A novel structural mechanism for redox regulation of uridine phosphorylase 2 activity

Journal of Structural Biology

Volumn 176, Issue 2, 2011, Pages 229-237

  Roosild, Tarmo P ^a   Castronovo, Samantha ^a   Villoso, Adelbert ^a   Ziemba, Amy ^a   Pizzorno, Giuseppe ^a  

^a NEVADA CANCER INSTITUTE   (United States)

Author keywords

5 Benzylacyclouridine; Conformational change; Protein structure; Redox regulation; Uridine phosphorylase; X ray crystallography

Indexed keywords

ARGININE; UNCLASSIFIED DRUG; URIDINE PHOSPHORYLASE; URIDINE PHOSPHORYLASE 2;

ARTICLE; DISULFIDE BOND; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME REGULATION; ENZYME STRUCTURE; MOLECULAR INTERACTION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYSTINE; ENZYME ASSAYS; HUMANS; HYDROGEN BONDING; MICE; MODELS, MOLECULAR; OXIDATION-REDUCTION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; URACIL; URIDINE PHOSPHORYLASE;

ANIMALIA; VERTEBRATA;

EID: 80053385096     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2011.08.002     Document Type: Article

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