Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening

Malaria Journal

Volumn 10, Issue , 2011, Pages

  Somsak, Voravuth ^a,b   Uthaipibull, Chairat ^a   Prommana, Parichat ^a   Srichairatanakool, Somdet ^b   Yuthavong, Yongyuth ^a   Kamchonwongpaisan, Sumalee ^a  

^a NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

^b Faculty of Medicine Chiang Mai University   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

ARTESUNATE; CHLOROQUINE; DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; PYRIMETHAMINE; THYMIDYLATE SYNTHASE; ANTIMALARIAL AGENT; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL DRUG RESISTANCE; ANTIMALARIAL DRUG SUSCEPTIBILITY; ARTICLE; CONTROLLED STUDY; DNA TRANSFECTION; DRUG METABOLISM; DRUG SCREENING; FEMALE; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PROTEIN EXPRESSION; PROTEIN TARGETING; TRANSGENICS; BIOSYNTHESIS; DRUG EFFECT; ENZYMOLOGY; GENETIC RECOMBINATION; GENETICS; GENOMIC INSTABILITY; HUMAN; ISOLATION AND PURIFICATION; METHODOLOGY; TRANSGENIC ORGANISM;

ANTIMALARIALS; DRUG EVALUATION, PRECLINICAL; FOLIC ACID ANTAGONISTS; GENOMIC INSTABILITY; HUMANS; ORGANISMS, GENETICALLY MODIFIED; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; RECOMBINANT PROTEINS; RECOMBINATION, GENETIC; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE;

EID: 80053530568     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-10-291     Document Type: Article

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