill ML, Koe GS, Koe JG, Middaugh CR. (2003). A fluorescence study of the structure and accessibility of plasmid DNA condensed with cationic gene delivery vehicles. J Pharm Sci, 92, 1272-1285 (Pubitemid 36676472)