Capillary electrophoretic investigation of the enantioselective metabolism of propafenone by human cytochrome P-450 SUPERSOMES: Evidence for atypical kinetics by CYP2D6 and CYP3A4

Electrophoresis

Volumn 27, Issue 8, 2006, Pages 1526-1536

  Afshar, Minoo ^a   Thormann, Wolfgang ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

5 Hydroxy propafenone; In vitro metabolism; N Despropyl propafenone; Stereoselective metabolism; Sulfated cyclodextrin

Indexed keywords

ENANTIOMERS; ENANTIOSELECTIVITY; ENZYMES; HYDROXYLATION; KINETICS; PHYSIOLOGY; STEREOSELECTIVITY;

5-HYDROXY-PROPAFENONE; CYP450 ENZYMES; DEALKYLATION; ENANTIOSELECTIVE; IN VITRO METABOLISM; IN-VITRO; N-DESPROPYL-PROPAFENONE; STEREO-SELECTIVE; STEREOSELECTIVE METABOLISM; SULPHATED Β-CYCLODEXTRIN;

METABOLISM;

5 HYDROXYPROPAFENONE; COMPLEMENTARY DNA; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DEPROPYLPROPAFENONE; PROPAFENONE;

ANALYTIC METHOD; ARTICLE; CAPILLARY ELECTROPHORESIS; CHEMICAL REACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEALKYLATION; DRUG CLEARANCE; DRUG HYDROXYLATION; DRUG METABOLISM; ENANTIOMER; ENANTIOSELECTIVITY; ENZYME KINETICS; HUMAN; IN VITRO STUDY; INHIBITION KINETICS; MICHAELIS MENTEN KINETICS; RACEMIC MIXTURE; STEREOCHEMISTRY;

EID: 33646241750     PISSN: 01730835     EISSN: 15222683     Source Type: Journal    
DOI: 10.1002/elps.200500664     Document Type: Article

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