메뉴 건너뛰기




Volumn 8, Issue 7, 2007, Pages 570-579

Safinamide for the treatment of Parkinson's disease, epilepsy and restless legs syndrome

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; AMPA RECEPTOR ANTAGONIST; DOPAMINE; GABAPENTIN; GANGLIOSIDE GM1; HARKOSERIDE; ICA 27243; KAINIC ACID; LAMOTRIGINE; LEVODOPA; NEURITE PROMOTING FACTOR; NEUROIMMUNOPHILIN; NS 1209; OXIDOPAMINE; POTASSIUM CHANNEL STIMULATING AGENT; RETIGABINE; SAFINAMIDE; SELEGILINE; TALAMPANEL; UBIDECARENONE; UNCLASSIFIED DRUG;

EID: 34347340522     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (31)

References (53)
  • 1
    • 0028152976 scopus 로고    scopus 로고
    • 179853 The anticonvulsant FCE 26743 is a selective and short-acting MAO-B inhibitor devoid of inducing properties towards cytochrome P450-dependent testosterone hydroxylation in mice and rats. Strolin Benedetti MS, Marrari P, Colombo M, Castelli MG, Arand M, Oesch F, Dostert P J PHARM PHARMACOL 1994 46 10 814-819
    • 179853 The anticonvulsant FCE 26743 is a selective and short-acting MAO-B inhibitor devoid of inducing properties towards cytochrome P450-dependent testosterone hydroxylation in mice and rats. Strolin Benedetti MS, Marrari P, Colombo M, Castelli MG, Arand M, Oesch F, Dostert P J PHARM PHARMACOL 1994 46 10 814-819
  • 2
    • 34347357837 scopus 로고    scopus 로고
    • 229912 Anticonvulsant profile of FCE26743A, a novel 2-amino-propionamide derivative. Salveti P, Algate C, Beard D, Bonsignori A, Cervini MA, McArthur RA, Maj R, Pevarello P, Varasi M, Fariello R, Post C ABSTR SOC NEUROSCI 1996 22 3 2109
    • 229912 Anticonvulsant profile of FCE26743A, a novel 2-amino-propionamide derivative. Salveti P, Algate C, Beard D, Bonsignori A, Cervini MA, McArthur RA, Maj R, Pevarello P, Varasi M, Fariello R, Post C ABSTR SOC NEUROSCI 1996 22 3 2109
  • 3
    • 15144352587 scopus 로고    scopus 로고
    • 279845 Synthesis and anticonvulsant activity of a new class of 2, arylalkylamino]alkanamide derivatives. Pevarello P, Bonsignori A, Dostert P, Heidempergher F, Pinciroli V, Colombo M, McArthur RA, Salvati P, Post C, Fariello RG, Varasi M J MED CHEM 1998 41 4 579-590
    • 279845 Synthesis and anticonvulsant activity of a new class of 2-[(arylalkyl)amino]alkanamide derivatives. Pevarello P, Bonsignori A, Dostert P, Heidempergher F, Pinciroli V, Colombo M, McArthur RA, Salvati P, Post C, Fariello RG, Varasi M J MED CHEM 1998 41 4 579-590
  • 4
    • 7144229372 scopus 로고    scopus 로고
    • 288997 Preclinical evaluation of PNU-151774E as a novel anticonvulsant. Fariello RG, McArthur RA, Bonsignori A, Cervini MA, Maj R, Marrari P, Pevarello P, Wolf HH, Woodhead JW, White HS, Varasi M et al J PHARMACOL EXP THER 1998 285 2 397-403
    • 288997 Preclinical evaluation of PNU-151774E as a novel anticonvulsant. Fariello RG, McArthur RA, Bonsignori A, Cervini MA, Maj R, Marrari P, Pevarello P, Wolf HH, Woodhead JW, White HS, Varasi M et al J PHARMACOL EXP THER 1998 285 2 397-403
  • 5
    • 0032538614 scopus 로고    scopus 로고
    • 308267 PNU-151774E protects against kainate-induced status epilepticus and hippocampal lesions in the rat. Maj R, Fariello RG, Ukmar G, Varasi M, Pevarello P, McArthur RA, Salvati P EUR J PHARMACOL 1998 359 1 27-32
    • 308267 PNU-151774E protects against kainate-induced status epilepticus and hippocampal lesions in the rat. Maj R, Fariello RG, Ukmar G, Varasi M, Pevarello P, McArthur RA, Salvati P EUR J PHARMACOL 1998 359 1 27-32
  • 6
    • 0033530142 scopus 로고    scopus 로고
    • 340887 Sodium channel activity and sigma binding of 2-amino-propanamide anticonvulsants. Pevarello P, Bonsignori A, Caccia C, Amici R, McArthur RA, Fariello R, Salvati P, Varasi M BIOORG MED CHEM LETT 1999 9 17 2521-2525
    • 340887 Sodium channel activity and sigma binding of 2-amino-propanamide anticonvulsants. Pevarello P, Bonsignori A, Caccia C, Amici R, McArthur RA, Fariello R, Salvati P, Varasi M BIOORG MED CHEM LETT 1999 9 17 2521-2525
  • 7
    • 34347365024 scopus 로고    scopus 로고
    • 345222 PNU-15177AE, a combined MAO-B and glutamate release inhibitor, is effective in animal models of Parkinson's disease. Mai R, Calabresi M, Caccia C, Salvati P, Fariello RG ABSTR SOC NEUROSCI 1999 25 2 Abs 640.16
    • 345222 PNU-15177AE, a combined MAO-B and glutamate release inhibitor, is effective in animal models of Parkinson's disease. Mai R, Calabresi M, Caccia C, Salvati P, Fariello RG ABSTR SOC NEUROSCI 1999 25 2 Abs 640.16
  • 8
    • 34347358997 scopus 로고    scopus 로고
    • 348351 Drug development pipeline: Newron. Newron Pharmaceuticals SpA COMPANY COMMUNICATION 1999 November 15
    • 348351 Drug development pipeline: Newron. Newron Pharmaceuticals SpA COMPANY COMMUNICATION 1999 November 15
  • 9
    • 34347340993 scopus 로고    scopus 로고
    • 373379 New anti-epileptic drugs, fifth Eilat conference Part A, Eilat, Israel 25-29 June 2000. Perucca E IDDB MEETING REPORT 2000 June 25-29
    • 373379 New anti-epileptic drugs - fifth Eilat conference (Part A), Eilat, Israel 25-29 June 2000. Perucca E IDDB MEETING REPORT 2000 June 25-29
  • 10
    • 0033958716 scopus 로고    scopus 로고
    • 373763 Acute behavioral and EEG effects of NW-1015 on electrically-induced afterdischarge in conscious monkeys. Fariello RG, Maj R, Marrari P, Beard D, Algate C, Salvati P EPILEPSY RES 2000 39 1 37-46
    • 373763 Acute behavioral and EEG effects of NW-1015 on electrically-induced afterdischarge in conscious monkeys. Fariello RG, Maj R, Marrari P, Beard D, Algate C, Salvati P EPILEPSY RES 2000 39 1 37-46
  • 11
    • 0342712672 scopus 로고    scopus 로고
    • 373764 Anticonvulsant activity of PNU-151774E in the amygdala kindled model of complex partial seizures. Maj R, Fariello RG, Pevarello P, Varasi M, McArthur RA, Salvati P EPILEPSIA 1999 40 11 1523-1528
    • 373764 Anticonvulsant activity of PNU-151774E in the amygdala kindled model of complex partial seizures. Maj R, Fariello RG, Pevarello P, Varasi M, McArthur RA, Salvati P EPILEPSIA 1999 40 11 1523-1528
  • 12
    • 0033054347 scopus 로고    scopus 로고
    • 373766 Biochemical and electrophysiological studies on the mechanism of action of PNU-151774E, a novel antiepileptic compound. Salvati P, Maj R, Caccia C, Cervini MA, Fornaretto MG, Lamberti E, Pevarello P, Skeen GA, White HS, Wolf HH, Faravelli L J PHARMACOL EXP THER 1999 288 3 1151-1159
    • 373766 Biochemical and electrophysiological studies on the mechanism of action of PNU-151774E, a novel antiepileptic compound. Salvati P, Maj R, Caccia C, Cervini MA, Fornaretto MG, Lamberti E, Pevarello P, Skeen GA, White HS, Wolf HH, Faravelli L J PHARMACOL EXP THER 1999 288 3 1151-1159
  • 13
    • 0029619615 scopus 로고    scopus 로고
    • 373771 Enantioselective recognition of two anticonvulsants, FCE 26743 and FCE 28073, by MAO, and relationship between MAO-B inhibition and FCE 26743 concentrations in rat brain. Strolin Benedetti M, Tocchetti P, Rocchetti M, Martignoni M, Marrari P, Poggesi I, Dostert P PROG BRAIN RES 1995 106 4 123-134
    • 373771 Enantioselective recognition of two anticonvulsants, FCE 26743 and FCE 28073, by MAO, and relationship between MAO-B inhibition and FCE 26743 concentrations in rat brain. Strolin Benedetti M, Tocchetti P, Rocchetti M, Martignoni M, Marrari P, Poggesi I, Dostert P PROG BRAIN RES 1995 106 4 123-134
  • 14
    • 0032744908 scopus 로고    scopus 로고
    • 395700 Effects of co-administration of anticonvulsant and putative anticonvulsant agents and sub/suprathreshold doses of L-dopa upon motor behavior of MPTP-treated mice. Fredriksson A, Palomo T, Archer T J NEURAL TRANSM 1999 106 9-10 889-909
    • 395700 Effects of co-administration of anticonvulsant and putative anticonvulsant agents and sub/suprathreshold doses of L-dopa upon motor behavior of MPTP-treated mice. Fredriksson A, Palomo T, Archer T J NEURAL TRANSM 1999 106 9-10 889-909
  • 15
    • 34347343196 scopus 로고    scopus 로고
    • 403425 Drug development pipeline, safinamide. Newron Pharmaceuticals COMPANY COMMUNICATION 2001 January 26
    • 403425 Drug development pipeline - safinamide. Newron Pharmaceuticals COMPANY COMMUNICATION 2001 January 26
  • 16
    • 34347358996 scopus 로고    scopus 로고
    • 410623 An important industrial initiative supported by international venture capital specialists. Newron Pharmaceuticals SpA PRESS RELEASE 1999 October 06
    • 410623 An important industrial initiative supported by international venture capital specialists. Newron Pharmaceuticals SpA PRESS RELEASE 1999 October 06
  • 17
    • 34347339115 scopus 로고    scopus 로고
    • 428392 Characterization of MAO-B inhibitory of safinamide (NW-105) in animals and healthy volunteers. Caccia CP, Musanti R, Calabresi M, Tocchetti P, Del Bo L, Fariello RG, Benatti L, Salvati P ABSTR SOC NEUROSCI 2001 27 14 Abs 862.16
    • 428392 Characterization of MAO-B inhibitory of safinamide (NW-105) in animals and healthy volunteers. Caccia CP, Musanti R, Calabresi M, Tocchetti P, Del Bo L, Fariello RG, Benatti L, Salvati P ABSTR SOC NEUROSCI 2001 27 14 Abs 862.16
  • 18
    • 34347354719 scopus 로고    scopus 로고
    • 491110 New drug candidate for Parkinson's. Fariello R SMI CONF, NEURODEGENERATIVE DISORDERS 2003 May 21-22
    • 491110 New drug candidate for Parkinson's. Fariello R SMI CONF - NEURODEGENERATIVE DISORDERS 2003 May 21-22
  • 19
    • 1842736312 scopus 로고    scopus 로고
    • 557481 Pharmacokinetics and pharmacodynamics of safinamide, a neuroprotectant with antiparkinsonian and anticonvulsant activity. Marzo A, Dal Bo L, Ceppi Monti N, Crivelli F, Ismaili S, Caccia C, Cattaneo C, Fariello RG PHARMACOL RES 2004 50 1 77-85
    • 557481 Pharmacokinetics and pharmacodynamics of safinamide, a neuroprotectant with antiparkinsonian and anticonvulsant activity. Marzo A, Dal Bo L, Ceppi Monti N, Crivelli F, Ismaili S, Caccia C, Cattaneo C, Fariello RG PHARMACOL RES 2004 50 1 77-85
  • 20
    • 34347353643 scopus 로고    scopus 로고
    • 558666 Newron's safinamide enters pivotal phase III study for PD. Newron Pharmaceuticals SpA PRESS RELEASE 2004 September 13
    • 558666 Newron's safinamide enters pivotal phase III study for PD. Newron Pharmaceuticals SpA PRESS RELEASE 2004 September 13
  • 21
    • 34347340990 scopus 로고    scopus 로고
    • 563871 Dynogen obtains rights to Newron's ion channel modulators. Dynogen Pharmaceuticals Inc PRESS RELEASE 2004 October 12
    • 563871 Dynogen obtains rights to Newron's ion channel modulators. Dynogen Pharmaceuticals Inc PRESS RELEASE 2004 October 12
  • 22
    • 34347331654 scopus 로고    scopus 로고
    • 579123 Newron's safinamide reduces restless legs symptoms in phase II trial. Newron Pharmaceuticals SpA PRESS RELEASE 2005 January 11
    • 579123 Newron's safinamide reduces restless legs symptoms in phase II trial. Newron Pharmaceuticals SpA PRESS RELEASE 2005 January 11
  • 23
    • 0041633741 scopus 로고    scopus 로고
    • 651125 Pressor response to intravenous tyramine in healthy subjects after safinamide, a novel neuroprotectant with selective, reversible monoamine oxidase B inhibition. Cattaneo C, Caccia C, Marzo A, Maj R, Fariello RG CLIN NEUROPHARMACOL 2003 26 4 213-217
    • 651125 Pressor response to intravenous tyramine in healthy subjects after safinamide, a novel neuroprotectant with selective, reversible monoamine oxidase B inhibition. Cattaneo C, Caccia C, Marzo A, Maj R, Fariello RG CLIN NEUROPHARMACOL 2003 26 4 213-217
  • 24
    • 34347355846 scopus 로고    scopus 로고
    • 674506 Newron's safinamide improves UPDRS scores in phase III Parkinson's trial. Newron Pharmaceuticals SpA PRESS RELEASE 2006 June 19
    • 674506 Newron's safinamide improves UPDRS scores in phase III Parkinson's trial. Newron Pharmaceuticals SpA PRESS RELEASE 2006 June 19
  • 25
    • 4143093673 scopus 로고    scopus 로고
    • 693810 Improvement of motor function in early Parkinson disease by safinamide. Stocchi F, Arnold G, Onofrj M, Kwiecinski H, Szczudlik A, Thomas A, Bonuccelli U, Van Dijk A, Cattaneo C, Sala P, Fariello RG NEUROLOGY 2004 63 4 746-748
    • 693810 Improvement of motor function in early Parkinson disease by safinamide. Stocchi F, Arnold G, Onofrj M, Kwiecinski H, Szczudlik A, Thomas A, Bonuccelli U, Van Dijk A, Cattaneo C, Sala P, Fariello RG NEUROLOGY 2004 63 4 746-748
  • 26
    • 34347340992 scopus 로고    scopus 로고
    • 693811 Motor improvement in early Parkinson disease under treatment with safinamide, a new neuroprotectant. Results from a parallel double blind placebo controlled multinational study. Stocchi F, Onofrj M, Arnold G, Kwiecinski H, Szczudlik A NEUROLOGY 2004 62 7
    • 693811 Motor improvement in early Parkinson disease under treatment with safinamide, a new neuroprotectant. Results from a parallel double blind placebo controlled multinational study. Stocchi F, Onofrj M, Arnold G, Kwiecinski H, Szczudlik A NEUROLOGY 2004 62 7
  • 27
    • 34347352529 scopus 로고    scopus 로고
    • 693815 Motor function: Follow-up in patients affected by Parkinson's disease treated previously with safinamide. Thomas A, Cattaneo C, Besana C, Sala P, Onofrj M, Baratti M, Nordera G, Fabbrini G, Barbanti P, Fariello RG J NEURAL TRANSM 2004 111 5 XLIII
    • 693815 Motor function: Follow-up in patients affected by Parkinson's disease treated previously with safinamide. Thomas A, Cattaneo C, Besana C, Sala P, Onofrj M, Baratti M, Nordera G, Fabbrini G, Barbanti P, Fariello RG J NEURAL TRANSM 2004 111 5 XLIII
  • 28
    • 34347354721 scopus 로고    scopus 로고
    • 693816 Safinamide add-on to levodopa and dopamine agonist in Parkinson disease. An open escalating dose six week trial. Stocchi F, Vacca L, Grassini P, Battaglia G, Altobrandi MG, Ruggieri S J NEURAL TRANSM 2004 111 5 XLI
    • 693816 Safinamide add-on to levodopa and dopamine agonist in Parkinson disease. An open escalating dose six week trial. Stocchi F, Vacca L, Grassini P, Battaglia G, Altobrandi MG, Ruggieri S J NEURAL TRANSM 2004 111 5 XLI
  • 29
    • 34347343194 scopus 로고    scopus 로고
    • 693817 A pilot study of safinamide in medically intractable epilepsy. Tolerability, drug-drug interaction and efficacy data. Perucca E, Avanzini G, Onofrj M, Thomas A, Manfredi M, Di BC, Sala P, Cattaneo C J NEURAL TRANSM 2004 111 5 XXIX
    • 693817 A pilot study of safinamide in medically intractable epilepsy. Tolerability, drug-drug interaction and efficacy data. Perucca E, Avanzini G, Onofrj M, Thomas A, Manfredi M, Di BC, Sala P, Cattaneo C J NEURAL TRANSM 2004 111 5 XXIX
  • 30
    • 34347354720 scopus 로고    scopus 로고
    • 731077 Serono licenses Newron's safinamide for cognitive disorders. Serono SA PRESS RELEASE 2006 October 16
    • 731077 Serono licenses Newron's safinamide for cognitive disorders. Serono SA PRESS RELEASE 2006 October 16
  • 31
    • 0037176802 scopus 로고    scopus 로고
    • 739846 Restless legs syndrome: Treatment with dopaminergic agents. Comella CL NEUROLOGY 2002 58 4 Suppl 1 S87-S92
    • 739846 Restless legs syndrome: Treatment with dopaminergic agents. Comella CL NEUROLOGY 2002 58 4 Suppl 1 S87-S92
  • 32
    • 33750529946 scopus 로고    scopus 로고
    • 739863 Efficacy and tolerability of ropinirole in patients with restless legs syndrome and a baseline IRLS total score ≥ 24 points, data from the ropinirole clinical trial programme. Giorgi L, Ritchie SY, Kirsch JM CURR MED RES OPIN 2006 22 10 1867-1877
    • 739863 Efficacy and tolerability of ropinirole in patients with restless legs syndrome and a baseline IRLS total score ≥ 24 points ? data from the ropinirole clinical trial programme. Giorgi L, Ritchie SY, Kirsch JM CURR MED RES OPIN 2006 22 10 1867-1877
  • 33
    • 33748128036 scopus 로고    scopus 로고
    • 743027 Pediatric posttraumatic seizures: Epidemiology, putative mechanisms of epileptogenesis and promising investigational progress. Statler KD DEV NEUROSCI 2006 28 4-5 354-363
    • 743027 Pediatric posttraumatic seizures: Epidemiology, putative mechanisms of epileptogenesis and promising investigational progress. Statler KD DEV NEUROSCI 2006 28 4-5 354-363
  • 34
    • 33744916983 scopus 로고    scopus 로고
    • 743030 Seizures and brain tumors. Sperling MR, Ko J SEMIN ONCOL 2006 33 3 333-341
    • 743030 Seizures and brain tumors. Sperling MR, Ko J SEMIN ONCOL 2006 33 3 333-341
  • 35
    • 13444291643 scopus 로고    scopus 로고
    • 743033 Voltage gated ion channels: Targets for anticonvulsant drugs. Errington AC, Stohr T, Lees G CURR TOP MED CHEM 2005 5 1 15-30
    • 743033 Voltage gated ion channels: Targets for anticonvulsant drugs. Errington AC, Stohr T, Lees G CURR TOP MED CHEM 2005 5 1 15-30
  • 36
    • 0036347770 scopus 로고    scopus 로고
    • 743035 Critical re-evaluation of previous preclinical strategies for the discovery and the development of new antiepileptic drugs. Loscher W, Leppik IE EPILEPSY RES 2002 50 1-2 17-20
    • 743035 Critical re-evaluation of previous preclinical strategies for the discovery and the development of new antiepileptic drugs. Loscher W, Leppik IE EPILEPSY RES 2002 50 1-2 17-20
  • 37
    • 33749985009 scopus 로고    scopus 로고
    • 743145 New pharmacologic horizons in the treatment of Parkinson disease. Bonuccelli U, Dotto PD NEUROLOGY 2006 67 7 Suppl 2 S30-S38
    • 743145 New pharmacologic horizons in the treatment of Parkinson disease. Bonuccelli U, Dotto PD NEUROLOGY 2006 67 7 Suppl 2 S30-S38
  • 38
    • 33747049831 scopus 로고    scopus 로고
    • 743147 Diverse mechanisms of antiepileptic drugs in the development pipeline. Rogawski MA EPILEPSY RES 2006 69 3 273-294
    • 743147 Diverse mechanisms of antiepileptic drugs in the development pipeline. Rogawski MA EPILEPSY RES 2006 69 3 273-294
  • 39
    • 34347362022 scopus 로고    scopus 로고
    • 743149 Long-term care of Parkinson's disease. Strategies for managing wearing off symptom re-emergence and dyskinesias. Hauser RA GERIATRICS 2006 61 9 14-20
    • 743149 Long-term care of Parkinson's disease. Strategies for managing "wearing off" symptom re-emergence and dyskinesias. Hauser RA GERIATRICS 2006 61 9 14-20
  • 40
    • 33646539184 scopus 로고    scopus 로고
    • 743157 Transdermal selegiline: The new generation of monoamine oxidase inhibitors. Patkar AA, Pae CU, Masand PS CNS SPECTR 2006 11 5 363-375
    • 743157 Transdermal selegiline: The new generation of monoamine oxidase inhibitors. Patkar AA, Pae CU, Masand PS CNS SPECTR 2006 11 5 363-375
  • 41
    • 33746887419 scopus 로고    scopus 로고
    • 743168 Experimental and clinical evidence for loss of effect (tolerance) during prolonged treatment with antiepileptic drugs. Loscher W, Schmidt D EPILEPSIA 2006 47 8 1253-1284
    • 743168 Experimental and clinical evidence for loss of effect (tolerance) during prolonged treatment with antiepileptic drugs. Loscher W, Schmidt D EPILEPSIA 2006 47 8 1253-1284
  • 42
    • 0036080782 scopus 로고    scopus 로고
    • 743172 Restless legs syndrome probably induced by risperidone treatment. Wetter TC, Brunner J, Bronisch T PHARMACOPSYCHIATRY 2002 35 3 109-111
    • 743172 Restless legs syndrome probably induced by risperidone treatment. Wetter TC, Brunner J, Bronisch T PHARMACOPSYCHIATRY 2002 35 3 109-111
  • 43
    • 0022496317 scopus 로고    scopus 로고
    • 743177 Monoamine oxidase activity and monoamine metabolism in brains of parkinsonian patients treated with l-deprenyl. Riederer P, Youdim MB J NEUROCHEM 1986 46 5 1359-1365
    • 743177 Monoamine oxidase activity and monoamine metabolism in brains of parkinsonian patients treated with l-deprenyl. Riederer P, Youdim MB J NEUROCHEM 1986 46 5 1359-1365
  • 44
    • 30544442259 scopus 로고    scopus 로고
    • 743184 Modulation of brain mitochondrial function by deprenyl. Czerniczyniec A, Bustamante J, Lores-Arnaiz S NEUROCHEM INT 2006 48 3 235-241
    • 743184 Modulation of brain mitochondrial function by deprenyl. Czerniczyniec A, Bustamante J, Lores-Arnaiz S NEUROCHEM INT 2006 48 3 235-241
  • 45
    • 33750026173 scopus 로고    scopus 로고
    • 743190 Safinamide: From molecular targets to a new anti-parkinson drug. Caccia C, Calabresi M, Maestroni S, Faravelli L, Curatolo Salvati P, Fariello RG NEUROLOGY 2006 67 Suppl S18-S23
    • 743190 Safinamide: From molecular targets to a new anti-parkinson drug. Caccia C, Calabresi M, Maestroni S, Faravelli L, Curatolo Salvati P, Fariello RG NEUROLOGY 2006 67 Suppl S18-S23
  • 46
    • 33750000049 scopus 로고    scopus 로고
    • 743262 Symptom relief in Parkinson disease by safinamide: Biochemical and clinical evidence of efficacy beyond MAO-B inhibition. Stocchi F, Vacca L, Grassini P, De Pandis MF, Battaglia G, Cattaneo C, Fariello RG NEUROLOGY 2006 67 7 Suppl 2 S24-S29
    • 743262 Symptom relief in Parkinson disease by safinamide: Biochemical and clinical evidence of efficacy beyond MAO-B inhibition. Stocchi F, Vacca L, Grassini P, De Pandis MF, Battaglia G, Cattaneo C, Fariello RG NEUROLOGY 2006 67 7 Suppl 2 S24-S29
  • 47
    • 23044514579 scopus 로고    scopus 로고
    • 743270 Clinical pharmacology of rasagiline: A novel, second-generation propargylamine for the treatment of Parkinson disease. Chen JJ, Swope DM J CLIN PHARMACOL 2005 45 8 878-894
    • 743270 Clinical pharmacology of rasagiline: A novel, second-generation propargylamine for the treatment of Parkinson disease. Chen JJ, Swope DM J CLIN PHARMACOL 2005 45 8 878-894
  • 48
    • 33644909875 scopus 로고    scopus 로고
    • 744992 Clinically relevant drug interactions with antiepileptic drugs. Perucca E BR J CLIN PHARMACOL 2006 61 3 246-255
    • 744992 Clinically relevant drug interactions with antiepileptic drugs. Perucca E BR J CLIN PHARMACOL 2006 61 3 246-255
  • 49
    • 34347355847 scopus 로고    scopus 로고
    • 789895 Phase III data on safinamide in Parkinson's disease presented at American Academy of Neurology 59th Annual Meeting. Merck Serono SA PRESS RELEASE 2007 May 02
    • 789895 Phase III data on safinamide in Parkinson's disease presented at American Academy of Neurology 59th Annual Meeting. Merck Serono SA PRESS RELEASE 2007 May 02
  • 50
    • 33845914088 scopus 로고    scopus 로고
    • 790612 Novel anticonvulsant drugs. Stefan H, Feuerstein TJ PHARMACOL THER 2007 113 1 165-183
    • 790612 Novel anticonvulsant drugs. Stefan H, Feuerstein TJ PHARMACOL THER 2007 113 1 165-183
  • 51
    • 34347326581 scopus 로고    scopus 로고
    • 790613 Safinamide, a new anti-parkinson agent is effective and well-tolerated in early PD patients on a stable dose of a single DA-agonist: Results of a randomized, international, placebo-controlled, phase III trial. Stocchi F, Onofrj M, Shapira A, Bhatt MH, Rossetti S, Lorenzana P ANN MEET AM ACAD NEUROL 2007 59 2 S200.001
    • 790613 Safinamide, a new anti-parkinson agent is effective and well-tolerated in early PD patients on a stable dose of a single DA-agonist: Results of a randomized, international, placebo-controlled, phase III trial. Stocchi F, Onofrj M, Shapira A, Bhatt MH, Rossetti S, Lorenzana P ANN MEET AM ACAD NEUROL 2007 59 2 S200.001
  • 52
    • 34347346493 scopus 로고    scopus 로고
    • 796397 End of drug-chemical hybrids? Spengler P, Maul T NATEXIS BLEICHROEDER INC 2006 November 29
    • 796397 End of drug-chemical hybrids? Spengler P, Maul T NATEXIS BLEICHROEDER INC 2006 November 29
  • 53
    • 34347360988 scopus 로고    scopus 로고
    • 796400 Pharma catalyst planner, catalysts, patents and pipelines. Plag S, Dodwell J, Garcia-Sagues U, Gasteyger S, Holford J, Bedford T, Hilliker I, Bardo S CREDIT SUISSE EUROPE 2007 March 27
    • 796400 Pharma catalyst planner - catalysts, patents and pipelines. Plag S, Dodwell J, Garcia-Sagues U, Gasteyger S, Holford J, Bedford T, Hilliker I, Bardo S CREDIT SUISSE EUROPE 2007 March 27


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.