A dynamical study of the mechanical stimuli and tissue differentiation within a CaP scaffold based on micro-CT finite element models

Biomechanics and Modeling in Mechanobiology

Volumn 10, Issue 4, 2011, Pages 565-576

  Sandino, Clara ^a   Lacroix, Damien ^a  

^a INSTITUTE FOR BIOENGINEERING OF CATALONIA IBEC   (Spain)

Author keywords

Calcium phosphate; Finite element modeling; Mechanoregulation; Micro computed tomography; Tissue engineering

Indexed keywords

BONE; CELL DEATH; CELL ENGINEERING; COMPUTERIZED TOMOGRAPHY; FINITE ELEMENT METHOD; FLOW OF FLUIDS; SCAFFOLDS (BIOLOGY); SHEAR STRAIN; SHEAR STRESS; VISCOSITY;

ELEMENT MODELS; FINITE ELEMENT MODELING; FLUID SHEAR STRESS; INLET VELOCITY; MECHANICAL STIMULUS; MECHANO-REGULATION; MICRO COMPUTED TOMOGRAPHY; PORE VOLUME; TISSUE DIFFERENTIATION; TISSUES ENGINEERINGS;

NEWTONIAN LIQUIDS;

CALCIUM PHOSPHATE; TISSUE SCAFFOLD;

ALGORITHM; ARTICLE; BIOLOGICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; DRUG EFFECT; ELASTICITY; FINITE ELEMENT ANALYSIS; FLOW KINETICS; MATERIALS TESTING; MECHANICAL STRESS; METHODOLOGY; MICRO-COMPUTED TOMOGRAPHY; POROSITY; TISSUE ENGINEERING;

ALGORITHMS; CALCIUM PHOSPHATES; COMPUTER SIMULATION; ELASTICITY; FINITE ELEMENT ANALYSIS; MATERIALS TESTING; MODELS, BIOLOGICAL; POROSITY; RHEOLOGY; STRESS, MECHANICAL; TISSUE ENGINEERING; TISSUE SCAFFOLDS; X-RAY MICROTOMOGRAPHY;

EID: 80054056953     PISSN: 16177959     EISSN: 16822978     Source Type: Journal    
DOI: 10.1007/s10237-010-0256-0     Document Type: Article

References (26)

1. Byrne DP, Lacroix D, Planell JA, Kelly DJ, Prendergast PJ (2007) Simulation of tissue differentiation in a scaffold as a function of porosity, Young's modulus and dissolution rate: application of mechanobiological models in tissue engineering. Biomaterials 28:5544-5554 (Pubitemid 47599648)
2. Carter DR, Beaupré GS (2001) Skeletal function and form. Cambridge university press, Cambridge
3. Cartmell SH, Porter BD, Garcia AJ, Guldberg RE (2003) Effects of medium perfusion rate on cell-seeded three-dimensional bone constructs in vitro. Tissue Eng 9:1197-1203 (Pubitemid 37467667)
4. Checa S, Prendergast PJ (2010) Effect of cell seeding and mechanical loading on vascularization and tissue formation inside a scaffold: a mechano-biological model using a lattice approach to simulate cell activity. J Biomech 43:961-968
5. Cioffi M, Boschetti F, Raimondi MT, Dubini G (2006) Modeling evaluation of the fluid-dynamic microenvironment in tissue-engineered constructs: a micro-CT based model. Biotechnol Bioeng 93:500-510 (Pubitemid 43232176)
6. Glowacki J, Trepman E, Folkman J (1983) Cell shape and phenotypic expression in chondrocytes. Proc Soc Exp Biol Med 172:93-98 (Pubitemid 13127895)
7. Holtorf HL, Sheffield TL, Ambrose CG, Jansen AJ, Mikos AG (2005) Flow perfusion culture of marrow stromal cells seeded on porous biphasic calcium phosphate ceramics. Ann Biomed Eng 33:1238-1248 (Pubitemid 41240017)
8. Isaksson H, Wilson W, van Donkelaar CC, Huiskes R, Ito K (2006) Comparison of biophysical stimuli for mechano-regulation of tissue differentiation during fracture healing. J Biomech 39:1507-1516
9. Kelly DJ, Prendergast PJ (2006) Prediction of the optimal mechanical properties for a scaffold used in osteochondral defect repair. Tissue Eng 12:1509-2519
10. Lacroix D, Château A, Ginebra MP, Planell JA (2006) Micro-finite element models of bone tissue-engineering scaffolds. Biomaterials 27:5326-5334 (Pubitemid 44096958)
11. Lacroix D, Planell JA, Prendergast PJ (2009) Computer-aided design and finite-element modelling of biomaterial scaffolds for bone tissue engineering. Phil Trans R Soc A 367:1993-2009
12. Lacroix D, Prendergast PJ, Li G, Marsh D (2002) Biomechanical model to simulate tissue differentiation and bone regeneration: application to fracture healing. Med Biol Eng Comput 40:14-21 (Pubitemid 34233053)
13. Lesman A, Blinder Y, Levenberg S (2010) Modeling of flow-induced shear stress applied on 3D cellular scaffolds: implications for vascular tissue engineering. Biotechnol Bioeng 105:645-654
14. Maes F, VanRansbeeck P, VanOosterwyck H, Verdonck P (2009) Modeling fluid flow through irregular scaffolds for perfusion bioreactors. Biotechnol Bioeng 103:621-630
15. Martin I, Wendt D, Heberer M (2004) The role of bioreactors in tissue engineering. Trends Biotechnol 22:80-86 (Pubitemid 38130175)
16. Milan JL, Planell JA, LacroixD (2009) Computationalmodelling of the mechanical environment of osteogenesis within a polylactic acid- calcium phosphate glass scaffold. Biomaterials 30:4219-4226
17. Navarro M, Michiardi A (2008) The challenge of combining cells, synthetic materials and growth factors to engineer bone tissue. In: Barnes SJ, Harris LP (eds) Tissue engineering: roles, materials and applications. Novapublishers, New York, pp 19-66
18. Olivares A, Marsal E, Planell JA, Lacroix D (2009) Finite element study of scaffold architecture design and culture conditions for tissue engineering. Biomaterials 30:6142-6149
19. Porter B, Zauel R, Stockman H, Guldberg R, Fyhrie D (2005) 3-D computationalmodeling ofmedia flowthrough scaffolds in a perfusion bioreactor. J Biomech 38:543-549 (Pubitemid 40126466)
20. Potier E, Noailly J, Ito K (2010) Directing bone marrow-derived stromal cell function with mechanics. J Biomech 43:807-817
21. Prendergast PJ, Huiskes R, Søballe K (1997) Biophysical stimuli on cells during tissue differentiation at implant interfaces. J Biomech 30:539-548 (Pubitemid 27214187)
22. Raimondi MT, Moretti M, Cioffi M, Giordano C, Boschetti F, Lagana K, Pietrabissa R (2006) The effect of hydrodynamic shear stress on 3D engineered chondrocyte systems subject to direct perfusion. Biorheol 43:215-222 (Pubitemid 44221904)
23. Sandino C, Checa S, Prendergast PJ, Lacroix D (2010) Simulation of angiogenesis and cell differentiation in a CaP scaffold subjected to compressive load strains using a lattice modeling approach. Biomaterials 31:2446-2452
24. Sandino C, Planell JA, Lacroix D (2008) A finite element study of mechanical stimuli in scaffolds for bone tissue engineering. J Biomech 41:1005-1014
25. Sikavitsas VI, Temenoff JS, Mikos AG (2001) Biomaterials and Bone mechanotransduction. Biomaterials 22:2581-2593 (Pubitemid 32727832)
26. Stops AJF, Heraty KB, Browne M, O'Brien FJ, McHugh PE (2010) A prediction of cell differentiation and proliferation within a collagen- glycosaminoglycan scaffold subjected to mechanical strain and perfusive fluid flow. J Biomech 43:618-626