-
1
-
-
41149149301
-
Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B
-
10.1101/gad.1643908, 2394721,2394721, 18347089
-
Hennighausen L, Robinson GW. Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B. Genes Dev 2008, 22:711-721. 10.1101/gad.1643908, 2394721,2394721, 18347089.
-
(2008)
Genes Dev
, vol.22
, pp. 711-721
-
-
Hennighausen, L.1
Robinson, G.W.2
-
2
-
-
33748158716
-
The Biological Functions of the Versatile Transcription Factors STAT3 and STAT5 and New Strategies for their Targeted Inhibition
-
10.1007/s10911-006-9014-4, 16947086
-
Desrivieres S, Kunz C, Barash I, Vafaizadeh V, Borghouts C, Groner B. The Biological Functions of the Versatile Transcription Factors STAT3 and STAT5 and New Strategies for their Targeted Inhibition. J Mammary Gland Biol Neoplasia 2006, 11:75-87. 10.1007/s10911-006-9014-4, 16947086.
-
(2006)
J Mammary Gland Biol Neoplasia
, vol.11
, pp. 75-87
-
-
Desrivieres, S.1
Kunz, C.2
Barash, I.3
Vafaizadeh, V.4
Borghouts, C.5
Groner, B.6
-
3
-
-
78650528780
-
The role of Stat5 transcription factors as tumor suppressors or oncogenes
-
Ferbeyre G, Moriggl R. The role of Stat5 transcription factors as tumor suppressors or oncogenes. Biochim Biophys Acta 2011, 1815:104-114.
-
(2011)
Biochim Biophys Acta
, vol.1815
, pp. 104-114
-
-
Ferbeyre, G.1
Moriggl, R.2
-
4
-
-
7944233465
-
Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis
-
10.1038/sj.onc.1208159, 15489919
-
Silva CM. Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis. Oncogene 2004, 23:8017-8023. 10.1038/sj.onc.1208159, 15489919.
-
(2004)
Oncogene
, vol.23
, pp. 8017-8023
-
-
Silva, C.M.1
-
5
-
-
0029115640
-
Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue
-
10.1073/pnas.92.19.8831, 41061, 7568026
-
Liu X, Robinson GW, Gouilleux F, Groner B, Hennighausen L. Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proc Natl Acad Sci USA 1995, 92:8831-8835. 10.1073/pnas.92.19.8831, 41061, 7568026.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 8831-8835
-
-
Liu, X.1
Robinson, G.W.2
Gouilleux, F.3
Groner, B.4
Hennighausen, L.5
-
6
-
-
0031057929
-
Stat5a is mandatory for adult mammary gland development and lactogenesis
-
10.1101/gad.11.2.179, 9009201
-
Liu X, Robinson GW, Wagner KU, Garrett L, Wynshaw-Boris A, Hennighausen L. Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev 1997, 11:179-186. 10.1101/gad.11.2.179, 9009201.
-
(1997)
Genes Dev
, vol.11
, pp. 179-186
-
-
Liu, X.1
Robinson, G.W.2
Wagner, K.U.3
Garrett, L.4
Wynshaw-Boris, A.5
Hennighausen, L.6
-
7
-
-
0031240308
-
Developing a mammary gland is a stat affair
-
10.1023/A:1026347313096, 10935024
-
Hennighausen L, Robinson GW, Wagner KU, Liu X. Developing a mammary gland is a stat affair. J Mammary Gland Biol Neoplasia 1997, 2:365-372. 10.1023/A:1026347313096, 10935024.
-
(1997)
J Mammary Gland Biol Neoplasia
, vol.2
, pp. 365-372
-
-
Hennighausen, L.1
Robinson, G.W.2
Wagner, K.U.3
Liu, X.4
-
8
-
-
0030961803
-
Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution
-
10.1073/pnas.94.7.3425, 20386, 9096410
-
Li M, Liu X, Robinson G, Bar-Peled U, Wagner KU, Young WS, Hennighausen L, Furth PA. Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution. Proc Natl Acad Sci USA 1997, 94:3425-3430. 10.1073/pnas.94.7.3425, 20386, 9096410.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 3425-3430
-
-
Li, M.1
Liu, X.2
Robinson, G.3
Bar-Peled, U.4
Wagner, K.U.5
Young, W.S.6
Hennighausen, L.7
Furth, P.A.8
-
9
-
-
0031671474
-
Functional rescue of Stat5a-null mammary tissue through the activation of compensating signals including Stat5b
-
Liu X, Gallego MI, Smith GH, Robinson GW, Hennighausen L. Functional rescue of Stat5a-null mammary tissue through the activation of compensating signals including Stat5b. Cell Growth Differ 1998, 9:795-803.
-
(1998)
Cell Growth Differ
, vol.9
, pp. 795-803
-
-
Liu, X.1
Gallego, M.I.2
Smith, G.H.3
Robinson, G.W.4
Hennighausen, L.5
-
10
-
-
0030833570
-
Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression
-
10.1073/pnas.94.14.7239, 23803, 9207075
-
Udy GB, Towers RP, Snell RG, Wilkins RJ, Park SH, Ram PA, Waxman DJ, Davey HW. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc Natl Acad Sci USA 1997, 94:7239-7244. 10.1073/pnas.94.14.7239, 23803, 9207075.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 7239-7244
-
-
Udy, G.B.1
Towers, R.P.2
Snell, R.G.3
Wilkins, R.J.4
Park, S.H.5
Ram, P.A.6
Waxman, D.J.7
Davey, H.W.8
-
11
-
-
79953116194
-
Activation of c-Src/HER1/STAT5b and HER1/ERK1/2 signaling pathways and cell migration by hexachlorobenzene in MDAMB-231 human breast cancer cell line
-
10.1093/toxsci/kfq390, 21205633
-
Pontillo C, Garcia M, Pena D, Cocca C, Chiappini F, Alvarez L, Kleiman de Pisarev D, Randi A. Activation of c-Src/HER1/STAT5b and HER1/ERK1/2 signaling pathways and cell migration by hexachlorobenzene in MDAMB-231 human breast cancer cell line. Toxicol Sci 2011, 120:284-296. 10.1093/toxsci/kfq390, 21205633.
-
(2011)
Toxicol Sci
, vol.120
, pp. 284-296
-
-
Pontillo, C.1
Garcia, M.2
Pena, D.3
Cocca, C.4
Chiappini, F.5
Alvarez, L.6
Kleiman de Pisarev, D.7
Randi, A.8
-
12
-
-
77950425377
-
Hemin inhibits cyclin D1 and IGF-1 expression via STAT5b under hypoxia in ERalpha-negative MDA-MB 231 breast cancer cells
-
Lim E-J, Joung Y-H, Jung S-M, Park SH, Park JH, Kim SY, Hwang TS, Hong DY, Chung SC, Ye S-K, Moon E-S, Park EU, Park T, Chung I-M, Yang YM. Hemin inhibits cyclin D1 and IGF-1 expression via STAT5b under hypoxia in ERalpha-negative MDA-MB 231 breast cancer cells. Int J Oncol 2010, 36:1243-1251.
-
(2010)
Int J Oncol
, vol.36
, pp. 1243-1251
-
-
Lim, E.-J.1
Joung, Y.-H.2
Jung, S.-M.3
Park, S.H.4
Park, J.H.5
Kim, S.Y.6
Hwang, T.S.7
Hong, D.Y.8
Chung, S.C.9
Ye, S.-K.10
Moon, E.-S.11
Park, E.U.12
Park, T.13
Chung, I.-M.14
Yang, Y.M.15
-
13
-
-
73649093445
-
Signal transducer and activator of transcription (STAT)-5A and STAT5B differentially regulate human mammary carcinoma cell behavior
-
10.1210/en.2009-0651, 19966185
-
Tang J-Z, Zuo Z-H, Kong X-J, Steiner M, Yin Z, Perry JK, Zhu T, Liu D-X, Lobie PE. Signal transducer and activator of transcription (STAT)-5A and STAT5B differentially regulate human mammary carcinoma cell behavior. Endocrinology 2010, 151:43-55. 10.1210/en.2009-0651, 19966185.
-
(2010)
Endocrinology
, vol.151
, pp. 43-55
-
-
Tang, J.-Z.1
Zuo, Z.-H.2
Kong, X.-J.3
Steiner, M.4
Yin, Z.5
Perry, J.K.6
Zhu, T.7
Liu, D.-X.8
Lobie, P.E.9
-
14
-
-
77449143515
-
A novel role for signal transducer and activator of transcription 5b (STAT5b) in beta1-integrinmediated human breast cancer cell migration
-
10.1186/bcr2341, 2750113, 19630967
-
Bernaciak TM, Zareno J, Parsons JT, Silva CM. A novel role for signal transducer and activator of transcription 5b (STAT5b) in beta1-integrinmediated human breast cancer cell migration. Breast Cancer Res 2009, 11:R52. 10.1186/bcr2341, 2750113, 19630967.
-
(2009)
Breast Cancer Res
, vol.11
-
-
Bernaciak, T.M.1
Zareno, J.2
Parsons, J.T.3
Silva, C.M.4
-
15
-
-
54849187900
-
Enhancement of hypoxia-induced apoptosis of human breast cancer cells via STAT5b by momilactone B
-
Joung Y-H, Lim E-J, Kim M-S, Lim SD, Yoon S-Y, Lim YC, Yoo YB, Ye S-K, Park T, Chung I-M, Bae K-Y, Yang YM. Enhancement of hypoxia-induced apoptosis of human breast cancer cells via STAT5b by momilactone B. Int J Oncol 2008, 33:477-484.
-
(2008)
Int J Oncol
, vol.33
, pp. 477-484
-
-
Joung, Y.-H.1
Lim, E.-J.2
Kim, M.-S.3
Lim, S.D.4
Yoon, S.-Y.5
Lim, Y.C.6
Yoo, Y.B.7
Ye, S.-K.8
Park, T.9
Chung, I.-M.10
Bae, K.-Y.11
Yang, Y.M.12
-
16
-
-
48249132499
-
Signal transducer and activator of transcription 5b, c-Src, and epidermal growth factor receptor signaling play integral roles in estrogen-stimulated proliferation of estrogen receptor-positive breast cancer cells
-
10.1210/me.2007-0419, 2505329, 18550772
-
Fox EM, Bernaciak TM, Wen J, Weaver AM, Shupnik MA, Silva CM. Signal transducer and activator of transcription 5b, c-Src, and epidermal growth factor receptor signaling play integral roles in estrogen-stimulated proliferation of estrogen receptor-positive breast cancer cells. Mol Endocrinol 2008, 22:1781-1796. 10.1210/me.2007-0419, 2505329, 18550772.
-
(2008)
Mol Endocrinol
, vol.22
, pp. 1781-1796
-
-
Fox, E.M.1
Bernaciak, T.M.2
Wen, J.3
Weaver, A.M.4
Shupnik, M.A.5
Silva, C.M.6
-
17
-
-
45849116295
-
Signal transducer and activator of transcription 5A/B in prostate and breast cancers
-
10.1677/ERC-08-0013, 18508994
-
Tan SH, Nevalainen MT. Signal transducer and activator of transcription 5A/B in prostate and breast cancers. Endocr Relat Cancer 2008, 15:367-390. 10.1677/ERC-08-0013, 18508994.
-
(2008)
Endocr Relat Cancer
, vol.15
, pp. 367-390
-
-
Tan, S.H.1
Nevalainen, M.T.2
-
18
-
-
0037936545
-
Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands
-
10.1083/jcb.200212066, 2172951, 12732616
-
Wang R-A, Vadlamudi RK, Bagheri-Yarmand R, Beuvink I, Hynes NE, Kumar R. Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands. J Cell Biol 2003, 161:583-592. 10.1083/jcb.200212066, 2172951, 12732616.
-
(2003)
J Cell Biol
, vol.161
, pp. 583-592
-
-
Wang, R.-A.1
Vadlamudi, R.K.2
Bagheri-Yarmand, R.3
Beuvink, I.4
Hynes, N.E.5
Kumar, R.6
-
19
-
-
78650210970
-
PTP1B suppresses prolactin activation of Stat5 in breast cancer cells
-
10.2353/ajpath.2010.090399, 20952588
-
Johnson KJ, Peck AR, Liu C, Tran TH, Utama FE, Sjolund AB, Schaber JD, Witkiewicz AK, Rui H. PTP1B suppresses prolactin activation of Stat5 in breast cancer cells. Am J Pathol 2010, 177:2971-2983. 10.2353/ajpath.2010.090399, 20952588.
-
(2010)
Am J Pathol
, vol.177
, pp. 2971-2983
-
-
Johnson, K.J.1
Peck, A.R.2
Liu, C.3
Tran, T.H.4
Utama, F.E.5
Sjolund, A.B.6
Schaber, J.D.7
Witkiewicz, A.K.8
Rui, H.9
-
20
-
-
40449135440
-
Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression
-
10.1007/s10911-008-9062-z, 18228120
-
Wagner KU, Rui H. Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression. J Mammary Gland Biol Neoplasia 2008, 13:93-103. 10.1007/s10911-008-9062-z, 18228120.
-
(2008)
J Mammary Gland Biol Neoplasia
, vol.13
, pp. 93-103
-
-
Wagner, K.U.1
Rui, H.2
-
21
-
-
70350091566
-
Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A
-
10.1101/gad.1840109, 2764497, 19833766
-
Yamaji D, Na R, Feuermann Y, Pechhold S, Chen W, Robinson GW, Hennighausen L. Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A. Genes Dev 2009, 23:2382-2387. 10.1101/gad.1840109, 2764497, 19833766.
-
(2009)
Genes Dev
, vol.23
, pp. 2382-2387
-
-
Yamaji, D.1
Na, R.2
Feuermann, Y.3
Pechhold, S.4
Chen, W.5
Robinson, G.W.6
Hennighausen, L.7
-
22
-
-
77953844220
-
New concepts in prolactin biology
-
10.1677/JOE-10-0069, 20371569
-
Bernichtein S, Touraine P, Goffin V. New concepts in prolactin biology. J Endocrinol 2010, 206:1-11. 10.1677/JOE-10-0069, 20371569.
-
(2010)
J Endocrinol
, vol.206
, pp. 1-11
-
-
Bernichtein, S.1
Touraine, P.2
Goffin, V.3
-
23
-
-
70349758953
-
Ovarian hormones are not required for PRL-induced mammary tumorigenesis, but estrogen enhances neoplastic processes
-
10.1677/JOE-09-0221, 2841967, 19635758
-
Arendt LM, Evans LC, Rugowski DE, Garcia-Barchino MJ, Rui H, Schuler LA. Ovarian hormones are not required for PRL-induced mammary tumorigenesis, but estrogen enhances neoplastic processes. J Endocrinol 2009, 203:99-110. 10.1677/JOE-09-0221, 2841967, 19635758.
-
(2009)
J Endocrinol
, vol.203
, pp. 99-110
-
-
Arendt, L.M.1
Evans, L.C.2
Rugowski, D.E.3
Garcia-Barchino, M.J.4
Rui, H.5
Schuler, L.A.6
-
24
-
-
84860390313
-
Prolactin-induced mouse mammary carcinomas model estrogen resistant luminal breast cancer
-
10.1186/bcr2819, 3109579, 21276249
-
Arendt LM, Rugowski DE, Grafwallner-Huseth TA, Garcia-Barchino MJ, Rui H, Schuler LA. Prolactin-induced mouse mammary carcinomas model estrogen resistant luminal breast cancer. Breast Cancer Res 2011, 13:R11. 10.1186/bcr2819, 3109579, 21276249.
-
(2011)
Breast Cancer Res
, vol.13
-
-
Arendt, L.M.1
Rugowski, D.E.2
Grafwallner-Huseth, T.A.3
Garcia-Barchino, M.J.4
Rui, H.5
Schuler, L.A.6
-
25
-
-
0037195519
-
The role of prolactin and growth hormone in mammary gland development
-
10.1016/S0303-7207(02)00286-1, 12431805
-
Kelly PA, Bachelot A, Kedzia C, Hennighausen L, Ormandy CJ, Kopchick JJ, Binart N. The role of prolactin and growth hormone in mammary gland development. Mol Cell Endocrinol 2002, 197:127-131. 10.1016/S0303-7207(02)00286-1, 12431805.
-
(2002)
Mol Cell Endocrinol
, vol.197
, pp. 127-131
-
-
Kelly, P.A.1
Bachelot, A.2
Kedzia, C.3
Hennighausen, L.4
Ormandy, C.J.5
Kopchick, J.J.6
Binart, N.7
-
26
-
-
34548348216
-
Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways
-
10.1210/me.2007-0173, 17550976
-
Neilson LM, Zhu J, Xie J, Malabarba MG, Sakamoto K, Wagner K-U, Kirken RA, Rui H. Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways. Mol Endocrinol 2007, 21:2218-2232. 10.1210/me.2007-0173, 17550976.
-
(2007)
Mol Endocrinol
, vol.21
, pp. 2218-2232
-
-
Neilson, L.M.1
Zhu, J.2
Xie, J.3
Malabarba, M.G.4
Sakamoto, K.5
Wagner, K.-U.6
Kirken, R.A.7
Rui, H.8
-
27
-
-
40749130891
-
Lactation failure in Src knockout mice is due to impaired secretory activation
-
10.1186/1471-213X-8-6, 2266720, 18215306
-
Watkin H, Richert MM, Lewis A, Terrell K, McManaman JP, Anderson SM. Lactation failure in Src knockout mice is due to impaired secretory activation. BMC Dev Biol 2008, 8:6. 10.1186/1471-213X-8-6, 2266720, 18215306.
-
(2008)
BMC Dev Biol
, vol.8
, pp. 6
-
-
Watkin, H.1
Richert, M.M.2
Lewis, A.3
Terrell, K.4
McManaman, J.P.5
Anderson, S.M.6
-
28
-
-
63649099281
-
Novel actions of estrogen to promote proliferation: integration of cytoplasmic and nuclear pathways
-
10.1016/j.steroids.2008.10.014, 2702758, 18996136
-
Fox EM, Andrade J, Shupnik MA. Novel actions of estrogen to promote proliferation: integration of cytoplasmic and nuclear pathways. Steroids 2009, 74:622-627. 10.1016/j.steroids.2008.10.014, 2702758, 18996136.
-
(2009)
Steroids
, vol.74
, pp. 622-627
-
-
Fox, E.M.1
Andrade, J.2
Shupnik, M.A.3
-
29
-
-
71549128378
-
A non-catalytic function of the Src family tyrosine kinases controls prolactin-induced Jak2 signaling
-
10.1016/j.cellsig.2009.10.013, 19892015
-
Garcia-Martinez JM, Calcabrini A, Gonzalez L, Martin-Forero E, Agullo-Ortuno MT, Simon V, Watkin H, Anderson SM, Roche S, Martin-Perez J. A non-catalytic function of the Src family tyrosine kinases controls prolactin-induced Jak2 signaling. Cell Signal 2010, 22:415-426. 10.1016/j.cellsig.2009.10.013, 19892015.
-
(2010)
Cell Signal
, vol.22
, pp. 415-426
-
-
Garcia-Martinez, J.M.1
Calcabrini, A.2
Gonzalez, L.3
Martin-Forero, E.4
Agullo-Ortuno, M.T.5
Simon, V.6
Watkin, H.7
Anderson, S.M.8
Roche, S.9
Martin-Perez, J.10
-
30
-
-
78249236544
-
Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation
-
10.1016/j.ccr.2010.10.025, 21075308
-
Liang K, Esteva FJ, Albarracin C, Stemke-Hale K, Lu Y, Bianchini G, Yang C-Y, Li Y, Li X, Chen C-T, Mills GB, Hortobagyi GN, Mendelsohn J, Hung M-C, Fan Z. Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation. Cancer Cell 2010, 18:423-435. 10.1016/j.ccr.2010.10.025, 21075308.
-
(2010)
Cancer Cell
, vol.18
, pp. 423-435
-
-
Liang, K.1
Esteva, F.J.2
Albarracin, C.3
Stemke-Hale, K.4
Lu, Y.5
Bianchini, G.6
Yang, C.-Y.7
Li, Y.8
Li, X.9
Chen, C.-T.10
Mills, G.B.11
Hortobagyi, G.N.12
Mendelsohn, J.13
Hung, M.-C.14
Fan, Z.15
-
31
-
-
78249241503
-
Unfavorable drug interactions in targeted breast cancer therapy
-
10.1016/j.ccr.2010.10.027, 21075302
-
Groner B, Hynes NE. Unfavorable drug interactions in targeted breast cancer therapy. Cancer Cell 2010, 18:401-402. 10.1016/j.ccr.2010.10.027, 21075302.
-
(2010)
Cancer Cell
, vol.18
, pp. 401-402
-
-
Groner, B.1
Hynes, N.E.2
-
32
-
-
0035162210
-
Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects
-
10.1006/dbio.2000.9961, 11133161
-
Gallego MI, Binart N, Robinson GW, Okagaki R, Coschigano KT, Perry J, Kopchick JJ, Oka T, Kelly PA, Hennighausen L. Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects. Dev Biol 2001, 229:163-175. 10.1006/dbio.2000.9961, 11133161.
-
(2001)
Dev Biol
, vol.229
, pp. 163-175
-
-
Gallego, M.I.1
Binart, N.2
Robinson, G.W.3
Okagaki, R.4
Coschigano, K.T.5
Perry, J.6
Kopchick, J.J.7
Oka, T.8
Kelly, P.A.9
Hennighausen, L.10
-
33
-
-
65549104656
-
Somatic mutations of ErbB4: selective loss-of-function phenotype affecting signal transduction pathways in cancer
-
Tvorogov D, Sundvall M, Kurppa K, Hollmen M, Repo S, Johnson MS, Elenius K. Somatic mutations of ErbB4: selective loss-of-function phenotype affecting signal transduction pathways in cancer. J Biol Chem 2009, 284:5582-5591.
-
(2009)
J Biol Chem
, vol.284
, pp. 5582-5591
-
-
Tvorogov, D.1
Sundvall, M.2
Kurppa, K.3
Hollmen, M.4
Repo, S.5
Johnson, M.S.6
Elenius, K.7
-
34
-
-
34548555698
-
Mapping ErbB receptors on breast cancer cell membranes during signal transduction
-
10.1242/jcs.007658, 17652160
-
Yang S, Raymond-Stintz MA, Ying W, Zhang J, Lidke DS, Steinberg SL, Williams L, Oliver JM, Wilson BS. Mapping ErbB receptors on breast cancer cell membranes during signal transduction. J Cell Sci 2007, 120:2763-2773. 10.1242/jcs.007658, 17652160.
-
(2007)
J Cell Sci
, vol.120
, pp. 2763-2773
-
-
Yang, S.1
Raymond-Stintz, M.A.2
Ying, W.3
Zhang, J.4
Lidke, D.S.5
Steinberg, S.L.6
Williams, L.7
Oliver, J.M.8
Wilson, B.S.9
-
35
-
-
0033523775
-
ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation
-
10.1083/jcb.147.1.77, 2164978, 10508857
-
Jones FE, Welte T, Fu XY, Stern DF. ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation. J Cell Biol 1999, 147:77-88. 10.1083/jcb.147.1.77, 2164978, 10508857.
-
(1999)
J Cell Biol
, vol.147
, pp. 77-88
-
-
Jones, F.E.1
Welte, T.2
Fu, X.Y.3
Stern, D.F.4
-
36
-
-
65549119187
-
Insulin-like growth factor-I receptor signal transduction and the Janus Kinase/Signal Transducer and Activator of Transcription (JAK-STAT) pathway
-
10.1002/biof.20, 19319849
-
Himpe E, Kooijman R. Insulin-like growth factor-I receptor signal transduction and the Janus Kinase/Signal Transducer and Activator of Transcription (JAK-STAT) pathway. Biofactors 2009, 35:76-81. 10.1002/biof.20, 19319849.
-
(2009)
Biofactors
, vol.35
, pp. 76-81
-
-
Himpe, E.1
Kooijman, R.2
-
37
-
-
59449093147
-
Transcriptional profiles of progestogen effects in the postmenopausal breast
-
10.1007/s10549-008-0003-8, 18404370
-
Wood CE, Register TC, Cline JM. Transcriptional profiles of progestogen effects in the postmenopausal breast. Breast Cancer Res Treat 2009, 114:233-242. 10.1007/s10549-008-0003-8, 18404370.
-
(2009)
Breast Cancer Res Treat
, vol.114
, pp. 233-242
-
-
Wood, C.E.1
Register, T.C.2
Cline, J.M.3
-
38
-
-
0032553304
-
Convergence of progesterone and epidermal growth factor signaling in breast cancer. Potentiation of mitogen-activated protein kinase pathways
-
10.1074/jbc.273.47.31308, 9813039
-
Lange CA, Richer JK, Shen T, Horwitz KB. Convergence of progesterone and epidermal growth factor signaling in breast cancer. Potentiation of mitogen-activated protein kinase pathways. J Biol Chem 1998, 273:31308-31316. 10.1074/jbc.273.47.31308, 9813039.
-
(1998)
J Biol Chem
, vol.273
, pp. 31308-31316
-
-
Lange, C.A.1
Richer, J.K.2
Shen, T.3
Horwitz, K.B.4
-
39
-
-
37549032769
-
Estrogen and progesterone are critical regulators of Stat5a expression in the mouse mammary gland
-
2194608, 17884938
-
Santos SJ, Haslam SZ, Conrad SE. Estrogen and progesterone are critical regulators of Stat5a expression in the mouse mammary gland. Endocrinology 2008, 149:329-338. 2194608, 17884938.
-
(2008)
Endocrinology
, vol.149
, pp. 329-338
-
-
Santos, S.J.1
Haslam, S.Z.2
Conrad, S.E.3
-
40
-
-
0032531138
-
EGF modulates expression of STAT5 in mammary epithelial cells
-
10.1006/excr.1998.4160, 9743594
-
Petersen H, Haldosen LA. EGF modulates expression of STAT5 in mammary epithelial cells. Exp Cell Res 1998, 243:347-358. 10.1006/excr.1998.4160, 9743594.
-
(1998)
Exp Cell Res
, vol.243
, pp. 347-358
-
-
Petersen, H.1
Haldosen, L.A.2
-
41
-
-
77949423550
-
Insulin, a key regulator of hormone responsive milk protein synthesis during lactogenesis in murine mammary explants
-
10.1007/s10142-009-0140-0, 19830464
-
Menzies KK, Lee HJ, Lefevre C, Ormandy CJ, Macmillan KL, Nicholas KR. Insulin, a key regulator of hormone responsive milk protein synthesis during lactogenesis in murine mammary explants. Funct Integr Genomics 2010, 10:87-95. 10.1007/s10142-009-0140-0, 19830464.
-
(2010)
Funct Integr Genomics
, vol.10
, pp. 87-95
-
-
Menzies, K.K.1
Lee, H.J.2
Lefevre, C.3
Ormandy, C.J.4
Macmillan, K.L.5
Nicholas, K.R.6
-
42
-
-
67349124434
-
Elf5 conditional knockout mice reveal its role as a master regulator in mammary alveolar development: failure of Stat5 activation and functional differentiation in the absence of Elf5
-
10.1016/j.ydbio.2009.02.032, 19269284
-
Choi YS, Chakrabarti R, Escamilla-Hernandez R, Sinha S. Elf5 conditional knockout mice reveal its role as a master regulator in mammary alveolar development: failure of Stat5 activation and functional differentiation in the absence of Elf5. Dev Biol 2009, 329:227-241. 10.1016/j.ydbio.2009.02.032, 19269284.
-
(2009)
Dev Biol
, vol.329
, pp. 227-241
-
-
Choi, Y.S.1
Chakrabarti, R.2
Escamilla-Hernandez, R.3
Sinha, S.4
-
43
-
-
77953939072
-
Role of ERalpha in the differential response of Stat5a loss in susceptibility to mammary preneoplasia and DMBA-induced carcinogenesis
-
10.1093/carcin/bgq048, 2878361, 20181624
-
Miermont AM, Parrish AR, Furth PA. Role of ERalpha in the differential response of Stat5a loss in susceptibility to mammary preneoplasia and DMBA-induced carcinogenesis. Carcinogenesis 2010, 31:1124-1131. 10.1093/carcin/bgq048, 2878361, 20181624.
-
(2010)
Carcinogenesis
, vol.31
, pp. 1124-1131
-
-
Miermont, A.M.1
Parrish, A.R.2
Furth, P.A.3
-
44
-
-
27644506173
-
Estrogen negatively regulates epidermal growth factor (EGF)-mediated signal transducer and activator of transcription 5 signaling in human EGF family receptor-overexpressing breast cancer cells
-
10.1210/me.2004-0439, 15976008
-
Boerner JL, Gibson MA, Fox EM, Posner ED, Parsons SJ, Silva CM, Shupnik MA. Estrogen negatively regulates epidermal growth factor (EGF)-mediated signal transducer and activator of transcription 5 signaling in human EGF family receptor-overexpressing breast cancer cells. Mol Endocrinol 2005, 19:2660-2670. 10.1210/me.2004-0439, 15976008.
-
(2005)
Mol Endocrinol
, vol.19
, pp. 2660-2670
-
-
Boerner, J.L.1
Gibson, M.A.2
Fox, E.M.3
Posner, E.D.4
Parsons, S.J.5
Silva, C.M.6
Shupnik, M.A.7
-
45
-
-
0034894006
-
Cross-talk between Stat5b and estrogen receptor-alpha and -beta in mammary epithelial cells
-
10.1677/jme.0.0270093, 11463580
-
Bjornstrom L, Kilic E, Norman M, Parker MG, Sjoberg M. Cross-talk between Stat5b and estrogen receptor-alpha and -beta in mammary epithelial cells. J Mol Endocrinol 2001, 27:93-106. 10.1677/jme.0.0270093, 11463580.
-
(2001)
J Mol Endocrinol
, vol.27
, pp. 93-106
-
-
Bjornstrom, L.1
Kilic, E.2
Norman, M.3
Parker, M.G.4
Sjoberg, M.5
-
46
-
-
33846032306
-
Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells
-
Buser AC, Gass-Handel EK, Wyszomierski SL, Doppler W, Leonhardt SA, Schaack J, Rosen JM, Watkin H, Anderson SM, Edwards DP. Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells. Mol Endocrinol 2007, 21:106-125.
-
(2007)
Mol Endocrinol
, vol.21
, pp. 106-125
-
-
Buser, A.C.1
Gass-Handel, E.K.2
Wyszomierski, S.L.3
Doppler, W.4
Leonhardt, S.A.5
Schaack, J.6
Rosen, J.M.7
Watkin, H.8
Anderson, S.M.9
Edwards, D.P.10
-
47
-
-
78649805673
-
Glucocorticoidinduced impairment of mammary gland involution is associated with STAT5 and STAT3 signaling modulation
-
10.1210/en.2010-0517, 20881248
-
Bertucci PY, Quaglino A, Pozzi AG, Kordon EC, Pecci A. Glucocorticoidinduced impairment of mammary gland involution is associated with STAT5 and STAT3 signaling modulation. Endocrinology 2010, 151:5730-5740. 10.1210/en.2010-0517, 20881248.
-
(2010)
Endocrinology
, vol.151
, pp. 5730-5740
-
-
Bertucci, P.Y.1
Quaglino, A.2
Pozzi, A.G.3
Kordon, E.C.4
Pecci, A.5
-
48
-
-
33845970592
-
Glucocorticoids repress bcl-X expression in lymphoid cells by recruiting STAT5B to the P4 promoter
-
10.1074/jbc.M602408200, 16959781
-
Rocha-Viegas L, Vicent GP, Barañao JL, Beato M, Pecci A. Glucocorticoids repress bcl-X expression in lymphoid cells by recruiting STAT5B to the P4 promoter. J Biol Chem 2006, 281:33959-33970. 10.1074/jbc.M602408200, 16959781.
-
(2006)
J Biol Chem
, vol.281
, pp. 33959-33970
-
-
Rocha-Viegas, L.1
Vicent, G.P.2
Barañao, J.L.3
Beato, M.4
Pecci, A.5
-
49
-
-
0242664926
-
NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain
-
10.1074/jbc.M303644200, 12954634
-
Litterst CM, Kliem S, Marilley D, Pfitzner E. NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain. J Biol Chem 2003, 278:45340-45351. 10.1074/jbc.M303644200, 12954634.
-
(2003)
J Biol Chem
, vol.278
, pp. 45340-45351
-
-
Litterst, C.M.1
Kliem, S.2
Marilley, D.3
Pfitzner, E.4
-
50
-
-
0031899361
-
Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells
-
121408, 9528750
-
Cella N, Groner B, Hynes NE. Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells. Mol Cell Biol 1998, 18:1783-1792. 121408, 9528750.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 1783-1792
-
-
Cella, N.1
Groner, B.2
Hynes, N.E.3
-
51
-
-
77649341620
-
PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development
-
10.1038/emboj.2009.406, 2837170, 20075866
-
Chan C-B, Liu X, Ensslin MA, Dillehay DL, Ormandy CJ, Sohn P, Serra R, Ye K. PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development. EMBO J 2010, 29:956-968. 10.1038/emboj.2009.406, 2837170, 20075866.
-
(2010)
EMBO J
, vol.29
, pp. 956-968
-
-
Chan, C.-B.1
Liu, X.2
Ensslin, M.A.3
Dillehay, D.L.4
Ormandy, C.J.5
Sohn, P.6
Serra, R.7
Ye, K.8
-
52
-
-
78650923969
-
Akt is required for Stat5 activation and mammary differentiation
-
10.1186/bcr2640, 3096959, 20849614
-
Chen CC, Boxer RB, Stairs DB, Portocarrero CP, Horton RH, Alvarez JV, Birnbaum MJ, Chodosh LA. Akt is required for Stat5 activation and mammary differentiation. Breast Cancer Res 2010, 12:R72. 10.1186/bcr2640, 3096959, 20849614.
-
(2010)
Breast Cancer Res
, vol.12
-
-
Chen, C.C.1
Boxer, R.B.2
Stairs, D.B.3
Portocarrero, C.P.4
Horton, R.H.5
Alvarez, J.V.6
Birnbaum, M.J.7
Chodosh, L.A.8
-
53
-
-
63849258679
-
Role of c-Myb during prolactin-induced signal transducer and activator of transcription 5a signaling in breast cancer cells
-
10.1210/en.2008-1079, 2659289, 19036881
-
Fang F, Rycyzyn MA, Clevenger CV. Role of c-Myb during prolactin-induced signal transducer and activator of transcription 5a signaling in breast cancer cells. Endocrinology 2009, 150:1597-1606. 10.1210/en.2008-1079, 2659289, 19036881.
-
(2009)
Endocrinology
, vol.150
, pp. 1597-1606
-
-
Fang, F.1
Rycyzyn, M.A.2
Clevenger, C.V.3
-
54
-
-
79952774372
-
Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells
-
10.1111/j.1349-7006.2010.01842.x, 21205088
-
Ikeda O, Mizushima A, Sekine Y, Yamamoto C, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T. Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells. Cancer Sci 2011, 102:756-761. 10.1111/j.1349-7006.2010.01842.x, 21205088.
-
(2011)
Cancer Sci
, vol.102
, pp. 756-761
-
-
Ikeda, O.1
Mizushima, A.2
Sekine, Y.3
Yamamoto, C.4
Muromoto, R.5
Nanbo, A.6
Oritani, K.7
Yoshimura, A.8
Matsuda, T.9
-
55
-
-
30344437854
-
Caveolin-1 deficiency (-/-) conveys premalignant alterations in mammary epithelia, with abnormal lumen formation, growth factor independence, and cell invasiveness
-
10.2353/ajpath.2006.050429, 1592656, 16400031
-
Sotgia F, Williams TM, Schubert W, Medina F, Minetti C, Pestell RG, Lisanti MP. Caveolin-1 deficiency (-/-) conveys premalignant alterations in mammary epithelia, with abnormal lumen formation, growth factor independence, and cell invasiveness. Am J Pathol 2006, 168:292-309. 10.2353/ajpath.2006.050429, 1592656, 16400031.
-
(2006)
Am J Pathol
, vol.168
, pp. 292-309
-
-
Sotgia, F.1
Williams, T.M.2
Schubert, W.3
Medina, F.4
Minetti, C.5
Pestell, R.G.6
Lisanti, M.P.7
-
56
-
-
0034878836
-
STAT5b is required for GH-induced liver IGF-I gene expression
-
10.1210/en.142.9.3836, 11517160
-
Davey HW, Xie T, McLachlan MJ, Wilkins RJ, Waxman DJ, Grattan DR. STAT5b is required for GH-induced liver IGF-I gene expression. Endocrinology 2001, 142:3836-3841. 10.1210/en.142.9.3836, 11517160.
-
(2001)
Endocrinology
, vol.142
, pp. 3836-3841
-
-
Davey, H.W.1
Xie, T.2
McLachlan, M.J.3
Wilkins, R.J.4
Waxman, D.J.5
Grattan, D.R.6
-
57
-
-
34547964291
-
Favorable prognostic value of SOCS2 and IGF-I in breast cancer
-
10.1186/1471-2407-7-136, 1948006, 17651480
-
Haffner MC, Petridou B, Peyrat JP, Revillion F, Muller-Holzner E, Daxenbichler G, Marth C, Doppler W. Favorable prognostic value of SOCS2 and IGF-I in breast cancer. BMC Cancer 2007, 7:136. 10.1186/1471-2407-7-136, 1948006, 17651480.
-
(2007)
BMC Cancer
, vol.7
, pp. 136
-
-
Haffner, M.C.1
Petridou, B.2
Peyrat, J.P.3
Revillion, F.4
Muller-Holzner, E.5
Daxenbichler, G.6
Marth, C.7
Doppler, W.8
-
58
-
-
15744398235
-
Identification of a distal STAT5-binding DNA region that may mediate growth hormone regulation of insulin-like growth factor-I gene expression
-
10.1074/jbc.M412808200, 15677453
-
Wang Y, Jiang H. Identification of a distal STAT5-binding DNA region that may mediate growth hormone regulation of insulin-like growth factor-I gene expression. J Biol Chem 2005, 280:10955-10963. 10.1074/jbc.M412808200, 15677453.
-
(2005)
J Biol Chem
, vol.280
, pp. 10955-10963
-
-
Wang, Y.1
Jiang, H.2
-
59
-
-
77956873199
-
Genetic manipulation of individual somatic mammary cells in vivo reveals a master role of STAT5a in inducing alveolar fate commitment and lactogenesis in the absence of reproductive hormones
-
10.1016/j.ydbio.2010.07.027, 20691178
-
Dong J, Tong T, Reynado AM, Rosen JM, Huang S, Li Y. Genetic manipulation of individual somatic mammary cells in vivo reveals a master role of STAT5a in inducing alveolar fate commitment and lactogenesis in the absence of reproductive hormones. Dev Biol 2010, 346:196-203. 10.1016/j.ydbio.2010.07.027, 20691178.
-
(2010)
Dev Biol
, vol.346
, pp. 196-203
-
-
Dong, J.1
Tong, T.2
Reynado, A.M.3
Rosen, J.M.4
Huang, S.5
Li, Y.6
-
60
-
-
7044272580
-
Deregulation of Stat5 expression and activation causes mammary tumors in transgenic mice
-
10.1002/ijc.20484, 15382041
-
Iavnilovitch E, Cardiff RD, Groner B, Barash I. Deregulation of Stat5 expression and activation causes mammary tumors in transgenic mice. Int J Cancer 2004, 112:607-619. 10.1002/ijc.20484, 15382041.
-
(2004)
Int J Cancer
, vol.112
, pp. 607-619
-
-
Iavnilovitch, E.1
Cardiff, R.D.2
Groner, B.3
Barash, I.4
-
61
-
-
77953436551
-
Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1
-
10.1128/MCB.00851-09, 2876679, 20385773
-
Creamer BA, Sakamoto K, Schmidt JW, Triplett AA, Moriggl R, Wagner K-U. Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1. Mol Cell Biol 2010, 30:2957-2970. 10.1128/MCB.00851-09, 2876679, 20385773.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 2957-2970
-
-
Creamer, B.A.1
Sakamoto, K.2
Schmidt, J.W.3
Triplett, A.A.4
Moriggl, R.5
Wagner, K.-U.6
-
62
-
-
77954530773
-
Signal transducer and activator of transcription 5a mediates mammary ductal branching and proliferation in the nulliparous mouse
-
10.1210/en.2009-1282, 2875824, 20392833
-
Santos SJ, Haslam SZ, Conrad SE. Signal transducer and activator of transcription 5a mediates mammary ductal branching and proliferation in the nulliparous mouse. Endocrinology 2010, 151:2876-2885. 10.1210/en.2009-1282, 2875824, 20392833.
-
(2010)
Endocrinology
, vol.151
, pp. 2876-2885
-
-
Santos, S.J.1
Haslam, S.Z.2
Conrad, S.E.3
-
63
-
-
0242495765
-
Receptor activator of NF-kappaB ligand induction via Jak2 and Stat5a in mammary epithelial cells
-
10.1074/jbc.M308545200, 12952963
-
Srivastava S, Matsuda M, Hou Z, Bailey JP, Kitazawa R, Herbst MP, Horseman ND. Receptor activator of NF-kappaB ligand induction via Jak2 and Stat5a in mammary epithelial cells. J Biol Chem 2003, 278:46171-46178. 10.1074/jbc.M308545200, 12952963.
-
(2003)
J Biol Chem
, vol.278
, pp. 46171-46178
-
-
Srivastava, S.1
Matsuda, M.2
Hou, Z.3
Bailey, J.P.4
Kitazawa, R.5
Herbst, M.P.6
Horseman, N.D.7
-
64
-
-
65549094595
-
Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation
-
10.1084/jem.20080003, 2715112, 19332876
-
Hosui A, Kimura A, Yamaji D, Zhu B-M, Na R, Hennighausen L. Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation. J Exp Med 2009, 206:819-831. 10.1084/jem.20080003, 2715112, 19332876.
-
(2009)
J Exp Med
, vol.206
, pp. 819-831
-
-
Hosui, A.1
Kimura, A.2
Yamaji, D.3
Zhu, B.-M.4
Na, R.5
Hennighausen, L.6
-
65
-
-
67649619334
-
Reciprocal effects of STAT5 and STAT3 in breast cancer
-
10.1158/1541-7786.MCR-08-0238, 19491198
-
Walker SR, Nelson EA, Zou L, Chaudhury M, Signoretti S, Richardson A, Frank DA. Reciprocal effects of STAT5 and STAT3 in breast cancer. Mol Cancer Res 2009, 7:966-976. 10.1158/1541-7786.MCR-08-0238, 19491198.
-
(2009)
Mol Cancer Res
, vol.7
, pp. 966-976
-
-
Walker, S.R.1
Nelson, E.A.2
Zou, L.3
Chaudhury, M.4
Signoretti, S.5
Richardson, A.6
Frank, D.A.7
-
66
-
-
77952361681
-
Mammary epithelial reconstitution with genemodified stem cells assigns roles to Stat5 in luminal alveolar cell fate decisions, differentiation, involution, and mammary tumor formation
-
Vafaizadeh V, Klemmt P, Brendel C, Weber K, Doebele C, Britt K, Grez M, Fehse B, Desrivieres S, Groner B. Mammary epithelial reconstitution with genemodified stem cells assigns roles to Stat5 in luminal alveolar cell fate decisions, differentiation, involution, and mammary tumor formation. Stem Cells 2010, 28:928-938.
-
(2010)
Stem Cells
, vol.28
, pp. 928-938
-
-
Vafaizadeh, V.1
Klemmt, P.2
Brendel, C.3
Weber, K.4
Doebele, C.5
Britt, K.6
Grez, M.7
Fehse, B.8
Desrivieres, S.9
Groner, B.10
-
67
-
-
53949100615
-
Different gene-expression profiles for the poorly differentiated carcinoma and the highly differentiated papillary adenocarcinoma in mammary glands support distinct metabolic pathways
-
10.1186/1471-2407-8-270, 2564980, 18811984
-
Eilon T, Barash I. Different gene-expression profiles for the poorly differentiated carcinoma and the highly differentiated papillary adenocarcinoma in mammary glands support distinct metabolic pathways. BMC Cancer 2008, 8:270. 10.1186/1471-2407-8-270, 2564980, 18811984.
-
(2008)
BMC Cancer
, vol.8
, pp. 270
-
-
Eilon, T.1
Barash, I.2
-
68
-
-
0036256358
-
Basal activation of transcription factor signal transducer and activator of transcription (Stat5) in nonpregnant mouse and human breast epithelium
-
10.1210/me.16.5.1108, 11981045
-
Nevalainen MT, Xie J, Bubendorf L, Wagner K-U, Rui H. Basal activation of transcription factor signal transducer and activator of transcription (Stat5) in nonpregnant mouse and human breast epithelium. Mol Endocrinol 2002, 16:1108-1124. 10.1210/me.16.5.1108, 11981045.
-
(2002)
Mol Endocrinol
, vol.16
, pp. 1108-1124
-
-
Nevalainen, M.T.1
Xie, J.2
Bubendorf, L.3
Wagner, K.-U.4
Rui, H.5
-
69
-
-
40249108932
-
The Ets transcription factor Elf5 specifies mammary alveolar cell fate
-
10.1101/gad.1614608, 2259028, 18316476
-
Oakes SR, Naylor MJ, Asselin-Labat M-L, Blazek KD, Gardiner-Garden M, Hilton HN, Kazlauskas M, Pritchard MA, Chodosh LA, Pfeffer PL, Lindeman GJ, Visvader JE, Ormandy CJ. The Ets transcription factor Elf5 specifies mammary alveolar cell fate. Genes Dev 2008, 22:581-586. 10.1101/gad.1614608, 2259028, 18316476.
-
(2008)
Genes Dev
, vol.22
, pp. 581-586
-
-
Oakes, S.R.1
Naylor, M.J.2
Asselin-Labat, M.-L.3
Blazek, K.D.4
Gardiner-Garden, M.5
Hilton, H.N.6
Kazlauskas, M.7
Pritchard, M.A.8
Chodosh, L.A.9
Pfeffer, P.L.10
Lindeman, G.J.11
Visvader, J.E.12
Ormandy, C.J.13
-
70
-
-
0034696398
-
Transforming growth factor alpha and mouse models of human breast cancer
-
10.1038/sj.onc.1203278, 10713694
-
Humphreys RC, Hennighausen L. Transforming growth factor alpha and mouse models of human breast cancer. Oncogene 2000, 19:1085-1091. 10.1038/sj.onc.1203278, 10713694.
-
(2000)
Oncogene
, vol.19
, pp. 1085-1091
-
-
Humphreys, R.C.1
Hennighausen, L.2
-
71
-
-
51449094934
-
Distinct roles of the three Akt isoforms in lactogenic differentiation and involution
-
10.1002/jcp.21518, 2871282, 18561256
-
Maroulakou IG, Oemler W, Naber SP, Klebba I, Kuperwasser C, Tsichlis PN. Distinct roles of the three Akt isoforms in lactogenic differentiation and involution. J Cell Physiol 2008, 217:468-477. 10.1002/jcp.21518, 2871282, 18561256.
-
(2008)
J Cell Physiol
, vol.217
, pp. 468-477
-
-
Maroulakou, I.G.1
Oemler, W.2
Naber, S.P.3
Klebba, I.4
Kuperwasser, C.5
Tsichlis, P.N.6
-
72
-
-
33845939336
-
Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation
-
10.1074/jbc.M607325200, 1761121, 16959766
-
Ke Y, Lesperance J, Zhang EE, Bard-Chapeau EA, Oshima RG, Muller WJ, Feng G-S. Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation. J Biol Chem 2006, 281:34374-34380. 10.1074/jbc.M607325200, 1761121, 16959766.
-
(2006)
J Biol Chem
, vol.281
, pp. 34374-34380
-
-
Ke, Y.1
Lesperance, J.2
Zhang, E.E.3
Bard-Chapeau, E.A.4
Oshima, R.G.5
Muller, W.J.6
Feng, G.-S.7
-
73
-
-
0032540383
-
Regulation of mammary differentiation by extracellular matrix involves protein-tyrosine phosphatases
-
10.1074/jbc.273.16.9495, 9545277
-
Edwards GM, Wilford FH, Liu X, Hennighausen L, Djiane J, Streuli CH. Regulation of mammary differentiation by extracellular matrix involves protein-tyrosine phosphatases. J Biol Chem 1998, 273:9495-9500. 10.1074/jbc.273.16.9495, 9545277.
-
(1998)
J Biol Chem
, vol.273
, pp. 9495-9500
-
-
Edwards, G.M.1
Wilford, F.H.2
Liu, X.3
Hennighausen, L.4
Djiane, J.5
Streuli, C.H.6
-
74
-
-
27944467950
-
Ablation of beta1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation
-
10.1083/jcb.200503144, 2171573, 16301336
-
Naylor MJ, Li N, Cheung J, Lowe ET, Lambert E, Marlow R, Wang P, Schatzmann F, Wintermantel T, Schuetz G, Clarke AR, Mueller U, Hynes NE, Streuli CH. Ablation of beta1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation. J Cell Biol 2005, 171:717-728. 10.1083/jcb.200503144, 2171573, 16301336.
-
(2005)
J Cell Biol
, vol.171
, pp. 717-728
-
-
Naylor, M.J.1
Li, N.2
Cheung, J.3
Lowe, E.T.4
Lambert, E.5
Marlow, R.6
Wang, P.7
Schatzmann, F.8
Wintermantel, T.9
Schuetz, G.10
Clarke, A.R.11
Mueller, U.12
Hynes, N.E.13
Streuli, C.H.14
-
75
-
-
78149370128
-
Dystroglycan controls signaling of multiple hormones through modulation of STAT5 activity
-
10.1242/jcs.070680, 2964112, 20940259
-
Leonoudakis D, Singh M, Mohajer R, Mohajer P, Fata JE, Campbell KP, Muschler JL. Dystroglycan controls signaling of multiple hormones through modulation of STAT5 activity. J Cell Sci 2010, 123:3683-3692. 10.1242/jcs.070680, 2964112, 20940259.
-
(2010)
J Cell Sci
, vol.123
, pp. 3683-3692
-
-
Leonoudakis, D.1
Singh, M.2
Mohajer, R.3
Mohajer, P.4
Fata, J.E.5
Campbell, K.P.6
Muschler, J.L.7
-
76
-
-
50249175859
-
TGF-beta inhibits prolactin-induced expression of beta-casein by a Smad3-dependent mechanism
-
10.1002/jcb.21734, 18335503
-
Wu W-J, Lee C-F, Hsin C-H, Du J-Y, Hsu T-C, Lin T-H, Yao T-Y, Huang C-H, Lee Y-J. TGF-beta inhibits prolactin-induced expression of beta-casein by a Smad3-dependent mechanism. J Cell Biochem 2008, 104:1647-1659. 10.1002/jcb.21734, 18335503.
-
(2008)
J Cell Biochem
, vol.104
, pp. 1647-1659
-
-
Wu, W.-J.1
Lee, C.-F.2
Hsin, C.-H.3
Du, J.-Y.4
Hsu, T.-C.5
Lin, T.-H.6
Yao, T.-Y.7
Huang, C.-H.8
Lee, Y.-J.9
-
77
-
-
38349124153
-
Smad signaling antagonizes STAT5-mediated gene transcription and mammary epithelial cell differentiation
-
Cocolakis E, Dai M, Drevet L, Ho J, Haines E, Ali S, Lebrun J-J. Smad signaling antagonizes STAT5-mediated gene transcription and mammary epithelial cell differentiation. J Biol Chem 2008, 283:1293-1307.
-
(2008)
J Biol Chem
, vol.283
, pp. 1293-1307
-
-
Cocolakis, E.1
Dai, M.2
Drevet, L.3
Ho, J.4
Haines, E.5
Ali, S.6
Lebrun, J.-J.7
-
78
-
-
66549086623
-
Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement
-
10.1182/blood-2008-09-181107, 2686137, 19258595
-
Wang Z, Li G, Tse W, Bunting KD. Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement. Blood 2009, 113:4856-4865. 10.1182/blood-2008-09-181107, 2686137, 19258595.
-
(2009)
Blood
, vol.113
, pp. 4856-4865
-
-
Wang, Z.1
Li, G.2
Tse, W.3
Bunting, K.D.4
-
79
-
-
40549121259
-
Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5
-
2248325, 18292815
-
Liu F, Kunter G, Krem MM, Eades WC, Cain JA, Tomasson MH, Hennighausen L, Link DC. Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5. J Clin Invest 2008, 118:946-955. 2248325, 18292815.
-
(2008)
J Clin Invest
, vol.118
, pp. 946-955
-
-
Liu, F.1
Kunter, G.2
Krem, M.M.3
Eades, W.C.4
Cain, J.A.5
Tomasson, M.H.6
Hennighausen, L.7
Link, D.C.8
-
80
-
-
32244444750
-
Stat5a/b are essential for normal lymphoid development and differentiation
-
10.1073/pnas.0507350103, 1327727, 16418296
-
Yao Z, Cui Y, Watford WT, Bream JH, Yamaoka K, Hissong BD, Li D, Durum SK, Jiang Q, Bhandoola A, Hennighausen L, O'Shea JJ. Stat5a/b are essential for normal lymphoid development and differentiation. Proc Natl Acad Sci USA 2006, 103:1000-1005. 10.1073/pnas.0507350103, 1327727, 16418296.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 1000-1005
-
-
Yao, Z.1
Cui, Y.2
Watford, W.T.3
Bream, J.H.4
Yamaoka, K.5
Hissong, B.D.6
Li, D.7
Durum, S.K.8
Jiang, Q.9
Bhandoola, A.10
Hennighausen, L.11
O'Shea, J.J.12
-
81
-
-
18944407603
-
Mammary stem cells, self-renewal pathways, and carcinogenesis
-
10.1186/bcr1021, 1143566, 15987436
-
Liu S, Dontu G, Wicha M. Mammary stem cells, self-renewal pathways, and carcinogenesis. Breast Cancer Res 2005, 7:86-95. 10.1186/bcr1021, 1143566, 15987436.
-
(2005)
Breast Cancer Res
, vol.7
, pp. 86-95
-
-
Liu, S.1
Dontu, G.2
Wicha, M.3
-
82
-
-
0037142617
-
Loss of Stat5a delays mammary cancer progression in a mouse model
-
10.1038/sj.onc.1205484, 12082622
-
Ren S, Cai HR, Li M, Furth PA. Loss of Stat5a delays mammary cancer progression in a mouse model. Oncogene 2002, 21:4335-4339. 10.1038/sj.onc.1205484, 12082622.
-
(2002)
Oncogene
, vol.21
, pp. 4335-4339
-
-
Ren, S.1
Cai, H.R.2
Li, M.3
Furth, P.A.4
-
83
-
-
77957586805
-
Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer
-
10.1038/onc.2010.274, 2997721, 20639901
-
Sakamoto K, Triplett AA, Schuler LA, Wagner KU. Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer. Oncogene 2010, 29:5359-5369. 10.1038/onc.2010.274, 2997721, 20639901.
-
(2010)
Oncogene
, vol.29
, pp. 5359-5369
-
-
Sakamoto, K.1
Triplett, A.A.2
Schuler, L.A.3
Wagner, K.U.4
-
84
-
-
2942672845
-
Signal transducer and activator of transcription-5 activation and breast cancer prognosis
-
10.1200/JCO.2004.11.046, 15169792
-
Nevalainen MT, Xie J, Torhorst J, Bubendorf L, Haas P, Kononen J, Sauter G, Rui H. Signal transducer and activator of transcription-5 activation and breast cancer prognosis. J Clin Oncol 2004, 22:2053-2060. 10.1200/JCO.2004.11.046, 15169792.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2053-2060
-
-
Nevalainen, M.T.1
Xie, J.2
Torhorst, J.3
Bubendorf, L.4
Haas, P.5
Kononen, J.6
Sauter, G.7
Rui, H.8
-
85
-
-
0346024125
-
Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers
-
10.1002/ijc.11619, 14696092
-
Cotarla I, Ren S, Zhang Y, Gehan E, Singh B, Furth PA. Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers. Int J Cancer 2004, 108:665-671. 10.1002/ijc.11619, 14696092.
-
(2004)
Int J Cancer
, vol.108
, pp. 665-671
-
-
Cotarla, I.1
Ren, S.2
Zhang, Y.3
Gehan, E.4
Singh, B.5
Furth, P.A.6
-
86
-
-
33751097277
-
Stat5 expression predicts response to endocrine therapy and improves survival in estrogen receptor-positive breast cancer
-
10.1677/erc.1.01095, 16954437
-
Yamashita H, Nishio M, Ando Y, Zhang Z, Hamaguchi M, Mita K, Kobayashi S, Fujii Y, Iwase H. Stat5 expression predicts response to endocrine therapy and improves survival in estrogen receptor-positive breast cancer. Endocr Relat Cancer 2006, 13:885-893. 10.1677/erc.1.01095, 16954437.
-
(2006)
Endocr Relat Cancer
, vol.13
, pp. 885-893
-
-
Yamashita, H.1
Nishio, M.2
Ando, Y.3
Zhang, Z.4
Hamaguchi, M.5
Mita, K.6
Kobayashi, S.7
Fujii, Y.8
Iwase, H.9
-
87
-
-
79959309120
-
Loss of nuclear localized and tyrosine phosphorylated stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure
-
10.1200/JCO.2010.30.3552, 21576635
-
Peck AR, Witkiewicz AK, Liu C, Stringer GA, Klimowicz AC, Pequignot E, Freydin B, Tran TH, Yang N, Rosenberg AL, Hooke JA, Kovatich AJ, Nevalainen MT, Shriver CD, Hyslop T, Sauter G, Rimm DL, Magliocco AM, Rui H. Loss of nuclear localized and tyrosine phosphorylated stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure. J Clin Oncol 2011, 29:2448-2458. 10.1200/JCO.2010.30.3552, 21576635.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2448-2458
-
-
Peck, A.R.1
Witkiewicz, A.K.2
Liu, C.3
Stringer, G.A.4
Klimowicz, A.C.5
Pequignot, E.6
Freydin, B.7
Tran, T.H.8
Yang, N.9
Rosenberg, A.L.10
Hooke, J.A.11
Kovatich, A.J.12
Nevalainen, M.T.13
Shriver, C.D.14
Hyslop, T.15
Sauter, G.16
Rimm, D.L.17
Magliocco, A.M.18
Rui, H.19
-
88
-
-
76749106107
-
Prolactin inhibits BCL6 expression in breast cancer through a Stat5a-dependent mechanism
-
10.1158/0008-5472.CAN-09-2314, 2822876, 20124477
-
Tran TH, Utama FE, Lin J, Yang N, Sjolund AB, Ryder A, Johnson KJ, Neilson LM, Liu C, Brill KL, Rosenberg AL, Witkiewicz AK, Rui H. Prolactin inhibits BCL6 expression in breast cancer through a Stat5a-dependent mechanism. Cancer Res 2010, 70:1711-1721. 10.1158/0008-5472.CAN-09-2314, 2822876, 20124477.
-
(2010)
Cancer Res
, vol.70
, pp. 1711-1721
-
-
Tran, T.H.1
Utama, F.E.2
Lin, J.3
Yang, N.4
Sjolund, A.B.5
Ryder, A.6
Johnson, K.J.7
Neilson, L.M.8
Liu, C.9
Brill, K.L.10
Rosenberg, A.L.11
Witkiewicz, A.K.12
Rui, H.13
-
89
-
-
55749085659
-
Identification of a gainof-function mutation of the prolactin receptor in women with benign breast tumors
-
10.1073/pnas.0800685105, 2567233, 18779591
-
Bogorad RL, Courtillot C, Mestayer C, Bernichtein S, Harutyunyan L, Jomain JB, Bachelot A, Kuttenn F, Kelly PA, Goffin V, Touraine P. Identification of a gainof-function mutation of the prolactin receptor in women with benign breast tumors. Proc Natl Acad Sci USA 2008, 105:14533-14538. 10.1073/pnas.0800685105, 2567233, 18779591.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 14533-14538
-
-
Bogorad, R.L.1
Courtillot, C.2
Mestayer, C.3
Bernichtein, S.4
Harutyunyan, L.5
Jomain, J.B.6
Bachelot, A.7
Kuttenn, F.8
Kelly, P.A.9
Goffin, V.10
Touraine, P.11
-
90
-
-
42449141532
-
Transcriptional activation of signal transducer and activator of transcription (STAT) 3 and STAT5B partially mediate homeobox A1-stimulated oncogenic transformation of the immortalized human mammary epithelial cell
-
10.1210/en.2007-1320, 18276758
-
Mohankumar KM, Perry JK, Kannan N, Kohno K, Gluckman PD, Emerald BS, Lobie PE. Transcriptional activation of signal transducer and activator of transcription (STAT) 3 and STAT5B partially mediate homeobox A1-stimulated oncogenic transformation of the immortalized human mammary epithelial cell. Endocrinology 2008, 149:2219-2229. 10.1210/en.2007-1320, 18276758.
-
(2008)
Endocrinology
, vol.149
, pp. 2219-2229
-
-
Mohankumar, K.M.1
Perry, J.K.2
Kannan, N.3
Kohno, K.4
Gluckman, P.D.5
Emerald, B.S.6
Lobie, P.E.7
-
91
-
-
77951177512
-
Erythropoietin-induced activation of the JAK2/STAT5, PI3K/Akt, and Ras/ERK pathways promotes malignant cell behavior in a modified breast cancer cell line
-
10.1158/1541-7786.MCR-09-0264, 20353997
-
Shi Z, Hodges VM, Dunlop EA, Percy MJ, Maxwell AP, El-Tanani M, Lappin TRJ. Erythropoietin-induced activation of the JAK2/STAT5, PI3K/Akt, and Ras/ERK pathways promotes malignant cell behavior in a modified breast cancer cell line. Mol Cancer Res 2010, 8:615-626. 10.1158/1541-7786.MCR-09-0264, 20353997.
-
(2010)
Mol Cancer Res
, vol.8
, pp. 615-626
-
-
Shi, Z.1
Hodges, V.M.2
Dunlop, E.A.3
Percy, M.J.4
Maxwell, A.P.5
El-Tanani, M.6
Lappin, T.R.J.7
-
92
-
-
38949105121
-
Co-overexpression of Janus kinase 2 and signal transducer and activator of transcription 5a promotes differentiation of mammary cancer cells through reversal of epithelial-mesenchymal transition
-
10.1111/j.1349-7006.2007.00685.x, 18271926
-
Sultan AS, Brim H, Sherif ZA. Co-overexpression of Janus kinase 2 and signal transducer and activator of transcription 5a promotes differentiation of mammary cancer cells through reversal of epithelial-mesenchymal transition. Cancer Sci 2008, 99:272-279. 10.1111/j.1349-7006.2007.00685.x, 18271926.
-
(2008)
Cancer Sci
, vol.99
, pp. 272-279
-
-
Sultan, A.S.1
Brim, H.2
Sherif, Z.A.3
-
93
-
-
34648831578
-
Stat5 activation inhibits prolactin-induced AP-1 activity: distinct prolactin-initiated signals in tumorigenesis dependent on cell context
-
10.1038/sj.onc.1210454, 3190200, 17438530
-
Gutzman JH, Rugowski DE, Nikolai SE, Schuler LA. Stat5 activation inhibits prolactin-induced AP-1 activity: distinct prolactin-initiated signals in tumorigenesis dependent on cell context. Oncogene 2007, 26:6341-6348. 10.1038/sj.onc.1210454, 3190200, 17438530.
-
(2007)
Oncogene
, vol.26
, pp. 6341-6348
-
-
Gutzman, J.H.1
Rugowski, D.E.2
Nikolai, S.E.3
Schuler, L.A.4
-
94
-
-
62449154733
-
SOCS3 as a tumor suppressor in breast cancer cells, and its regulation by PRL
-
10.1002/ijc.24172, 19115200
-
Barclay JL, Anderson ST, Waters MJ, Curlewis JD. SOCS3 as a tumor suppressor in breast cancer cells, and its regulation by PRL. Int J Cancer 2009, 124:1756-1766. 10.1002/ijc.24172, 19115200.
-
(2009)
Int J Cancer
, vol.124
, pp. 1756-1766
-
-
Barclay, J.L.1
Anderson, S.T.2
Waters, M.J.3
Curlewis, J.D.4
-
95
-
-
77952061964
-
Protein-tyrosine phosphatase PTPN9 negatively regulates ErbB2 and epidermal growth factor receptor signaling in breast cancer cells
-
10.1074/jbc.M109.099879, 2865303, 20335174
-
Yuan T, Wang Y, Zhao ZJ, Gu H. Protein-tyrosine phosphatase PTPN9 negatively regulates ErbB2 and epidermal growth factor receptor signaling in breast cancer cells. J Biol Chem 2010, 285:14861-14870. 10.1074/jbc.M109.099879, 2865303, 20335174.
-
(2010)
J Biol Chem
, vol.285
, pp. 14861-14870
-
-
Yuan, T.1
Wang, Y.2
Zhao, Z.J.3
Gu, H.4
-
96
-
-
63849316576
-
Heat shock protein-90-alpha, a prolactin-STAT5 target gene identified in breast cancer cells, is involved in apoptosis regulation
-
10.1186/bcr2193, 2656886, 19014541
-
Perotti C, Liu R, Parusel CT, Bocher N, Schultz J, Bork P, Pfitzner E, Groner B, Shemanko CS. Heat shock protein-90-alpha, a prolactin-STAT5 target gene identified in breast cancer cells, is involved in apoptosis regulation. Breast Cancer Res 2008, 10:R94. 10.1186/bcr2193, 2656886, 19014541.
-
(2008)
Breast Cancer Res
, vol.10
-
-
Perotti, C.1
Liu, R.2
Parusel, C.T.3
Bocher, N.4
Schultz, J.5
Bork, P.6
Pfitzner, E.7
Groner, B.8
Shemanko, C.S.9
-
97
-
-
67649352637
-
Nuclear cyclin D1: an oncogenic driver in human cancer
-
10.1002/jcp.21791, 2874239, 19415697
-
Kim JK, Diehl JA. Nuclear cyclin D1: an oncogenic driver in human cancer. J Cell Physiol 2009, 220:292-296. 10.1002/jcp.21791, 2874239, 19415697.
-
(2009)
J Cell Physiol
, vol.220
, pp. 292-296
-
-
Kim, J.K.1
Diehl, J.A.2
-
98
-
-
33745211914
-
Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer
-
10.1016/j.mce.2006.03.018, 16647191
-
Sarfstein R, Maor S, Reizner N, Abramovitch S, Werner H. Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer. Mol Cell Endocrinol 2006, 252:241-246. 10.1016/j.mce.2006.03.018, 16647191.
-
(2006)
Mol Cell Endocrinol
, vol.252
, pp. 241-246
-
-
Sarfstein, R.1
Maor, S.2
Reizner, N.3
Abramovitch, S.4
Werner, H.5
-
99
-
-
33750985375
-
Co-expression of steroid receptors (estrogen receptor alpha and/or progesterone receptors) and Her-2/neu: clinical implications
-
10.1016/j.jsbmb.2006.09.008, 17049840
-
Ciocca DR, Gago FE, Fanelli MA, Calderwood SK. Co-expression of steroid receptors (estrogen receptor alpha and/or progesterone receptors) and Her-2/neu: clinical implications. J Steroid Biochem Mol Biol 2006, 102:32-40. 10.1016/j.jsbmb.2006.09.008, 17049840.
-
(2006)
J Steroid Biochem Mol Biol
, vol.102
, pp. 32-40
-
-
Ciocca, D.R.1
Gago, F.E.2
Fanelli, M.A.3
Calderwood, S.K.4
|