Enantioselective capillary electrophoresis for the assessment of CYP3A4-mediated ketamine demethylation and inhibition in vitro

Electrophoresis

Volumn 32, Issue 19, 2011, Pages 2738-2745

  Kwan, Hiu Ying ^a   Thormann, Wolfgang ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Capillary electrophoresis; Inhibition constant; Kinetic parameters; Stereoselective metabolism; Sulfated cyclodextrin

Indexed keywords

ALKALINITY; AMINES; CYCLODEXTRINS; ENANTIOMERS; ENANTIOSELECTIVITY; KINETICS; STEREOSELECTIVITY;

DEMETHYLATION; ENANTIOSELECTIVE; IN-VITRO; INHIBITION CONSTANTS; KETAMINE; KINETICS PARAMETER; SINGLE ENANTIOMERS; STEREO-SELECTIVE; STEREOSELECTIVE METABOLISM; SULFATED CYCLODEXTRINS;

CAPILLARY ELECTROPHORESIS;

BETA CYCLODEXTRIN DERIVATIVE; CYTOCHROME P450 3A; DRUG METABOLITE; GAMMA CYCLODEXTRIN DERIVATIVE; KETAMINE; KETOCONAZOLE; NORKETAMINE; PHOSPHORIC ACID; RECOMBINANT CYTOCHROME P450 3A; UNCLASSIFIED DRUG;

ARTICLE; CAPILLARY ELECTROPHORESIS; CHEMICAL REACTION KINETICS; COMPETITIVE INHIBITION; CONTROLLED STUDY; DEMETHYLATION; ENANTIOMER; ENANTIOSELECTIVITY; ENZYME INHIBITION; HILL KINETICS; IN VITRO STUDY; INTERMETHOD COMPARISON; LIQUID LIQUID EXTRACTION; MICHAELIS MENTEN KINETICS; PH; RACEMIC MIXTURE;

EID: 80053637676     PISSN: 01730835     EISSN: 15222683     Source Type: Journal    
DOI: 10.1002/elps.201100095     Document Type: Article

References (38)

1. Baselt, R. C., Cravey, R. H., Disposition of Toxic Drugs and Chemicals in Man, 4th Edn, Chemical Toxicology Institute, Foster City, CA 1995, pp. 412-414.
2. Moffat, A. C., Osselton, M. D., Widdop, B., Galichet, L. Y. (Eds.), Clarke's Analysis of Drugs and Poisons in Pharmaceuticals, Body Fluids and Postmortem Material, 3rd Edn, Pharmaceutical Press, London, UK 2004, pp. 1152-1153.
3. Adams, H. A., Werner, C., Anaesthesist 1997, 46, 1026-1042.
4. Craven, R., Anaesthesia 2007, 62, 48-53.
5. Sinner, B., Graf, B. M., Handb. Exp. Pharmacol. 2008, 182, 313-333.
6. Aroni, F., Iacovidou, N., Dontas, I., Pourzitaki, C., Xanthos, T., J. Clin. Phramacol. 2009, 49, 957-964.
7. Machado-Vieira, R., Salvadore, G., DiazGranados, N., Zarate, C. A., Pharmacol. Ther. 2009, 123, 143-150.
8. Adams, J. D., Baillie, T. A., Trevor, A. J., Castagnoli, N., Biomed. Mass Spectrom. 1981, 8, 527-538.
9. Woolf, T. F., Adams, J. D., Xenobiotica 1987, 17, 839-847.
10. Kharasch, E. D., Labroo, R., Anesthesiology 1992, 77, 1201-1207.
11. Savchuk, S. A., Brodskii, E. S., Rudenko, B. A., Formanovskii, A. A., Mikhura, I. V., Davydova, N. A., J. Anal. Chem. 1997, 52, 1175-1186.
12. Yanagihara, Y., Kariya, S., Ohtani, M., Uchino, K., Aoyama, T., Yamamura, Y., Iga, T., Drug Metab. Dispos. 2001, 29, 887-890.
13. Hijazi, Y., Boulieu, R., Drug Metab. Dispos. 2002, 30, 853-858.
14. Turfus, S. C., Parkin, M. C., Cowan, D. A., Halket, J. M., Smith, N. W., Braithwaite, R. A., Elliot, S. P., Steventon, G. B., Kicman, A. T., Drug Metab. Dispos. 2009, 37, 1769-1778.
15. Schmitz, A., Theurillat, R., Lassahn, P.-G., Mevissen, M., Thormann, W., Electrophoresis 2009, 30, 2912-2921.
16. Schmitz, A., Thormann, W., Moessner, L., Theurillat, R., Helmja, K., Mevissen, M., Electrophoresis 2010, 31, 1506-1516.
17. Portmann, S., Kwan, H. Y., Theurillat, R., Schmitz, A., Mevissen, M., Thormann, W., J. Chromatogr. A. 2010, 1217, 7942-7948.
18. Zaugg, S., Thormann, W., J. Chromatogr. A 2000, 875, 27-41.
19. Bonato, P. S., Electrophoresis 2003, 24, 4078-4094.
20. Caslavska, J., Thormann, W., J. Chromatogr. A 2011, 1218, 588-601.
21. Afshar, M., Thormann, W., Electrophoresis 2006, 27, 1526-1536.
22. Ha, P. T. T., Sluyts, I., Van Dyck, S., Zhang, J., Gilissen, R. A. H. J., Hoogmartens, J., Van Schepdael, A., J. Chromatogr. A 2006, 1120, 94-101.
23. Hai, X., Adams, E., Hoogmartens, J., Van Schepdael, A., Electrophoresis 2009, 30, 1248-1257.
24. Schmitz, A., Portier, C. J., Thormann, W., Theurillat, R., Mevissen, M., J. Vet. Pharmacol. Ther. 2008, 31, 446-455.
25. Capponi, L., Schmitz, A., Thormann, W., Theurillat, R., Mevissen, M., Am. J. Vet. Res. 2009, 70, 777-786.
26. Knobloch, M., Portier, C. J., Levionnois, O. L., Theurillat, R., Thormann, W., Spadavecchia, C., Mevissen, M., Toxicol. Appl. Pharmacol. 2006, 216, 373-386.
27. Larenza, M. P., Landoni, M. F., Levionnois, O. L., Knobloch, M., Kronen, P. W., Theurillat, R., Schatzmann, U., Thormann, W., Br. J. Anaesth. 2007, 98, 204-212.
28. Theurillat, R., Knobloch, M., Levionnois, O., Larenza, P., Mevissen, M., Thormann, W., Electrophoresis 2005, 26, 3942-3951.
29. Theurillat, R., Knobloch, M., Schmitz, A., Lassahn, P. G., Mevissen, M., Thormann, W., Electrophoresis 2007, 28, 2748-2757.
30. Chen, F.-T. A., Shen, G., Evangelista, R. A., J. Chromatogr. A 2001, 924, 523-532.
31. U.S. Department of Health and Human Services, Guidance for Industry: Drug Interactions Studies - Study Design, Data Analysis and Implications for Dosing and Labeling, Center for Drug Evaluation and Research and Center for Biologics Evaluation and Research, Rockville, MD, USA 2006, pp. 1-52.
32. Houston, J. B., Kenworthy, K. E., Drug Metab. Dispos. 2000, 28, 246-254.
33. Tracy, T. S., Hummel, M. A., Drug Metab. Rev. 2004, 36, 231-242.
34. Thummel, K. E., Wilkinson, G. R., Annu. Rev. Pharmacol. Toxicol. 1998, 38, 389-430.
35. Motulsky, H., Christopoulos, A., Fitting Models to Biological Data Using Linear and Nonlinear Regression: A Practical Guide to Curve Fitting, Oxford University Press, New York, USA 2004, p. 213.
36. Cheng, Y., Prusoff, W. H., Biochem. Pharmacol. 1973, 22, 3099-3108.
37. Lu, C., Hatsis, P., Berg, C., Lee, F. W., Balani, S. K., Drug Metab. Dispos. 2008, 36, 1255-1260.
38. Konečnỳ, J., Mičíková, I., Řemínek, R., Glatz, Z., J. Chromatogr. A 2008, 1189, 274-277.