Clustering and internalization of toxic amylin oligomers in pancreatic cells require plasma membrane cholesterol

Journal of Biological Chemistry

Volumn 286, Issue 41, 2011, Pages 36086-36097

  Trikha, Saurabh ^a   Jeremic, Aleksandar M ^a  

^a GEORGE WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL MECHANISMS; BIOCHEMICAL STUDIES; CELL SURFACES; CHOLESTEROL DEPLETION; CLATHRIN-DEPENDENT ENDOCYTOSIS; CYTOSKELETONS; ESSENTIAL COMPONENT; EUKARYOTIC CELLS; EXTRACELLULAR; HUMAN ISLETS; INTRACELLULAR CHOLESTEROL; MODEL MEMBRANES; PANCREATIC CELLS; PANCREATIC HORMONES; PATHOPHYSIOLOGICAL; TYPE 2 DIABETES MELLITUS;

ACTIVATION ANALYSIS; CELL MEMBRANES; CONFOCAL MICROSCOPY; ENZYME ACTIVITY; MEMBRANES; MOLECULAR BIOLOGY; MOLECULAR RECOGNITION; MONOMERS; OLIGOMERS; PLASMAS; TOXICITY;

CHOLESTEROL;

AMYLIN; CHOLESTEROL; CLATHRIN; MONOMER; OLIGOMER;

ANIMAL CELL; ARTICLE; BIOACCUMULATION; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; CYTOSKELETON; CYTOTOXICITY; ENDOCYTOSIS; HORMONE BINDING; HUMAN; HUMAN CELL; INTERNALIZATION; INTRACELLULAR SPACE; MOLECULAR RECOGNITION; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN TARGETING; RAT;

ANIMALS; CELL LINE, TUMOR; CELL MEMBRANE; CHOLESTEROL; CLATHRIN; DIABETES MELLITUS, TYPE 2; ENDOCYTOSIS; HUMANS; INSULIN-SECRETING CELLS; ISLET AMYLOID POLYPEPTIDE; PROTEIN MULTIMERIZATION; RATS;

EUKARYOTA; RATTUS;

EID: 80053898059     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.240762     Document Type: Article

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