Radiolabeled amino acids for tumor imaging with PET: Radiosynthesis and biological evaluation of 2-amino-3-[18F]fluoro-2-methylpropanoic acid and 3-[18F]fluoro-2-methyl-2-(methylamino)propanoic acid

Journal of Medicinal Chemistry

Volumn 45, Issue 11, 2002, Pages 2240-2249

  McConathy, Jonathan ^a   Martarello, Laurent ^a   Malveaux, Eugene J ^a   Camp, Vernon M ^a   Simpson, Nicholas E ^a   Simpson, Chiab P ^a   Bowers, Geoffrey D ^a   Olson, Jeffrey J ^a   Goodman, Mark M ^a  

^a EMORY UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 2 METHYLPROPIONIC ACID; 2 AMINO 3 FLUORO 2 METHYLPROPANOIC ACID F 18; 3 FLUORO 2 METHYL 2 (METHYLAMINO)PROPANOIC ACID F 18; FLUORINE 18; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TUMOR; CONTROLLED STUDY; DRUG SYNTHESIS; GLIOSARCOMA; ISOTOPE LABELING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOCHEMISTRY; RAT; RAT STRAIN;

AMINO ACID TRANSPORT SYSTEM A; AMINO ACIDS; AMINOISOBUTYRIC ACIDS; ANIMALS; BRAIN; BRAIN NEOPLASMS; FLUORINE RADIOISOTOPES; GLIOSARCOMA; ISOTOPE LABELING; LIGANDS; MALE; NEOPLASM TRANSPLANTATION; PROPIONIC ACIDS; RADIOPHARMACEUTICALS; RATS; RATS, INBRED F344; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED; TUMOR CELLS, CULTURED;

EID: 0037161591     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010241x     Document Type: Article

References (36)

1. Comparison of PET with conventional imaging techniques
2. PET in differentiation of recurrent brain tumor from radiation injury
3. Brain metastases from noncentral nervous system tumors: Evaluation with PET
4. Introduction to imaging brain tumor metabolism with positron emission tomography
5. Intratumoral distribution of fluorine-18-fluorodeoxyglucose in vivo: High accumulation in macrophages and granulation tissue studied with microrautoradiography
6. Micoautoradiographic study for the differentiation of intratumoral macrophages, granulation tissues and cancer cells by the dynamics of fluorine-18-fluorodeoxyglucose uptake
7. Cerebral glioma: Evaluation with methionine PET
8. Radiolabeled amino acids: Basic aspects and clinical applications in oncology
9. The in vivo metabolic investigation of brain gliomas with positron emission tomography
10. Glucose and methionine uptake and proliferative activity in meningiomas
11. Tumor imaging with carbon-11 labeled α-aminoisobutyric acid (AIB) in a patient with advanced malignant melanoma
12. 18F α-methyl tyrosine PET studies in patients with brain tumors
13. 11C] methionine uptake in brain tumors: Initial results of a comparative study
14. 18F]1-amino-3-fluorocyclobutane-1-carboxylic acid to image brain tumors
15. Molecular biology of mammalian plasma membrane amino acid transporters
16. The stimulation of Na, K, Cl cotransport of system A for neutral amino acid transport is a mechanism for cell volume increase during the cell cycle
17. Neutral amino acid transport systems in animal cells: Potential targets of oncogene action and regulators of cell growth
18. Tumor localization of α-aminoisobutyric acid (AIB) in human melanoma heterotransplants
19. Imaging experimental brain tumors and 1-aminocyclopentane carboxylic acid and α-aminoisobutyric acid: Comparison to fluorodeoxyglucose and diethylenetriaminepentaacetic acid in morphologically defined tumor regions
20. Blood flow and blood-to-tissue transport in 9L gliosarcomas: The role of the brain tumor model in drug delivery research
21. 11C in normal and prostate cancer-bearing rat after chemotheraphy
22. The regulation of neutral amino acid transport in mammalian cells
23. The use of N-methylation to direct the route of mediated transport of amino acids
24. 11C]methyl trifiate and HPLC metabolite analysis of plasma samples after intravenous administration in man
25. 2-Phenyl isopropyl and tert-butyl trichloroacetimidates: Useful reagents for ester preparation of N-protected amino acids under neutral conditions
26. NMDA receptor channels: Labeling of MK-801 with Iodine-125 and Fluorine-18
27. Fluorine for hydroxy substitution in biogenic amines: Asymmetric synthesis and biological evaluation of fluorine-18-labeled β-fluorophenylalkylamines as model systems
28. Generation of unnatural α,α-disubstituted amino acid derivatives from cyclic sulfamidates
29. 18F]-fluoroamines; precursors to β-selective adrenergic ligands
30. Substituted diphenylmethyl protecting groups in peptide synthesis
31. Selective removal of the tert-butyloxycarbonyl protecting group in the presence of tertbutyl and p-methoxybenzyl esters
32. 18FDG preparations and detection of the chemical impurity 2-deoxy-2-chloro-D-glucose
33. Polarity of the blood-brain barrier: Neutral amino acid transport into isolated brain capillaries
34. Tumor detection with carbon-11-labeled amino acids
35. Functional analogues of CC-1065 and the duocarmycins incorporating the 9a-(chloromethyl)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (C2BI) alkylation subunit: Synthesis and preliminary DNA alkylation studies
36. Structure-activity relationship studies of novel 4-[2-[bis(4-fluorophenyl)methoxyl ethyl]-1(3-phenylpropyl)piperidine analogues: Synthesis and biological evaluation at the dopamine and serotonin transporter sites