Nitrite consumption in ischemic rat heart catalyzed by distinct blood-borne and tissue factors

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 295, Issue 5, 2008, Pages

  McNulty, Patrick H ^a,b   Scott, Sophia ^a   Kehoe, Valerie ^a   Kozak, Mark ^a   Sinoway, Lawrence I ^a   Li, Jinhua ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b BASSETT HEALTHCARE   (United States)

Author keywords

Erythrocyte; Myocardial ischemia; Nitric oxide; Xanthine oxidoreductase

Indexed keywords

ALLOPURINOL; GLYCOGEN; MYOGLOBIN; NITRIC OXIDE; NITRITE; XANTHINE OXIDASE;

ACIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALYSIS; CIRCULATION; CONTROLLED STUDY; CRYSTALLOID; ERYTHROCYTE; HEART MUSCLE ISCHEMIA; IN VITRO STUDY; MALE; NONHUMAN; OXYGEN TENSION; PH MEASUREMENT; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

ALLOPURINOL; ANIMALS; ANOXIA; CATALYSIS; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; ERYTHROCYTES; GLUCOSE; GLYCOGEN; HYDROGEN-ION CONCENTRATION; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; MYOGLOBIN; NITRIC OXIDE; NITRITES; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; XANTHINE DEHYDROGENASE;

EID: 57049122984     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00050.2008     Document Type: Article

References (28)

1. Bolli R. Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischemia and preconditioning: an overview of a decade of research. J Mol Cell Cardiol 33: 1897-1918, 2001.
2. Cosby K, Partovi KS, Crawford JH, Patel RP, Reiter CD, Martyr S, Yang BK, Waclawiw MA, Zalos G, Xu X, Huang KT, Shields H, Kim-Shapiro DB, Schechter AN, Cannon RO 3rd, Gladwin MT. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med 9: 1498-1505, 2003.
3. Dimmeler S, Zeiher AM. Nitric oxide and apoptosis: another paradigm for the double-edged role of nitric oxide. Nitric Oxide 1: 275-281, 1997.
4. Duranski MR, Greer JJ, Dejam A, Jaganmohan S, Hogg N, Langston W, Patel RP, Yet SF, Wang X, Kevil CG, Gladwin MT, Lefer DJ. Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. J Clin Invest 115: 1232-1240, 2005.
5. Ferrari R, Cargnoni A, Bernocchi P, Pasini E, Curello S, Ceconi C, Ruigrok TJ. Metabolic adaptation during a sequence of no-flow and low-flow ischemia. A possible trigger for hibernation. Circulation 94: 2587-2596, 1996.
6. Gladwin MT. Role of the red blood cell in nitric oxide homeostasis and hypoxic vasodilation. Adv Exp Med Biol 588: 189-205, 2006.
7. Godber BL, Doel JJ, Sapkota GP, Blake DR, Stevens CR, Eisenthal R, Harrison R. Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase. J Biol Chem 275: 7757-7763, 2000.
8. Hataishi R, Rodrigues AC, Neilan TG, Morgan JG, Buys E, Shiva S, Tambouret R, Jassal DS, Raher MJ, Furutaine E, Ichinose F, Gladwin MT, Rosenzweig A, Zapol WM, Bloch KD, Scherrer-Crosbie M. Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 291: H379-H384, 2006.
9. Johnson G 3rd, Tsao PS, Mulloy D, Lefer AM. Cardioprotective effects of acidified sodium nitrite in myocardial ischemia with reperfusion. J Phamacol Exp Ther 252: 35-41, 1990.
10. Jones SP. Endothelial nitric oxide synthase overexpression attenuates myocardial reperfusion injury. Am J Physiol Heart Circ Physiol 286: H276-H282, 2004.
11. Jones SP, Bolli R. The ubiquitous role of nitric oxide in cardioprotection. J Mol Cell Cardiol 40: 16-23, 2006.
12. Kanno S. Attenuation of myocardial ischemia/reperfusion injury by superinduction of inducible nitric oxide synthase. Circulation 101: 2742-2748, 2000.
13. Lefer DJ, Nakanishi K, Johnston WE, Vinten-Johansen J. Antineutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion in dogs. Circulation 88: 2337-2350, 1993.
14. Li H, Samouilov A, Liu X, Zweier JL. Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrite reduction. Evaluation of its role in nitric oxide generation in anoxic tissues. J Biol Chem 276: 24482-24489, 2001.
15. McNulty PH, Jagasia D, Cline G, Whiting JM, Ng C, Garg P, Shulman GI, Soufer R. Persistent changes in myocardial glucose metabolism in vivo during reperfusion of a limited-duration coronary occlusion. Circulation 101: 917-922, 2000.
16. McNulty PH, King N, Hartman G, McCann J, Kozak M, Chambers CE, Sinoway LI. Effect of supplemental oxygen administration on coronary blood flow in patients undergoing cardiac catheterization. Am J Physiol Heart Circ Physiol 288: H1057-H1062, 2005.
17. McNulty PH, Luba MC. Transient ischemia induces regional myocardial glycogen synthase activation and glycogen synthesis in vivo. Am J Physiol Heart Circ Physiol 268: H364-H370, 1995.
18. Millar TM, Stevens CR, Benjamin N, Eisenthal R, Harrison R, Blake DR. Xanthine oxidoreductase catalyzes the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions. FEBS Lett 427: 225-228, 1998.
19. Nagababu E, Ramasamy S, Abernethy DR, Rifkind JM. Active nitric oxide produced in the red cell under hypoxic conditions by deoxyhemoglobin- mediated nitrite reduction. J Biol Chem 278: 11065-11073, 2003.
20. Rakhit RD, Mojer MH, Marber MS, Duchen MR. Mitochondria as targets for nitric-oxide-induced protection during simulated ischemia and reoxygenation in isolated neonatal cardiomyocytes. Circulation 103: 2617-2623, 2001.
21. Rassaf T, Flagel U, Drexhage C, Hengden-Cotta U, Kelm M, Schrader J. Nitrite reductase function of deoxymyoglobin. Oxygen sensor and regulator of cardiac energetics and function. Circ Res 100: 1749-1754, 2007.
22. Schulz R, Wambolt R. Inhibition of nitric oxide synthesis protects the isolated working rabbit heart from ischemia-reperfusion injury. Cardiovasc Res 30: 432-439, 1995.
23. Shiva S, Huang Z, Grubina R, Sun J, Ringward LA, MacArthur PH, Xu X, Murphey E, Darley-Usman VM, Gladwin MT. Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration. Circ Res 100: 654-661, 2007.
24. Tiravanti E, Samouliov A, Zweier JL. Nitrosyl-heme complexes are formed in the ischemic heart: evidence of nitrite-derived nitric oxide formation, storage, and signaling in post-ischemic tissues. J Biol Chem 279: 11065-11073, 2004.
25. Webb A, Bond R, McLean P, Uppal R, Benjamin N, Ahluwalia A. Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemic-reperfusion damage. Proc Natl Acad Sci USA 101: 13683-13688, 2004.
26. Woolfson RG, Patel VC, Neild GH, Yellon DM. Inhibition of nitric oxide synthesis reduces infarct size by an adenosine-dependent mechanism. Circulation 91: 1545-1551, 1995.
27. Zhang Z, Naughton DP, Blake DR, Benjamin N, Stevens CR, Winyard PG, Symons MC, Harrison R. Human xanthine oxidase converts nitrite ions to nitric oxide (NO). Biochem Soc Trans 25: 524S, 1997.
28. Zweier JL, Wang P, Samouilov A, Kuppusamy P. Enzyme-independent formation of nitric oxide in biological tissues. Nat Med 1: 804-809, 1995.