Encapsulation of Aβ 1-15 in PLGA microparticles enhances serum antibody response in mice immunized by subcutaneous and intranasal routes

European Journal of Pharmaceutical Sciences

Volumn 44, Issue 3, 2011, Pages 200-206

  Puras, G ^a,b   Salvador, A ^a,b   Igartua, M ^a,b   Hernandez R M ^a,b   Pedraz, J L ^a,b  

^a BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^b UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

Amyloid 1 15; Alzheimer's disease; Mice; Microparticles; PLGA; Vaccine

Indexed keywords

AMYLOID BETA PROTEIN ANTIBODY; AMYLOID BETA PROTEIN[1-15]; ANTIGEN; EPITOPE; FREUND ADJUVANT; POLYGLACTIN; SOLVENT; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DRUG EFFICACY; DRUG ISOLATION; DRUG RELEASE; DRUG SAFETY; EMULSION; ENZYME LINKED IMMUNOSORBENT ASSAY; EVAPORATION; FEMALE; IMMUNOGENICITY; IMMUNOTHERAPY; MEMBRANE MICROPARTICLE; MICROENCAPSULATION; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL;

ADMINISTRATION, INTRANASAL; ALZHEIMER DISEASE; ALZHEIMER VACCINES; AMYLOID BETA-PEPTIDES; ANIMALS; DRUG ADMINISTRATION SCHEDULE; DRUG CARRIERS; DRUG COMPOUNDING; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES, B-LYMPHOCYTE; EPITOPES, T-LYMPHOCYTE; IMMUNOGLOBULIN G; INJECTIONS, SUBCUTANEOUS; LACTIC ACID; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; PEPTIDE FRAGMENTS; POLYGLYCOLIC ACID; SURFACE PROPERTIES;

EID: 80053911485     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.07.010     Document Type: Article

References (46)

1. M.G. Agadjanyan, A. Ghochikyan, I. Petrushina, V. Vasilevko, N. Movsesyan, M. Mkrtichyan, T. Saing, and D.H. Cribbs Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from beta-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide J. Immunol. 174 2005 1580 1586
2. R. Aharoni, D. Teitelbaum, O. Leitner, A. Meshorer, M. Sela, and R. Arnon Specific Th2 cells accumulate in the central nervous system of mice protected against experimental autoimmune encephalomyelitis by copolymer 1 Proc. Natl Acad. Sci. USA 97 2000 11472 11477
3. F. Bard, C. Cannon, R. Barbour, R.L. Burke, D. Games, H. Grajeda, T. Guido, K. Hu, J. Huang, K. Johnson-Wood, K. Khan, D. Kholodenko, M. Lee, I. Lieberburg, R. Motter, M. Nguyen, F. Soriano, N. Vasquez, K. Weiss, B. Welch, P. Seubert, D. Schenk, and T. Yednock Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease Nat. Med. 6 2000 916 919 (Pubitemid 30644751)
4. A.J. Bayer, R. Bullock, R.W. Jones, D. Wilkinson, K.R. Paterson, L. Jenkins, S.B. Millais, and S. Donoghue Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD Neurology 64 2005 94 101 (Pubitemid 40082943)
5. D.J. Brayden, L. Templeton, S. McClean, R. Barbour, J. Huang, M. Nguyen, D. Ahern, R. Motter, K. Johnson-Wood, N. Vasquez, D. Schenk, and P. Seubert Encapsulation in biodegradable microparticles enhances serum antibody response to parenterally-delivered beta-amyloid in mice Vaccine 19 2001 4185 4193 (Pubitemid 32703639)
6. A.M. Carcaboso, R.M. Hernandez, M. Igartua, J.E. Rosas, M.E. Patarroyo, and J.L. Pedraz Potent, long lasting systemic antibody levels and mixed Th1/Th2 immune response after nasal immunization with malaria antigen loaded PLGA microparticles Vaccine 22 2004 1423 1432 (Pubitemid 38446918)
7. J.L. Cleland Single-administration vaccines: controlled-release technology to mimic repeated immunizations Trends Biotechnol. 17 1999 25 29 (Pubitemid 29246023)
8. D.H. Cribbs, A. Ghochikyan, V. Vasilevko, M. Tran, I. Petrushina, N. Sadzikava, D. Babikyan, P. Kesslak, T. Kieber-Emmons, C.W. Cotman, and M.G. Agadjanyan Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid Int. Immunol. 15 2003 505 514 (Pubitemid 36432403)
9. F.D. Finkelman, J. Holmes, I.M. Katona, J.F. Urban Jr., M.P. Beckmann, L.S. Park, K.A. Schooley, R.L. Coffman, T.R. Mosmann, and W.E. Paul Lymphokine control of in vivo immunoglobulin isotype selection Annu. Rev. Immunol. 8 1990 303 333
10. P.T. Francis, A.M. Palmer, M. Snape, and G.K. Wilcock The cholinergic hypothesis of Alzheimer's disease: a review of progress J. Neurol. Neurosurg. Psychiatry 66 1999 137 147 (Pubitemid 29103513)
11. H.J. Fu, B. Liu, J.L. Frost, and C.A. Lemere Amyloid-beta immunotherapy for Alzheimer's disease CNS Neurol. Disord. Drug Targets 9 2010 197 206
12. V. Geylis, V. Kourilov, Z. Meiner, I. Nennesmo, N. Bogdanovic, and M. Steinitz Human monoclonal antibodies against amyloid-beta from healthy adults Neurobiol. Aging 26 2005 597 606 (Pubitemid 40228751)
13. I. Gutierro, R.M. Hernandez, M. Igartua, A.R. Gascon, and J.L. Pedraz Size dependent immune response after subcutaneous, oral and intranasal administration of BSA loaded nanospheres Vaccine 21 2002 67 77 (Pubitemid 35351352)
14. J. Hardy, and D.J. Selkoe The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 2002 353 356 (Pubitemid 34790756)
15. J. Hu, G. Li, H. Wang, X. Lin, and Z. Yao Prevention of pathological change and cognitive degeneration of Tg2576 mice by inoculating Abeta(1-15) vaccine Sci. China C Life Sci. 51 2008 743 750
16. M. Igartua, R.M. Hernandez, A. Esquisabel, A.R. Gascon, M.B. Calvo, and J.L. Pedraz Influence of formulation variables on the in-vitro release of albumin from biodegradable microparticulate systems J. Microencapsul. 14 1997 349 356 (Pubitemid 27190282)
17. M. Igartua, R.M. Hernandez, A. Esquisabel, A.R. Gascon, M.B. Calvo, and J.L. Pedraz Enhanced immune response after subcutaneous and oral immunization with biodegradable PLGA microspheres J. Control. Release 56 1998 63 73 (Pubitemid 28511127)
18. C. Janus, J. Pearson, J. McLaurin, P.M. Mathews, Y. Jiang, S.D. Schmidt, M.A. Chishti, P. Horne, D. Heslin, J. French, H.T. Mount, R.A. Nixon, M. Mercken, C. Bergeron, P.E. Fraser, P. St George-Hyslop, and D. Westaway A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease Nature 408 2000 979 982 (Pubitemid 32101644)
19. R. Langer, J.L. Cleland, and J. Hanes New advances in microsphere-based single-dose vaccines Adv. Drug Deliv. Rev. 28 1997 97 119 (Pubitemid 27497676)
20. C.A. Lemere, A. Beierschmitt, M. Iglesias, E.T. Spooner, J.K. Bloom, J.F. Leverone, J.B. Zheng, T.J. Seabrook, D. Louard, D. Li, D.J. Selkoe, R.M. Palmour, and F.R. Ervin Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet Am. J. Pathol. 165 2004 283 297 (Pubitemid 38821835)
21. C.A. Lemere, M. Maier, Y. Peng, L. Jiang, and T.J. Seabrook Novel Abeta immunogens: is shorter better? Curr. Alzheimer Res. 4 2007 427 436 (Pubitemid 47416637)
22. C.A. Lemere, E.T. Spooner, J.F. Leverone, C. Mori, and J.D. Clements Intranasal immunotherapy for the treatment of Alzheimer's disease: Escherichia coli LT and LT(R192G) as mucosal adjuvants Neurobiol. Aging 23 2002 991 1000 (Pubitemid 35447779)
23. J.F. Leverone, E.T. Spooner, H.K. Lehman, J.D. Clements, and C.A. Lemere Abeta1-15 is less immunogenic than Abeta1-40/42 for intranasal immunization of wild-type mice but may be effective for "boosting" Vaccine 21 2003 2197 2206
24. S.B. Li, H.Q. Wang, X. Lin, J. Xu, Y. Xie, Q.F. Yuan, and Z.B. Yao Specific humoral immune responses in rhesus monkeys vaccinated with the Alzheimer's disease-associated beta-amyloid 1-15 peptide vaccine Chin. Med. J. (Engl) 118 2005 660 664 (Pubitemid 40585028)
25. S.B. Li, H.Q. Wang, X. Lin, J. Xu, and Z.B. Yao Specific humoral immune response in Rhesus monkeys vaccinated immune response with Abeta42 peptide vaccine Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 21 2005 202 204
26. M. Maier, T.J. Seabrook, N.D. Lazo, L. Jiang, P. Das, C. Janus, and C.A. Lemere Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response J. Neurosci. 26 2006 4717 4728 (Pubitemid 44315311)
27. E. Mata, A.M. Carcaboso, R.M. Hernandez, M. Igartua, G. Corradin, and J.L. Pedraz Adjuvant activity of polymer microparticles and Montanide ISA 720 on immune responses to Plasmodium falciparum MSP2 long synthetic peptides in mice Vaccine 25 2007 877 885 (Pubitemid 44856124)
28. J. McLaurin, R. Cecal, M.E. Kierstead, X. Tian, A.L. Phinney, M. Manea, J.E. French, M.H. Lambermon, A.A. Darabie, M.E. Brown, C. Janus, M.A. Chishti, P. Horne, D. Westaway, P.E. Fraser, H.T. Mount, M. Przybylski, and P. St George-Hyslop Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis Nat. Med. 8 2002 1263 1269 (Pubitemid 35373558)
29. N. Moretto, A. Bolchi, C. Rivetti, B.P. Imbimbo, G. Villetti, V. Pietrini, L. Polonelli, S. Del Signore, K.M. Smith, R.J. Ferrante, and S. Ottonello Conformation-sensitive antibodies against alzheimer amyloid-beta by immunization with a thioredoxin-constrained B-cell epitope peptide J. Biol. Chem. 282 2007 11436 11445 (Pubitemid 47100761)
30. D. Morgan, D.M. Diamond, P.E. Gottschall, K.E. Ugen, C. Dickey, J. Hardy, K. Duff, P. Jantzen, G. DiCarlo, D. Wilcock, K. Connor, J. Hatcher, C. Hope, M. Gordon, and G.W. Arendash A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease Nature 408 2000 982 985 (Pubitemid 32101645)
31. A. Muhs, D.T. Hickman, M. Pihlgren, N. Chuard, V. Giriens, C. Meerschman, I. van der Auwera, F. van Leuven, M. Sugawara, M.C. Weingertner, B. Bechinger, R. Greferath, N. Kolonko, L. Nagel-Steger, D. Riesner, R.O. Brady, A. Pfeifer, and C. Nicolau Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice Proc. Natl Acad. Sci. USA 104 2007 9810 9815 (Pubitemid 47175348)
32. J. Naslund, V. Haroutunian, R. Mohs, K.L. Davis, P. Davies, P. Greengard, and J.D. Buxbaum Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline JAMA 283 2000 1571 1577 (Pubitemid 30161512)
33. D.T. O'Hagan, H. Jeffery, and S.S. Davis Long-term antibody responses in mice following subcutaneous immunization with ovalbumin entrapped in biodegradable microparticles Vaccine 11 1993 965 969 (Pubitemid 23218807)
34. J.M. Orgogozo, S. Gilman, J.F. Dartigues, B. Laurent, M. Puel, L.C. Kirby, P. Jouanny, B. Dubois, L. Eisner, S. Flitman, B.F. Michel, M. Boada, A. Frank, and C. Hock Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization Neurology 61 2003 46 54 (Pubitemid 36818745)
35. F. Panza, V. Frisardi, B.P. Imbimbo, D. Seripa, V. Solfrizzi, and A. Pilotto Monoclonal antibodies against beta-amyloid (Abeta) for the treatment of Alzheimer's disease: the Abeta target at a crossroads Expert Opin. Biol. Ther. 11 2011 679 686
36. G.L. Plosker, and R.N. Brogden Leuprorelin. A review of its pharmacology and therapeutic use in prostatic cancer, endometriosis and other sex hormone-related disorders Drugs 48 1994 930 967
37. R. Rajkannan, V. Arul, E.J. Malar, and R. Jayakumar Preparation, physiochemical characterization, and oral immunogenicity of Abeta(1-12), Abeta(29-40), and Abeta(1-42) loaded PLG microparticles formulations J. Pharm. Sci. 98 2009 2027 2039
38. J.E. Rosas, J.L. Pedraz, R.M. Hernandez, A.R. Gascon, M. Igartua, F. Guzman, R. Rodriguez, J. Cortes, and M.E. Patarroyo Remarkably high antibody levels and protection against P. falciparum malaria in Aotus monkeys after a single immunisation of SPf66 encapsulated in PLGA microspheres Vaccine 20 2002 1707 1710 (Pubitemid 34242824)
39. D. Schenk Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning Nat. Rev. Neurosci. 3 2002 824 828 (Pubitemid 135706694)
40. D. Schenk, R. Barbour, W. Dunn, G. Gordon, H. Grajeda, T. Guido, K. Hu, J. Huang, K. Johnson-Wood, K. Khan, D. Kholodenko, M. Lee, Z. Liao, I. Lieberburg, R. Motter, L. Mutter, F. Soriano, G. Shopp, N. Vasquez, C. Vandevert, S. Walker, M. Wogulis, T. Yednock, D. Games, and P. Seubert Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse Nature 400 1999 173 177 (Pubitemid 29327547)
41. T.J. Seabrook, J.K. Bloom, M. Iglesias, E.T. Spooner, D.M. Walsh, and C.A. Lemere Species-specific immune response to immunization with human versus rodent A beta peptide Neurobiol. Aging 25 2004 1141 1151 (Pubitemid 39094017)
42. T.J. Seabrook, K. Thomas, L. Jiang, J. Bloom, E. Spooner, M. Maier, G. Bitan, and C.A. Lemere Dendrimeric Abeta1-15 is an effective immunogen in wildtype and APP-tg mice Neurobiol. Aging 28 2007 813 823 (Pubitemid 46589741)
43. D.J. Selkoe Alzheimer's disease: a central role for amyloid J. Neuropathol. Exp. Neurol. 53 1994 438 447 (Pubitemid 24276802)
44. D.J. Selkoe Translating cell biology into therapeutic advances in Alzheimer's disease Nature 399 1999 A23 31
45. R.H. Swanborg Experimental autoimmune encephalomyelitis in the rat: lessons in T-cell immunology and autoreactivity Immunol. Rev. 184 2001 129 135 (Pubitemid 34123770)
46. J. Zou, Z. Yao, G. Zhang, H. Wang, J. Xu, D.T. Yew, and E.L. Forster Vaccination of Alzheimer's model mice with adenovirus vector containing quadrivalent foldable Abeta(1-15) reduces Abeta burden and behavioral impairment without Abeta-specific T cell response J. Neurol. Sci. 272 2008 87 98