Costunolide inhibits proinflammatory cytokines and iNOS in activated murine BV2 microglia

Frontiers in Bioscience - Elite

Volumn 3 E, Issue 3, 2011, Pages 1079-1091

  Rayan, Nirmala Arul ^b   Baby, Nimmi ^a   Pitchai, Daisy ^b   Indraswari, Fransisca ^a   Ling, Eng Ang ^a   Lu, Jia ^c   Dheen, Thameem ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b HOLY CROSS COLLEGE   (India)

^c DSO NATIONAL LABORATORIES   (Singapore)

Author keywords

BV2 microglia; Costunolide; Inflammation; Interleukins; MAPK pathway; Nitrite release

Indexed keywords

COSTUNOLIDE; CYCLOOXYGENASE 2; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; ENZYME INHIBITOR; NITRIC OXIDE; PRIMER DNA; SESQUITERPENE;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL NUCLEUS; CELL VIABILITY; CHEILOCOSTUS SPECIOSUS; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION; GENE TRANSLOCATION; IN VITRO STUDY; MICROGLIA; MOUSE; NONHUMAN; PLANT ROOT; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; DRUG ANTAGONISM; ENZYMOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

COSTUS SPECIOSUS; MURINAE;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CYTOKINES; DNA PRIMERS; ENZYME INHIBITORS; FLUORESCENT ANTIBODY TECHNIQUE; INFLAMMATION MEDIATORS; MICE; MICROGLIA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SESQUITERPENES;

EID: 80053584078     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: None     Document Type: Article

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