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Volumn 18, Issue 11, 2008, Pages 3188-3191

Design and synthesis of 6-amino-1,4-oxazepane-3,5-dione derivatives as novel broad spectrum anticonvulsants

Author keywords

6 Amino 1,4 oxazepane 3,5 dione; Anticonvulsant; MES test; PTZ test

Indexed keywords

6 AMINO 1,4 OXAZEPANE 3,5 DIONE DERIVATIVE; ANTICONVULSIVE AGENT; PENTETRAZOLE;

EID: 44249123775     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.04.067     Document Type: Article
Times cited : (38)

References (13)
  • 1
    • 44249104809 scopus 로고    scopus 로고
    • Bell, G. S.; Sandler, J. W. In The Epidermiology: The Size of the Problem (Suppl. A), pp 306-314.
    • Bell, G. S.; Sandler, J. W. In The Epidermiology: The Size of the Problem (Suppl. A), pp 306-314.
  • 11
    • 44249111724 scopus 로고    scopus 로고
    • note
    • 2), 7.32 (s, 1H, NH)
  • 12
    • 0018129707 scopus 로고    scopus 로고
    • Krall, R. L.; Penry, J. K.; White, B. G.; Kapferberg, H. J.; Swinyard, E. A. Epilepsia 1978, 19, 409. The Pharmacological tests were carried out as follows: All tested compounds were dissolved in polyethylene glycol 400 and administered ip to ICR male mice at dose of 25, 50, 75, and 100 mg/kg, and anticonvulsant test was performed 30 min after the administration in groups of four mice. We also determined the lowest dose that with which all the tested animals could be induced with a seizure at the stage of preliminary screening. The seizure was artificially induced by either electric shock or pentylenetetrazole. The maximal electroshock seizure (MES) test was elicited with a 60-cycle a.c. of 50 mA intensity delivered for 0.2 s via corneal electrodes with ECT unit (UGO Baseline, Italy). A drop of 0.9% saline was instilled in the eye prior to application of electrodes. Protection in this test was defined as the abolition of the hind limb tonic extension component of the seizure.
    • 50 was estimated from the dose-response data.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.