Synthesis, biological evaluation and molecular docking of quinazoline-4(1H)-one derivatives as anti-inflammatory and analgesic agents

Acta Poloniae Pharmaceutica - Drug Research

Volumn 68, Issue 5, 2011, Pages 665-675

  Mohamed, Mosaad S ^a   Kamel, Mohsen M ^b   Kassem, Emad M M ^b   Abotaleb, Nageh ^a   Khedr, M ^c   Ahmed, Marwa F ^a  

^a Helwan   (Egypt)

^b NATIONAL RESEARCH CENTRE   (Egypt)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Analgesic; Anti inflammatory; Molecular docking; Quinazolin 4 ones; Ulcerogenic effect

Indexed keywords

3 {4 [6 (P TOLYL) 2 OXO 1,2,5,6 TETRAHYDROPYRIMIDIN 4 YL] PHENYL} 6,8 DIBROMO 2 PHENYL 3H QUINAZOLIN 4 ONE; 6 BROMO 2 PHENYL 3 (4 ACETYLPHENYL) 4(3H) QUINAZOLINONE; 6 BROMO 2 PHENYL 3 {4 [(E) 3 (4 METHOXYPHENYL ACRYLOYL] PHENYL} 3H QUINAZOLIN 4 ONE; 6 BROMO 2 PHENYL 3 {4 [(E) 3 (NAPHTHALENE 2YL) ACRYLOYL] PHENYL} 3H QUINAZOLIN 4 ONE; 6 BROMO 2 PHENYL 3 {4 [5 (P ANISYL) 4,5 DIHYDRO 1 ACETYL 1H PYRAZOL 3 YL] PHENYL} 3H QUINAZOLIN 4 ONE; 6 {4 [6 BROMO 2 PHENYL 4 OXO 4H QUINAZOLIN 3 YL] PHENYL} 2 AMINO 4 (P TOLYL) 4,4 DIHYDROPYRAN 3 CARBONITRILE; 6 {4 [6 BROMO 2 PHENYL 4 OXO 4H QUINAZOLIN 3 YL] PHENYL} 2 IMINO 4 (2 HYDROXYPHENYL) 1,2 DIHYDROPYRIDINE 3 CARBONITRILE; 6 {4 [6 BROMO 2 PHENYL 4 OXO 4H QUINAZOLIN 3 YL] PHENYL} 2 OXO 4 (FURAN 2 YL)] 1,2 DIHYDROPYRIDINE 3 CARBONITRILE; 6 {4 [6,8 DIBROMO 2 PHENYL 4 OXO 4H QUINAZOLIN 3 YL] PHENYL} 2 AMINO 4 PHENYL 4,4 DIHYDROPYRAN 3 CARBONITRILE; 6 {4 [6,8 DIBROMO 2 PHENYL 4 OXO 4H QUINAZOLIN 3 YL] PHENYL} 2 IMINO 4 (2 HYDROXYPHENYL) 1,2 DIHYDROPYRIDINE 3 CARBONITRILE; 6 {4 [6,8 DIBROMO 2 PHENYL 4 OXO 4H QUINAZOLIN 3 YL] PHENYL} 2 OXO 4 (FURAN 2 YL)] 1,2 DIHYDROPYRIDINE 3 CARBONITRILE; 6,8 DIBROMO 2 PHENYL 3 (4 ACETYLPHENYL) 4(3H) QUINAZOLINONE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; INDOMETACIN; QUINAZOLINE 4 (1H) ONE DERIVATIVE; QUINAZOLINONE DERIVATIVE; UNCLASSIFIED DRUG; CARRAGEENAN; DIAGNOSTIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; QUINAZOLINE DERIVATIVE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SAFETY; DRUG SCREENING; DRUG SYNTHESIS; MOLECULAR DOCKING; NONHUMAN; RAT; ANIMAL; CHEMICAL STRUCTURE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG DESIGN; DRUG EFFECT; EDEMA; FEMALE; HEAT; MALE; METABOLISM; MOUSE; PAIN ASSESSMENT; REACTION TIME; STOMACH ULCER; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; CYCLOOXYGENASE 2; DRUG DESIGN; EDEMA; FEMALE; HOT TEMPERATURE; INDOMETHACIN; MALE; MICE; MODELS, MOLECULAR; PAIN MEASUREMENT; QUINAZOLINES; RATS; REACTION TIME; STOMACH ULCER; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80054012375     PISSN: 00016837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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