Evaluation of antioxidant and antiulcerogenic activities of Opuntia ficus indica f. inermis flowers extract in rats

Environmental Toxicology and Pharmacology

Volumn 32, Issue 3, 2011, Pages 406-416

  Alimi, Hichem ^a,b   Hfaiedh, Najla ^c   Bouoni, Zouhour ^a   Sakly, Mohsen ^b   Ben Rhouma, Khémais ^b  

^a UNIVERSITY OF GAFSA   (Tunisia)

^b University of Carthage   (Tunisia)

^c Faculté des Sciences de Sfax   (Tunisia)

Author keywords

Antioxidant; Antiulcerogenic, Opuntia; DNA; Ethanol; Flowers

Indexed keywords

ANTIOXIDANT; ANTIULCER AGENT; ASCORBIC ACID; CATECHIN; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; MYELOPEROXIDASE; OPUNTIA FICUS INDICA INERMIS EXTRACT; PLANT EXTRACT; RANITIDINE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ANTIULCEROGENIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA FRAGMENTATION; DOSE RESPONSE; DRUG ACTIVITY; DRUG DETERMINATION; DRUG MECHANISM; ENZYME ACTIVITY; FLOWER; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; LIPID PEROXIDATION; MALE; NONHUMAN; OPUNTIA; OPUNTIA FICUS INDICA INERMIS; PRIORITY JOURNAL; PROTEIN METABOLISM; RAT; STOMACH ULCER; TOXICITY TESTING;

ANIMALS; ANTI-ULCER AGENTS; ANTIOXIDANTS; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENZYMES; ETHANOL; FLAVONOIDS; FLOWERS; FREE RADICAL SCAVENGERS; INTESTINAL MUCOSA; LINOLEIC ACID; LIPID PEROXIDATION; MALE; OPUNTIA; PHENOLS; PLANT EXTRACTS; RATS; RATS, WISTAR; STOMACH ULCER; TOXICITY TESTS, ACUTE;

OPUNTIA; OPUNTIA FICUS-INDICA; RATTUS;

EID: 80054118216     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2011.08.007     Document Type: Article

References (65)

1. Aebi H. Catalase in vitro. Methods Enzymol. (Bergneyer H.U.) 1984, 105:121-126.
2. Ajaikumar K.B., Asheef M., Babu B.H., Padikkala J. The inhibition of gastric mucosal injury by Punica granatum L. (pomegranate) methanolic extract. J. Ethnopharmacol. 2005, 96:171-176.
3. Alimi H., Hfaiedh N., Bouoni Z., Hfaiedh M., Sakly M., Zourgui L., Ben Rhouma K. Antioxidant and antiulcerogenic activities of Opuntia ficus indica f. inermis root extract in rats. Phytomedicine 2010, 17:1120-1126.
4. Amarowicz R., Pegg R.B., Raim-Mohaddam P., Bral B., Weil J.A. Free radical scavenging capacity and antioxidant activity of selected plant species from the Canadian Prairies. Food Chem. 2004, 84:551-562.
5. Arun M., Asha V.V. Gastroprotective effect of Dodonaea viscosa on various experimental ulcer models. J. Ethnopharmacol. 2008, 118:460-465.
6. Bandyopadhyay D., Biswas K., Bhattacharyya M., Reiter R.J., Banerjee R.K. Involvement of reactive oxygen species in gastric ulceration: protection by melatonin. Ind. J. Exp. Biol. 2002, 40:693-705.
7. Blasiak J., Trzeciak A., Malecka-Panas E., Drzewoski J., Wojewôdzka M. In vitro genotoxicity of ethanol and acetaldehyde in human lymphocytes and the gastrointestinal tract mucosa cells. Toxicol. In Vitro 2000, 14:287-295.
8. Bradley P.P., Priebat D.A., Christensen R.D., Rothstein G. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J. Invest. Dermatol. 1982, 206:206-209.
9. Cadirci E., Suleyman H., Aksoy H., Halici Z., Ozgen U., Koc A., Ozturk N. Effects of Onosma armeniacum root extract on ethanol-induced oxidative stress in stomach tissue of rats. Chem. Biol. Interact. 2007, 170:40-48.
10. Choi C.W., Kim S.C., Hwang S.S., Choi B.K., Ahn H.J., Lee M.Y., Park S.H., Kim S.K. Antioxidant activity and free radical scavenging capacity between Korean medicinal plants and flavonoids by assay-guided comparison. Plant Sci. 2002, 163:1161-1168.
11. Choi E.Y., Hwang H.J., Kim I.H., Nam T.J. Protective effects of a polysaccharide from Hizikia fusiformis against ethanol toxicity in rats. Food Chem. Toxicol. 2009, 47:134-139.
12. Chu Y.H., Chang C.L., Hsu H.F. Flavonoid content of several vegetables and their antioxidant activity. J. Sci. Food Agric. 2000, 80:561-566.
13. Cipriani T.R., Mellinger C.G., Bertolini M.L.C., Baggio C.H., Freitas C.S., Marques M.C.A., Gorin P.A.J., Sassaki G.L., Iacomini M. Gastroprotective effect of a type I arabino-galactan from soybean meal. Food Chem. 2009, 115:687-690.
14. Daniela M., Sewerynek E., Reiter R.J., Ortiz G.G., Poeggeler B., Nistico G. Suppressive effect of melatonin administration on ethanol-induced gastroduodenal injury in rats in vivo. Br. J. Pharmacol. 1997, 121:264-270.
15. De Leo M., De Abreu M.B., Pawlowska A.M., Cioni P.L., Braca A. Profiling the chemical content of Opuntia ficus-indica flowers by HPLC-PDA-ESI-MS and GC/EIMS analyses. Phytochem. Lett. 2010, 3:48-52.
16. Devi R.S., Narayan S., Vani G., Devi C.S.S. Gastroprotective effect of Terminalia arjuna bark on diclofenac sodium induced gastric ulcer. Chem. Biol. Interact. 2007, 167:71-83.
17. Djeridane A., Yousfi M., Nadjemi B., Boutassouna D., Stocker P., Vidal N. Antioxidant activity of some Algerian medicinal plants extracts containing phenols compounds. Food Chem. 2006, 97:654-660.
18. Dong Q., Liu X., Yao J., Dong X., Ma C., Xu Y., Fang J., Ding K. Structural characterization of a pectic polysaccharide from Nerium indicum flowers. Phytochemistry 2010, 71:1430-1437.
19. Dubois M., Gilles K.A., Hamilton J.K., Rebers P.A., Smith F. Colorimetric method for determination of sugars and related substances. Anal. Chem. 1956, 28:350-356.
20. Ferreira I.C.F.R., Baptista P., Vilas-Boas M., Barros L. Free-radical scavenging capacity and reducing power of wild edible mushrooms from northeast Portugal: individual cap and stipe activity. Food Chem. 2007, 100:1511-1516.
21. Ferraro G., Anesini C., Ouvina A., Retta D., Filip R., Gattuso M., Gattuso S., Hnatyszyn O., Bandoni A. Total phenolic content and antioxidant activity of extracts of Achyrocline satureioides flowers from different zones in Argentina. Lat. Am. J. Pharm. 2008, 27:626-628.
22. Galati E.M., Monforte M.T., Tripodo M.M., d'Aquino A., Mondello M.R. Antiulcer activity of Opuntia ficus indica (L.) Mill. (Cactaceae): ultrastructural study. J. Ethnopharmacol. 2001, 76:1-9.
23. Galati E.M., Pergolizzi S., Miceli N., Monforte M.T., Tripodo M.M. Study on the increment of the production of gastric mucus in rats treated with Opuntia ficus indica (L.) Mill. cladodes. J. Ethnopharmacol. 2002, 83:229-233.
24. Galati G., O'Brien J.P. Potential toxicity of flavonoids and others dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic. Biol. Med. 2004, 37:283-287.
25. Gouthamchandra K., Mahmood R., Manjunatha H. Free radical scavenging, antioxidant enzymes and wound healing activities of leaves extracts from Clerodendrum infortunatum L. Environ. Toxicol. Pharmacol. 2010, 30:11-12.
26. Govind P., Saurabh J. Antiulcer activity of Nerium indicum in rats. Res. J. Pharmacol. 2010, 4:66-68.
27. Grzegorczyk I., Matkowski A., Wysokinska H. Antioxidant activity of extracts from in vitro cultures of Salvia officinalis L. Food Chem. 2007, 104:536-541.
28. Guslandi M. Effects of ethanol on the gastric mucosa. Dig. Dis. Sci. 1987, 5:21-32.
29. Habibi Y., Heyraud A., Mahrouz M., Vignon M.R. Structural features of pectic polysaccharides from the skin of Opuntia ficus indica prickly pear fruits. Carbohydr. Res. 2004, 339:1119-1127.
30. Halici M., Odabasoglu F., Suleyman H., Cakir A., Aslan A., Bayir Y. Effects of water extract of Usnea longissima on antioxidant enzyme activity and mucosal damage caused by indomethacin in rats. Phytomedicine 2005, 12:656-662.
31. Hamauzu Y., Forest F., Hiramatsu K., Sugimoto M. Effect of pear (Pyrus communis L.) procyanidins on gastric lesions induced by HCl/ethanol in rats. Food Chem. 2007, 100:255-263.
32. Huang D., Ou B., Prior R.L. The chemistry behind antioxidant capacity assays. J. Agric. Food Chem. 2005, 53:1841.
33. Inal M.E., Kahraman A. The protective effect of flavonol quercetin against ultraviolet a induced oxidative stress in rats. Toxicology 2000, 154:21-29.
34. Kahraman A., Erkasap N., Köken T., Serteser M., Aktepe F., Erkasap S. The antioxidative and antihistaminic properties of quercetin in ethanol-induced gastric lesions. Toxicology 2003, 183:133-142.
35. Kasagi N. Ethanol induces apoptosis in human gastric carcinoma cells: the role of apoptosis-related molecules. Yonago Acta Med. 1999, 42:113-124.
36. Lamaison J.L., Carnat A. Teneurs en acide rosmarinique, en dérivés hydroxy-cinnamiques totaux et activités antioxydantes chez les Apiacées, les Borraginacées et les Lamiacées médicinales. Pharm. Acta Helv. 1990, 65:315-320.
37. Lowry O.H., Rosenbrough N.J., Randall R. Protein measurement with the folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
38. Li C.Y., Xu H.D., Zhao B.T., Chang H.I., Rhee H.I. Gastroprotective effect of cyanidin 3-glucoside on ethanol-induced gastric lesions in rats. Alcohol 2008, 42:683-687.
39. Li X.M., Li X.L., Zhou A.G. Evaluation of antioxidant activity of the polysaccharides extracted from Lycium barbarum fruits in vitro. Eur. Polym. J. 2007, 43:488-497.
40. Misra H.P., Fridovich I. The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase. J. Biol. Chem. 1972, 247:3170-3175.
41. Navarini L., Gilli R., Gombac V., Abatangelo A., Bosco M., Toffanin R. Polysaccharides from hot water extracts of roasted Coffea arabica beans: isolation and characterization. Carbohydr. Polym. 1999, 40:71-81.
42. Nguelefack T.B., Feumebo C.B., Ateufack G., Watcho P., Tatsimo S., Atsamo A.D., Tane P., Kamanyi A. Anti-ulcerogenic properties of the aqueous and methanol extracts from the leaves of Solanum torvum Swartz (Solanaceae) in rats. J. Ethnopharmacol. 2008, 119:135-140.
43. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979, 95:351-358.
44. Okawa M., Kinjo J., Nohara T., Masateru O. DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity of flavonoids obtained from some medicinal plants. Biol. Pharm. Bull. 2001, 24:1202-1205.
45. O'Malley P. Gastric ulcers and GERD: the new " plagues" of 21st century update for the clinical nurse specialist. Clin. Nurse Spec. 2003, 17:286-289.
46. Panico A.M., Cardile V., Garufi F., Puglia C., Bonina F., Ronsisvalle G. Effect of hyaluronic acid and polysaccharides from Opuntia ficus indica (L.) cladodes on the metabolism of human chondrocyte cultures. J. Ethnopharmacol. 2007, 111:315-321.
47. Park K.Y., Jung G.O., Lee K.T., Choi J., Choi M.Y., Kim G.T., Jung H.J., Park H.J. Antimutagenic activity of flavonoids from the heartwood of Rhus verniciflua. J. Ethnopharmacol. 2004, 90:73-79.
48. Pihan G., Regillo C., Szabo S. Free radicals and lipid peroxidation in ethanol or aspirin-induced gastric mucosal injury. Dig. Dis. Sci. 1987, 32:1395-1401.
49. Rice-Evans C.A., Miller N.J., Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic. Biol. Med. 1996, 20:933-956.
50. Roussel Y., Wilks M., Harris A., Mein C., Tabaqchali S. Evaluation of DNA extraction methods from mouse stomachs for the quantification of H. pylori by real-time PCR. J. Microbiol. Methods 2005, 62:71-81.
51. Santin J.R., Lemos M., Klein Júnior L.C., Niero R., Faloni de Andrade S. Antiulcer effects of Achyrocline satureoides (Lam.) DC (Asteraceae) (Marcela), a folk medicine plant, in different experimental models. J. Ethnopharmacol. 2010, 130:334-339.
52. Sazuka Y., Tanizawa H., Takino Y. Effect of adriamycin on the activities of superoxide dismutase, glutathione peroxidase and catalase in tissues of mice. Jpn. J. Cancer Res. 1989, 80:89-94.
53. Sehirli O., Tatlidede E., Yuksel M., Erzik C., Cetinel S., Yeĝen B.C., Sener G. Antioxidant effect of alpha-lipoic acid against ethanol-induced gastric mucosal erosion in rats. Pharmacology 2008, 81:173-180.
54. Shaker E., Mahmoud H., Mnaa S. Anti-inflammatory and anti-ulcer activity of the extract from Alhagi maurorum (camelthorn). Food Chem. Toxicol. 2010, 48:2785-2790.
55. Siddaraju M.N., Nayaka H., Annaiah M., Dharmesh S.M. Gastroprotective effect of ginger rhizome (Zingiber officinale) extract: role of gallic acid and cinnamic acid inH+, K+-ATPase/H. pylori inhibition and anti-oxidative mechanism. eCAM 2009, 1:1-13.
56. Singh S., Khajuria A., Taneja S.C., Khajuria R.K., Singh J., Johri R.K., Qazi G.N. The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats. Phytomedicine 2008, 15:408-415.
57. Singleton V.L., Orthofer R., Lamuela-Raventos R.M. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol. 1999, 299:152-178.
58. Smith G.S., Mercer D.W., Cross J.M., Barreto J.C., Miller T.A. Gastric injury induced by ethanol and ischemia-reperfusion in the rat. Dig. Dis. Sci. 1996, 41:1157-1164.
59. Swarnakar S., Ganguly K., Kundu P., Banerjee A., Maity P., Sharma A.V. Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. J. Biol. Chem. 2005, 280:9409-9415.
60. Vinayagam A., Sudha N. Antioxidant activity of methanolic extracts of leaves and flowers of Nerium indicum. Int. J. Pharm. Sci. Res. 2011, 2:1548-1553.
61. Wong P.Y.Y., Kitts D.D. Studies on the dual antioxidant and antibacterial properties of parsley (Petroselinum crispum) and cilantro (Coriandrum sativum) extracts. Food Chem. 2006, 97:505-515.
62. Yuan Y., Padol I.T., Hunt R.H. Peptic ulcer disease today. Nat. Clin. Pract. Gastroenterol. Hepatol. 2006, 3:80-89.
63. Zhang Z., Jin J., Shi L. Antioxidant activity of the derivatives of polysaccharide extracted from a Chinese medical herb (Ramulus mori). Food Sci. Technol. Res. 2008, 14:160-168.
64. Zhong X.K., Jin X., Lai F.Y., Lin Q.S., Jiang J.G. Chemical analysis and antioxidant activities in vitro of polysaccharide extracted from Opuntia ficus indica Mill. cultivated in China. Carbohydr. Polym. 2010, 82:722-727.
65. Zhu Q.Y., Hackman R.M., Ensunsa J.L., Holt R.R., Keen C.L. Antioxidative activities of Oolong tea. J. Agric. Food Chem. 2002, 50:6929-6934.