Replacement of the interchain disulfide bridge-forming amino acids A7 and B7 by glutamate impairs the structure and activity of insulin

Biological Chemistry

Volumn 385, Issue 12, 2004, Pages 1171-1175

  Guo, Zhan Yun ^a   Jia, Xiao Yuan ^a   Feng, You Min ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

Activity; Disulfide bond; Folding; Insulin; Structure

Indexed keywords

GLUTAMIC ACID; INSULIN; INSULIN RECEPTOR;

AMINO ACID SUBSTITUTION; ARTICLE; CHEMICAL MODIFICATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISULFIDE BOND; EXPRESSION VECTOR; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS;

AMINO ACIDS; CIRCULAR DICHROISM; DISULFIDES; ESCHERICHIA COLI; GLUTAMIC ACID; INSULIN; PROTEIN ENGINEERING; RECEPTOR, INSULIN; SACCHAROMYCES CEREVISIAE; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 12144250303     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2004.151     Document Type: Article

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