Tumor-specific gene expression using regulatory elements of the glucose transporter isoform 1 gene

Cancer Gene Therapy

Volumn 11, Issue 1, 2004, Pages 41-51

  Sieger, Stephanie ^a   Jiang, Shiming ^a   Kleinschmidt, Jürgen ^b   Eskerski, Helmut ^a   Schönsiegel, Frank ^a   Altmann, Annette ^a   Mier, Walter ^c   Haberkorn, Uwe ^a,c  

^a Clin Coop Unit Nuclear Medicine   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

AAV; Glucose transporter promoter; HSV thymidine kinase; Suicide gene

Indexed keywords

DEOXYCYTIDINE; GANCICLOVIR; GLUCOSE TRANSPORTER 1; GREEN FLUORESCENT PROTEIN; IODINE 125; ISOPROTEIN; THYMIDINE; THYMIDINE KINASE; TRITIUM;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER REGRESSION; CELL COUNT; CELL LINE; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOTOXICITY; DNA DRUG COMPLEX; ENZYME PHOSPHORYLATION; FLUORESCENCE; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; ISOTOPE LABELING; MALE; MOLECULAR CLONING; NONHUMAN; ONCOGENE; ONCOGENE RAS; PRIORITY JOURNAL; PROMOTER REGION; RAT; REGULATOR GENE; STATISTICAL SIGNIFICANCE; SUICIDE GENE; TARGET CELL; TISSUE SPECIFICITY; VIRUS PARTICLE;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL DIVISION; CELL LINE, TUMOR; DEOXYCYTIDINE; DEPENDOVIRUS; FLOW CYTOMETRY; GANCICLOVIR; GENE EXPRESSION REGULATION; GENE THERAPY; GENES, REPORTER; HUMANS; MICE; MONOSACCHARIDE TRANSPORT PROTEINS; NEOPLASM TRANSPLANTATION; ORGAN SPECIFICITY; PROTEIN ISOFORMS; RATS; RATS, INBRED ACI; SIMPLEXVIRUS; THYMIDINE KINASE;

ADENO-ASSOCIATED VIRUS; ANIMALIA; CYTOMEGALOVIRUS; SIMPLEXVIRUS;

EID: 0346725983     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700654     Document Type: Article

References (39)

1. Colombo BM, Benedetti S, Ottolenghi S, et al. The 'bystander effect': association of U-87 cell death with ganciclovir-mediated apoptosis of nearby cells and lack of effect in athymic mice. Hum Gene Ther. 1995;6:763-772.
2. Moolten FL. Tumor chemosensitivity conferred by inserted herpes virus thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res. 1986;4:5276-5281.
3. Dachs GU, Dougherty GJ, Startford IJ, et al. Targeting gene therapy to cancer: a review. Oncol Res. 1997;9: 313-323.
4. Anderson LM, Swaminathan S, Zackon I, et al. Adenovirus-mediated tissue-targeted expression of the HSVtk gene for the treatment of breast cancer. Gene Therapy. 1999;6:854-864.
5. Shirakawa T, Ko SC, Gardner TA, et al. In vivo suppression of osteosarcoma pulmonary metastasis with intravenous osteocalcin promoter-based toxic gene therapy. Cancer Gene Ther. 1998;5:274-280.
6. Jiang S, Altmann A, Grimm D, et al. Tissue-specific gene expression in medullary thyroid carcinoma cells employing calcitonin regulatory elements and AAV vectors. Cancer Gene Ther. 2001;8:469-472.
7. Harris JD, Gutierrez AA, Hurst HC, et al. Gene therapy for cancer using tumor-specific prodrug activation. Gene Therapy. 1994;1:170-175.
8. Ring CJA, Harris JD, Hurst HC, et al. Suicide gene expression induced in tumor cells transduced with recombinant adenoviral, retroviral and plasmid vectors containing the ERBB2 promoter. Gene Therapy. 1996;3:1094-1103.
9. Ring CJA, Blouin P, Martin LA, et al. Use of transcriptional regulatory elements of the MUC1 and ERBB2 genes to drive tumor-selective expression of a prodrug activating enzyme. Gene Therapy. 1997;4:1045-1052.
10. Majumdar AS, Hughes DE, Lichtsteiner SP, et al. The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatoxicity encountered with constitutive promoters. Gene Therapy. 2001;8:568-578.
11. Lipinski KS, Djeha HD, Ismail T, et al. High-level, β -catenin/TCF-dependent transgene expression in secondary colorectal cancer tissue. Mol Ther, 2001;4:365-371.
12. Warburg O. Biochem. Z. 1923;142:317.
13. Flier JS, Mueckler MM, Usher P, et al. Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Science. 1987;235:1492-1495.
14. Hiraki Y, deHerreros AG, Birnbaum MJ. Transformation stimulates glucose transporter gene expression in the absence of protein kinase C. Proc Natl Acad Sci USA. 1989;86:8252-8256.
15. Godwin AK, Lieberman MW. Elevation of glucose transporter, c-myc and transin RNA levels by Ha-rasT24 is independent of its effect on the cell cycle. Mol Carcinog. 1991;4:275-285.
16. White MK, Weber MJ. Transformation by the src oncogene alters glucose transport into rat and chicken cells by different mechanisms. Mol Cell Biol. 1988;8:138-144.
17. White MK, Weber MJ. The src oncogene can regulate a human glucose transporter expressed in chicken embryo fibro blasts. Mol Cell Biol. 1990;10:301-306.
18. Sistonen L, Hölttä E, Mäkelä TP, et al. The cellular response to induction of the p21c-Ha-ras oncoprotein includes stimulation of jun gene expression. EMBO J. 1989;9:815-822.
19. Birnbaum MJ, Haspel HC, Rosen OM. Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription. Science. 1987;235:1495-1498.
20. Shawver LK, Olson SA, White MK, et al. Degradation and biosynthesis of the glucose transporter protein in chicken embryo fibroblasts transformed by the src oncogene. Mol Cell Biol. 1987;7:2112-2118.
21. Godwin AK, Lieberman MW. Early and late responses to induction of ras T24 expression in Rat-1 cells. Oncogene. 1990;5:1231-1241.
22. Nishioka T, Oda Y, Seino Y, et al. Distribution of the glucose transporters in human brain tumors. Cancer Res. 1992;52:3972-3979.
23. Yamamoto T, Seino Y, Fukumoto H, et al. Over-expression of facilitative glucose transporter genes in human cancer. Biochem. Biophys Res Commun. 1990;170:223-230.
24. Mueckler M. Facilitative glucose transporters. Eur J Biochem. 1994;219:713-725.
25. Murakami T, Nishiyama T, Shirotani T, et al. Identification of two enhancer elements in the gene encoding the type 1 glucose transporter from the mouse which are responsive to serum, growth factor, and oncogenes. J Biol Chem. 1992;267:9300-9306.
26. Todaka M, Nishiyama T, Murakami T, et al. The role of insulin in activation of two enhancers in the mouse GLUT1 gene. J Biol Chem. 1994;269:29265-29270.
27. Flotte TR, Carter BJ. Adeno-associated virus vectors for gene therapy. Methods Enzymol. 1998;292:717-732.
28. Ponnazhagan S, Curiel DT, Shaw DR, et al. Adenoassociated virus for cancer gene therapy. Cancer Res. 2001;615:6313-6321.
29. Aitken ML, Moss RB, Waltz DA, et al. A phase I study of aerosolized administration of tgAAVCF to cystic fibrosis subjects with mild lung disease. Hum Gene Ther. 2001;12:1907-1916.
30. Fusenig NE, Boukamp P. Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes. Mol Carcinog. 1998;23:144-158.
31. Boukamp P, Petrusevska RT, Breitkreutz D, et al. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol. 1988;106:761-771.
32. Haberkorn U, Khazaie K, Morr I, et al. Ganciclovir uptake in human mammary carcinoma cells expressing herpes simplex virus thymidine kinase. J Nucl Med Biol. 1998;25:367-673.
33. Salvetti A, Oreve S, Chadeuf G, et al. Factors influencing recombinant adeno-associated virus production. Hum Gene Ther. 1998;9:695-706.
34. Zolotukhin S, Potter M, Hauswirth WW, et al. A 'humanized' green fluorescent protein cDNA adapted for high-level expression in mammalian cells. J Virol. 1996;70:4646-4654.
35. Grimm D, Kern A, Rittner K, et al. Novel tools for production and purification of recombinant adenoassociated virus vectors. Hum Gene Ther. 1998;9:2745-2760.
36. Haberkorn U, Altmann A, Morr I, et al. Monitoring gene therapy with herpes simplex virus thymidine kinase in hepatoma cells: uptake of specific substrates. J Nucl Med. 1997;38:287-294.
37. Bi WL, Parysk LM, Warnick R, et al. In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV-tk retroviral gene therapy. Hum Gene Ther. 1993;4:725-731.
38. Nottebrock H, Then R. Thymidine concentrations in serum and urine of different animal species and man. Biochem Pharmacol. 1977;26:2175-2179.
39. Haberkorn U, Bellemann ME, Gerlach L, et al. Uncoupling of 2-fluoro-2-deoxyglucose transport and phosphorylation in rat hepatoma during gene therapy with HSV thymidine kinase. Gene Therapy. 1998;5:880-887.