A human TREK-1/HEK cell line: A highly efficient screening tool for drug development in neurological diseases

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Moha ou Maati, Hamid ^a   Peyronnet, Rémi ^a   Devader, Christelle ^a   Veyssiere, Julie ^a   Labbal, Fabien ^a   Gandin, Carine ^a   Mazella, Jean ^a   Heurteaux, Catherine ^a   Borsotto, Marc ^a  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOXETINE; NEUROPEPTIDE; POLYUNSATURATED FATTY ACID; POTASSIUM CHANNEL; POTASSIUM CHANNEL TREK 1; RILUZOLE; SORTILIN; SPADIN; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; GREEN FLUORESCENT PROTEIN; NEUROPROTECTIVE AGENT; PEPTIDE; POTASSIUM CHANNEL PROTEIN TREK 1; POTASSIUM CHANNEL PROTEIN TREK-1; SPADIN PEPTIDE; TANDEM PORE DOMAIN POTASSIUM CHANNEL; UNSATURATED FATTY ACID;

ARTICLE; CELL CLONE; CELL STRAIN; CONTROLLED STUDY; DRUG DEVELOPMENT; DRUG SCREENING; HUMAN; HUMAN CELL; HYPOXIA; NEUROLOGIC DISEASE; NEUROPROTECTION; NUCLEOTIDE SEQUENCE; PH; PROTEIN EXPRESSION; TREK 1 HEK CELL LINE; CELL HYPOXIA; CELL STRAIN HEK293; CHANNEL GATING; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; MECHANICAL STRESS; METABOLISM; METHODOLOGY; PATCH CLAMP; PROTEIN TRANSPORT;

CELL HYPOXIA; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; FATTY ACIDS, UNSATURATED; FLUOXETINE; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; NERVOUS SYSTEM DISEASES; NEUROPROTECTIVE AGENTS; PATCH-CLAMP TECHNIQUES; PEPTIDES; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; PROTEIN TRANSPORT; RECEPTORS, CELL SURFACE; RILUZOLE; STRESS, MECHANICAL;

EID: 80054102999     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025602     Document Type: Article

References (50)

1. Kim D, (2005) Physiology and pharmacology of two-pore domain potassium channels. Curr Pharm Des 11: 2717-2736.
2. Honore E, (2007) The neuronal background K2P channels: focus on TREK1. Nat Rev Neurosci 8: 251-261.
3. Lauritzen I, Zanzouri M, Honore E, Duprat F, Ehrengruber MU, et al. (2003) K+-dependent cerebellar granule neuron apoptosis. Role of task leak K+ channels. J Biol Chem 278: 32068-32076.
4. Bittner S, Meuth SG, Gobel K, Melzer N, Herrmann AM, et al. (2009) TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system. Brain 132: 2501-2516.
5. Barel O, Shalev SA, Ofir R, Cohen A, Zlotogora J, et al. (2008) Maternally inherited Birk Barel mental retardation dysmorphism syndrome caused by a mutation in the genomically imprinted potassium channel KCNK9. Am J Hum Genet 83: 193-199.
6. Davies LA, Hu C, Guagliardo NA, Sen N, Chen X, et al. (2008) TASK channel deletion in mice causes primary hyperaldosteronism. Proc Natl Acad Sci U S A 105: 2203-2208.
7. Lafreniere RG, Cader MZ, Poulin JF, Andres-Enguix I, Simoneau M, et al. (2010) A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura. Nat Med 16: 1157-1160.
8. Alloui A, Zimmermann K, Mamet J, Duprat F, Noel J, et al. (2006) TREK-1, a K+ channel involved in polymodal pain perception. EMBO J 25: 2368-2376.
9. Noel J, Zimmermann K, Busserolles J, Deval E, Alloui A, et al. (2009) The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception. EMBO J 28: 1308-1318.
10. Hervieu GJ, Cluderay JE, Gray CW, Green PJ, Ranson JL, et al. (2001) Distribution and expression of TREK-1, a two-pore-domain potassium channel, in the adult rat CNS. Neuroscience 103: 899-919.
11. Medhurst AD, Rennie G, Chapman CG, Meadows H, Duckworth MD, et al. (2001) Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery. Brain Res Mol Brain Res 86: 101-114.
12. Talley EM, Solorzano G, Lei Q, Kim D, Bayliss DA, (2001) Cns distribution of members of the two-pore-domain (KCNK) potassium channel family. J Neurosci 21: 7491-7505.
13. Fink M, Duprat F, Lesage F, Reyes R, Romey G, et al. (1996) Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. EMBO J 15: 6854-6862.
14. Blondeau N, Petrault O, Manta S, Giordanengo V, Gounon P, et al. (2007) Polyunsaturated fatty acids are cerebral vasodilators via the TREK-1 potassium channel. Circ Res 101: 176-184.
15. Gardener MJ, Johnson IT, Burnham MP, Edwards G, Heagerty AM, et al. (2004) Functional evidence of a role for two-pore domain potassium channels in rat mesenteric and pulmonary arteries. Br J Pharmacol 142: 192-202.
16. Garry A, Fromy B, Blondeau N, Henrion D, Brau F, et al. (2007) Altered acetylcholine, bradykinin and cutaneous pressure-induced vasodilation in mice lacking the TREK1 potassium channel: the endothelial link. EMBO Rep 8: 354-359.
17. Tan JH, Liu W, Saint DA, (2004) Differential expression of the mechanosensitive potassium channel TREK-1 in epicardial and endocardial myocytes in rat ventricle. Exp Physiol 89: 237-242.
18. Terrenoire C, Lauritzen I, Lesage F, Romey G, Lazdunski M, (2001) A TREK-1-like potassium channel in atrial cells inhibited by beta-adrenergic stimulation and activated by volatile anesthetics. Circ Res 89: 336-342.
19. Lauritzen I, Blondeau N, Heurteaux C, Widmann C, Romey G, et al. (2000) Polyunsaturated fatty acids are potent neuroprotectors. Embo J 19: 1784-1793.
20. Maingret F, Lauritzen I, Patel AJ, Heurteaux C, Reyes R, et al. (2000) TREK-1 is a heat-activated background K(+) channel. EMBO J 19: 2483-2491.
21. Maingret F, Patel AJ, Lesage F, Lazdunski M, Honore E, (2000) Lysophospholipids open the two-pore domain mechano-gated K(+) channels TREK-1 and TRAAK. J Biol Chem 275: 10128-10133.
22. Heurteaux C, Guy N, Laigle C, Blondeau N, Duprat F, et al. (2004) TREK-1, a K(+) channel involved in neuroprotection and general anesthesia. Embo J 23: 2684-2695.
23. Heurteaux C, Laigle C, Blondeau N, Jarretou G, Lazdunski M, (2006) Alpha-linolenic acid and riluzole treatment confer cerebral protection and improve survival after focal brain ischemia. Neuroscience 137: 241-251.
24. Gruss M, Bushell TJ, Bright DP, Lieb WR, Mathie A, et al. (2004) Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane. Mol Pharmacol 65: 443-452.
25. Heurteaux C, Lucas G, Guy N, El Yacoubi M, Thümmler S, et al. (2006) Deletion of TREK-1, a background potassium channel, results in a depression-resistant phenotype. Nature Neurosci 9: 1134-1141.
26. Sandoz G, Bell SC, Isacoff EY, (2011) Optical probing of a dynamic membrane interaction that regulates the TREK1 channel. Proc Natl Acad Sci U S A 108: 2605-2610.
27. Li ZB, Zhang HX, Li LL, Wang XL, (2005) Enhanced expressions of arachidonic acid-sensitive tandem-pore domain potassium channels in rat experimental acute cerebral ischemia. Biochem Biophys Res Commun 327: 1163-1169.
28. Mazella J, Petrault O, Lucas G, Deval E, Beraud-Dufour S, et al. (2010) Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol 8: e1000355.
29. Franks NP, Honore E, (2004) The TREK K2P channels and their role in general anaesthesia and neuroprotection. Trends Pharmacol Sci 25: 601-608.
30. Moha ou Maati H, Veyssiere J, Labbal F, Coppola T, Gandin C, et al. (2011) Spadin as a new antidepressant: absence of TREK-1-related side effects. Neuropharmacology doi:10.1016/j.neuropharm.2011.07.019.
31. Maingret F, Patel AJ, Lesage F, Lazdunski M, Honore E, (1999) Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel. J Biol Chem 274: 26691-26696.
32. Patel A, Lazdunski M, Honore E, (2001) Lipid and mechano-gated 2P domain K(+) channels. Curr Opin Cell Biol 13: 422-428.
33. Duprat F, Lesage F, Patel AJ, Fink M, Romey G, et al. (2000) The Neuroprotective Agent Riluzole Activates the Two P-Domain K+ Channels TREK-1 and TRAAK. Mol Pharmacol 57: 906-912.
34. Lang-Lazdunski L, Heurteaux C, Vaillant N, Widmann C, Lazdunski M, (1999) Riluzole prevents ischemic spinal cord injury caused by aortic crossclamping. J Thorac Cardiovasc Surg 117: 881-889.
35. Malgouris C, Bardot F, Daniel M, Pellis F, Rataud J, et al. (1989) Riluzole, a novel antiglutamate prevents memory loss and hippocampal neuronal damage in ischemic gerbils. J Neurosci 9: 3720-3727.
36. Goldberg MP, Choi DW, (1993) Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury. J Neurosci 13: 3510-3524.
37. Tauskela JS, Brunette E, O'Reilly N, Mealing G, Comas T, et al. (2005) An alternative Ca2+-dependent mechanism of neuroprotection by the metalloporphyrin class of superoxide dismutase mimetics. FASEB J 19: 1734-1736.
38. Cohen A, Sagron R, Somech E, Segal-Hayoun Y, Zilberberg N, (2009) Pain-associated signals, acidosis and lysophosphatidic acid, modulate the neuronal K(2P)2.1 channel. Mol Cell Neurosci 40: 382-389.
39. Finlayson K, Witchel HJ, McCulloch J, Sharkey J, (2004) Acquired QT interval prolongation and HERG: implications for drug discovery and development. Eur J Pharmacol 500: 129-142.
40. Kang J, Cheng H, Ji J, Incardona J, Rampe D, (2010) In vitro electrocardiographic and cardiac ion channel effects of (-)-epigallocatechin-3-gallate, the main catechin of green tea. J Pharmacol Exp Ther 334: 619-626.
41. Ren XQ, Liu GX, Organ-Darling LE, Zheng R, Roder K, et al. (2010) Pore mutants of HERG and KvLQT1 downregulate the reciprocal currents in stable cell lines. Am J Physiol Heart Circ Physiol 299: H1525-1534.
42. Ducroq J, Moha ou Maati H, Guilbot S, Dilly S, Laemmel E, et al. (2010) Dexrazoxane protects the heart from acute doxorubicin-induced QT prolongation: a key role for I(Ks). Br J Pharmacol 159: 93-101.
43. Buckler KJ, Honore E, (2005) The lipid-activated two-pore domain K+ channel TREK-1 is resistant to hypoxia: implication for ischaemic neuroprotection. J Physiol 562: 213-222.
44. Caley AJ, Gruss M, Franks NP, (2005) The effects of hypoxia on the modulation of human TREK-1 potassium channels. J Physiol 562: 205-212.
45. Patel AJ, Honore E, Maingret F, Lesage F, Fink M, et al. (1998) A mammalian two pore domain mechano-gated S-like K+ channel. EMBO J 17: 4283-4290.
46. Blondeau N, Lauritzen I, Widmann C, Lazdunski M, Heurteaux C, (2002) A potent protective role of lysophospholipids against global cerebral ischemia and glutamate excitotoxicity in neuronal cultures. J Cereb Blood Flow Metab 22: 821-834.
47. Blondeau N, Widmann C, Lazdunski M, Heurteaux C, (2002) Polyunsaturated fatty acids induce ischemic and epileptic tolerance. Neuroscience 109: 231-241.
48. Lang-Lazdunski L, Blondeau N, Jarretou G, Lazdunski M, Heurteaux C, (2003) Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats. J Vasc Surg 38: 564-575.
49. Pratt J, Rataud J, Bardot F, Roux M, Blanchard JC, et al. (1992) Neuroprotective actions of riluzole in rodent models of global and focal cerebral ischaemia. Neurosci Lett 140: 225-230.
50. Wahl F, Allix M, Plotkine M, Boulu RG, (1993) Effect of riluzole on focal cerebral ischemia in rats. Eur J Pharmacol 230: 209-214.