Pulmonary vasodilator responses to sodium nitrite are mediated by an allopurinol-sensitive mechanism in the rat

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 296, Issue 2, 2009, Pages

  Casey, David B ^a   Badejo, Adeleke M ^a   Dhaliwal, Jasdeep S ^a   Murthy, Subramanyam N ^a   Hyman, Albert L ^a   Nossaman, Bobby D ^a,b   Kadowitz, Philip J ^a  

^a TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b OCHSNER CLINIC FOUNDATION   (United States)

Author keywords

Nitric oxide; Nitric oxide synthase; Pulmonary hypertension; Xanthine oxidoreductase

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ALLOPURINOL; DIETHYLAMINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE DONOR; NITRITE; NITROPRUSSIDE SODIUM; SODIUM NITRITE; XANTHINE OXIDASE; 1,1 DIETHYL 2 HYDROXY 2 NITROSOHYDRAZINE; 1,1-DIETHYL-2-HYDROXY-2-NITROSOHYDRAZINE; ENZYME INHIBITOR; HYDRAZINE DERIVATIVE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIPURINOL; VASOCONSTRICTOR AGENT; VASODILATOR AGENT;

AMBIENT AIR; ANIMAL MODEL; ARTERIAL GAS; ARTERIAL PRESSURE; ARTICLE; BREATHING; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM; HEART OUTPUT; HYPOXIA; LUNG ARTERY PRESSURE; LUNG BLOOD VESSEL; LUNG FUNCTION; LUNG VASCULAR RESISTANCE; LUNG VENTILATION; MALE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; VASODILATATION; ANIMAL; ANOXIA; BLOOD PRESSURE; COMPARATIVE STUDY; DISEASE MODEL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; PATHOPHYSIOLOGY; PULMONARY ARTERY; SPRAGUE DAWLEY RAT; TIME;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ALLOPURINOL; ANIMALS; ANOXIA; BLOOD PRESSURE; CARDIAC OUTPUT; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HYDRAZINES; INJECTIONS, INTRAVENOUS; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE; OXYPURINOL; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; SODIUM NITRITE; TIME FACTORS; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS; XANTHINE OXIDASE;

EID: 61949204559     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00543.2008     Document Type: Article

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