COX2 activity promotes organic osmolyte accumulation and adaptation of renal medullary interstitial cells to hypertonic stress

Journal of Biological Chemistry

Volumn 278, Issue 21, 2003, Pages 19352-19357

  Moeckel, Gilbert W ^a,b   Zhang, Li ^a   Fogo, Agnes B ^a   Hao, Chuan Ming ^a   Pozzi, Ambra ^a   Breyer, Matthew D ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; CELL CULTURE; DEHYDRATION; RNA;

ORGANIC OSMOLYTES;

CELLS;

4 [5 (4 CHLOROPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; ALDEHYDE REDUCTASE; BETAINE; CARRIER PROTEIN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; HYPERTONIC SOLUTION; INOSITOL; MATRIX METALLOPROTEINASE INHIBITOR; MESSENGER RNA; OSMOTIC AGENT; SODIUM MYOINOSITOL TRANSPORTER; SORBITOL; UNCLASSIFIED DRUG; CASP3 PROTEIN, HUMAN; CASP3 PROTEIN, MOUSE; CASPASE; CASPASE 3; COTRANSPORTER; DNA FRAGMENT; HEAT SHOCK PROTEIN; ISOENZYME; MEMBRANE PROTEIN; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; SLC5A3 PROTEIN, HUMAN; TRITIUM;

ANALGESIC NEPHROPATHY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEHYDRATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; INCUBATION TIME; INHIBITION KINETICS; KIDNEY INTERSTITIUM; KIDNEY MEDULLA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRESS; TISSUE DISTRIBUTION; WILD TYPE; ADAPTATION; ANIMAL; APOPTOSIS; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION; GENETICS; METABOLISM; MOUSE MUTANT; NICK END LABELING;

ANIMALIA;

ADAPTATION, PHYSIOLOGICAL; ALDEHYDE REDUCTASE; ANIMALS; APOPTOSIS; BETAINE; CASPASE 3; CASPASES; CELL SURVIVAL; CELLS, CULTURED; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DEHYDRATION; DNA FRAGMENTATION; GENE EXPRESSION; HEAT-SHOCK PROTEINS; HYPERTONIC SOLUTIONS; IN SITU NICK-END LABELING; INOSITOL; ISOENZYMES; KIDNEY MEDULLA; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RNA, MESSENGER; SORBITOL; SYMPORTERS; TRITIUM;

EID: 0037805638     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302209200     Document Type: Article

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