Reciprocal regulation of cellular nitric oxide formation by nitric oxide synthase and nitrite reductases

Medical Science Monitor

Volumn 17, Issue 10, 2011, Pages

  Stefano, George B ^a   Kream, Richard M ^a  

^a STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Immune; Mitochondria; Nitric oxide; Nitric oxide synthase; Nitrite; Nitrite reductases; Vascular; Xanthine

Indexed keywords

ALDEHYDE DEHYDROGENASE; ARGININE; CYTOCHROME C; CYTOCHROME C OXIDASE; HYPOXANTHINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; NITRITE REDUCTASE; XANTHINE; XANTHINE OXIDASE;

ANTIINFLAMMATORY ACTIVITY; BIOSYNTHESIS; CARDIOVASCULAR FUNCTION; CELL METABOLISM; CYTOSOL; ENERGY METABOLISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MECHANISM; HUMAN; LUNG PERFUSION; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; REDUCTION; REGULATORY MECHANISM; REPERFUSION INJURY; REVIEW; SIGNAL TRANSDUCTION;

EID: 80054012333     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.881972     Document Type: Review

References (119)

1. Garraza MH, Forneris M, Virginia GL, Oliveros LB: Norepinephrine modulates the effect of neuropeptides in coeliac ganglion on ovarian hormones release: its relationship with ovarian nitric oxide and nerve growth factor. Neuro Endocrinol Lett, 2010; 31: 103-12
2. Jancinova V, Nosal R, Lojek A et al: Formation of reactive oxygen and nitrogen species in the presence of pinosylvin - an analogue of resve-ratrol. Neuro Endocrinol Lett, 2010; 31(Suppl.2): 79-83
3. Krejcova D, Pekarova M, Safrankova B, Kubala L: The effect of different molecular weight hyaluronan on macrophage physiology. Neuro Endocrinol Lett, 2009; 30(Suppl.1): 106-11
4. Ozkul A, Ayhan M, Yenisey C et al: The role of oxidative stress and en-dothelial injury in diabetic neuropathy and neuropathic pain. Neuro Endocrinol Lett, 2010; 31: 261-64
5. Papezikova I, Pekarova M, Lojek A, Kubala L: The effect of uric acid on homocysteine-induced endothelial dysfunction in bovine aortic en-dothelial cells. Neuro Endocrinol Lett, 2009; 30(Suppl.1): 112-15
6. Xu J, Xu Q, Chen X et al: Neuronal expression of inducible nitric oxide synthase in hypothyroid rat. Neuro Endocrinol Lett, 2010; 31: 848-51
7. Moncada S, Palmer RMJ, Higgs EA: Nitric oxide: physiology, pathophys-iology, and pharmacology. Pharmacol Rev, 1991; 43: 109-42
8. Moncada S, Higgs A: The L-arginine-nitric oxide pathway. New Eng J Med, 1993; 329: 2002-12
9. Murad F: Nitric oxide signaling: would you believe that a simple free radical could be a second messenger, autacoid, paracrine substance, neu-rotransmitter, and hormone? Recent Prog Horm Res, 1998; 53: 43-59
10. Denninger JW, Marletta MA: Guanylate cyclase and the NO/cGMP signaling pathway. Biochimi Biophys Acta, 1999; 1411: 334-50
11. Salvemini D: Regulation of cyclooxygenase enzymes by nitric oxide. Cell Mol Life Sci, 1997; 53: 576-82
12. Kream RM, Stefano GB: Endogenous morphine and nitric oxide coupled regulation of mitochondrial processes. Med Sci Monit, 2009; 15(12): RA263-68
13. Esch T, Stefano GB: The neurobiology of stress management. Neuro Endocrinol Lett, 2010; 31: 19-39
14. Mantione KJ, Kream RM, Stefano GB: Variations in critical morphine biosynthesis genes and their potential to infuence human health. REVIEW. Neuro Endocrinol Lett, 2010; 31: 11-18
15. Mantione KJ, Angert R, Cadet P et al: Identifcation of a μ Opiate Receptor Signaling Mechanism in Human Placenta. Med Sci Monit, 2010; 16(11): BR347-52
16. Stefano GB, Esch T, Bilfnger TV, Kream RM: Proinfammation and preconditioning protection are part of a common nitric oxide mediated process. Med Sci Monit, 2010; 16(6): RA125-30
17. Cable DG, Celotto AC, Evora PR, Schaff HV: Asymmetric dimethylar-ginine endogenous inhibition of nitric oxide synthase causes differential vasculature effects. Med Sci Monit, 2009; 15(9): BR248-53
18. Ilic MD, Ilic S, Lazarevic G et al: Impact of reversible myocardial isch-aemia on nitric oxide and asymmetric dimethylarginine production in patients with high risk for coronary heart disease. Med Sci Monit, 2010; 16(9): CR397-404
19. Kocsis GF, Csont T, Varga-Orvos Z et al: Expression of genes related to oxidative/nitrosative stress in mouse hearts: effect of preconditioning and cholesterol diet. Med Sci Monit, 2010; 16(1): BR32-39
20. Weerateerangkul P, Chattipakorn S, Chattipakorn N: Roles of the nitric oxide signaling pathway in cardiac ischemic preconditioning against myocardial ischemia-reperfusion injury. Med Sci Monit, 2011; 17(2): RA44-52.
21. Faraci FM, Heistad DD: Regulation of the cerebral circulation: role of endothelium and potassium channels. Phys Rev, 1998; 78: 53-97
22. Kinoshita H, Tsutsui M, Milstien S, Katusic ZS: Tetrahydrobiopterin, nitric oxide and regulation of cerebral arterial tone. Prog Neurobiol, 1997; 52: 295-302
23. Cooke JP, Dzau VJ: Nitric oxide synthase: role in the genesis of vascular disease. Ann Rev Med, 1997; 48: 489-509
24. Moncada S, Palmer RM, Higgs EA: The discovery of nitric oxide as the endogenous nitrovasodilator. Hypertension, 1988; 12: 365-72
25. Stefano GB, Scharrer B, Smith EM et al: Opioid and opiate immuno-regulatory processes. Crit Rev in Immunol, 1996; 16: 109-44
26. Fimiani C, Mattocks DW, Cavani F et al: Morphine and anandamide stimulate intracellular calcium transients in human arterial endotheli-al endothelial cells: coupling to nitric oxide release. Cellular Signaling, 1999; 11: 189-93
27. Stefano GB, Salzet M, Magazine HI, Bilfnger TV: Antagonist of LPS and IFN-g induction of iNOS in human saphenous vein endothelium by morphine and anandamide by nitric oxide inhibition of adenylate cyclase. J Cardiovasc Pharmacol, 1998; 31: 813-20
28. Prevot V, Croix D, Rialas CM et al: Estradiol coupling to endothelial nitric oxide production stimulates GnRH release from rat median eminence. Endocrinol, 1999; 140: 652-59
29. Mariotto S, Cuzzolin L, Adami A et al: Inhibition by sodium nitroprus-side of the expression of inducible nitric oxide synthase in rat neutro-phils. Br J Pharmacol, 1995; 114: 1105-6
30. Colasanti M, Persichini T, Menegazzi M et al: Induction of nitric oxide synthase mRNA expression. Suppression by exogenous nitric oxide. J Biol Chem, 1995; 270: 26731-33
31. Park SK, Lin HL, Murphy S: Nitric oxide regulates nitric oxide synthase-2 gene expression by inhibiting NF-kappa B binding to DNA. Biochem J, 1997; 322: 609-13
32. Taylor BS, Kim YM, Wang Q et al: Nitric oxide down-regulates hepato-cyte-inducible nitric oxide synthase gene expression. Arch Surg, 1997; 132: 1177-83
33. Togashi H, Sasaki M, Frohman E et al: Neuronal (type 1) nitric oxide synthase regulates nuclear factor kappa B activity and immunolog-ic (type II) nitric oxide synthase expression. Proc Natl Acad Sci USA, 1997; 94: 2676-80
34. Katsuyama K, Shichiri M, Marumo F, Hirata Y: NO inhibits cytokine-induced iNOS expression and NF-kappaB activation by interfering with phosphorylation and degradation of IkappaB-alpha. Arterioscler Thromb Vasc Biol, 1998; 18: 1796-802
35. Park SK, Lin HL, Murphy S: Nitric oxide limits transcriptional induction of nitric oxide synthase in CNS glial cells. Biochem Biophys Res Commun, 1994; 201: 762-68
36. Magazine HI: Detection of endothelial cell-derived nitric oxide: current trends and future directions. Adv Neuroimmunol, 1995; 5: 479-85
37. Esch T, Stefano GB: The neurobiological link between compassion and love. Med Sci Monit, 2011; 17(3): RA65-75
38. Stefano GB, Kream RM, Mantione KJ, Ptacek R: Endogenous morphine, stress and psychiatric disorders - review of actual fndings. J Czech Psychol, 2011; In Press
39. Atmanene C, Laux A, Glattard E et al: Characterization of human and bovine phosphatidylethanolamine-binding protein (PEBP/RKIP) interactions with morphine and morphine-glucuronides determined by non-covalent mass spectrometry. Med Sci Monit, 2009; 15(7): BR178-187
40. Stefano GB, Esch T, Kream RM: Xenobiotic perturbation of endogenous morphine signaling: paradoxical opiate hyperalgesia. Med Sci Monit, 2009; 15(5): RA107-10
41. Stefano GB, Kream RM, Esch T: Revisiting tolerance from the endogenous morphine perspective. Med Sci Monit, 2009; 15(9): RA189-98
42. Chen Z, Stamler JS: Bioactivation of nitroglycerin by the mitochondri-al aldehyde dehydrogenase. Trends Cardiovasc Med, 2006; 16: 259-65
43. Nohl H, Staniek K, Kozlov AV: The existence and signifcance of a mi-tochondrial nitrite reductase. Redox Rep, 2005; 10: 281-86
44. Kollau A, Hofer A, Russwurm M et al: Contribution of aldehyde dehy-drogenase to mitochondrial bioactivation of nitroglycerin: evidence for the activation of purifed soluble guanylate cyclase through direct formation of nitric oxide. Biochem J, 2005; 385: 769-77
45. Sarti P, Giuffre A, Barone MC et al: Nitric oxide and cytochrome oxi-dase: reaction mechanisms from the enzyme to the cell. Free Radic Biol Med, 2003; 34: 509-20
46. Kozlov AV, Staniek K, Nohl H: Nitrite reductase activity is a novel function of mammalian mitochondria. FEBS Lett, 1999; 454: 127-30
47. Basu S, Azarova NA, Font MD et al: Nitrite reductase activity of cyto-chrome c. J Biol Chem, 2008; 283: 32590-97
48. Hendgen-Cotta UB, Merx MW, Shiva S et al: Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocar-dial ischemia-reperfusion injury. Proc Natl Acad Sci USA, 2008; 105: 10256-61
49. Maia LB, Moura JJ: Nitrite reduction by xanthine oxidase family enzymes: a new class of nitrite reductases. J Biol Inorg Chem, 2011; 16: 443-60
50. Badejo AM Jr, Hodnette C, Dhaliwal JS et al: Mitochondrial aldehyde dehydrogenase mediates vasodilator responses of glyceryl trinitrate and sodium nitrite in the pulmonary vascular bed of the rat. Am J Physiol Heart Circ Physiol, 2010; 299: H819-26
51. Huang L, Borniquel S, Lundberg JO: Enhanced xanthine oxidoreduc-tase expression and tissue nitrate reduction in germ free mice. Nitric Oxide, 2010; 22: 191-95
52. Jansson EA, Huang L, Malkey R et al: A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis. Nat Chem Biol, 2008; 4: 411-17
53. Shiva S, Huang Z, Grubina R et al: Deoxymyoglobin is a nitrite reduc-tase that generates nitric oxide and regulates mitochondrial respiration. Circ Res, 2007; 100: 654-61
54. Li H, Samouilov A, Liu X, Zweier JL: Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrate reduction: evaluation of its role in nitrite and nitric oxide generation in anoxic tissues. Biochemistry, 2003; 42: 1150-59
55. Godber BL, Doel JJ, Sapkota GP et al: Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase. J Biol Chem, 2000; 275: 7757-63
56. Millar TM, Stevens CR, Benjamin N et al: Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypox-ic conditions. FEBS Lett, 1998; 427: 225-28
57. Golwala NH, Hodenette C, Murthy SN et al: Vascular responses to nitrite are mediated by xanthine oxidoreductase and mitochondrial aldehyde dehydrogenase in the rat. Can J Physiol Pharmacol, 2009; 87: 1095-101
58. Zuckerbraun BS, Shiva S, Ifedigbo E et al: Nitrite potently inhibits hy-poxic and infammatory pulmonary arterial hypertension and smooth muscle proliferation via xanthine oxidoreductase-dependent nitric oxide generation. Circulation, 2010; 121: 98-109
59. Isenberg JS, Shiva S, Gladwin M: Thrombospondin-1-CD47 blockade and exogenous nitrite enhance ischemic tissue survival, blood fow and angiogenesis via coupled NO-cGMP pathway activation. Nitric Oxide, 2009; 21: 52-62
60. Casey DB, Badejo AM Jr, Dhaliwal JS et al: Pulmonary vasodilator responses to sodium nitrite are mediated by an allopurinol-sensitive mechanism in the rat. Am J Physiol Heart Circ Physiol, 2009; 296: H524-33
61. McNulty PH, Scott S, Kehoe V et al: Nitrite consumption in ischemic rat heart catalyzed by distinct blood-borne and tissue factors. Am J Physiol Heart Circ Physiol, 2008; 295: H2143-48
62. Baker JE, Su J, Fu X et al: Nitrite confers protection against myocar-dial infarction: role of xanthine oxidoreductase, NADPH oxidase and K(ATP) channels. J Mol Cell Cardiol, 2007; 43: 437-44
63. Saraiva RM, Minhas KM, Zheng M et al: Reduced neuronal nitric oxide synthase expression contributes to cardiac oxidative stress and ni-troso-redox imbalance in ob/ob mice. Nitric Oxide, 2007; 16: 331-38
64. Tripatara P, Patel NS, Webb A et al: Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: role for xan-thine oxidoreductase. J Am Soc Nephrol, 2007; 18: 570-80
65. Fujita K, Wada K, Nozaki Y et al: Serum nitric oxide metabolite as a bio-marker of visceral fat accumulation: clinical signifcance of measurement for nitrate/nitrite. Med Sci Monit, 2011; 17(3): CR123-31
66. Kucukatay V, Hacioglu G, Ozkaya G et al: The effect of diabetes melli-tus on active avoidance learning in rats: the role of nitric oxide. Med Sci Monit, 2009; 15(3): BR88-93
67. Lobo SM, Soriano FG, Barbeiro DF et al: Effects of dobutamine on gut mucosal nitric oxide production during endotoxic shock in rabbits. Med Sci Monit, 2009; 15(2): BR37-42
68. Klocke R, Mani AR, Moore KP et al: Inactivation of xanthine oxidore-ductase is associated with increased joint swelling and nitrotyrosine formation in acute antigen-induced arthritis. Clin Exp Rheumatol, 2005; 23: 345-50
69. Kelley EE, Batthyany CI, Hundley NJ et al: Nitro-oleic acid, a novel and irreversible inhibitor of xanthine oxidoreductase. J Biol Chem, 2008; 283: 36176-84
70. Godber BL, Doel JJ, Durgan J et al: A new route to peroxynitrite: a role for xanthine oxidoreductase. FEBS Lett, 2000; 475: 93-96
71. Webb AJ, Patel N, Loukogeorgakis S et al: Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension, 2008; 51: 784-90
72. Lu P, Liu F, Yao Z et al: Nitrite-derived nitric oxide by xanthine ox-idoreductase protects the liver against ischemia-reperfusion injury. Hepatobiliary Pancreat Dis Int, 2005; 4: 350-55
73. Duranski MR, Greer JJ, Dejam A et al: Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. J Clin Invest, 2005; 115: 1232-40
74. Webb A, Bond R, McLean P et al: Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage. Proc Natl Acad Sci USA, 2004; 101: 13683-88
75. Berry CE, Hare JM: Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications. J Physiol, 2004; 555: 589-606
76. Aliciguzel Y, Ozen I, Aslan M, Karayalcin U: Activities of xanthine ox-idoreductase and antioxidant enzymes in different tissues of diabetic rats. J Lab Clin Med, 2003; 142: 172-77
77. Castello PR, Woo DK, Ball K et al: Oxygen-regulated isoforms of cyto-chrome c oxidase have differential effects on its nitric oxide production and on hypoxic signaling. Proc Natl Acad Sci USA, 2008; 105: 8203-8
78. Shiva S, Rassaf T, Patel RP, Gladwin MT: The detection of the nitrite re-ductase and NO-generating properties of haemoglobin by mitochon-drial inhibition. Cardiovasc Res, 2011; 89: 566-73
79. Godber BL, Doel JJ, Goult TA et al: Suicide inactivation of xanthine oxidoreductase during reduction of inorganic nitrite to nitric oxide. Biochem J, 2001; 358: 325-33
80. Zuckerbraun BS, George P, Gladwin MT: Nitrite in pulmonary arterial hypertension: therapeutic avenues in the setting of dysregulated argi-nine/nitric oxide synthase signalling. Cardiovasc Res, 2011; 89: 542-52
81. Nossaman VE, Nossaman BD, Kadowitz PJ: Nitrates and nitrites in the treatment of ischemic cardiac disease. Cardiol Rev, 2010; 18: 190-97
82. Tota B, Quintieri AM, Angelone T: The emerging role of nitrite as an endogenous modulator and therapeutic agent of cardiovascular function. Curr Med Chem, 2010; 17: 1915-25
83. Gupta KJ, Igamberdiev AU, Kaiser WM: New insights into the mito-chondrial nitric oxide production pathways. Plant Signal Behav, 2010; 5: 999-1001
84. Feelisch M, Fernandez BO, Bryan NS et al: Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and -scavenging systems. J Biol Chem, 2008; 283: 33927-34
85. Benamar A, Rolletschek H, Borisjuk L et al: Nitrite-nitric oxide control of mitochondrial respiration at the frontier of anoxia. Biochim Biophys Acta, 2008; 1777: 1268-75
86. Stefano GB: Autoimmunovascular regulation: Morphine and anan-damide stimulated nitric oxide release. J Neuroimmunol, 1998; 83: 70-76
87. Stefano GB, Salzet M, Rialas C et al: Macrophage behavior associated with acute and chronic exposure to HIV GP120, morphine and anan-damide: Endothelial implications. Int J Cardiol, 1998; 64: S3-S13
88. Kubes P, Granger DN: Nitric oxide modulates microvascular permeability. Am J Physiol, 1992; 262: H611-15
89. Kubes P, Kanwar S, Niu XF et al: Nitric oxide synthesis inhibition induces leukocyte adhesion via superoxide and mast cells. FASEB J, 1993; 7: 1293-99
90. Kubes P, Suzuki MM, Granger DN: Nitric oxide an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA, 1991; 88: 4651-55
91. Kurose I, Kubes P, Wolf R: Inhibition of nitric oxide production: Mechanisms of vascular albumin leakage. Circ Res, 1993; 73: 164-71
92. Niu XF, Smith CW, Kubes P: Intracellular oxidative stress induced by nitric oxide synthesis inhibition increases endothelial cell adhesion to neutrophils. Circ Res, 1995; 74: 1133-40
93. Stefano GB, Goumon Y, Bilfnger TV et al: Basal nitric oxide limits immune, nervous and cardiovascular excitation: Human endothelia express a mu opiate receptor. Progress in Neurobiology, 2000; 60: 513-30
94. Bilfnger TV, Hartman A, Liu Y et al: Cryopreserved veins in myocar-dial revascularization: Possible mechanism for their increased failure. Ann Thorac Surg, 1997; 63: 1063-69
95. Bath PMW, Hasall DG, Gladwin AM et al: Nitric oxide and prostacyclin. Divergence of inhibitory effects on monocyte chemotaxis and adhesion to endothelium in vitro. Arterioscler Thromb, 1991; 11: 254-60
96. Stefano GB, Salzet M, Bilfnger TV: Long-term exposure of human blood vessels to HIV gp120, morphine and anandamide increases endothe-lial adhesion of monocytes: Uncoupling of Nitric Oxide. J Cardiovasc Pharmacol, 1998; 31: 862-68
97. Magazine HI, Liu Y, Bilfnger TV et al: Morphine-induced conforma-tional changes in human monocytes,granulocytes, and endothelial cells and in invertebrate immunocytes and microglia are mediated by nitric oxide. J Immunol, 1996; 156: 4845-50
98. Brown GC, Cooper CE: Nanomolar concentrations of nitric oxide re-versibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Letters, 1994; 356: 295-98
99. Brown GC: Nitric oxide and mitochondrial respiration. Biochim Biophys Acta, 1999; 1411: 351-69
100. Ockaili R, Emani VR, Okubo S et al: Opening of mitochondrial KATP channel induces early and delayed cardioprotective effect: role of nitric oxide. Am J Physiol, 1999; 277: H2425-34
101. Cleeter MW, Cooper JM, Darley-Usmar VM et al: Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Letters, 1994; 345: 50-54
102. Schweizer M, Richter C: Nitric oxide potently and reversibly deenergiz-es mitochondria at low oxygen tension. Biochem Biophys Res Commun, 1994; 204: 169-75
103. Takehara Y, Kanno T, Yoshioka T et al: Oxygen-dependent regulation of mitochondrial energy metabolism by nitric oxide. Arch Biochem Biophys, 1995; 323: 27-32
104. Nishikawa M, Sato EF, Kuroki T, Inoue M: Role of glutathione and nitric oxide in the energy metabolism of rat liver mitochondria. FEBS Letters, 1997; 415: 341-45
105. Shen W, Hintze TH, Wolin MS: Nitric oxide. An important signaling mechanism between vascular endothelium and parenchymal cells in the regulation of oxygen consumption. Circulation, 1995; 92: 3505-12
106. Shen W, Xu X, Ochoa M et al: Role of nitric oxide in the regulation of oxygen consumption in conscious dogs. Circulation Research, 1994; 75: 1086-95
107. Laycock SK, Vogel T, Forfa PR et al: Role of nitric oxide in the control of renal oxygen consumption and the regulation of chemical work in the kidney. Circulation Research, 1998; 82: 1263-71
108. King CE, Melinyshyn MJ, Mewburn JD et al: Canine hindlimb blood fow and O2 uptake after inhibition of EDRF/NO synthesis. J Appl Physiol, 1994; 76: 1166-71
109. Ishibashi Y, Duncker DJ, Zhang J, Bache RJ: ATP-sensitive K+ channels, adenosine, and nitric oxide-mediated mechanisms account for coronary vasodilation during exercise. Circulation Research, 1998; 82: 346-59
110. Bates TE, Loesch A, Burnstock G, Clark JB: Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation? Biochem Biophys Res Comm, 1996; 218: 40-44
111. Blokhina O, Fagerstedt KV: Reactive oxygen species and nitric oxide in plant mitochondria: origin and redundant regulatory systems. Physiol Plant, 2010; 138: 447-62
112. Igamberdiev AU, Hill RD: Plant mitochondrial function during anaero-biosis. Ann Bot, 2009; 103: 259-68
113. Stoimenova M, Igamberdiev AU, Gupta KJ, Hill RD: Nitrite-driven anaerobic ATP synthesis in barley and rice root mitochondria. Planta, 2007; 226: 465-74
114. Kollau A, Beretta M, Russwurm M et al: Mitochondrial nitrite reduction coupled to soluble guanylate cyclase activation: lack of evidence for a role in the bioactivation of nitroglycerin. Nitric Oxide, 2009; 20: 53-60
115. Wright RM, McManaman JL, Repine JE: Alcohol-induced breast cancer: a proposed mechanism. Free Radic Biol Med, 1999; 26: 348-54
116. Maciel ME, Castro GD, Castro JA: Inhibition of the rat breast cytosol-ic bioactivation of ethanol to acetaldehyde by some plant polyphenols and folic acid. Nutr Cancer, 2004; 49: 94-99
117. Alef MJ, Vallabhaneni R, Carchman E et al: Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against inti-mal hyperplasia in Sprague-Dawley rats. J Clin Invest, 2011; 121: 1646-56
118. Cooke JP, Ghebremariam YT: Dietary nitrate, nitric oxide, and resteno-sis. J Clin Invest, 2011; 121: 1258-60
119. Larsen FJ, Schiffer TA, Borniquel S et al: Dietary inorganic nitrate improves mitochondrial effciency in humans. Cell Metab, 2011; 13: 149-59