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Heart disease and stroke statistics - 2007 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
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An excellent summary of the demographics of CVD in the US, •
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Rosamond W, Flegal K, Friday G, Furie K, Go A, Greenlund K, Haase N, Ho M, Howard V, Kissela B, Kittner S et al: Heart disease and stroke statistics - 2007 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation (2007) 115(5):e69-e171. • An excellent summary of the demographics of CVD in the US.
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Howard, V.9
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Kittner, S.11
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0022970945
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Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium
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The first paper to describe the phenomenon of IPC and the consequent reduction in infarct size in dogs, •
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Murry CE, Jennings RB, Reimer KB: Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium. Circulation (1986) 74(5):1124-1136. • The first paper to describe the phenomenon of IPC and the consequent reduction in infarct size in dogs.
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Inhibition of myocardial injury by ischemic postconditioning during reperfusion: Comparison with ischemic preconditioning
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The first paper to describe the phenomenon of ischemic postconditioning during reperfusion and compare its efficacy with that of ischemic IPC, •
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Zhao ZQ, Corvera JS, Halkos ME, Kerendi F, Wang NP, Guyton RA, Vinten-Johansen J: Inhibition of myocardial injury by ischemic postconditioning during reperfusion: Comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol (2003) 285(2):H579-H588. • The first paper to describe the phenomenon of ischemic postconditioning during reperfusion and compare its efficacy with that of ischemic IPC.
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Spector AA, Norris AW: Action of epoxyeicosatrienoic acids on cellular function. Am J Physiol Cell Physiol (2007) 292(3):C996-C1012. • A thorough review of the cellular actions of the EETs in different organs.
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Spector AA, Norris AW: Action of epoxyeicosatrienoic acids on cellular function. Am J Physiol Cell Physiol (2007) 292(3):C996-C1012. • A thorough review of the cellular actions of the EETs in different organs.
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5
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0842299582
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Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors
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Granville DJ, Tashakkor B, Takeuchi C, Gustafsson AB, Huang C, Sayen MR, Wentworth P Jr, Yeager M, Gottlieb RA: Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors. Proc Natl Acad Sci USA (2004) 101(5):1321-1326.
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Wentworth Jr, P.7
Yeager, M.8
Gottlieb, R.A.9
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6
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33847419892
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Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts
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Gross GJ, Hsu A, Falck JR, Nithipatikom K: Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts. J Mol Cell Cardiol (2007) 42(3):687-691.
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0035337058
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Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs
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The first evidence that EETs are cardioprotective, and that 20-HETE results in a greater degree of injury in canine hearts, •
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Nithipatikom K, DiCamelli RF, Kohler S, Gumina RJ, Falck JR, Campbell WB, Gross GJ: Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs. Anal Biochem (2001) 292(1):115-124. • The first evidence that EETs are cardioprotective, and that 20-HETE results in a greater degree of injury in canine hearts.
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Gross, G.J.7
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Morisseau C, Goodrow MH, Dowdy D, Zheng J, Greene JF, Sanborn JR, Hammock BD: Potent urea and carbamate inhibitors of soluble epoxide hydrolases. Proc Natl Acad Sci USA (1999) 96(16):8849-8854. •• Publication of the first discovery of selective and potent inhibitors of sEHs, including AUDA, and demonstration that these compounds may have anti-inflammatory effects.
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Morisseau C, Goodrow MH, Dowdy D, Zheng J, Greene JF, Sanborn JR, Hammock BD: Potent urea and carbamate inhibitors of soluble epoxide hydrolases. Proc Natl Acad Sci USA (1999) 96(16):8849-8854. •• Publication of the first discovery of selective and potent inhibitors of sEHs, including AUDA, and demonstration that these compounds may have anti-inflammatory effects.
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9
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0034704156
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Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation
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Siinal CJ, Miyata M, Tohkin M, Nagata K, Bend JR, Gonzalez FJ: Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation. J Biol Chem (2000) 275(51):40504-40510.
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Seubert JM, Sinal CJ, Graves J, DeGraff LM, Bradbury JA, Lee CR, Goralski K, Carey MA, Luria A, Newman JW, Hammock BD et al: Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function. Circ Res (2006) 99(4):442-450. •• The first study to demonstrate a cardioprotective effect of knocking-out the sEH gene in mice. sEH null mice demonstrated a greater recovery of contractile function than corresponding wild-type mice, and had a slightly smaller infarct size after 20 min of ischemia, followed by 40 min of reperfusion.
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Seubert JM, Sinal CJ, Graves J, DeGraff LM, Bradbury JA, Lee CR, Goralski K, Carey MA, Luria A, Newman JW, Hammock BD et al: Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function. Circ Res (2006) 99(4):442-450. •• The first study to demonstrate a cardioprotective effect of knocking-out the sEH gene in mice. sEH null mice demonstrated a greater recovery of contractile function than corresponding wild-type mice, and had a slightly smaller infarct size after 20 min of ischemia, followed by 40 min of reperfusion.
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Gross GJ, Gauthier KM, Moore JM, Falck JR, Hammock BD, Campbell WB, Nithipatikom K: Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart. Am J Physiol Heart Circ Physiol (2008) 294(6):H2838- H2844. •• The first study to demonstrate that the inhibition of sEH by AUDA produced a marked and dose-related reduction in infarct size in the canine heart. In the presence of a low-dose of AUDA, 14,15-EET produced a greater reduction in infarct size than either AUDA or 14,15-EET provided when administered alone an additive effect, In addition, the protective effect of AUDA was blocked by the selective EET antagonist 14, 15-EEZE, which suggests that AUDA was acting via preservation of endogenous EETs
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Gross GJ, Gauthier KM, Moore JM, Falck JR, Hammock BD, Campbell WB, Nithipatikom K: Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart. Am J Physiol Heart Circ Physiol (2008) 294(6):H2838- H2844. •• The first study to demonstrate that the inhibition of sEH by AUDA produced a marked and dose-related reduction in infarct size in the canine heart. In the presence of a low-dose of AUDA, 14,15-EET produced a greater reduction in infarct size than either AUDA or 14,15-EET provided when administered alone (an additive effect). In addition, the protective effect of AUDA was blocked by the selective EET antagonist 14, 15-EEZE, which suggests that AUDA was acting via preservation of endogenous EETs.
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Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo
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Motoki A, Merkel MJ, Packwood WH, Cao Z, Liu L, Iliff J, Alkayed NJ, Van Winkle DM: Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo. Am J Phys Heart Circ Physiol (2008) 295(5):H2128-H2134.
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Epoxyeicosatrienoic acid prevents postischemic electrocardiogram abnormalities in an isolated heart model
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Batchu SN, Law E, Brocks DR, Falck JR, Seubert JM: Epoxyeicosatrienoic acid prevents postischemic electrocardiogram abnormalities in an isolated heart model. J Mol Cell Cardiol (2009) 46(1):67-74.
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14
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14,15-Epoxyeicosa-5(Z)-enoic acid: A selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries
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Gauthier KM, Deeter C, Krishna UM, Reddy YK, Bondlela M, Falck JR, Campbell WB: 14,15-Epoxyeicosa-5(Z)-enoic acid: A selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries. Circ Res (2002) 90(9):1028-1036.
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Bondlela, M.5
Falck, J.R.6
Campbell, W.B.7
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15
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Opioid-induced cardioprotection occurs via glycogen synthase kinase β inhibition during reperfusion in intact rat hearts
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Gross ER, Hsu AK, Gross GJ: Opioid-induced cardioprotection occurs via glycogen synthase kinase β inhibition during reperfusion in intact rat hearts. Circ Res (2004) 94(7):960-966.
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Inhibition of GSK3β by postconditioning is required to prevent opening of the mitochondrial permeability transition pore during reperfusion
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Gomez L, Paillard M, Thibault H, Derumeaux G, Ovize M: Inhibition of GSK3β by postconditioning is required to prevent opening of the mitochondrial permeability transition pore during reperfusion. Circulation (2008) 117(21):2761-2768.
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17
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Epoxyeicosatrienoic acids in cardioprotection: Ischemic versus reperfusion injury
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The first evidence to suggest that EETs produce benefits on both ischemic and reperfusion injury in a canine model of infarction, •
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Nithipatikom K, Moore JM, Isbell MA, Falck JR, Gross GJ: Epoxyeicosatrienoic acids in cardioprotection: Ischemic versus reperfusion injury. Am J Physiol Heart Circ Physiol (2006) 291(2):H537- H542. • The first evidence to suggest that EETs produce benefits on both ischemic and reperfusion injury in a canine model of infarction.
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Am J Physiol Heart Circ Physiol
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Nithipatikom, K.1
Moore, J.M.2
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Falck, J.R.4
Gross, G.J.5
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18
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Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors
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The first study to demonstrate that sEH inhibitors can prevent or reverse LVH and abate the arrhythmias that usually accompany cardiac hypertrophy in mice, •
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Xu D, Li N, He Y, Timofeyev V, Lu L, Tsai HJ, Kim IH, Tuteja D, Mateo RKP, Singapuri A, Davis BB et al: Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors. Proc Natl Acad Sci USA (2006) 103(49):18733-18738. • The first study to demonstrate that sEH inhibitors can prevent or reverse LVH and abate the arrhythmias that usually accompany cardiac hypertrophy in mice.
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Proc Natl Acad Sci USA
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Xu, D.1
Li, N.2
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Lu, L.5
Tsai, H.J.6
Kim, I.H.7
Tuteja, D.8
Mateo, R.K.P.9
Singapuri, A.10
Davis, B.B.11
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19
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Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease
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Monti J, Fischer J, Paskas S, Heinig M, Schulz H, Gösele C, Heuser A, Fischer R, Schmidt C, Schirdewan A, Gross V et al: Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease. Nat Genet (2008) 40(5):529-537.
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Monti, J.1
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Gösele, C.6
Heuser, A.7
Fischer, R.8
Schmidt, C.9
Schirdewan, A.10
Gross, V.11
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Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs)
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A concise review of the results of inhibiting sEH by gene knockout or with selective pharmacological inhibitors in different organ systems, and their potential as therapeutic agents in various diseases, •
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Inceoglu B, Schmelzer KR, Morisseau C, Jinks SL, Hammock BD: Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs). Prostaglandins Other Lipid Mediat (2007) 82(1-4):42-49. • A concise review of the results of inhibiting sEH by gene knockout or with selective pharmacological inhibitors in different organ systems, and their potential as therapeutic agents in various diseases.
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Imig JD: Cardiovascular therapeutic aspects of soluble epoxide hydrolase inhibitors. Cardiovasc Drug Rev (2006) 24(2):169- 188.
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The potential role of soluble epoxide hydrolase in the treatment of cardiac hypertrophy
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Harris TR, Li N, Chiamvimonvat N, Hammock BD: The potential role of soluble epoxide hydrolase in the treatment of cardiac hypertrophy. Congest Heart Fail (2008) 14(4):219-224.
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Hutchens MP, Nakano T, Dunlap J, Traystman RJ, Hurn PD, Alkayed NJ: Soluble epoxide hydrolase gene depletion reduces survival after cardiac arrest and cardiopulmonary resuscitation. Resuscitation (2008) 76(1):89-94.
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The soluble epoxide hydrolase encoded by EPHX2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity
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Newman JW, Morisseau C, Harris TR, Hammock BD: The soluble epoxide hydrolase encoded by EPHX2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. Proc Natl Acad Sci USA (2003) 100(4):1558-1563.
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Miura T, Miki T: Limitation of myocardial infarct size in the clinical setting: Current status and challenges in translating animal experiments into clinical therapy. Basic Res Cardiol (2008) 103(6):501-513.
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