Enantioselective in-line and off-line CE methods for the kinetic study on cimetidine and its chiral metabolites with reference to flavin-containing monooxygenase genetic isoforms

Electrophoresis

Volumn 30, Issue 7, 2009, Pages 1248-1257

  Hai, Xin ^a   Adams, Erwin ^a   Hoogmartens, Jos ^a   Van Schepdael, Ann ^a  

^a DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

Author keywords

Chiral CE; Cimetidine; Electrophoretically mediated microanalysis; Flavin containing monooxygenase; In vitro drug metabolism

Indexed keywords

BIOMOLECULES; CHROMATOGRAPHY; METABOLISM; METABOLITES; MICROANALYSIS; PHYSIOLOGY; STEREOSELECTIVITY; X RAY CRYSTALLOGRAPHY;

CHIRAL CE; CHIRAL SELECTOR; CIMETIDINE; DRUG METABOLISMS; ELECTROPHORETICALLY MEDIATED MICROANALYSIS; FLAVIN CONTAINING MONOOXYGENASE; IN VITRO DRUG METABOLISM; IN-VITRO; ISOFORMS; S OXIDES;

ENANTIOMERS;

CIMETIDINE; CIMETIDINE SULFOXIDE; DIMETHYLANILINE MONOOXYGENASE; FLAVIN CONTAINING MONOOXYGENASE 1; FLAVIN CONTAINING MONOOXYGENASE 2; UNCLASSIFIED DRUG;

ARTICLE; CAPILLARY ELECTROPHORESIS; CHIRALITY; CONTROLLED STUDY; DRUG METABOLISM; DRUG STRUCTURE; ENANTIOSELECTIVITY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; MICHAELIS CONSTANT; MICROANALYSIS; OXYGENATION; STEREOCHEMISTRY;

EID: 65949120203     PISSN: 01730835     EISSN: 15222683     Source Type: Journal    
DOI: 10.1002/elps.200800604     Document Type: Article

References (35)

1. Cashman, J. R., Zhang, J., Annu. Rev. Pharmacol. Toxicol. 2006, 46, 65-100.
2. Krueger, S. K., Williams, D. E., Pharmacol. Ther. 2005, 106, 357-387.
3. Hines, R. N., Cashman, J. R., Philpot, R. M., Williams, D. E., Ziegler, D. M., Toxicol. Appl. Pharmacol. 1994, 125, 1-6.
4. Lawton, M. P., Cashman, J. R., Cresteil, T., Dolphin, C. T. et al., Arch. Biochem. Biophys. 1994, 308, 254-257.
5. Philips, I. R., Dolphin, C. T., Clair, P., Hadley, M. R. et al., Chem. Biol. Interact. 1995, 96, 17-32.
6. Cashman, J. R., Park, S. B., Berkman, C. E.,Cashman, L. E., Chem. Biol. Interact. 1995, 96, 33-46.
7. Cashman, J. R., Camp, K., Fakharzadeh, S. S., Fennessey, P. V. et al., Curr. Drug Metab. 2003, 4, 151-170.
8. Motika, M. S., Zhang, J., Cashman, J. R., Expert Opin. Drug Metab. Toxicol. 2007, 3, 831-845.
9. Whittle, C. L., Fakharzadeh, S., Eades, J., Preti, G., Ann. NY Acad. Sci. 2007, 1098, 252-266.
10. Cashman, J. R., Curr. Drug Metab. 2000, 1, 181-191.
11. Lipsy, R. J., Fennerty, B., Fagan, T. C., Arch. Intern. Med. 1990, 150, 745-751.
12. Humphries, T. J., Merritt, G. J., Aliment. Pharmacol. Ther. 1999, 13, 18-26.
13. Cashman, J. R., Park, S. B., Yang, Z. C.,Washington, C. B. et al., Drug Metab. Dispos. 1993, 21, 587-597.
14. Kuzel, R. A., Bhasin, S. K., Oldham, H. G., Damani, L. A. et al., Chirality 1994, 6, 607-614.
15. Schentag, J. J., Cerra, F. B., Calleri, G. M., Leising, M. E. et al., Clin. Pharmacol. Ther. 1981, 29, 737-743.
16. Gubitz, G., Schmid, M. G., Electrophoresis 2007, 28, 114-126.
17. Zhang, J., Konecny, J., Glatz, Z., Hoogmartens, J., Van Schepdael, A., Curr. Anal. Chem. 2007, 3, 197-217.
18. Eddershaw, P. J., Dickins, M., Pharm. Sci. Technol. Today 1999, 2, 13-19.
19. Bao, J., Regnier, F. E., J. Chromatogr. 1992, 608, 217-224.
20. Novakova, S., Van Dyck, S., Van Schepdael, A., Hoogmartens, J., Glatz, Z., J. Chromatogr. A 2004, 1032, 173-184.
21. Glatz, Z., J. Chromatogr. B 2006, 841, 23-37.
22. Hardley, M. R., Gabriac, S. D., Hutt, A. J., Chirality 1999, 11, 409-415.
23. Szökö, É., Tábi, T., Borgis, T., Dalmadi, B. et al., Electrophoresis 2004, 25, 2866-2875.
24. Hai, X., Konecny, J., Zeisbergerova, M., Adams, E. et al., Electrophoresis 2008, 29, 3817-3824.
25. Pitchen, P., Dunach, E., Deshmukh, M. N., Kagan, H. B., J. Am. Chem. Soc. 1984, 106, 8188-8193.
26. Luksa, J., Josic, D., J. Chromatogr. B 1995, 667, 321-327.
27. Ellis, D. R., Palmer, M. E., Tetler, L. W., Eckers, C., J. Chromatogr. A 1998, 808, 269-275.
28. Talt, R. J., Thompson, D. O., Stella, V. J., Stobaugh, J. F., Anal. Chem., 1994, 66, 4013-4018.
29. Van Dyck, S., Van Schepdael, A., Hoogmartens, J., Electrophoresis 2001, 22, 1436-1442.
30. Sadeque, A. J. M., Thummel, K. E., Rettie, A. E., Biochim. Biophys. Acta. 1993, 1162, 127-134.
31. Lattard, V., Buronfosse, T., Lachuer, J., Longin-Sauvageon, C. et al., Arch. Biochem. Biophys. 2001, 391, 30-40.
32. Lattard, V., Longin-Sauvageon, C., Benoit, E., Mol. Pharmacol. 2003, 63, 253-261.
33. Bjornsson, T. D., Callaghan, J. T., Einolf, H. J., Fischer, V. et al., Drug Metab. Dispos. 2003, 31, 815-832.
34. Ioannides, C., Enzyme Systems that Metabolise Drugs and Other Xenobiotics, Wiley, UK 2001.
35. Overby, L. H., Carver, G. C., Philpot, R. M., Chem. Biol. Interact. 1997, 106, 29-45.