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Volumn 8, Issue 10, 2007, Pages 1369-1383

Genetic variation in the cytochrome P450 epoxygenase pathway and cardiovascular disease risk

Author keywords

Arachidonic acid; Atherosclerosis; Cardiovascular disease; CYP2C8; CYP2C9; CYP2J2; EETs; EPHX2; Polymorphism; Soluble epoxide hydrolase

Indexed keywords

ARACHIDONIC ACID; CYTOCHROME P450; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2J2; CYTOCHROME P450 EPOXYGENASE; EPOXIDE HYDROLASE; EPOXYICOSATRIENOIC ACID; UNCLASSIFIED DRUG;

EID: 36448993993     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/14622416.8.10.1369     Document Type: Review
Times cited : (45)

References (73)
  • 1
    • 0030834058 scopus 로고    scopus 로고
    • Human cytochrome P450 enzymes: A status report summarizing their reactions, substrates, inducers, and inhibitors
    • Rendic S, Di Carlo FJ: Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metab. Rev. 29, 413-580 (1997).
    • (1997) Drug Metab. Rev , vol.29 , pp. 413-580
    • Rendic, S.1    Di Carlo, F.J.2
  • 2
    • 0033588022 scopus 로고    scopus 로고
    • Lipoxygenases: Occurrence, functions, catalysis, and acquisition of substrate
    • Brash AR: Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate. J. Biol. Chem. 274, 23679-23682 (1999)
    • (1999) J. Biol. Chem , vol.274 , pp. 23679-23682
    • Brash, A.R.1
  • 3
    • 0019195393 scopus 로고
    • Prostaglandins, arachidonic acid, and inflammation
    • Kuehl FA Jr, Egan RW: Prostaglandins, arachidonic acid, and inflammation. Science 210, 978-984 (1980).
    • (1980) Science , vol.210 , pp. 978-984
    • Kuehl Jr, F.A.1    Egan, R.W.2
  • 4
    • 0030479496 scopus 로고    scopus 로고
    • Prostaglandin endoperoxide H synthases (cyclooxygenases) -1 and -2
    • Smith WL, Garavito RM, DeWitt DL: Prostaglandin endoperoxide H synthases (cyclooxygenases) -1 and -2. J. Biol. Chem. 271, 33157-33160 (1996).
    • (1996) J. Biol. Chem , vol.271 , pp. 33157-33160
    • Smith, W.L.1    Garavito, R.M.2    DeWitt, D.L.3
  • 5
    • 0036080081 scopus 로고    scopus 로고
    • P-450 metabolites of arachidonic acid in the control of cardiovascular function
    • Roman RJ: P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol. Rev. 82, 131-195 (2002).
    • (2002) Physiol. Rev , vol.82 , pp. 131-195
    • Roman, R.J.1
  • 6
    • 0035965327 scopus 로고    scopus 로고
    • Epoxygenase pathways of arachidonic acid metabolism
    • Zeldin DC: Epoxygenase pathways of arachidonic acid metabolism. J. Biol. Chem. 276, 36059-36062 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 36059-36062
    • Zeldin, D.C.1
  • 7
    • 1842430562 scopus 로고    scopus 로고
    • Distribution of soluble epoxide hydrolase and of cytochrome P450 2C8. 2C9, and 2J2 in human tissues
    • Enayetallah AE, French RA, Thibodeau MS, Grant DF: Distribution of soluble epoxide hydrolase and of cytochrome P450 2C8. 2C9, and 2J2 in human tissues. J. Histochem. Cytochem. 52, 447-454 (2004).
    • (2004) J. Histochem. Cytochem , vol.52 , pp. 447-454
    • Enayetallah, A.E.1    French, R.A.2    Thibodeau, M.S.3    Grant, D.F.4
  • 8
    • 0033588034 scopus 로고    scopus 로고
    • Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids
    • Node K, Huo Y, Ruan X et al.: Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science 285, 1276-1279 (1999).
    • (1999) Science , vol.285 , pp. 1276-1279
    • Node, K.1    Huo, Y.2    Ruan, X.3
  • 9
    • 33644849675 scopus 로고    scopus 로고
    • Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: Implications for soluble epoxide hydrolase inhibition
    • Larsen BT, Miura H, Hatoum OA et al.: Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition. Am. J. Physiol. Heart Circ. Physiol. 290, H491-499 (2006).
    • (2006) Am. J. Physiol. Heart Circ. Physiol , vol.290
    • Larsen, B.T.1    Miura, H.2    Hatoum, O.A.3
  • 10
    • 0030051805 scopus 로고    scopus 로고
    • Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors
    • Campbell WB, Gebremedhin D, Pratt PF, Harder DR: Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ. Res. 78, 415-423 (1996).
    • (1996) Circ. Res , vol.78 , pp. 415-423
    • Campbell, W.B.1    Gebremedhin, D.2    Pratt, P.F.3    Harder, D.R.4
  • 11
    • 0033619262 scopus 로고    scopus 로고
    • Cytochrome P450 2C is an EDHF synthase in coronary arteries
    • Fisslthaler B, Popp R, Kiss L et al.: Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature 401, 493-497 (1999).
    • (1999) Nature , vol.401 , pp. 493-497
    • Fisslthaler, B.1    Popp, R.2    Kiss, L.3
  • 12
    • 28044434102 scopus 로고    scopus 로고
    • The antiinflammatory effect of laminar flow: The role of PPARgamma, epoxyeicosatrienoic acids. and soluble epoxide hydrolase
    • Liu Y, Zhang Y, Schmelzer K et al.: The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids. and soluble epoxide hydrolase. Proc. Natl Acad. Sci. USA 102, 16747-16752 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 16747-16752
    • Liu, Y.1    Zhang, Y.2    Schmelzer, K.3
  • 14
    • 4444236138 scopus 로고    scopus 로고
    • Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway
    • Seubert J. Yang B, Bradbury JA et al.: Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway. Circ. Res. 95, 506-514 (2004).
    • (2004) Circ. Res , vol.95 , pp. 506-514
    • Seubert, J.1    Yang, B.2    Bradbury, J.A.3
  • 15
    • 33747422507 scopus 로고    scopus 로고
    • Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function
    • Seubert JM, Sinal CJ, Graves J et al.: Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function. Circ. Res. 99, 442-450 (2006).
    • (2006) Circ. Res , vol.99 , pp. 442-450
    • Seubert, J.M.1    Sinal, C.J.2    Graves, J.3
  • 16
    • 33644697099 scopus 로고    scopus 로고
    • An epoxide hydrolase inhibitor, 12-(3-adamantan- 1 -y1-ureido)dodecanoic acid (AUDA), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats
    • Dorrance AM, Rupp N, Pollock DM, Newman JW, Hammock BD, Imig JD: An epoxide hydrolase inhibitor, 12-(3-adamantan- 1 -y1-ureido)dodecanoic acid (AUDA), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats. J. Cardiovasc. Pharmacol. 46, 842-848 (2005).
    • (2005) J. Cardiovasc. Pharmacol , vol.46 , pp. 842-848
    • Dorrance, A.M.1    Rupp, N.2    Pollock, D.M.3    Newman, J.W.4    Hammock, B.D.5    Imig, J.D.6
  • 17
    • 34247525219 scopus 로고    scopus 로고
    • Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury
    • Koerner IP, Jacks R, DeBarber AE et al.. Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury. J. Neurosci. 27, 4642-4649 (2007).
    • (2007) J. Neurosci , vol.27 , pp. 4642-4649
    • Koerner, I.P.1    Jacks, R.2    DeBarber, A.E.3
  • 18
    • 0035844126 scopus 로고    scopus 로고
    • Activation of G alphas mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids
    • Node K, Ruan XL, Dai J et al.: Activation of G alphas mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids. J. Biol. Chem. 276, 15983-15989(2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 15983-15989
    • Node, K.1    Ruan, X.L.2    Dai, J.3
  • 19
    • 0034109792 scopus 로고    scopus 로고
    • Cerebral microvascular endothelial cell tube formation: Role of astrocytic epoxyeicosatrienoic acid release
    • Munzenmaier DH, Harder DR: Cerebral microvascular endothelial cell tube formation: role of astrocytic epoxyeicosatrienoic acid release. Am. J. Physiol. Heart Circ. Physiol. 278, H1163-1167 (2000).
    • (2000) Am. J. Physiol. Heart Circ. Physiol , vol.278
    • Munzenmaier, D.H.1    Harder, D.R.2
  • 20
    • 0037123925 scopus 로고    scopus 로고
    • Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids
    • Sun J. Sui X, Bradbury JA, Zeldin DC, Conte MS, Liao JK: Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids. Circ. Res. 90, 1020-1027 (2002).
    • (2002) Circ. Res , vol.90 , pp. 1020-1027
    • Sun, J.1    Sui, X.2    Bradbury, J.A.3    Zeldin, D.C.4    Conte, M.S.5    Liao, J.K.6
  • 21
    • 0034704156 scopus 로고    scopus 로고
    • Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation
    • Sinal CJ, Miyata M, Tohkin M, Nagata K, Bend JR, Gonzalez FJ: Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation. J. Biol. Chem. 275, 40504-40510, (2000).
    • (2000) J. Biol. Chem , vol.275 , pp. 40504-40510
    • Sinal, C.J.1    Miyata, M.2    Tohkin, M.3    Nagata, K.4    Bend, J.R.5    Gonzalez, F.J.6
  • 22
    • 36448975919 scopus 로고    scopus 로고
    • Imig JD, Zhao X, Capdevila JH, Morisseau C, Hammock BD: Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension
    • Imig JD, Zhao X, Capdevila JH, Morisseau C, Hammock BD: Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension.
  • 23
    • 33644654633 scopus 로고    scopus 로고
    • An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension
    • Imig JD, Zhao X, Zaharis CZ et al.: An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Hypertension 46, 975-981 (2005).
    • (2005) Hypertension , vol.46 , pp. 975-981
    • Imig, J.D.1    Zhao, X.2    Zaharis, C.Z.3
  • 25
    • 0037144475 scopus 로고    scopus 로고
    • The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands
    • Cowart LA, Wei S, Hsu MH et al.: The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands. J. Biol. Chem. 277, 35105-35112 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 35105-35112
    • Cowart, L.A.1    Wei, S.2    Hsu, M.H.3
  • 26
    • 0030063499 scopus 로고    scopus 로고
    • Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart
    • Wu S, Moomaw CR, Tomer KB, Falck JR, Zeldin DC: Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart. J. Biol. Chem. 271. 3460-3468 (1996).
    • (1996) J. Biol. Chem , vol.271 , pp. 3460-3468
    • Wu, S.1    Moomaw, C.R.2    Tomer, K.B.3    Falck, J.R.4    Zeldin, D.C.5
  • 27
    • 33751191888 scopus 로고    scopus 로고
    • Variability of CYP2J2 expression in human fetal tissues
    • Gaedigk A, Baker DW, Totah RA et al.: Variability of CYP2J2 expression in human fetal tissues. J. Pharmacol. Exp. Ther. 319, 523-532 (2006).
    • (2006) J. Pharmacol. Exp. Ther , vol.319 , pp. 523-532
    • Gaedigk, A.1    Baker, D.W.2    Totah, R.A.3
  • 28
    • 18344377326 scopus 로고    scopus 로고
    • Cloning of CYP2J2 gene and identification of functional polymorphisms
    • King LM, Ma J, Srettabunjong S et al.: Cloning of CYP2J2 gene and identification of functional polymorphisms. Mol. Pharmacol. 61, 840-852 (2002).
    • (2002) Mol. Pharmacol , vol.61 , pp. 840-852
    • King, L.M.1    Ma, J.2    Srettabunjong, S.3
  • 29
    • 17644385223 scopus 로고    scopus 로고
    • Identification and functional characterization of novel CYP2J2 variants: G312R variant causes loss of enzyme catalytic activity
    • Lee SS, Jeong HE, Liu KH et al.: Identification and functional characterization of novel CYP2J2 variants: G312R variant causes loss of enzyme catalytic activity. Pharmacogenet. Genomics 15, 105-113 (2005).
    • (2005) Pharmacogenet. Genomics , vol.15 , pp. 105-113
    • Lee, S.S.1    Jeong, H.E.2    Liu, K.H.3
  • 30
    • 33845712373 scopus 로고    scopus 로고
    • Inter-individual variation of cytochrome P4502J2 expression and catalytic activities in liver microsomes from Japanese and Caucasian populations
    • Yamazaki H, Okayama A, Imai N, Guengerich FP, Shimizu M: Inter-individual variation of cytochrome P4502J2 expression and catalytic activities in liver microsomes from Japanese and Caucasian populations. Xenobiotica 36, 1201-1209 (2006).
    • (2006) Xenobiotica , vol.36 , pp. 1201-1209
    • Yamazaki, H.1    Okayama, A.2    Imai, N.3    Guengerich, F.P.4    Shimizu, M.5
  • 31
    • 20844452556 scopus 로고    scopus 로고
    • Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2
    • Spiecker M, Darius H, Hankein T et al.: Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2. Circulation 110, 2132-2136 (2004).
    • (2004) Circulation , vol.110 , pp. 2132-2136
    • Spiecker, M.1    Darius, H.2    Hankein, T.3
  • 32
    • 36448966070 scopus 로고    scopus 로고
    • Synergistic effect of cytochrome P450 epoxygenase CYP2J2*7 polymorphism with smoking on the onset of premature myocardial infarction
    • Epub ahead of print
    • Liu PY, Li YH, Chao TH et al.: Synergistic effect of cytochrome P450 epoxygenase CYP2J2*7 polymorphism with smoking on the onset of premature myocardial infarction. Atherosclerosis (2006) (Epub ahead of print).
    • (2006) Atherosclerosis
    • Liu, P.Y.1    Li, Y.H.2    Chao, T.H.3
  • 33
    • 36448954380 scopus 로고    scopus 로고
    • Spiecker M, Zeldin DC, Mugge A, Tenderich G, Liao JK, Milting H: Reduced human myocardial mRNA expression of CYP2J2 in individuals with the G-50T promoter polymorphism. American Heart Association Scientific Sessions. Chicago, USA, Circulation 691, II-117 (2006).
    • Spiecker M, Zeldin DC, Mugge A, Tenderich G, Liao JK, Milting H: Reduced human myocardial mRNA expression of CYP2J2 in individuals with the G-50T promoter polymorphism. American Heart Association Scientific Sessions. Chicago, USA, Circulation 691, II-117 (2006).
  • 34
    • 33947419679 scopus 로고    scopus 로고
    • The -50G>T polymorphism in the promoter of the CYP2J2 gene in coronary heart disease: The Ludwigshafen Risk and Cardiovascular Health study
    • Hoffmann MM, Bogert P, Seelhorst U et al.: The -50G>T polymorphism in the promoter of the CYP2J2 gene in coronary heart disease: the Ludwigshafen Risk and Cardiovascular Health study. Clin. Chem. 53, 539-540 (2007).
    • (2007) Clin. Chem , vol.53 , pp. 539-540
    • Hoffmann, M.M.1    Bogert, P.2    Seelhorst, U.3
  • 35
    • 34247182994 scopus 로고    scopus 로고
    • CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: The Atherosclerosis Risk in Communities (ARIC) study
    • Lee CR, North KE, Bray MS, Couper DJ, Heiss G, Zeldin DC: CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study. Pharmacogenet. Genomics 17, 349-358 (2007).
    • (2007) Pharmacogenet. Genomics , vol.17 , pp. 349-358
    • Lee, C.R.1    North, K.E.2    Bray, M.S.3    Couper, D.J.4    Heiss, G.5    Zeldin, D.C.6
  • 36
    • 85047278388 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension
    • King LM, Gainer JV, David GL et al.: Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension. Pharmacogenet. Genomics 15, 7-13 (2005).
    • (2005) Pharmacogenet. Genomics , vol.15 , pp. 7-13
    • King, L.M.1    Gainer, J.V.2    David, G.L.3
  • 37
    • 34249869860 scopus 로고    scopus 로고
    • Evidence for association of polymorphisms in CYP2J2 and susceptibility to essential hypertension
    • Wu SN, Zhang Y, Gardner CO et al.: Evidence for association of polymorphisms in CYP2J2 and susceptibility to essential hypertension. Ann. Hum. Genet. 71, 519-525 (2007).
    • (2007) Ann. Hum. Genet , vol.71 , pp. 519-525
    • Wu, S.N.1    Zhang, Y.2    Gardner, C.O.3
  • 38
    • 25844438367 scopus 로고    scopus 로고
    • The Prevalence of CYP2C8, 2C9, 2J2, and soluble epoxide hydrolase polymorphisms in African Americans with hypertension
    • Dreisbach AW, Japa S, Sigel A et al.: The Prevalence of CYP2C8, 2C9, 2J2, and soluble epoxide hydrolase polymorphisms in African Americans with hypertension. Am. J. Hypertens. 18, 1276-1281 (2005).
    • (2005) Am. J. Hypertens , vol.18 , pp. 1276-1281
    • Dreisbach, A.W.1    Japa, S.2    Sigel, A.3
  • 39
    • 0242428240 scopus 로고    scopus 로고
    • Cytochrome P450 2J2 polymorphism in healthy Caucasians and those with diabetes mellitus
    • Pucci L, Lucchesi D, Chiruili V et al.: Cytochrome P450 2J2 polymorphism in healthy Caucasians and those with diabetes mellitus. Am. J. Pharmacogenomics. 3, 355-358 (2003).
    • (2003) Am. J. Pharmacogenomics , vol.3 , pp. 355-358
    • Pucci, L.1    Lucchesi, D.2    Chiruili, V.3
  • 40
    • 0028590127 scopus 로고
    • Biochemistry and molecular biology of the human CYP2C subfamily
    • Goldstein JA, de Morais SM: Biochemistry and molecular biology of the human CYP2C subfamily. Pharmacogenetics 4, 285-299 (1994).
    • (1994) Pharmacogenetics , vol.4 , pp. 285-299
    • Goldstein, J.A.1    de Morais, S.M.2
  • 41
    • 0032604625 scopus 로고    scopus 로고
    • Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs
    • Klose TS, Blaisdell JA, Goldstein JA: Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs. J. Biochem. Mol. Toxicol. 13, 289-295 (1999).
    • (1999) J. Biochem. Mol. Toxicol , vol.13 , pp. 289-295
    • Klose, T.S.1    Blaisdell, J.A.2    Goldstein, J.A.3
  • 42
    • 0036433338 scopus 로고    scopus 로고
    • Linkage between the CYP2C8 and CYP2C9 genetic polymorphisms
    • Yasar U, Lundgren S, Eliasson E et al.: Linkage between the CYP2C8 and CYP2C9 genetic polymorphisms. Biochem. Biophys. Res. Commun. 299, 25-28 (2002).
    • (2002) Biochem. Biophys. Res. Commun , vol.299 , pp. 25-28
    • Yasar, U.1    Lundgren, S.2    Eliasson, E.3
  • 43
    • 19144368324 scopus 로고    scopus 로고
    • Cytochrome P450 2C8: Substrates, inhibitors, pharmacogenetics, and clinical relevance
    • Totah RA, Rettie AE: Cytochrome P450 2C8: substrates, inhibitors, pharmacogenetics, and clinical relevance. Clin. Pharmacol. Ther. 77, 341-352 (2005).
    • (2005) Clin. Pharmacol. Ther , vol.77 , pp. 341-352
    • Totah, R.A.1    Rettie, A.E.2
  • 44
    • 0036263813 scopus 로고    scopus 로고
    • Cytochrome P450 2C9 polymorphisms: A comprehensive review of the in vitro and human data
    • Lee CR, Goldstein JA, Pieper JA: Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in vitro and human data. Pharmacogenetics 12, 251-263 (2002).
    • (2002) Pharmacogenetics , vol.12 , pp. 251-263
    • Lee, C.R.1    Goldstein, J.A.2    Pieper, J.A.3
  • 45
    • 0036889666 scopus 로고    scopus 로고
    • CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes
    • Bahadur N, Leathart JB, Mutch E et al.: CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes. Biochem. Pharmacol. 64, 1579-1589 (2002).
    • (2002) Biochem. Pharmacol , vol.64 , pp. 1579-1589
    • Bahadur, N.1    Leathart, J.B.2    Mutch, E.3
  • 46
    • 0034791777 scopus 로고    scopus 로고
    • Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid
    • Dai D, Zeldin DC, Blaisdell JA et al.: Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid. Pharmacogenetics 11, 597-607 (2001).
    • (2001) Pharmacogenetics , vol.11 , pp. 597-607
    • Dai, D.1    Zeldin, D.C.2    Blaisdell, J.A.3
  • 47
    • 0035214173 scopus 로고    scopus 로고
    • Non-synonymous single nucleotide alterations found in the CYP2C8 gene result in reduced in vitro paclitaxel metabolism
    • Soyama A, Saito Y, Hanioka N et al.: Non-synonymous single nucleotide alterations found in the CYP2C8 gene result in reduced in vitro paclitaxel metabolism. Biol. Pharm. Bull. 24, 1427-1430 (2001).
    • (2001) Biol. Pharm. Bull , vol.24 , pp. 1427-1430
    • Soyama, A.1    Saito, Y.2    Hanioka, N.3
  • 48
  • 50
    • 0029658591 scopus 로고    scopus 로고
    • The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism
    • Sullivan-Klose TH, Ghanavem BI, Bell DA et al.: The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism. Pharmacogenetics 6, 341-349 (1996).
    • (1996) Pharmacogenetics , vol.6 , pp. 341-349
    • Sullivan-Klose, T.H.1    Ghanavem, B.I.2    Bell, D.A.3
  • 51
    • 1842558550 scopus 로고    scopus 로고
    • Allelic variants of cytochromes P450 2C modify the risk for acute myocardial infarction
    • Yasar U, Bennet AM, Eliasson E et al.: Allelic variants of cytochromes P450 2C modify the risk for acute myocardial infarction. Pharmacogenetics 13, 715-720 (2003).
    • (2003) Pharmacogenetics , vol.13 , pp. 715-720
    • Yasar, U.1    Bennet, A.M.2    Eliasson, E.3
  • 52
    • 34250222451 scopus 로고    scopus 로고
    • The risk of myocardial infarction in patients with reduced activity of cytochrome P450 2C9
    • Visser LE, van Schalk RH, Jan Danser AH et al.: The risk of myocardial infarction in patients with reduced activity of cytochrome P450 2C9. Pharmacogenet. Genomics 17, 473-479 (2007).
    • (2007) Pharmacogenet. Genomics , vol.17 , pp. 473-479
    • Visser, L.E.1    van Schalk, R.H.2    Jan Danser, A.H.3
  • 53
    • 0037452577 scopus 로고    scopus 로고
    • The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity
    • Newman JW, Morisseau C, Harris TR, Hammock BD: The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. Proc. Natl Acad. Sci. USA 100, 1558-1563 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 1558-1563
    • Newman, J.W.1    Morisseau, C.2    Harris, T.R.3    Hammock, B.D.4
  • 54
    • 0029984341 scopus 로고    scopus 로고
    • Structural characterization of the human soluble epoxide hydrolase gene (EPHX2)
    • Sandberg M, Meijer J: Structural characterization of the human soluble epoxide hydrolase gene (EPHX2). Biochem. Biophys. Res. Commun. 221, 333-339 (1996).
    • (1996) Biochem. Biophys. Res. Commun , vol.221 , pp. 333-339
    • Sandberg, M.1    Meijer, J.2
  • 55
    • 2942579253 scopus 로고    scopus 로고
    • Polymorphisms in human soluble epoxide hydrolase: Effects on enzyme activity, enzyme stability, and quaternary structure
    • Srivastava PK, Sharma VK, Kalonia DS, Grant DF: Polymorphisms in human soluble epoxide hydrolase: effects on enzyme activity, enzyme stability, and quaternary structure. Arch. Biochem. Biophys. 427, 164-169 (2004).
    • (2004) Arch. Biochem. Biophys , vol.427 , pp. 164-169
    • Srivastava, P.K.1    Sharma, V.K.2    Kalonia, D.S.3    Grant, D.F.4
  • 57
    • 0034666150 scopus 로고    scopus 로고
    • Identification and functional characterization of human soluble epoxide hydrolase genetic polymorphisms
    • Sandberg M, Hassett C, Adman ET, Meijer J, Omieciriski CJ: Identification and functional characterization of human soluble epoxide hydrolase genetic polymorphisms. J. Biol. Chem. 275, 28873-28881 (2000).
    • (2000) J. Biol. Chem , vol.275 , pp. 28873-28881
    • Sandberg, M.1    Hassett, C.2    Adman, E.T.3    Meijer, J.4    Omieciriski, C.J.5
  • 58
    • 33745222033 scopus 로고    scopus 로고
    • Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study
    • Lee CR, North KE, Bray MS et al.: Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study. Hum. Mol. Genet. 15, 1640-1649 (2006).
    • (2006) Hum. Mol. Genet , vol.15 , pp. 1640-1649
    • Lee, C.R.1    North, K.E.2    Bray, M.S.3
  • 59
    • 1642458135 scopus 로고    scopus 로고
    • Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: The Coronary Artery Risk Development in Young Adults (CARDIA) study
    • Fornage M, Boerwinkle E, Doris PA, Jacobs D, Liu K, Wong ND: Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: the Coronary Artery Risk Development in Young Adults (CARDIA) study. Circulation 109, 335-339 (2004).
    • (2004) Circulation , vol.109 , pp. 335-339
    • Fornage, M.1    Boerwinkle, E.2    Doris, P.A.3    Jacobs, D.4    Liu, K.5    Wong, N.D.6
  • 60
    • 33845535114 scopus 로고    scopus 로고
    • Sequence variation in the soluble epoxide hydrolase gene and subclinical coronary atherosclerosis: Interaction with cigarette smoking
    • Wei Q, Doris PA, Pollizotto MV et al.: Sequence variation in the soluble epoxide hydrolase gene and subclinical coronary atherosclerosis: interaction with cigarette smoking. Atherosclerosis 190, 26-34 (2007).
    • (2007) Atherosclerosis , vol.190 , pp. 26-34
    • Wei, Q.1    Doris, P.A.2    Pollizotto, M.V.3
  • 61
    • 26444506849 scopus 로고    scopus 로고
    • The soluble epoxide hydrolase gene harbors sequence variation associated with susceptibility to and protection from incident ischemic stroke
    • Fornage M, Lee CR, Doris PA et al.: The soluble epoxide hydrolase gene harbors sequence variation associated with susceptibility to and protection from incident ischemic stroke. Hum. Mol. Genet. 14, 2829-2837 (2005).
    • (2005) Hum. Mol. Genet , vol.14 , pp. 2829-2837
    • Fornage, M.1    Lee, C.R.2    Doris, P.A.3
  • 62
    • 10744225519 scopus 로고    scopus 로고
    • Soluble epoxide hydrolase variant (Glu287Arg) modifies plasma total cholesterol and triglyceride phenotype in familial hypercholesterolemia: Intrafamilial association study in an eight-generation hyperlipidemic kindred
    • Sato K, Emi M, Ezura Y et al.: Soluble epoxide hydrolase variant (Glu287Arg) modifies plasma total cholesterol and triglyceride phenotype in familial hypercholesterolemia: intrafamilial association study in an eight-generation hyperlipidemic kindred. J. Hum. Genet. 49, 29-34 (2004).
    • (2004) J. Hum. Genet , vol.49 , pp. 29-34
    • Sato, K.1    Emi, M.2    Ezura, Y.3
  • 63
    • 17444380409 scopus 로고    scopus 로고
    • Association of soluble epoxide hydrolase gene polymorphism with insulin resistance in Type 2 diabetic patients
    • Ohtoshi K, Kaneto H, Node K et al.: Association of soluble epoxide hydrolase gene polymorphism with insulin resistance in Type 2 diabetic patients. Biochem. Biophys. Res. Commun. 331, 347-350 (2005).
    • (2005) Biochem. Biophys. Res. Commun , vol.331 , pp. 347-350
    • Ohtoshi, K.1    Kaneto, H.2    Node, K.3
  • 64
    • 34249997024 scopus 로고    scopus 로고
    • Replicating genotype-phenotype associations
    • Chanock SJ, Manolio T, Boehnke M et al.: Replicating genotype-phenotype associations. Nature 447, 655-660 (2007).
    • (2007) Nature , vol.447 , pp. 655-660
    • Chanock, S.J.1    Manolio, T.2    Boehnke, M.3
  • 65
    • 0037426052 scopus 로고    scopus 로고
    • Problems of reporting genetic associations with complex outcomes
    • Colhoun HM, McKeigue PM, Davey Smith G: Problems of reporting genetic associations with complex outcomes. Lancet 361, 865-872 (2003).
    • (2003) Lancet , vol.361 , pp. 865-872
    • Colhoun, H.M.1    McKeigue, P.M.2    Davey Smith, G.3
  • 66
    • 0742288585 scopus 로고    scopus 로고
    • The complex interplay among factors that influence allelic association
    • Zondervan KT, Cardon LR: The complex interplay among factors that influence allelic association. Nat. Rev. Genet. 5, 89-100 (2004).
    • (2004) Nat. Rev. Genet , vol.5 , pp. 89-100
    • Zondervan, K.T.1    Cardon, L.R.2
  • 69
    • 33747594330 scopus 로고    scopus 로고
    • Cardiac adrenoceptors: Physiological and pathophysiological relevance
    • Brodde OE, Bruck H, Leineweber K: Cardiac adrenoceptors: physiological and pathophysiological relevance. J. Pharmacol. Sci. 100, 323-337 (2006).
    • (2006) J. Pharmacol. Sci , vol.100 , pp. 323-337
    • Brodde, O.E.1    Bruck, H.2    Leineweber, K.3
  • 70
    • 2942610581 scopus 로고    scopus 로고
    • Dysfunction of endothelial nitric oxide synthase and atherosclerosis
    • Kawashima S, Yokoyama M: Dysfunction of endothelial nitric oxide synthase and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 24, 998-1005 (2004).
    • (2004) Arterioscler. Thromb. Vasc. Biol , vol.24 , pp. 998-1005
    • Kawashima, S.1    Yokoyama, M.2
  • 71
    • 2442547743 scopus 로고    scopus 로고
    • The pathophysiology of cigarette smoking and cardiovascular disease: An update
    • Ambrose JA, Barua RS: The pathophysiology of cigarette smoking and cardiovascular disease: an update. J. Am. Coll. Cardiol. 43, 1731-1737 (2004).
    • (2004) J. Am. Coll. Cardiol , vol.43 , pp. 1731-1737
    • Ambrose, J.A.1    Barua, R.S.2
  • 72
    • 34247867952 scopus 로고    scopus 로고
    • Cardiovascular therapeutic aspects of soluble-epoxide hydrolase inhibitors
    • Imig JD: Cardiovascular therapeutic aspects of soluble-epoxide hydrolase inhibitors. Cardiovasc. Drug Rev. 24, 169-188 (2006).
    • (2006) Cardiovasc. Drug Rev , vol.24 , pp. 169-188
    • Imig, J.D.1
  • 73
    • 0024591825 scopus 로고
    • The Atherosclerosis Risk in Communities (ARIC) Study: Design and objectives
    • The ARIC Investigators
    • The ARIC Investigators: The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. Am. J. Epidemiol. 129, 687-702 (1989).
    • (1989) Am. J. Epidemiol , vol.129 , pp. 687-702


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