Primary amino acid derivatives: Substitution of the 4′-N′- benzylamide site in (R)-N′-benzyl 2-amino-3-methylbutanamide, (R)-N′-benzyl 2-amino-3,3-dimethylbutanamide, and (R)-N′-benzyl 2-amino-3-methoxypropionamide provides potent anticonvulsants with pain-attenuating properties

Journal of Medicinal Chemistry

Volumn 54, Issue 19, 2011, Pages 6417-6431

  King, Amber M ^a   Salomé, Christophe ^a   Salomé Grosjean, Elise ^a   De Ryck, Marc ^b   Kaminski, Rafal ^b   Valade, Anne ^b   Stables, James P ^c   Kohn, Harold ^a,d  

^a University of North Carolina   (United States)

^b UCB PHARMA   (Belgium)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^d University of North Carolina at Chapel Hill   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 FLUOROPHENOXYMETHYL; 4' N' BENZYLAMIDE; AMINO ACID DERIVATIVE; ANTICONVULSIVE AGENT; HYDROCARBON; METHYL GROUP; N' BENZYL 2 AMINO 3 METHOXYPROPIONAMIDE; N' BENZYL 2 AMINO 3 METHYLBUTANAMIDE; N' BENZYL 2 AMINO 3,3 DIMETHYLBUTANAMIDE; PHENYTOIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; ELECTRON; INFORMATION; MALE; MOUSE; NEUROPATHIC PAIN; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

AMINO ACIDS; ANALGESICS; ANIMALS; ANTICONVULSANTS; BUTYRIC ACIDS; MALE; MICE; NEURALGIA; PAIN MEASUREMENT; PROPIONIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80053914898     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200759t     Document Type: Article

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