Molecular manipulation associated with disulfide bond formation to enhance the stability of recombinant therapeutic protein

Protein Expression and Purification

Volumn 75, Issue 1, 2011, Pages 28-39

  Zhang, Lin ^a   Moo Young, Murray ^a   Chou, C Perry ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Disulfide bond; Escherichia coli; Human CD83; Protein stability; Therapeutic protein

Indexed keywords

CD83 ANTIGEN; CYSTEINE; DISULFIDE; IMMUNOGLOBULIN; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; MUTANT PROTEIN; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; ESCHERICHIA COLI; GENE EXPRESSION; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; ANTIGENS, CD; CYSTEINE; DISULFIDES; ESCHERICHIA COLI; GENE EXPRESSION; HUMANS; IMMUNOGLOBULINS; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS;

ESCHERICHIA COLI;

EID: 78049269377     PISSN: 10465928     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pep.2010.08.006     Document Type: Article

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