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Volumn 31, Issue 41, 2011, Pages 14677-14687

The residence time of GABA ARs at inhibitory synapses is determined by direct binding of the receptor α1 subunit to gephyrin

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; GEPHYRIN; THREONINE;

EID: 80054044911     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2001-11.2011     Document Type: Article
Times cited : (128)

References (51)
  • 1
    • 78650636251 scopus 로고    scopus 로고
    • Protein kinase C phosphorylation regulates membrane insertion of GABA(A) receptor subtypes that mediate tonic inhibition
    • Abramian AM, Comenencia-Ortiz E, Vithlani M, Tretter EV, Sieghart W, Davies PA, Moss SJ (2010) Protein kinase C phosphorylation regulates membrane insertion of GABA(A) receptor subtypes that mediate tonic inhibition. J Biol Chem 285:41795-41805
    • (2010) J Biol Chem , vol.285 , pp. 41795-41805
    • Abramian, A.M.1    Comenencia-Ortiz, E.2    Vithlani, M.3    Tretter, E.V.4    Sieghart, W.5    Davies, P.A.6    Moss, S.J.7
  • 2
    • 12744273084 scopus 로고    scopus 로고
    • Distinct gamma2 subunit domains mediate clustering and synaptic function of postsynaptic GABAA receptors and gephyrin
    • Alldred MJ, Mulder-Rosi J, Lingenfelter SE, Chen G, Luscher B (2005) Distinct gamma2 subunit domains mediate clustering and synaptic function of postsynaptic GABAA receptors and gephyrin. J Neurosci 25:594-603
    • (2005) J Neurosci , vol.25 , pp. 594-603
    • Alldred, M.J.1    Mulder-Rosi, J.2    Lingenfelter, S.E.3    Chen, G.4    Luscher, B.5
  • 3
    • 34250184742 scopus 로고    scopus 로고
    • Imaging the lateral diffusion of membrane molecules with quantum dots
    • Bannai H, Levi S, Schweizer C, Dahan M, Triller A (2006) Imaging the lateral diffusion of membrane molecules with quantum dots. Nat Protoc 1:2628-2634
    • (2006) Nat Protoc , vol.1 , pp. 2628-2634
    • Bannai, H.1    Levi, S.2    Schweizer, C.3    Dahan, M.4    Triller, A.5
  • 6
    • 0027938035 scopus 로고
    • Distribution, prevalence, and drug binding profile of gamma-aminobutyric acid type A receptor subtypes differing in the beta-subunit variant
    • Benke D, Fritschy JM, Trzeciak A, Bannwarth W, Mohler H (1994) Distribution, prevalence, and drug binding profile of gamma-aminobutyric acid type A receptor subtypes differing in the beta-subunit variant. J Biol Chem 269:27100-27107
    • (1994) J Biol Chem , vol.269 , pp. 27100-27107
    • Benke, D.1    Fritschy, J.M.2    Trzeciak, A.3    Bannwarth, W.4    Mohler, H.5
  • 8
    • 0035804244 scopus 로고    scopus 로고
    • Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance
    • Brickley SG, Revilla V, Cull-Candy SG, Wisden W, Farrant M (2001) Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance. Nature 409:88-92
    • (2001) Nature , vol.409 , pp. 88-92
    • Brickley, S.G.1    Revilla, V.2    Cull-Candy, S.G.3    Wisden, W.4    Farrant, M.5
  • 9
    • 0037185248 scopus 로고    scopus 로고
    • Intact sorting, targeting and clustering of gamma-aminobutyric acid A receptor subtypes in hippocampal neurons in vitro
    • Brunig I, Scotti E, Sidler C, Fritschy JM (2002) Intact sorting, targeting and clustering of gamma-aminobutyric acid A receptor subtypes in hippocampal neurons in vitro. J Comp Neurol 443:43-55
    • (2002) J Comp Neurol , vol.443 , pp. 43-55
    • Brunig, I.1    Scotti, E.2    Sidler, C.3    Fritschy, J.M.4
  • 10
    • 0030043594 scopus 로고    scopus 로고
    • Assembly and cell surface expression of heteromeric and homomeric gammaaminobutyric acid type A receptors
    • Connolly CN, Krishek BJ, McDonald BJ, Smart TG, Moss SJ (1996) Assembly and cell surface expression of heteromeric and homomeric gammaaminobutyric acid type A receptors. J Biol Chem 271:89-96
    • (1996) J Biol Chem , vol.271 , pp. 89-96
    • Connolly, C.N.1    Krishek, B.J.2    McDonald, B.J.3    Smart, T.G.4    Moss, S.J.5
  • 11
    • 0033579497 scopus 로고    scopus 로고
    • Cell surface stability of gamma-aminobutyric acid type A receptors. Dependence on protein kinase C activity and subunit composition
    • Connolly CN, Kittler JT, Thomas P, Uren JM, Brandon NJ, Smart TG, Moss SJ (1999) Cell surface stability of gamma-aminobutyric acid type A receptors. Dependence on protein kinase C activity and subunit composition. J Biol Chem 274:36565-36572
    • (1999) J Biol Chem , vol.274 , pp. 36565-36572
    • Connolly, C.N.1    Kittler, J.T.2    Thomas, P.3    Uren, J.M.4    Brandon, N.J.5    Smart, T.G.6    Moss, S.J.7
  • 12
    • 0038044682 scopus 로고    scopus 로고
    • Association of gephyrin with synaptic and extrasynaptic GABAA receptor varies during development in cultured hippocampal neurons
    • Danglot L, Triller A, Bessis A (2003) Association of gephyrin with synaptic and extrasynaptic GABAA receptor varies during development in cultured hippocampal neurons. Mol Cell Neurosci 23:264-278
    • (2003) Mol Cell Neurosci , vol.23 , pp. 264-278
    • Danglot, L.1    Triller, A.2    Bessis, A.3
  • 14
    • 33644665247 scopus 로고    scopus 로고
    • Postsynaptic clustering of major GABAA receptor subtypes requires the gamma 2 subunit and gephyrin
    • Essrich C, Lorez M, Benson JA, Fritschy JM, Luscher B (1998) Postsynaptic clustering of major GABAA receptor subtypes requires the gamma 2 subunit and gephyrin. Nat Neurosci 1:563-571
    • (1998) Nat Neurosci , vol.1 , pp. 563-571
    • Essrich, C.1    Lorez, M.2    Benson, J.A.3    Fritschy, J.M.4    Luscher, B.5
  • 15
    • 14844323722 scopus 로고    scopus 로고
    • Variations on an inhibitory theme: Phasic and tonic activation of GABA(A) receptors
    • Farrant M, Nusser Z (2005) Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors. Nat Rev Neurosci 6:215-229
    • (2005) Nat Rev Neurosci , vol.6 , pp. 215-229
    • Farrant, M.1    Nusser, Z.2
  • 16
    • 0032514872 scopus 로고    scopus 로고
    • Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity
    • Feng G, Tintrup H, Kirsch J, Nichol MC, Kuhse J, Betz H, Sanes JR (1998) Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity. Science 282:1321-1324
    • (1998) Science , vol.282 , pp. 1321-1324
    • Feng, G.1    Tintrup, H.2    Kirsch, J.3    Nichol, M.C.4    Kuhse, J.5    Betz, H.6    Sanes, J.R.7
  • 17
    • 0034722853 scopus 로고    scopus 로고
    • Reduced synaptic clustering of GABA and glycine receptors in the retina of the gephyrin null mutant mouse
    • Fischer F, Kneussel M, Tintrup H, Haverkamp S, Rauen T, Betz H, Wassle H (2000) Reduced synaptic clustering of GABA and glycine receptors in the retina of the gephyrin null mutant mouse. J Comp Neurol 427:634-648
    • (2000) J Comp Neurol , vol.427 , pp. 634-648
    • Fischer, F.1    Kneussel, M.2    Tintrup, H.3    Haverkamp, S.4    Rauen, T.5    Betz, H.6    Wassle, H.7
  • 19
    • 36549058202 scopus 로고    scopus 로고
    • Activation of GABAA receptors: Views from outside the synaptic cleft
    • Glykys J, Mody I (2007) Activation of GABAA receptors: views from outside the synaptic cleft. Neuron 56:763-770
    • (2007) Neuron , vol.56 , pp. 763-770
    • Glykys, J.1    Mody, I.2
  • 20
    • 38949092526 scopus 로고    scopus 로고
    • Which GABA(A) receptor subunits are necessary for tonic inhibition in the hippocampus?
    • Glykys J, Mann EO, Mody I (2008) Which GABA(A) receptor subunits are necessary for tonic inhibition in the hippocampus? J Neurosci 28:1421-1426
    • (2008) J Neurosci , vol.28 , pp. 1421-1426
    • Glykys, J.1    Mann, E.O.2    Mody, I.3
  • 21
    • 33646850883 scopus 로고    scopus 로고
    • Activity-dependent movements of postsynaptic scaffolds at inhibitory synapses
    • Hanus C, Ehrensperger MV, Triller A (2006) Activity-dependent movements of postsynaptic scaffolds at inhibitory synapses. J Neurosci 26:4586-4595
    • (2006) J Neurosci , vol.26 , pp. 4586-4595
    • Hanus, C.1    Ehrensperger, M.V.2    Triller, A.3
  • 25
    • 42349109493 scopus 로고    scopus 로고
    • GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition
    • Jacob TC, Moss SJ, Jurd R (2008) GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition. Nat Rev Neurosci 9:331-343
    • (2008) Nat Rev Neurosci , vol.9 , pp. 331-343
    • Jacob, T.C.1    Moss, S.J.2    Jurd, R.3
  • 26
    • 34547643210 scopus 로고    scopus 로고
    • PDZ domains: Folding and binding
    • Jemth P, Gianni S (2007) PDZ domains: folding and binding. Biochemistry 46:8701-8708
    • (2007) Biochemistry , vol.46 , pp. 8701-8708
    • Jemth, P.1    Gianni, S.2
  • 28
    • 0033994755 scopus 로고    scopus 로고
    • Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin
    • Kins S, Betz H, Kirsch J (2000) Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin. Nat Neurosci 3:22-29
    • (2000) Nat Neurosci , vol.3 , pp. 22-29
    • Kins, S.1    Betz, H.2    Kirsch, J.3
  • 29
    • 0028998303 scopus 로고
    • The postsynaptic localization of the glycine receptor-associated protein gephyrin is regulated by the cytoskeleton
    • Kirsch J, Betz H (1995) The postsynaptic localization of the glycine receptor-associated protein gephyrin is regulated by the cytoskeleton. J Neurosci 15:4148-4156
    • (1995) J Neurosci , vol.15 , pp. 4148-4156
    • Kirsch, J.1    Betz, H.2
  • 30
    • 0034310719 scopus 로고    scopus 로고
    • Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons
    • Kittler JT, Delmas P, Jovanovic JN, Brown DA, Smart TG, Moss SJ (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J Neurosci 20:7972-7977
    • (2000) J Neurosci , vol.20 , pp. 7972-7977
    • Kittler, J.T.1    Delmas, P.2    Jovanovic, J.N.3    Brown, D.A.4    Smart, T.G.5    Moss, S.J.6
  • 31
    • 4344624896 scopus 로고    scopus 로고
    • Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating gamma-aminobutyric acid type A receptor membrane trafficking
    • Kittler JT, Thomas P, Tretter V, Bogdanov YD, Haucke V, Smart TG, Moss SJ (2004) Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating gamma-aminobutyric acid type A receptor membrane trafficking. Proc Natl Acad Sci U S A 101:12736-12741
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 12736-12741
    • Kittler, J.T.1    Thomas, P.2    Tretter, V.3    Bogdanov, Y.D.4    Haucke, V.5    Smart, T.G.6    Moss, S.J.7
  • 32
    • 0034284148 scopus 로고    scopus 로고
    • Clustering of inhibitory neurotransmitter receptors at developing postsynaptic sites: The membrane activation model
    • Kneussel M, Betz H (2000) Clustering of inhibitory neurotransmitter receptors at developing postsynaptic sites: the membrane activation model. Trends Neurosci 23:429-435
    • (2000) Trends Neurosci , vol.23 , pp. 429-435
    • Kneussel, M.1    Betz, H.2
  • 33
    • 34249790850 scopus 로고    scopus 로고
    • Trafficking and synaptic anchoring of ionotropic inhibitory neurotransmitter receptors
    • Kneussel M, Loebrich S (2007) Trafficking and synaptic anchoring of ionotropic inhibitory neurotransmitter receptors. Biol Cell 99:297-309
    • (2007) Biol Cell , vol.99 , pp. 297-309
    • Kneussel, M.1    Loebrich, S.2
  • 36
    • 79959916248 scopus 로고    scopus 로고
    • The cell adhesion molecule neurofascin stabilizes axoaxonic GABAergic terminals at the axon initial segment
    • Kriebel M, Metzger J, Trinks S, Chugh D, Harvey RJ, Harvey K, Volkmer H (2011) The cell adhesion molecule neurofascin stabilizes axoaxonic GABAergic terminals at the axon initial segment. J Biol Chem 286:24385-24395
    • (2011) J Biol Chem , vol.286 , pp. 24385-24395
    • Kriebel, M.1    Metzger, J.2    Trinks, S.3    Chugh, D.4    Harvey, R.J.5    Harvey, K.6    Volkmer, H.7
  • 37
    • 0842301334 scopus 로고    scopus 로고
    • Gephyrin is critical for glycine receptor clustering but not for the formation of functional GABAergic synapses in hippocampal neurons
    • Levi S, Logan SM, Tovar KR, Craig AM (2004) Gephyrin is critical for glycine receptor clustering but not for the formation of functional GABAergic synapses in hippocampal neurons. J Neurosci 24:207-217
    • (2004) J Neurosci , vol.24 , pp. 207-217
    • Levi, S.1    Logan, S.M.2    Tovar, K.R.3    Craig, A.M.4
  • 38
    • 3042818495 scopus 로고    scopus 로고
    • Regulation of GABAA receptor trafficking, channel activity, and functional plasticity of inhibitory synapses
    • Luscher B, Keller CA (2004) Regulation of GABAA receptor trafficking, channel activity, and functional plasticity of inhibitory synapses. Pharmacol Ther 102:195-221
    • (2004) Pharmacol Ther , vol.102 , pp. 195-221
    • Luscher, B.1    Keller, C.A.2
  • 39
    • 0029670123 scopus 로고    scopus 로고
    • Which GABAA-receptor subtypes really occur in the brain?
    • McKernan RM, Whiting PJ (1996) Which GABAA-receptor subtypes really occur in the brain? Trends Neurosci 19:139-143
    • (1996) Trends Neurosci , vol.19 , pp. 139-143
    • McKernan, R.M.1    Whiting, P.J.2
  • 40
    • 0020405932 scopus 로고
    • Purification by affinity chromatography of the glycine receptor of rat spinal cord
    • Pfeiffer F, Graham D, Betz H (1982) Purification by affinity chromatography of the glycine receptor of rat spinal cord. J Biol Chem 257:9389-9393
    • (1982) J Biol Chem , vol.257 , pp. 9389-9393
    • Pfeiffer, F.1    Graham, D.2    Betz, H.3
  • 41
    • 63849095895 scopus 로고    scopus 로고
    • Control of the postsynaptic membrane viscosity
    • Renner M, Choquet D, Triller A (2009) Control of the postsynaptic membrane viscosity. J Neurosci 29:2926-2937
    • (2009) J Neurosci , vol.29 , pp. 2926-2937
    • Renner, M.1    Choquet, D.2    Triller, A.3
  • 42
    • 30844456191 scopus 로고    scopus 로고
    • GABA-based therapeutic approaches: GABAA receptor subtype functions
    • Rudolph U, Mohler H (2006) GABA-based therapeutic approaches: GABAA receptor subtype functions. Curr Opin Pharmacol 6:18-23
    • (2006) Curr Opin Pharmacol , vol.6 , pp. 18-23
    • Rudolph, U.1    Mohler, H.2
  • 44
    • 0033931548 scopus 로고    scopus 로고
    • Mini-review: Gephyrin, a major postsynaptic protein of GABAergic synapses
    • Sassoe-Pognetto M, Fritschy JM (2000) Mini-review: gephyrin, a major postsynaptic protein of GABAergic synapses. Eur J Neurosci 12:2205-2210
    • (2000) Eur J Neurosci , vol.12 , pp. 2205-2210
    • Sassoe-Pognetto, M.1    Fritschy, J.M.2
  • 46
    • 2442629473 scopus 로고    scopus 로고
    • Biochemical characterization of the high affinity binding between the glycine receptor and gephyrin
    • Schrader N, Kim EY, Winking J, Paulukat J, Schindelin H, Schwarz G (2004) Biochemical characterization of the high affinity binding between the glycine receptor and gephyrin. J Biol Chem 279:18733-18741
    • (2004) J Biol Chem , vol.279 , pp. 18733-18741
    • Schrader, N.1    Kim, E.Y.2    Winking, J.3    Paulukat, J.4    Schindelin, H.5    Schwarz, G.6
  • 47
    • 0036673411 scopus 로고    scopus 로고
    • Subunit composition, distribution and function of GABA(A) receptor subtypes
    • Sieghart W, Sperk G (2002) Subunit composition, distribution and function of GABA(A) receptor subtypes. Curr Top Med Chem 2:795-816
    • (2002) Curr Top Med Chem , vol.2 , pp. 795-816
    • Sieghart, W.1    Sperk, G.2
  • 48
    • 38949182650 scopus 로고    scopus 로고
    • The clustering of GABA(A) receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor alpha 2 subunits to gephyrin
    • Tretter V, Jacob TC, Mukherjee J, Fritschy JM, Pangalos MN, Moss SJ (2008) The clustering of GABA(A) receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor alpha 2 subunits to gephyrin. J Neurosci 28:1356-1365
    • (2008) J Neurosci , vol.28 , pp. 1356-1365
    • Tretter, V.1    Jacob, T.C.2    Mukherjee, J.3    Fritschy, J.M.4    Pangalos, M.N.5    Moss, S.J.6
  • 49
    • 48749085218 scopus 로고    scopus 로고
    • New concepts in synaptic biology derived from single-molecule imaging
    • Triller A, Choquet D (2008) New concepts in synaptic biology derived from single-molecule imaging. Neuron 59:359-374
    • (2008) Neuron , vol.59 , pp. 359-374
    • Triller, A.1    Choquet, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.