JNK1, but not JNK2, is required in two mechanistically distinct models of inflammatory arthritis

American Journal of Pathology

Volumn 179, Issue 4, 2011, Pages 1884-1893

  Denninger, Katja ^a   Rasmussen, Susanne ^a   Larsen, Jeppe Madura ^a   Ørskov, Catrine ^a   Seier Poulsen, Steen ^a   Sørensen, Poul ^a   Christensen, Jan Pravsgaard ^a   Illges, Harald ^b   Ødum, Niels ^a,c   Labuda, Tord ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b LEO PHARMA A S   (Denmark)

^c BONN RHEIN SIEG UNIVERSITY OF APPLIED SCIENCES   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD86 ANTIGEN; COLLAGEN; ISOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE 1;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C57BL 6 MOUSE; MACROPHAGE; MALE; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS;

ANIMALS; ANTIGENS, CD86; ARTHRITIS, EXPERIMENTAL; COLLAGEN TYPE II; DISEASE MODELS, ANIMAL; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; INFLAMMATION; JOINTS; MACROPHAGES; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; SERUM; UP-REGULATION;

EID: 80053251651     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.06.019     Document Type: Article

References (49)

1. W.B. van den Berg Anti-cytokine therapy in chronic destructive arthritis Arthritis Res 3 2001 18 26
2. G. Schett, M. Tohidast-Akrad, J.S. Smolen, B.J. Schmid, C.W. Steiner, P. Bitzan, P. Zenz, K. Redlich, Q. Xu, and G. Steiner Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis Arthritis Rheum 43 2000 2501 2512
3. Z. Han, D.L. Boyle, L. Chang, B. Bennett, M. Karin, L. Yang, A.M. Manning, and G.S. Firestein c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis J Clin Invest 108 2001 73 81 (Pubitemid 32634924)
4. Z. Han, L. Chang, Y. Yamanishi, M. Karin, and G.S. Firestein Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis Arthritis Rheum 46 2002 818 823 (Pubitemid 34214265)
5. M. Koller, S. Hayer, K. Redlich, R. Ricci, J.P. David, G. Steiner, J.S. Smolen, E.F. Wagner, and G. Schett JNK1 is not essential for TNF-mediated joint disease Arthritis Res Ther 7 2005 R166 R173
6. M. Guma, J. Kashiwakura, B. Crain, Y. Kawakami, B. Beutler, G.S. Firestein, T. Kawakami, M. Karin, and M. Corr JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis Proc Natl Acad Sci U S A 107 2010 22122 22127
7. M. Guma, L.M. Ronacher, G.S. Firestein, M. Karin, and M. Corr JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis Arthritis Rheum 63 2011 1603 1612
8. R.O. Williams Collagen-induced arthritis in mice Methods Mol Med 136 2007 191 199
9. B. Joe, M.M. Griffiths, E.F. Remmers, and R.L. Wilder Animal models of rheumatoid arthritis and related inflammation Curr Rheumatol Rep 1 1999 139 148
10. I.K. Campbell, J.A. Hamilton, and I.P. Wicks Collagen-induced arthritis in C57BL/6 (H-2b) mice: new insights into an important disease model of rheumatoid arthritis Eur J Immunol 30 2000 1568 1575 (Pubitemid 30342798)
11. J.J. Inglis, G. Criado, M. Medghalchi, M. Andrews, A. Sandison, M. Feldmann, and R.O. Williams Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen Arthritis Res Ther 9 2007 R113
12. P.A. Monach, C. Benoist, and D. Mathis The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease Adv Immunol 82 2004 217 248 (Pubitemid 38209512)
13. C. Dong, D.D. Yang, M. Wysk, A.J. Whitmarsh, R.J. Davis, and R.A. Flavell Defective T cell differentiation in the absence of Jnk1 Science 282 1998 2092 2095 (Pubitemid 29001267)
14. D.D. Yang, D. Conze, A.J. Whitmarsh, T. Barrett, R.J. Davis, M. Rincon, and R.A. Flavell Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2 Immunity 9 1998 575 585 (Pubitemid 28499208)
15. V. Kouskoff, A.S. Korganow, V. Duchatelle, C. Degott, C. Benoist, and D. Mathis Organ-specific disease provoked by systemic autoimmunity Cell 87 1996 811 822 (Pubitemid 26404281)
16. G. Schett, and B. Tuerk Bone histomorphometry in arthritis models 1 Methods Mol Med 135 2007 269 283
17. P.A. Monach, D. Mathis, and C. Benoist The K/BxN arthritis model Curr Protoc Immunol 2008 Chapter 15:Unit 15.22
18. B. Bonnesen, C. Orskov, S. Rasmussen, P.J. Holst, J.P. Christensen, K.W. Eriksen, K. Qvortrup, N. Odum, and T. Labuda MEK kinase 1 activity is required for definitive erythropoiesis in the mouse fetal liver Blood 106 2005 3396 3404 (Pubitemid 41609173)
19. N. Seki, Y. Sudo, T. Yoshioka, S. Sugihara, T. Fujitsu, S. Sakuma, T. Ogawa, T. Hamaoka, H. Senoh, and H. Fujiwara Type II collagen-induced murine arthritis, I: induction and perpetuation of arthritis require synergy between humoral and cell-mediated immunity J Immunol 140 1988 1477 1484
20. B. Wang, C. Feliciani, I. Freed, Q. Cai, and D.N. Sauder Insights into molecular mechanisms of contact hypersensitivity gained from gene knockout studies J Leukoc Biol 70 2001 185 191 (Pubitemid 32751508)
21. S. Nakae, A. Nambu, K. Sudo, and Y. Iwakura Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice J Immunol 171 2003 6173 6177 (Pubitemid 37467240)
22. D.E. Zhang, C.J. Hetherington, H.M. Chen, and D.G. Tenen The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor Mol Cell Biol 14 1994 373 381
23. K. Schroder, M. Lichtinger, K.M. Irvine, K. Brion, A. Trieu, I.L. Ross, T. Ravasi, K.J. Stacey, M. Rehli, D.A. Hume, and M.J. Sweet PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages J Leukoc Biol 81 2007 1577 1590 (Pubitemid 46827980)
24. T.J. Lang, P. Nguyen, R. Peach, W.C. Gause, and C.S. Via In vivo CD86 blockade inhibits CD4+ T cell activation, whereas CD80 blockade potentiates CD8+ T cell activation and CTL effector function J Immunol 168 2002 3786 3792 (Pubitemid 34298378)
25. A. Jaeschke, M. Karasarides, J.J. Ventura, A. Ehrhardt, C. Zhang, R.A. Flavell, K.M. Shokat, and R.J. Davis JNK2 is a positive regulator of the cJun transcription factor Mol Cell 23 2006 899 911 (Pubitemid 44344520)
26. K. Sabapathy, Y. Hu, T. Kallunki, M. Schreiber, J.P. David, W. Jochum, E.F. Wagner, and M. Karin JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development Curr Biol 9 1999 116 125 (Pubitemid 29087541)
27. S.L. Constant, C. Dong, D.D. Yang, M. Wysk, R.J. Davis, and R.A. Flavell JNK1 is required for T cell-mediated immunity against Leishmania major infection J Immunol 165 2000 2671 2676 (Pubitemid 30660716)
28. L.M. Stasiuk, O. Abehsira-Amar, and C. Fournier Collagen-induced arthritis in DBA/1 mice: cytokine gene activation following immunization with type II collagen Cell Immunol 173 1996 269 275 (Pubitemid 26381406)
29. P.J. Williams, R.H. Jones, and T.W. Rademacher Correlation between IgG anti-type II collagen levels and arthritic severity in murine arthritis Autoimmunity 27 1998 201 207 (Pubitemid 28242886)
30. W.C. Watson, and A.S. Townes Genetic susceptibility to murine collagen II autoimmune arthritis: proposed relationship to the IgG2 autoantibody subclass response, complement C5, major histocompatibility complex (MHC) and non-MHC loci J Exp Med 162 1985 1878 1891 (Pubitemid 16149683)
31. E.H. Tran, Y.T. Azuma, M. Chen, C. Weston, R.J. Davis, and R.A. Flavell Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain Proc Natl Acad Sci U S A 103 2006 13451 13456 (Pubitemid 44380128)
32. I.K. Campbell, M.J. Rich, R.J. Bischof, and J.A. Hamilton The colony-stimulating factors and collagen-induced arthritis: exacerbation of disease by M-CSF and G-CSF and requirement for endogenous M-CSF J Leukoc Biol 68 2000 144 150
33. L. Guery, G. Chiocchia, F. Batteux, M.C. Boissier, and C. Fournier Collagen II-pulsed antigen-presenting cells genetically modified to secrete IL-4 down-regulate collagen-induced arthritis Gene Ther 8 2001 1855 1862 (Pubitemid 34141492)
34. E. Michaelsson, M. Holmdahl, A. Engstrom, H. Burkhardt, A. Scheynius, and R. Holmdahl Macrophages, but not dendritic cells, present collagen to T cells Eur J Immunol 25 1995 2234 2241
35. S.R. Himes, D.P. Sester, T. Ravasi, S.L. Cronau, T. Sasmono, and D.A. Hume The JNK are important for development and survival of macrophages J Immunol 176 2006 2219 2228 (Pubitemid 43201669)
36. C. Mao, D. Ray-Gallet, A. Tavitian, and F. Moreau-Gachelin Differential phosphorylations of Spi-B and Spi-1 transcription factors Oncogene 12 1996 863 873 (Pubitemid 26072272)
37. A.F. Valledor, F.E. Borras, M. Cullell-Young, and A. Celada Transcription factors that regulate monocyte/macrophage differentiation J Leukoc Biol 63 1998 405 417 (Pubitemid 28163180)
38. W. Lim, K. Gee, S. Mishra, and A. Kumar Regulation of B7.1 costimulatory molecule is mediated by the IFN regulatory factor-7 through the activation of JNK in lipopolysaccharide-stimulated human monocytic cells J Immunol 175 2005 5690 5700 (Pubitemid 41508051)
39. A. Poltorak, X. He, I. Smirnova, M.Y. Liu, H.C. Van, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, M. Freudenberg, P. Ricciardi-Castagnoli, B. Layton, and B. Beutler Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene Science 282 1998 2085 2088 (Pubitemid 29001265)
40. M. Muzio, G. Natoli, S. Saccani, M. Levrero, and A. Mantovani The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6) J Exp Med 187 1998 2097 2101 (Pubitemid 28285580)
41. S.T. Qureshi, L. Lariviere, G. Leveque, S. Clermont, K.J. Moore, P. Gros, and D. Malo Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) J Exp Med 189 1999 615 625 (Pubitemid 29193362)
42. B. Beutler, and A. Cerami Tumor necrosis, cachexia, shock, and inflammation: a common mediator Annu Rev Biochem 57 1988 505 518
43. C.A. Dinarello Interleukin-1 and interleukin-1 antagonism Blood 77 1991 1627 1652
44. H. Ji, K. Ohmura, U. Mahmood, D.M. Lee, F.M. Hofhuis, S.A. Boackle, K. Takahashi, V.M. Holers, M. Walport, C. Gerard, A. Ezekowitz, M.C. Carroll, M. Brenner, R. Weissleder, J.S. Verbeek, V. Duchatelle, C. Degott, C. Benoist, and D. Mathis Arthritis critically dependent on innate immune system players Immunity 16 2002 157 168 (Pubitemid 34211957)
45. J.Y. Choe, B. Crain, S.R. Wu, and M. Corr Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by toll-like receptor 4 signaling J Exp Med 197 2003 537 542 (Pubitemid 36278608)
46. D.M. Lee, D.S. Friend, M.F. Gurish, C. Benoist, D. Mathis, and M.B. Brenner Mast cells: a cellular link between autoantibodies and inflammatory arthritis Science 297 2002 1689 1692 (Pubitemid 35000781)
47. B.T. Wipke, and P.M. Allen Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis J Immunol 167 2001 1601 1608 (Pubitemid 32703161)
48. S. Solomon, N. Rajasekaran, E. Jeisy-Walder, S.B. Snapper, and H. Illges A crucial role for macrophages in the pathology of K/B x N serum-induced arthritis Eur J Immunol 35 2005 3064 3073 (Pubitemid 41555102)
49. H.J. Ditzel The K/BxN mouse: a model of human inflammatory arthritis Trends Mol Med 10 2004 40 45 (Pubitemid 38156198)