Disulfide bond formation and its impact on the biological activity and stability of recombinant therapeutic proteins produced by Escherichia coli expression system

Biotechnology Advances

Volumn 29, Issue 6, 2011, Pages 923-929

  Zhang, Lin ^a   Chou, C Perry ^a   Moo Young, Murray ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Biological activity; Disulfide bond formation scrambling; Recombinant therapeutic protein; Stability

Indexed keywords

DISULFIDE BOND FORMATION; DISULFIDE BONDS; ESCHERICHIA COLI EXPRESSION SYSTEMS; RECOMBINANT PROTEIN; RESEARCH PROGRESS; STORAGE STABILITY; STRUCTURAL CHANGE; THERAPEUTIC PROTEIN;

BIOACTIVITY; CONVERGENCE OF NUMERICAL METHODS; COVALENT BONDS; ESCHERICHIA COLI; STABILITY;

PROTEINS;

DISULFIDE; RECOMBINANT PROTEIN;

BIOACTIVITY; BIOTECHNOLOGY; CHEMICAL BONDING; DISEASE TREATMENT; DRUG; FECAL COLIFORM; GENE EXPRESSION; PROTEIN; RECOMBINATION; RESEARCH WORK; SULFIDE;

BIOSYNTHESIS; BIOTECHNOLOGY; ESCHERICHIA COLI; GENETICS; METABOLISM; METHODOLOGY; PROTEIN STABILITY; REVIEW;

BIOTECHNOLOGY; DISULFIDES; ESCHERICHIA COLI; PROTEIN STABILITY; RECOMBINANT PROTEINS;

ESCHERICHIA COLI;

EID: 80053442444     PISSN: 07349750     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biotechadv.2011.07.013     Document Type: Review

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