Chiral capillary electrophoretic analysis of verapamil metabolism by cytochrome P450 3A4

Journal of Chromatography A

Volumn 1120, Issue 1-2, 2006, Pages 94-101

  Ha, Pham Thi Thanh ^a   Sluyts, Inge ^a   Dyck, Sigrid Van ^a   Zhang, Jie ^a   Gilissen, Ron A H J ^b   Hoogmartens, Jos ^a   Schepdael, Ann Van ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Capillary electrophoresis; Chiral; Cytochrome P450 3A4; Metabolism; N demethylation; Verapamil

Indexed keywords

BIOASSAY; CAPILLARY FLOW; ENZYMES; LIQUID CHROMATOGRAPHY; METABOLISM; REACTION KINETICS; SUBSTRATES;

CAPILLARY ELECTROPHORESIS; CYTOCHROME P450 3A4; N-DEMETHYLATION; VERAPAMIL;

ELECTROPHORESIS;

CYTOCHROME P450 3A4; NORVERAPAMIL; VERAPAMIL;

ARTICLE; CAPILLARY ELECTROPHORESIS; CHIRALITY; DRUG METABOLISM; ENANTIOSELECTIVITY; ENZYME ACTIVITY; PRIORITY JOURNAL; VALIDATION PROCESS;

CYTOCHROME P-450 ENZYME SYSTEM; ELECTROPHORESIS, CAPILLARY; HUMANS; ISOENZYMES; MOLECULAR STRUCTURE; REPRODUCIBILITY OF RESULTS; STEREOISOMERISM; VERAPAMIL;

EID: 33745076175     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2005.11.120     Document Type: Article

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