Modeling fluid flow through irregular scaffolds for perfusion bioreactors

Biotechnology and Bioengineering

Volumn 103, Issue 3, 2009, Pages 621-630

  Maes, Frédéric ^a,b   Van Ransbeeck, Peter ^a   Van Oosterwyck, Hans ^c   Verdonck, Pascal ^b  

^a UNIVERSITY COLLEGE GHENT   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

CFD; Micro CT; Scaffold; Shear stress; Tissue engineering

Indexed keywords

BONE SCAFFOLDS; CFD; FLUID FLOW; IN-VITRO; INLET CONDITIONS; INLET VELOCITY; MECHANICAL ASPECTS; MESH RESOLUTION; MICRO ARCHITECTURES; MICRO-CT; MODEL SELECTION; MODEL SIZE; NUMERICAL MODELS; OSTEOGENESIS; OSTEOGENIC DIFFERENTIATION; PERFUSION BIOREACTOR; REGIONS OF INTEREST; TISSUE ENGINEERED CONSTRUCTS; WALL SHEAR STRESS; WASTE TRANSPORT;

APATITE; BIOREACTORS; COMPUTERIZED TOMOGRAPHY; FLOW OF FLUIDS; FLUID DYNAMICS; HUMAN COMPUTER INTERACTION; HYDROXYAPATITE; IMAGING TECHNIQUES; INDUSTRIAL CHEMICALS; MODEL STRUCTURES; SHEAR STRESS; STRENGTH OF MATERIALS; THREE DIMENSIONAL; TISSUE ENGINEERING; TITANIUM;

SCAFFOLDS;

ARTICLE; BIOREACTOR; FLUID FLOW; MATHEMATICAL MODEL; SHEAR STRESS; TISSUE ENGINEERING; CULTURE MEDIUM; MECHANICAL STRESS; METHODOLOGY;

BIOREACTORS; CULTURE MEDIA; STRESS, MECHANICAL; TISSUE ENGINEERING;

EID: 65549164186     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22277     Document Type: Article

References (22)

1. Bakker AD, Soejima K, Klein-Nulend J, Burger EH. 2001. The production of nitric oxide and prostaglandin E-2 by primary bone cells is shear stress dependent. J Biomech 34(5):671-677. (Pubitemid 32328255)
2. Bancroft GN, Sikavitsast VI, van den Dolder J, Sheffield TL, Ambrose CG, Jansen JA, Mikos AG. 2002. Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteloblasts in a dose-dependent manner. Proc Natl Acad Sci USA 99(20):12600-12605.
3. Boschetti F, Raimondi MT, Mighavacca F, Dubini G. 2006. Prediction of the micro-fluid dynamic environment imposed to three-dimensional engineered cell systems in bioreactors. J Biomech 39(3):418-425. (Pubitemid 43028504)
4. Botchwey EA, Pollack SR, El-Amin S, Levine EM, Tuan RS, Laurencin CT. 2003. Human osteoblast-like cells in three-dimensional culture with fluid flow. Biorheology 40(1-3):299-306.
5. Cartmell SH, Porter BD, Garcia AJ, Guldberg RE. 2003. Effects of medium perfusion rate on cell-seeded three-dimensional bone constructs in vitro. Tissue Eng 9(6):1197-1203. (Pubitemid 37467667)
6. Chung CA, Chen CW, Chen CP, Tseng CS. 2007. Enhancement of cell growth in tissue-engineering constructs under direct perfusion: Modeling and simulation. Biotechnol Bioeng 97(6):1603-1616. (Pubitemid 47204038)
7. Cioffi M, Boschetti F, Raimondi MT, Dubini G. 2006. Modeling evaluation of the fluid-dynamic microenvironment in tissue-engineered constructs: A micro-CT based model. Biotechnol Bioeng 93(3):500-510. (Pubitemid 43232176)
8. Coletti F, Macchietto S, Elvassore N. 2006. Mathematical modeling of three-dimensional cell cultures in perfusion bioreactors. Ind Eng Chem Res 45(24):8158-8169. (Pubitemid 44876453)
9. Einhorn TA. 1999. Clinically applied models of bone regeneration in tissue engineering research. Clin Orthop Relat Res (367):S59-S67. (Pubitemid 29501487)
10. Giannoni P, Mastrogiacomo M, Alini M, Pearce SG, Corsi A, Santolini F, Muraglia A, Bianco P, Cancedda R. 2008. Regeneration of large bone defects in sheep using bone marrow stromal cells. J Tissue Eng Regenerative Med 2(5):253-262.
11. Glowacki J, Mizuno S, Greenberger JS. 1998. Perfusion enhances functions of bone marrow stromal cells in three-dimensional culture. Cell Transplant 7(3):319-326. (Pubitemid 28280860)
12. Griffith CK, Miller C, Sainson RCA, Calvert JW, Jeon NL, Hughes CCW, George SC. 2005. Diffusion limits of an in vitro thick prevascularized tissue. Tissue Eng 11(1-2):257-266. (Pubitemid 40515193)
13. Klein-Nulend J, Bacabac RG, Mullender MG. 2005. Mechanobiology of bone tissue. Pathol Biol 53(10):576-580. (Pubitemid 41814469)
14. McGarry JG, Klein-Nulend J, Mullender MG, Prendergast PJ. 2004. A comparison of strain and fluid shear stress in stimulating bone cell responses - A computational and experimental study. FASEB J 18(15):482-484.
15. Mullender M, El Haj AJ, Yang Y, van Duin MA, Burger EH, Klein-Nulend J. 2004. Mechanotransduction of bone cells in vitro: Mechanobiology of bone tissue. Med Biol Eng Comput 42(1):14-121. (Pubitemid 38196274)
16. Porter B, Zauel R, Stockman H, Guldberg R, Fyhrie D. 2005. 3-D computational modeling of media flow through scaffolds in a perfusion bioreactor. J Biomech 38(3):543-549. (Pubitemid 40126466)
17. Porter BD, Lin AS, Peister A, Hutmacher D, Guldberg RE. 2007. Noninvasive image analysis of 3D construct mineralization in a perfusion bioreactor. Biomaterials 28(15):2525-2533. (Pubitemid 46365909)
18. Raimondi MT, Boschetti F, Falcone L, Fiore GB, Remuzzi A, Marinoni E, Marazzi M, Pietrabissa R. 2002. Mechanobiology of engineered cartilage cultured under a quantified fluid-dynamic environment. Biomech Model Mechanobiol 1(1):69-82.
19. Raimondi MT, Moretti M, Cioffi M, Giordano C, Boschetti F, Lagana K, Pietrabissa R. 2006. The effect of hydrodynamic shear on 3D engineered chondrocyte systems subject to direct perfusion. Biorheology 43(3- 4):215-222. (Pubitemid 44221904)
20. Singh H, Ang ES, Lim TT, Hutmacher DW. 2007. Flow modeling in a novel non-perfusion conical bioreactor. Biotechnol Bioeng 97(5):1291-1299. (Pubitemid 47195323)
21. Smith RL, Carter DR, Schurman DJ. 2004. Pressure and shear differentially alter human articular chondrocyte metabolism - A review. Clin Orthop Relat Res (427):S89-S95. (Pubitemid 39362806)
22. Wilson DJ, King JR, Byrne HM. 2007. Modelling scaffold occupation by a growing, nutrient-rich tissue. Math Models Methods Appl Sci 17(1):1721-1750.