Affinity purification of a framework 1 engineered mouse/human chimeric IgA2 antibody from tobacco

Biotechnology and Bioengineering

Volumn 108, Issue 12, 2011, Pages 2804-2814

  Boes, A ^a   Spiegel, H ^a   Delbruck H ^b   Fischer, R ^a,b   Schillberg, S ^a   Sack, M ^b  

^a FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME   (Germany)

^b RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Biologicals; Immunoglobulin A; Molecular farming; Protein engineering; Protein L; Recombinant antibodies; Surface plasmon resonance

Indexed keywords

BIOLOGICALS; IMMUNOGLOBULIN A; MOLECULAR FARMING; PROTEIN ENGINEERING; RECOMBINANT ANTIBODY; SURFACE PLASMONS;

AFFINITY CHROMATOGRAPHY; BINDING ENERGY; DRUG THERAPY; GENETIC ENGINEERING; GRAFTING (CHEMICAL); PURIFICATION; SURFACE PLASMON RESONANCE; TOBACCO;

ANTIBODIES;

IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN A2 ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN KAPPA CHAIN; SECRETORY IMMUNOGLOBULIN; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; CELL KILLING; CHIMERA; HUMAN; NONHUMAN; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN EXPRESSION; TOBACCO;

ANIMALS; BIOTECHNOLOGY; CHROMATOGRAPHY, AFFINITY; HUMANS; IMMUNOGLOBULIN A; MICE; PLANTS, GENETICALLY MODIFIED; RECOMBINANT PROTEINS; TECHNOLOGY, PHARMACEUTICAL; TOBACCO;

MURINAE; NICOTIANA OBTUSIFOLIA; NICOTIANA TABACUM;

EID: 80054048785     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.23262     Document Type: Article

References (49)

1. Apter FM, Lencer WI, Finkelstein RA, Mekalanos JJ, Neutra MR. 1993. Monoclonal immunoglobulin A antibodies directed against cholera toxin prevent the toxin-induced chloride secretory response and block toxin binding to intestinal epithelial cells in vitro. Infect Immun 61(12): 5271-5278.
2. Bonner A, Almogren A, Futado PB, Kerr MA, Perkins SJ. 2009a. Location of secretory component on the Fc edge of dimeric IgA1 reveals insight into the role of secretory IgA1 in mucosal immunity. Mucosal Immunol 2(8): 74-84.
3. Bonner A, Almogren A, Futado PB, Kerr MA, Perkins SJ. 2009b. The nonplanar secretory IgA2 and near planar secretory IgA1 solution structures rationalize their different mucosal immune responses. J Biol Chem 284(8): 5077-5087.
4. Calarese DA, Scanlan CN, Zwick MB, Deechongkit S, Mimura Y, Kunert R, Zhu P, Wormald MR, Stanfield RL, Roux KH, Kelly JW, Rudd PM, Dwek RA, Katinger H, Burton DR, Wilson IA. 2003. Antibody domain exchange is an immunological solution to carbohydrate cluster recognition. Science 300(5628): 2065-2071.
5. Carayannopoulos L, Max EE, Capra JD. 1994. Recombinant human-IgA expressed in insect cells. Proc Natl Acad Sci USA 91(18): 8348-8352.
6. Carrington JC, Freed DD. 1990. Cap-independent enhancement of translation by a plant potyvirus 5' nontranslated region. J Virol 64(4): 1590-1597.
7. Castilho A, Strasser R, Stadlmann J, Grass J, Jez J, Gattinger P, Kunert R, Quendler H, Pabst M, Leonard R, Altmann F, Steinkellner H. 2010. In planta protein sialylation through overexpression of the respective mammalian pathway. J Biol Chem 285(21): 15923-15930.
8. Chintalacharuvu KR, Morrison SL. 1997. Production of secretory immunoglobulin A by a single mammalian cell. Proc Natl Acad Sci USA 94(12): 6364-6368.
9. Corthesy B. 2002. Recombinant immunoglobulin A: Powerful tools for fundamental and applied research. Trends Biotechnol 20(2): 65-71.
10. Crottet P, Corthesy B. 1998. Secretory component delays the conversion of secretory IgA into antigen-binding competent F(ab')2: A possible implication for mucosal defense. J Immunol 161(10): 5445-5453.
11. Dechant M, Valerius T. 2001. IgA antibodies for cancer therapy. Crit Rev Oncol Hematol 39(1-2): 69-77.
12. Dechant M, Beyer T, Schneider-Merck T, Weisner W, Peipp M, van de Winkel JGJ, Valerius T. 2007. Effector mechanisms of recombinant IgA antibodies against epidermal growth factor receptor. J Immunol 179(5): 2936-2943.
13. Fischer R, Twyman RM, Hellwig S, Drossard J, Schillberg S. 2007. Facing the future with pharmaceuticals from plants. In: Xu Z, Li J, Xue Y, Yang W editors Biotechnology and sustainable agriculture 2006 and beyond. Proceedings of the 11th IAPTC&B Congress, August 13-18, 2006 Beijing, China. Springer, NY, p 13-32.
14. Giritch A, Marillonnet S, Engler C, van Eldik G, Botterman J, Klimyuk V, Gleba Y. 2006. Rapid high-yield expression of full-size IgG antibodies in plants coinfected with noncompeting viral vectors. Proc Natl Acad Sci USA 103(40): 14701-14706.
15. Gleba Y, Klimyuk V, Marillonnet S. 2005. Magnifection-A new platform for expressing recombinant vaccines in plants. Vaccine 23(17-18): 2042-2048.
16. Graille M, Stura EA, Housden NG, Beckingham JA, Bottomley SP, Beale D, Taussig MJ, Sutton BJ, Gore MG, Charbonnier JB. 2001. Complex between Peptostreptococcus magnus protein L and a human antibody reveals structural convergence in the interaction modes of Fab binding proteins. Structure 9(8): 679-687.
17. Gregory RL, Rundegren J, Arnold RR. 1987. Separation of human IgA1 and IgA2 using Jacalin-agarose chromatography. J Immunol Methods 99(1): 101-106.
18. Hellens R, Mullineaux P, Klee H. 2000. A guide to Agrobacterium binary Ti vectors. Trends Plant Sci 5(10): 446-451.
19. Huls G, Heijnen IAFM, Cuomo E, van der Linden J, Boel E, van de Winkel JGJ, Logtenberg T. 1999. Antitumor immune effector mechanisms recruited by phage display-derived fully human IgG1 and IgA1 monoclonal antibodies. Cancer Res 59(22): 5778-5784.
20. Kathuria S, Sriraman R, Sack M, Pal R, Artsaenko O, Talwar GP, Fischer R, Finnern R. 2002. Efficacy of plant-produced recombinant antibodies against HCG. Hum Reprod 17(8): 2054-2061.
21. Kay R, Chan A, Daly M, Mcpherson J. 1987. Duplication of CAMV 35S promoter sequences creates a strong enhancer for plant genes. Science 236(4806): 1299-1302.
22. Ma JKC, Lehner T, Stabila P, Fux CI, Hiatt A. 1994. Assembly of monoclonal-antibodies with IgG1 and IgA heavy-chain domains in transgenic tobacco plants. Eur J Immunol 24(1): 131-138.
23. Ma JKC, Hiatt A, Hein M, Vine ND, Wang F, Stabila P, Vandolleweerd C, Mostov K, Lehner T. 1995. Generation and assembly of secretory antibodies in plants. Science 268(5211): 716-719.
24. Ma JKC, Hikmat BY, Wycoff K, Vine ND, Chargelegue D, Yu L, Hein MB, Lehner T. 1998. Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in humans. Nat Med 4(5): 601-606.
25. Mantis NJ, Palaia J, Hessell AJ, Mehta S, Zhu Z, Corthesy B, Neutra MR, Burton DR, Janoff EN. 2007. Inhibition of HIV-1 infectivity and epithelial cell transfer by human monoclonal IgG and IgA antibodies carrying the b12V region. J Immunol 179(5): 3144-3152.
26. Marillonnet S, Thoeringer C, Kandzia R, Klimyuk V, Gleba Y. 2005. Systemic Agrobacterium tumefaciens-mediated transfection of viral replicons for efficient transient expression in plants. Nat Biotechnol 23(6): 718-723.
27. Mikol V. 1996. Structure of the Fab fragment of SDZ CH I621: A chimeric antibody against CD25. Acta Crystallogr D Biol Crystallogr 52: 534-542.
28. Morton HC, Atkin JD, Owens RJ, Woof JM. 1993. Purification and characterization of chimeric human IgA1 and IgA2 expressed in COS and Chinese-hamster ovary cells. J Immunol 151(9): 4743-4752.
29. Muzard J, Adi-Bessalem S, Juste M, Laraba-Djebari F, Aubrey N, Billiald P. 2009. Grafting of protein L-binding activity onto recombinant antibody fragments. Anal Biochem 388(2): 331-338.
30. Nilson BHK, Solomon A, Bjorck L, Akerstrom B. 1992. Protein-L from Peptostreptococcus magnus binds to the kappa-light chain variable domain. J Biol Chem 267(4): 2234-2239.
31. Nilson BHK, Logdberg L, Kastern W, Bjorck L, Akerstrom B. 1993. Purification of antibodies using protein L-binding framework structures in the light-chain variable domain. J Immunol Methods 164(1): 33-40.
32. Otten MA, Rudolph E, Dechant M, Tuk CW, Reijmers RM, Beelen RHJ, van de Winkel JGJ, van Egmond M. 2005. Immature neutrophils mediate tumor cell killing via IgA but not IgG Fc receptors. J Immunol 174(9): 5472-5480.
33. Pelham HR. 1990. The retention signal for soluble proteins of the endoplasmic reticulum. Trends Biochem Sci 15(12): 483-486.
34. Ramessar K, Rademacher T, Sack M, Stadlmann J, Platis D, Stiegler G, Labrou N, Altmann F, Ma J, Stoger E, Capell T, Christou P. 2008. Cost-effective production of a vaginal protein microbicide to prevent HIV transmission. Proc Natl Acad Sci USA 105(10): 3727-3732.
35. Reimold U, Kroger M, Kreuzaler F, Hahlbrock K. 1983. Coding and 3' non-coding nucleotide sequence of chalcone synthase mRNA and assignment of amino acid sequence of the enzyme. EMBO J 2(10): 1801-1805.
36. Sack M, Paetz A, Kunert R, Bomble M, Hesse F, Stiegler G, Fischer R, Katinger H, Stoeger E, Rademacher T. 2007. Functional analysis of the broadly neutralizing human anti-HIV-1 antibody 2F5 produced in transgenic BY-2 suspension cultures. FASEB J 21(8): 1655-1664.
37. Sainsbury F, Sack M, Stadlmann J, Quendler H, Fischer R, Lomonossoff GP. 2010. Rapid transient production in plants by replicating and non-replicating vectors yields high quality functional anti-HIV antibody. PLoS ONE 5(11): e13976. DOI: 10.1371/journal.pone.0013976.
38. Santi L, Giritch A, Roy CJ, Marillonnet S, Klimyuk V, Gleba Y, Webb R, Arntzen CJ, Mason HS. 2006. Protection conferred by recombinant Yersinia pestis antigens produced by a rapid and highly scalable plant expression system. Proc Natl Acad Sci USA 103(4): 861-866.
39. Schwede T, Kopp J, Guex N, Peitsch MC. 2003. SWISS-MODEL: An automated protein homology-modeling server. Nucleic Acids Res 31(13): 3381-3385.
40. Stockmeyer B, Dechant M, van Egmond M, Tutt AL, Sundarapandiyan K, Graziano RF, Repp R, Kalden JR, Gramatzki M, Glennie MJ, van de Winkel JG, Valerius T. 2000. Triggering FC alpha-receptor I (CD89) recruits neutrophils as effector cells for CD20-directed antibody therapy. J Immunol 165(10): 5954-5961.
41. Stubbe H, Berdoz J, Kraehenbuhl JP, Corthesy B. 2000. Polymeric IgA is superior to monomeric IgA and IgG carrying the same variable domain in preventing Clostridium difficile toxin A damaging of T84 monolayers. J Immunol 164(4): 1952-1960.
42. Topfer R, Prols M, Schell J, Steinbiss HH. 1988. Transient gene-expression in tobacco protoplasts. 2. Comparison of the reporter gene systems for CAT, NPT-II, and GUS. Plant Cell Rep 7(4): 225-228.
43. Tudor D, Derrien M, Diomede L, Drillet AS, Houimel M, Moog C, Reynes JM, Lopalco L, Bomsel M. 2009. HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4(+) cell infection: An IgA gene and functional analysis. Mucosal Immunol 2(5): 412-426.
44. Vaquero C, Sack M, Chandler J, Drossard J, Schuster F, Monecke M, Schillberg S, Fischer R. 1999. Transient expression of a tumor-specific single-chain fragment and a chimeric antibody in tobacco leaves. Proc Natl Acad Sci USA 96(20): 11128-11133.
45. Whaley KJ, Zeitlin L. 2005. Preventing transmission: Plant-derived microbicides and mucosal vaccines for reproductive health. Vaccine 23(15): 1819-1822.
46. Wolbank S, Kunert R, Stiegler G, Katinger H. 2003. Characterization of human class-switched polymeric (immunoglobulinM [IgM] and IgA) anti-human immunodeficiency virus type 1 antibodies 2F5 and 2G12. J Virol 77(7): 4095-4103.
47. Wong C, Sridhara S, Bardwell JCA, Jakob U. 2000. Heating greatly speeds coomassie blue staining and destaining. Biotechniques 28(3): 426-432.
48. Wycoff KL. 2005. Secretory IgA antibodies from plants. Curr Pharm Des 11(19): 2429-2437.
49. Zhao J, Kuroki M, Shibaguchi H, Wang L, Huo Q, Takami N, Tanaka T, Kinugasa T, Kuroki M. 2008. Recombinant human monoclonal IgA antibody against CEA to recruit neutrophils to CEA-expressing cells. Oncol Res 17(5): 217-222.