Complex between Peptostreptococcus magnus protein L and a human antibody reveals structural convergence in the interaction modes of Fab binding proteins

Structure

Volumn 9, Issue 8, 2001, Pages 679-687

  Graille, Marc ^a   Stura, Enrico A ^a   Housden, Nicholas G ^b   Beckingham, Jennifer A ^b   Bottomley, Stephen P ^b   Beale, Dennis ^c   Taussig, Michael J ^c   Sutton, Brian J ^d   Gore, Michael G ^b   Charbonnier, Jean Baptiste ^a  

^a CEA SACLAY   (France)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c BABRAHAM INSTITUTE   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Antibody complex; Cell surface protein; Immunoglobulin binding proteins (IBP); X ray structure

Indexed keywords

BACTERIAL PROTEIN; BINDING PROTEIN; IMMUNOGLOBULIN F(AB) FRAGMENT; PEPTOSTREPTOCOCCUS MAGNUS PROTEIN L; PROTEIN ANTIBODY; PROTEIN G; PROTEIN SUBUNIT; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPARATIVE STUDY; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; MOLECULE; NONHUMAN; PEPTOSTREPTOCOCCUS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANTIGEN-ANTIBODY COMPLEX; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; DNA-BINDING PROTEINS; HUMANS; HYDROGEN BONDING; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN M; IMMUNOGLOBULINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTOSTREPTOCOCCUS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

BACTERIA (MICROORGANISMS); FINEGOLDIA MAGNA; MAMMALIA; PEPTOSTREPTOCOCCUS;

EID: 0034887503     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(01)00630-X     Document Type: Article

References (45)

1. Protein L. A novel bacterial cell wall protein with affinity for Ig L chains
2. Demonstration on protein A of two distinct immunoglobulin-binding sites and their role in the mitogenic activity of Staphylococcus aureus Cowan I on human B cells
3. Purification and some properties of streptococcal protein G, a novel IgG-binding reagent
4. Protein L, a bacterial immunoglobulin-binding protein and possible virulence determinant
5. The functional units of a peptostreptococcal protein L
6. Structure of peptostreptococcal protein L and identification of a repeated immunoglobulin light chain-binding domain
7. Three-dimensional solution structure of an immunoglobulin light chain-binding domain of protein L. Comparison with the IgG-binding domains of protein G
8. Protein L from Peptostreptococcus magnus binds to the kappa light chain variable domain
9. On the interaction between protein L and immunoglobulins of various mammalian species
10. Protein L. A bacterial Ig-binding protein that activates human basophils and mast cells
11. Bacterial immunoglobulin superantigen proteins A and L activate human heart mast cells by interacting with immunoglobulin E
12. Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity
13. Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: Structural basis for recognition of B-cell receptors and superantigen activity
14. Interactions between a single immunoglobulin-binding domain of protein L from Peptostreptococcus magnus and a human kappa light chain
15. Cloning, expression and purification of Ppl-1, a kappa-chain binding protein, based upon protein L from Peptostreptococcus magnus
16. Attempts to locate complementarity-determining residues in the variable positions of light and heavy chains
17. Standard conformations for the canonical structures of immunoglobulins
18. Antibody-antigen interactions: Contact analysis and binding site topography
19. Protein L: An immunoglobulin light chain-binding bacterial protein. Characterization of binding and physicochemical properties
20. Mapping of the immunoglobulin light chain-binding site of protein L
21. Studies on a single immunoglobulin-binding domain of protein L from Peptostreptococcus magnus: The role of tyrosine-53 in the reaction with human IgG
22. The hydrogen bond in molecular recognition
23. The atomic structure of protein-protein recognition sites
24. Specific versus non-specific contacts in protein crystals
25. Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex
26. Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule
27. Refined structure of an intact IgG2a monoclonal antibody
28. Crystallographic structure of an intact IgG1 monoclonal antibody
29. Molecular evolution of bacterial cell-surface proteins
30. The third IgG-binding domain from streptococcal protein G. An analysis by X-ray crystallography of the structure alone and in a complex with Fab
31. Crystal structure of a streptococcal protein G domain bound to an Fab fragment
32. Use of streptococcal protein G in obtaining crystals of an antibody Fab fragment in complex with a meningococcal antigen
33. Crystallization of macromolecular complexes: Combinatorial complex crystallization
34. Fv fragment-mediated crystallization of the membrane protein bacterial cytochrome c oxidase
35. Crystallization and preliminary X-ray analysis of the Fab fragment of a human monoclonal IgM rheumatoid factor (2A2)
36. Crystallization of macromolecular complexes: Stoichiometric variation screening
37. AMoRe: An Automated Package for Molecular Replacement
38. Improved methods for binding protein models in electron density maps and the location of errors in these models
39. Crystallography + NMR system: A new software suite for macromolecular structure determination
40. Molmol: A program for display and analysis of macromolecular structures
41. The CCP4 Suite: Programs for protein crystallography
42. Satisfying hydrogen bonding potential in proteins