Antitumor immune effector mechanisms recruited by phage display-derived fully human IgG1 and IgA1 monoclonal antibodies

Cancer Research

Volumn 59, Issue 22, 1999, Pages 5778-5784

  Huls, Gerwin ^a,b   Heijnen, Ingmar A F M ^a   Cuomo, Emanuela ^a   Van Der Linden, Joke ^a   Boel, Edwin ^a   Van De Winkel, Jan G J ^a,c   Logtenberg, Ton ^a,b,d  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b Utrecht Biotechnology Systems   (Netherlands)

^c Medarex Europe   (Netherlands)

^d UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

FC RECEPTOR; GRANULOCYTE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN A1; IMMUNOGLOBULIN G1; MONOCLONAL ANTIBODY; TUMOR ANTIGEN;

ANIMAL CELL; ANTIBODY PRODUCTION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; EFFECTOR CELL; HUMAN; HUMAN CELL; NONHUMAN; PHAGE DISPLAY; PHAGOCYTOSIS; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; RAT;

ANTIBODIES, MONOCLONAL; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; ANTIGENS, CD; ANTIGENS, NEOPLASM; CELL ADHESION MOLECULES; COMPLEMENT SYSTEM PROTEINS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOTHERAPY; MACROPHAGES; NEUTROPHILS; PHAGOCYTOSIS; RECEPTORS, FC; RECEPTORS, IGG; RECOMBINANT PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0033571164     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Vaughan, T. J., Osbourn, J. K., and Tempest, P. R. Human antibodies by design. Nat. Biotechnol., 16: 535-539, 1998.
2. Holliger, P., and Hoogenboom, H. Antibodies come back from the brink. Nat. Biotechnol., 16: 1015-1016, 1998.
3. Heijnen, I. A. F. M., and van de Winkel, J. G. J. Human IgG Fc receptors. Int. Rev. Immunol., 16: 29-56, 1997.
4. van de Winkel, J. G. J., and Capel, P. J. A. Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications. Immunol. Today, 14: 215-221, 1993.
5. Guyre, P. M., Morganelli, P. M., and Miller, R. Recombinant immune interferon increases immunoglobulin Fc receptors on cultured human mononuclear phagocytes. J. Clin. Investig., 72: 393-397, 1983.
6. Repp, R., Valerius, T., Sendler, A., Gramatzki, M., Iro, H., Kalden, J. R., and Platzer, E. Neutrophils express the high affinity receptor for IgG (Fc-γRI:CD64) after in vivo application of rhG-CSF. Blood, 78: 885-889, 1991.
7. Hulett, M. D., and Hogarth, P. M. Molecular basis of Fc receptor function. Adv. Immunol., 57: 1-127, 1994.
8. Amigorena, S., Bonnerot, C., Drake, J., Choquet, D., Hunziker, W., Guillet, J. G., Webster, P., Sautes, C., Mellman, I., and Fridman, W. H. Cytoplasmic domain heterogeneity and functions of IgG Fc receptors in B-lymphocytes. Science (Washington DC), 156: 1808-1812, 1992.
9. Ono, M., Bolland, S., Tempst, P., and Ravetch, J. V. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the FcyRIIB. Nature (Lond.), 383: 263-265, 1996.
10. D'Ambrioso, D., Hippen, K. L., Minskoff, S. A., Mellman, I., Pani, G., Siminovitch, K. A., and Cambier, J. C. Recruitment and activation of PTP-1C in negative regulation of antigen receptor signaling by FcγRIIb. Science (Washington DC), 268: 293-296, 1995.
11. Däeron, M., Latour, S., Malbec, O., Espinosa, E., Pina, P., Pasmans, S., and Fridman, W. H. The same tyrosine-based inhibition motif, in the intracytoplasmic domain of Fc-γRIIB, regulates negatively BCR-, TCR, and FcR-dependent cell activation. Immunity, 3: 635-646, 1995.
12. Morton, H. C., Van Egmond, M., and van de Winkel, J. G. J. Structure and function of human IgA Fc receptors (FcαR). Crit. Rev. Immunol., 16: 423-440, 1996.
13. Shen. L. Receptors for IgA on phagocytic cells. Immunol. Res., 11: 273-282, 1992.
14. Valerius, T., Stockmeyer, B., Van Spriel, A., Graziano, R. F., Van den Herik-Oudijk, I. E., Repp, R., Deo, Y. M., Lynd, J., Kalden, J. R., Gramatzki, M., and van de Winkel, J. G. J. FcαRI (CD89) as a novel trigger molecule for bispecific antibody therapy. Blood, 90: 4485-4492, 1997.
15. Deo, Y. M., Sundarapandiyan, K., Keler, T., Wallace, P. K., and Graziano, R. F. Bispecific molecules directed to the Fc receptor for IgA (FcαRI, CD89) and tumor antigens efficiently promote cell-mediated cytotoxicity of tumor targets in whole blood. J. Immunol., 160: 1677-1686, 1998.
16. Collombo, M. P., Ferrari, G., Stoppacciaro, A., Parenza, M., Rodolfo, M., Mavilio, F., and Parmiani, G. Granulocyte colony-stimulating factor gene transfer suppresses tumorigenicity of a murine adenocarcinoma in vivo. J. Exp. Med., 173: 889-897, 1991.
17. Midorikawa, Y., Yamashita, T., and Sendo, R. Modulation of the immune response to transplanted tumors in rats by selective depletion of neutrophils in vivo using a monoclonal antibody: abrogation of specific transplantation resistance to chemical carcinogen-induced syngeneic tumors by selective depletion of neutrophils in vivo. Cancer Res., 50: 6243-6247, 1990.
18. Valerius, T., Repp, R., de Wit, T. P. M., Berthold, S., Platzer, E., Kalden, J. R., Gramatzki, M., and van de Winkel, J. G. J. Involvement of the high affinity receptor for IgG (FcαRI: CD64) in enhanced tumor cell cytotoxicity of neutrophils during G-CSF therapy. Blood, 82: 931-939, 1993.
19. Stockmeyer, B., Valerius, T., Repp, R., Heijnen, I. A. F. M., Buhring, H. J., Deo, Y. M., Kalden, J. R., Gramatzki, M., and van de Winkel, J. G. J. Preclinical studies with FcγR bispecific antibodies and granulocyte colony-stimulating factor-primed neutrophils as effector cells against HER-2/neu overexpressing breast cancer. Cancer Res., 57: 696-701, 1997.
20. Riethmüller, G., Holz, E., Schlimok, G., Schmiegel, W., Raab, R., Höffken, K., Gruber, R., Funke, I., Pichlmaier, H., Hirche, H., Buggisch, P., Witte, J., and Pichlmayr, R. J. Monoclonal antibody therapy for resected Duke's C colorectal cancer: seven-year outcome of a multicenter randomised trial. Clin. Oncol., 16: 1788-1794, 1998.
21. Huls, G. A., Heijnen, I. A. F. M., Cuomo, M. E., Koningsberger, J. C., Wiegman, L., Boel, E., van der Vuurst de Vries, A-R., Loyson, S. A. J., Helfrich, W., van Berge Henegouwen, G. P., van Meyer, M., de Uzlip, J., and Logtenberg, T. A recombinant, fully human monoclonal antibody with anti-tumor activity constructed from phage displayed antibody fragments. Nat. Biotechnol., 17: 276-281, 1999.
22. Lankhof, H. Structure and function of human von Willebrand factor (Ph.D. Thesis). Utrecht, the Netherlands: University of Utrecht, 1996.
23. Balzar, M., Bakker, H. A., Briaire-de Bruijn, I. H., Fleuren, G. J., Warnaar, S. O., and Litvinov, S. O. Cytoplasmic tail regulates the intercellular adhesion function of the epithelial cell adhesion molecule. Mol. Cell. Biol., 18: 4833-4843, 1998.
24. Warmerdam, P. A. M., van den Herik-Oudijk, I. E., Parren, P. W. H. I., Westerdaal, N. A. C., van de Winkel, J. G. J., and Capel, P. J. A. Interaction of a human FcγRIIb1 (CD32) isoform with murine and human IgG subclasses. Int. Immunol., 5: 239-247, 1992.
25. Boel, E. Phages and phagocytes (Ph.D. thesis). Utrecht, the Netherlands: University of Utrecht, 1998.
26. Van Strijp, J. A. G., Van Kessel, K. P. M., Van der Tol, M. E., and Verhoef, J. Complement-mediated phagocytosis of herpes simplex virus by human granulocytes: binding or ingestion. J. Clin. Investig., 84: 107-112, 1989.
27. Ely, P., Wallace, P. K., Givan, A. L., Graziano, R. F., Guyre, P. M., and Fanger, M. W. Bispecific-armed, interferonγ-primed macrophage-mediated phagocytosis of malignant non-Hodgkin's lymphoma. Blood, 87: 3813-3821, 1996.
28. Brooks, D. G., Qiu, W. Q., Luster, A. D., and Ravetch, J. V. Structure and expression of human IgG FcγRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes. J. Exp. Med., 170: 1369-1385, 1989.
29. Cassel, D. L., Keller, M. A., Surrey, S., Schwartz, E., Schreiber, A. D., Rappaport, E. F., and McKenzie, S. E. Differential expression of FcγRIIA, FcγRIIB and FcγRIIC in hematopoietic cells: analysis of transcripts. Mol. Immunol., 30: 451-460, 1989.
30. Morton, H. C., Van den Herik-Oudijk, I. E., Vossebeld, P., Snijders, A., Verhoeven, A. J. Capel, P. J. A., and van de Winkel, J. G. J. Functional association between the human myeloid IgA Fc receptor (CD89) and the FcR γ-chain. Molecular basis for CD89/FcR γ-chain association. J. Biol. Chem., 270: 29781-29787, 1995.
31. Morton, H. C., Alkin, J. D., Owens, R. J., and Woof, J. M. Purification and characterization of chimeric human IgA1 and IgA2 expressed in COS and Chinese hamster ovary cells. J. Immunol., 151: 4743-4752, 1993.
32. Russel, M. W., and Mansa, B. Complement-fixing properties of human IgA antibodies. Scand. J. Immunol., 30: 175-183, 1989.
33. Cooper, N. R. The classical complement pathway. Activation and regulation of the first complement component. Adv. Immunol., 37: 151-216, 1985.
34. Sim, R. B., and Reid, K. B. M. C1: molecular interactions with activating systems. Immunol. Today, 12: 307-311, 1991.