Arylsulfonamides as a new class of cannabinoid CB1 receptor ligands: Identification of a lead and initial SAR studies

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 1, 2007, Pages 272-277

  Lambeng, N ^a   Lebon, F ^a   Christophe, B ^a   Burton, M ^a   De Ryck, M ^a   Quere L ^a  

^a UCB PHARMA   (Belgium)

Author keywords

Arylsulfonamide; Cannabinoids; CB1; CB1 agonist; Pain

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; CANNABINOID 1 RECEPTOR; CANNABIS; DRONABINOL; LIGAND; NABILONE; PIPERIDINYLSULFONYL BENZOIC ESTER DERIVATIVE; SULFONAMIDE;

AGONIST; ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANALGESICS; ANIMALS; BENZOATES; HUMANS; LIGANDS; MALE; MICE; MICE, INBRED STRAINS; RECEPTOR, CANNABINOID, CB1; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 33845604363     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.09.049     Document Type: Article

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