Radiosynthesis and in vivo evaluation of [11C]MC80 for P-glycoprotein imaging

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 17, 2010, Pages 6489-6495

  Bruyne, Sylvie De ^a   Wyffels, Leonie ^a   Moerman, Lieselotte ^a   Sambre, Johan ^b   Colabufo, Nicola A ^c   Berardi, Francesco ^c   Perrone, Roberto ^c   Vos, Filip De ^a  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c UNIVERSITY OF BARI   (Italy)

Author keywords

Blood brain barrier; Drug resistance; P glycoprotein; PET

Indexed keywords

6,7 DIMETHOXY 2 (6 METHOXY NAPHTHALEN 2 YLMETHYL) 1,2,3,4 TETRAHYDROISOQUINOLINE C 11; CYCLOSPORIN A; GLYCOPROTEIN P; METHYL IODIDE; MULTIDRUG RESISTANCE PROTEIN 1; N DESMETHYL LOPERAMIDE C 11; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; VERAPAMIL C 11;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; INTESTINE; KINETICS; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PANCREAS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; WILD TYPE;

ANIMALS; BRAIN; CARBON RADIOISOTOPES; ISOTOPE LABELING; MICE; MICE, KNOCKOUT; P-GLYCOPROTEIN; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; TETRAHYDROISOQUINOLINES; TISSUE DISTRIBUTION;

MUS;

EID: 77955981707     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.097     Document Type: Article

References (27)

1. F. Thiebaut, T. Tsuruo, H. Hamada, M.M. Gottesman, I. Pastan, and M.C. Willingham Proc. Natl. Acad. Sci. 84 1987 7735
2. A.H. Schinkel, and J.W. Jonker Adv. Drug Delivery Rev. 55 2003 3
3. A.H. Schinkel, E. Wagenaar, C.A.A.M. Mol, and L. van Deemter J. Clin. Invest. 97 1996 2517
4. K. Linnet, and T.B. Ejsing Eur. Neuropsychopharmacol. 18 2008 157
5. C. Luna-Tortós, M. Fedrowitz, and W. Löscher Neuropharmacology 55 2008 1364
6. R.B. Kim, M.F. Fromm, C. Wandel, B. Leake, and A.J.J. Wood J. Clin. Invest. 101 1998 289
7. D. Szabo, G. Szabo, I. Ocsovszki, A. Aszalos, and J. Molnar Cancer Lett. 139 1999 115
8. M.M. Gottesman, and I. Pastan Annu. Rev. Biochem. 62 1993 385
9. M.M. Gottesmann, T. Fojo, and S.E. Bates Nat. Rev. Cancer 2 2002 48
10. P. Kwan, and M.J. Brodie Epilepsia 46 2005 224
11. G. Turgut, M. Bastemir, S. Turgut, F. Akin, R. Kursunluoglu, and B. Kaptanoglu Mol. Biol. Rep. 35 2008 693
12. R. Kortekaas, K.L. Leenders, J.C.H. van Oostrom, W. Vaalburg, J. Bart, and A.T.M. Willemsen Ann. Neurol. 57 2005 176
13. D. Langford, A. Grigorian, R. Hurford, A. Adame, R.J. Ellis, and L. Hansen J. Neuropath. Exp. Neurol. 63 2004 1038
14. F.C. Lam, R. Liu, P. Lu, A.B. Shapiro, J-M. Renoir, and F.J. Sharom J. Neurochem. 76 2001 1121
15. S. Vogelgesang, I. Cascorbi, E. Schroeder, J. Pahnke, H.K. Kroemer, and W. Siegmund Pharmacogenetics 12 2002 535
16. N.H. Hendrikse, A.H. Schinkel, E.G.E. de Vries, E. Fluks, W.T.A. van der Graaf, and A.T.M. Willemsen Br. J. Pharmacol. 124 1998 1413
17. Y.-J. Lee, J. Maeda, H. Kusuhara, T. Okauchi, M. Inaji, and Y. Nagai J. Pharmacol. Exp. Ther. 316 2006 647
18. N. Lazarova, S.S. Zoghbi, J. Hong, N. Seneca, E. Tuan, and R.L. Gladding J. Med. Chem. 51 2008 6034
19. S.S. Zoghbi, J.-S.L. Liow, F. Yasuno, J. Hong, E. Tuan, and N. Lazarova J. Nucl. Med. 49 2008 649
20. N. Seneca, S.S. Zoghbi, JS. Liow, W. Kreisl, P. Herscovitsh, and K. Jenko J. Nucl. Med. 50 2009 807
21. J.R. Ballinger, H.A. Hua, B.W. Berry, P. Firby, and I. Boxen Nucl. Med. Commun. 16 1995 253
22. L. Kostakoglu, N. Elahi, P. Kïratlï, S. Ruacan, I. Sayek, and E. Baltalï J. Nucl. Med. 38 1997 1003
23. N.A. Colabufo, F. Berardi, M. Cantore, M.G. Perrone, M. Contino, and C. Inglese Bioorg. Med. Chem. 16 2008 3732
24. R.N. Waterhouse Mol. Imaging Biol. 5 2003 376
25. A.A. Wilson, A. Garcia, J.N. DaSilva, and S. Houle Appl. Radiat. Isot. 54 2001 203
26. A.H. Schinkel Adv. Drug Delivery Rev. 36 1999 179
27. J.M. Croop, M. Raymond, D. Haber, A. Devault, R.J. Arceci, P. Gros, and D.E. Housman Mol. Cell Biol. 9 1989 1346