Development and characterization of novel derivatives of the antiepileptic drug lacosamide that exhibit far greater enhancement in slow inactivation of voltage-gated sodium channels

ACS Chemical Neuroscience

Volumn 2, Issue 2, 2011, Pages 90-106

  Wang, Yuying ^a   Park, Ki Duk ^c   Salomé, Christophe ^c   Wilson, Sarah M ^a   Stables, James P ^d   Liu, Rihe ^c   Khanna, Rajesh ^a   Kohn, Harold ^b,c  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b University of North Carolina at Chapel Hill   (United States)

^c University of North Carolina at Chapel Hill   (United States)

^d NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

affinity bait; Lacosamide; slow inactivation; sodium channel

Indexed keywords

HARKOSERIDE; HARKOSERIDE DERIVATIVE; PHENOBARBITAL; PHENYTOIN; UNCLASSIFIED DRUG; VALPROIC ACID; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL EXPERIMENT; ARTICLE; CATECHOLAMINE NERVE CELL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INDICATION; DRUG MECHANISM; DRUG PROTEIN BINDING; FOCAL EPILEPSY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

RODENTIA;

EID: 79951845626     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn100089b     Document Type: Article

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