Differential and constitutive expression of neuronal, inducible, and endothelial nitric oxide synthase mRNAs and proteins in pathologically normal human tissues

Nitric Oxide - Biology and Chemistry

Volumn 4, Issue 5, 2000, Pages 459-471

  Park, Chang Shin ^a   Krishna, Gopal ^b   Ahn, Mi Sun ^a   Kang, Ju Hee ^a   Chung, Woon Gye ^a   Kim, Dae Joong ^a   Hwang, Hweung Kon ^c   Lee, Jung Nam ^d   Paik, Sang Gi ^e   Cha, Young Nam ^a  

^a Inha University   (South Korea)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c Sejong General Hospital   (South Korea)

^d Gachon University College of Medicine   (South Korea)

^e Chungnam National University   (South Korea)

Author keywords

Alternative splicing; Human normal tissues; mRNA; Nitric oxide synthases; Protein

Indexed keywords

MESSENGER RNA; NITRIC OXIDE SYNTHASE; PROTEIN;

ALTERNATIVE RNA SPLICING; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE DISTRIBUTION; TISSUE SPECIFICITY;

EID: 0033793980     PISSN: 10898603     EISSN: None     Source Type: Journal    
DOI: 10.1006/niox.2000.0300     Document Type: Article

References (45)

1. Nitric oxide: A physiologic messenger molecule
2. The nitric oxide synthase family of proteins
3. Isolation of nitric oxide synthase: A calmodulin-requiring enzyme
4. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide
5. L-Arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells
6. Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle
7. Cloning and expression of a cDNA encoding human endothelial derived relaxing factor/nitric oxide synthase
8. Molecular cloning and characterization of human endothelial nitric oxide synthase
9. Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes
10. Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte
11. Neuronal nitric oxide synthase-mu, an alternatively spliced isoform expressed in differentiated skeletal muscle
12. Structural diversity of neuronal nitric oxide synthase mRNA in the nervous system
13. Structural organization of the human neuronal nitric oxide synthase gene (NOS1)
14. Regulation of neuronal nitric oxide synthase through alternative transcripts
15. Neuronal nitric oxide synthase alternatively spliced forms: Prominent functional localizations in the brain
16. A novel, testis-specific mRNA transcript encoding an NH2-terminal truncated nitric oxide synthase
17. Tissue- and development-specific expression of multiple alternatively spliced transcripts of rat neuronal nitric oxide synthase
18. Nitric oxide synthase 1 mRNA: Tissue-specific variants from rat with alternative first exons
19. Isolation and characterization of a novel, human neuronal nitric oxide synthase cDNA
20. Characterization and splice variants of neuronal nitric oxide synthase in rat small intestine
21. Cloning and characterization of human inducible nitric oxide synthase splice variants: A domain, encoded by exons 8 and 9, is critical for dimerization
22. Alternative splicing of human inducible nitric oxide synthase mRNA. Tissue-specific regulation and induction by cytokines
23. Constitutive expression and structural diversity of inducible isoform of nitric oxide synthase in human tissues
24. Structural diversity in the 5'-untranslated region of cytokine-stimulated human inducible nitric oxide synthase mRNA
25. Genomic analysis and expression patterns reveal distinct genes for endothelial and brain nitric oxide synthase
26. Human retina expresses both constitutive and inducible isoforms of nitric oxide synthase mRNA
27. Neuronal isoform of nitric oxide synthase is expressed at low levels in human retina
28. Expression of preproenkephalin in human articular chondrocytes is linked to cell proliferation
29. Characterization of the promoter of human prostaglandin H synthase-1 gene
30. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and ≃1-syntrophin mediated by PDZ domains
31. Subcellular localization and characterization of neuronal nitric oxide synthase
32. The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein
33. Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy
34. Regional distribution and characterization of nitric oxide synthase activity in the brain of the common marmoset
35. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase
36. Nitric oxide synthase protein and mRNA are discretely localised in neuronal populations of the mammalian CNS together with NADPH diaphorase
37. Nitric oxide as a neuronal messenger
38. Involvement of endogenous nitric oxide in the regulation of rat intestinal motility in vivo
39. Insulin secretion from pancreatic β cells caused by L-arginine-derived nitrogen oxides
40. NO at work
41. 2+-independent nitric oxide synthase
42. In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases
43. Inducible nitric oxide synthase in the central nervous system
44. Spontaneous expression of inducible nitric oxide synthase and its possible role in normal human jejunum
45. Constitutive endothelial nitric oxide synthase gene expression is regulated during lung development