Biomechanical model to simulate tissue differentiation and bone regeneration: Application to fracture healing

Medical and Biological Engineering and Computing

Volumn 40, Issue 1, 2002, Pages 14-21

  Lacroix, D ^a   Prendergast, P J ^a   Li, G ^b   Marsh, D ^b  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Computer simulation; Fracture healing; Mechanobiology; Mesenchymal stem cells

Indexed keywords

ALGORITHMS; BONE; CELLS; FINITE ELEMENT METHOD; PROSTHETICS; TISSUE;

FIBROBLASTS;

BIOMEDICAL ENGINEERING;

ALGORITHM; ARTICLE; BIOMECHANICS; BONE MARROW; BONE MATRIX; BONE PROSTHESIS; BONE REGENERATION; CALLUS; CARTILAGE CELL; CARTILAGINOUS TISSUE; CELL DIFFERENTIATION; CELL SHAPE; CELL SPREADING; COMPUTER SIMULATION; CONNECTIVE TISSUE; CONTROLLED STUDY; ENCHONDRAL OSSIFICATION; FIBROBLAST; FINITE ELEMENT ANALYSIS; FRACTURE HEALING; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERSTITIAL FLUID; LONG BONE; MODEL; MUSCLE; OSTEOBLAST; PERIOSTEUM; PHENOTYPE; STEM CELL; STIMULUS RESPONSE; TISSUE DIFFERENTIATION;

EID: 0036120586     PISSN: 01400118     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02347690     Document Type: Article

References (29)

1. 'Role of mechanical loading in the progressive ossification of a fracture callus'
2. 'Correlations between mechanical stress history and tissue differentiation in initial fracture healing'
3. 'Effects of mechanical factors on the fracture healing process'
4. 'Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing'
5. 'Bone poroelasticity'
6. 'The cell and molecular biology of fracture healing'
7. 'The influence of mechanical stimulus on the pattern of tissue differentiation in a long bone fracture-an FEM study'
8. 'Mechanical properties of the fibrous tissue found at the bone-cement interface following total joint replacement'
9. 'A biomechanical regulatory model of peri-prosthetic tissue differentiation'
10. 'Localization and quantification of proliferating cells during rat fracture repair: Detection of proliferating cell nuclear antigen by immunohistochemistry'
11. 'Computer simulation of fracture callus formation and stiffness restoration'
12. 'A homogenization procedure to prevent numerical instabilities in poroelastic tissue differentiation models'
13. 'A 3D finite element model of a tibia to simulate the regenerative and resportive phases during fracture healing'
14. 'The biology of fracture healing in long bones'
15. 'Biphasic creep and stress relaxation of articular cartilage: Theory and experiments'
16. 'Permeability of bovine cancellous bone'
17. 'A mathematical model for fibro-proliferative wound healing disorders'
18. 'Grundrieβ einer Biomechanik der Frakturheilung'
19. 'Eine Neue Theorie über den Einfluβ Mechanischer Reize auf die Differenzierung der Stützgewebe'
20. 'Physical and biological aspects of fracture healing with special reference to internal fixation'
21. 'A comparison of finite element codes for the solution of biphasic poroelastic problems'
22. 'Mechanics of bone regeneration'
23. 'Finite element models in tissue mechanics and orthopaedic implant design'
24. 'Biophysical stimuli on cells during tissue differentiation at implant interfaces'
25. 'Tibial blood supply in relation to fracture healing'
26. 'Mathematical models of would healing in embryonic and adult epidermis'
27. 'Biomechanics in orthopaedic trauma'
28. 'The role of osteochondral progenitor cells in fracture repair'
29. Analysis of intracellular osteopontin as a marker of osteoblastic cell differentiation and mesenchymal cell migration