-
1
-
-
0037161024
-
Chemotherapy in adult high-grade glioma: A systematic review and meta-analysis of individual patient data from 12 randomised trials
-
Stewart LA. Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials. Lancet 359(9311), 1011-1018 (2002).
-
(2002)
Lancet
, vol.359
, Issue.9311
, pp. 1011-1018
-
-
Stewart, L.A.1
-
2
-
-
35449003659
-
Racial/ethnic differences in survival among elderly patients with a primary glioblastoma
-
Barnholtz-Sloan JS, Maldonado JL, Williams VL et al. Racial/ethnic differences in survival among elderly patients with a primary glioblastoma. J. Neurooncol. 85(2), 171-180 (2007).
-
(2007)
J. Neurooncol.
, vol.85
, Issue.2
, pp. 171-180
-
-
Barnholtz-Sloan, J.S.1
Maldonado, J.L.2
Williams, V.L.3
-
3
-
-
45949107833
-
Glioblastoma in adults
-
Brandes AA, Tosoni A, Franceschi E, Reni M, Gatta G, Vecht C. Glioblastoma in adults. Crit. Rev. Oncol. Hematol. 67(2), 139-152 (2008).
-
(2008)
Crit. Rev. Oncol. Hematol
, vol.67
, Issue.2
, pp. 139-152
-
-
Brandes, A.A.1
Tosoni, A.2
Franceschi, E.3
Reni, M.4
Gatta, G.5
Vecht, C.6
-
4
-
-
48249125791
-
Malignant gliomas in adults
-
Excellent, comprehensive review of malignant glioma
-
Wen PY, Kesari S. Malignant gliomas in adults. N. Engl. J. Med. 359(5), 492-507 (2008). Excellent, comprehensive review of malignant glioma.
-
(2008)
N. Engl. J. Med.
, vol.359
, Issue.5
, pp. 492-507
-
-
Wen, P.Y.1
Kesari, S.2
-
5
-
-
0036192918
-
The WHO classification of tumors of the nervous system
-
discussion 226-219
-
Kleihues P, Louis DN, Scheithauer BW et al. The WHO classification of tumors of the nervous system. J. Neuropathol. Exp. Neurol. 61(3), 215-225; discussion 226-219 (2002).
-
(2002)
J. Neuropathol. Exp. Neurol.
, vol.61
, Issue.3
, pp. 215-225
-
-
Kleihues, P.1
Louis, D.N.2
Scheithauer, B.W.3
-
6
-
-
33646847941
-
The central nervous system
-
Kumar V, Abbas AK, Fausto N Eds. Elsevier Saunders, PA, USA
-
Frosch MP, Anthony DC, De Girolami U. The Central Nervous System. In: Robbins and Cotran Pathologic Basis of Disease. Kumar V, Abbas AK, Fausto N (Eds). Elsevier Saunders, PA, USA 1347-1419 (2005).
-
(2005)
Robbins and Cotran Pathologic Basis of Disease
, pp. 1347-1419
-
-
Frosch, M.P.1
Anthony, D.C.2
De Girolami, U.3
-
8
-
-
4944255253
-
Genetic pathways to glioblastoma: A population-based study
-
Ohgaki H, Dessen P, Jourde B et al. Genetic pathways to glioblastoma: a population-based study. Cancer Res. 64(19), 6892-6899 (2004).
-
(2004)
Cancer Res.
, vol.64
, Issue.19
, pp. 6892-6899
-
-
Ohgaki, H.1
Dessen, P.2
Jourde, B.3
-
9
-
-
65649121938
-
Glioblastoma multiforme oncogenomics and signaling pathways
-
Kanu OO, Hughes B, Di C et al. Glioblastoma multiforme oncogenomics and signaling pathways. Clin. Med. Oncol. 3, 39-52 (2009).
-
(2009)
Clin. Med. Oncol.
, vol.3
, pp. 39-52
-
-
Kanu, O.O.1
Hughes, B.2
Di, C.3
-
10
-
-
37048999570
-
Adjuvant chemotherapy for adults with malignant glioma: A systematic review
-
Perry J, Laperriere N, Zuraw L, Chambers A, Spithoff K, Cairncross JG. Adjuvant chemotherapy for adults with malignant glioma: a systematic review. Can. J. Neurol. Sci. 34(4), 402-410 (2007).
-
(2007)
Can. J. Neurol. Sci.
, vol.34
, Issue.4
, pp. 402-410
-
-
Perry, J.1
Laperriere, N.2
Zuraw, L.3
Chambers, A.4
Spithoff, K.5
Cairncross, J.G.6
-
11
-
-
20044366163
-
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
-
Breakthrough study describing the benefits of temozolomide in glioma treatment
-
Stupp R, Mason WP, van den Bent MJ et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. 352(10), 987-996 (2005). Breakthrough study describing the benefits of temozolomide in glioma treatment.
-
(2005)
N. Engl. J. Med.
, vol.352
, Issue.10
, pp. 987-996
-
-
Stupp, R.1
Mason, W.P.2
Van Den Bent, M.J.3
-
12
-
-
0031818983
-
Long-term glioblastoma multiforme survivors: A population-based study
-
Scott JN, Rewcastle NB, Brasher PM et al. Long-term glioblastoma multiforme survivors: a population-based study. Can. J. Neurol. Sci. 25(3), 197-201 (1998).
-
(1998)
Can. J. Neurol. Sci.
, vol.25
, Issue.3
, pp. 197-201
-
-
Scott, J.N.1
Rewcastle, N.B.2
Brasher, P.M.3
-
13
-
-
62549136102
-
Boron neutron capture therapy for newly diagnosed glioblastoma
-
Yamamoto T, Nakai K, Kageji T et al. Boron neutron capture therapy for newly diagnosed glioblastoma. Radiother. Oncol. 91(1), 80-84 (2009).
-
(2009)
Radiother. Oncol.
, vol.91
, Issue.1
, pp. 80-84
-
-
Yamamoto, T.1
Nakai, K.2
Kageji, T.3
-
14
-
-
66249120034
-
Design and application of oncolytic HSV vectors for glioblastoma therapy
-
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC. Design and application of oncolytic HSV vectors for glioblastoma therapy. Expert Rev. Neurother. 9(4), 505-517 (2009).
-
(2009)
Expert Rev. Neurother.
, vol.9
, Issue.4
, pp. 505-517
-
-
Grandi, P.1
Peruzzi, P.2
Reinhart, B.3
Cohen, J.B.4
Chiocca, E.A.5
Glorioso, J.C.6
-
15
-
-
47549101044
-
Molecular predictors in glioblastoma: Toward personalized therapy
-
Colman H, Aldape K. Molecular predictors in glioblastoma: toward personalized therapy. Arch. Neurol. 65(7), 877-883 (2008).
-
(2008)
Arch. Neurol.
, vol.65
, Issue.7
, pp. 877-883
-
-
Colman, H.1
Aldape, K.2
-
16
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
Network TTR. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455(7216), 1061-1068 (2008).
-
(2008)
Nature
, vol.455
, Issue.7216
, pp. 1061-1068
-
-
Network, T.T.R.1
-
17
-
-
70350449411
-
Advances in the genetics of glioblastoma: Are we reaching critical mass?
-
Purow B, Schiff D. Advances in the genetics of glioblastoma: are we reaching critical mass? Nat. Rev. Neurol. 5(8), 419-426 (2009).
-
(2009)
Nat. Rev. Neurol.
, vol.5
, Issue.8
, pp. 419-426
-
-
Purow, B.1
Schiff, D.2
-
18
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
Parsons DW, Jones S, Zhang X et al. An integrated genomic analysis of human glioblastoma multiforme. Science 321(5897), 1807-1812 (2008).
-
(2008)
Science
, vol.321
, Issue.5897
, pp. 1807-1812
-
-
Parsons, D.W.1
Jones, S.2
Zhang, X.3
-
19
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan H, Parsons DW, Jin G et al. IDH1 and IDH2 mutations in gliomas. N. Engl. J. Med. 360(8), 765-773 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, Issue.8
, pp. 765-773
-
-
Yan, H.1
Parsons, D.W.2
Jin, G.3
-
20
-
-
35949002429
-
Malignant astrocytic glioma: Genetics, biology, and paths to treatment
-
Furnari FB, Fenton T, Bachoo RM et al. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev. 21(21), 2683-2710 (2007).
-
(2007)
Genes Dev.
, vol.21
, Issue.21
, pp. 2683-2710
-
-
Furnari, F.B.1
Fenton, T.2
Bachoo, R.M.3
-
21
-
-
33644877965
-
Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells
-
Rao RD, Mladek AC, Lamont JD et al. Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells. Neoplasia 7(10), 921-929 (2005).
-
(2005)
Neoplasia
, vol.7
, Issue.10
, pp. 921-929
-
-
Rao, R.D.1
Mladek, A.C.2
Lamont, J.D.3
-
22
-
-
0030724320
-
PTEN/MMAC1 mutations and EGFR amplification in glioblastomas
-
Liu W, James CD, Frederick L, Alderete BE, Jenkins RB. PTEN/MMAC1 mutations and EGFR amplification in glioblastomas. Cancer Res. 57(23), 5254-5257 (1997).
-
(1997)
Cancer Res.
, vol.57
, Issue.23
, pp. 5254-5257
-
-
Liu, W.1
James, C.D.2
Frederick, L.3
Alderete, B.E.4
Jenkins, R.B.5
-
23
-
-
70449517400
-
Antiangiogenic therapies for high-grade glioma
-
Norden AD, Drappatz J, Wen PY. Antiangiogenic therapies for high-grade glioma. Nat. Rev. Neurol. 5(11), 610-620 (2009).
-
(2009)
Nat. Rev. Neurol.
, vol.5
, Issue.11
, pp. 610-620
-
-
Norden, A.D.1
Drappatz, J.2
Wen, P.Y.3
-
24
-
-
77649237309
-
NF-κB and cancer: How intimate is this relationship
-
Prasad S, Ravindran J, Aggarwal BB. NF-κB and cancer: how intimate is this relationship. Mol. Cell. Biochem. 1336 (1-2), 25-37 (2010).
-
(2010)
Mol. Cell. Biochem.
, vol.1336
, Issue.1-2
, pp. 25-37
-
-
Prasad, S.1
Ravindran, J.2
Aggarwal, B.B.3
-
25
-
-
69149098253
-
Signal transducer and activator of transcription-3, inflammation, and cancer: How intimate is the relationship?
-
Aggarwal BB, Kunnumakkara AB, Harikumar KB et al. Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship? Ann. NY Acad. Sci. 1171, 59-76 (2009).
-
(2009)
Ann. NY Acad. Sci.
, vol.1171
, pp. 59-76
-
-
Aggarwal, B.B.1
Kunnumakkara, A.B.2
Harikumar, K.B.3
-
26
-
-
16644367311
-
IkBaM suppresses angiogenesis and tumorigenesis promoted by a constitutively active mutant EGFR in human glioma cells
-
Wu JL, Abe T, Inoue R, Fujiki M, Kobayashi H. IkBaM suppresses angiogenesis and tumorigenesis promoted by a constitutively active mutant EGFR in human glioma cells. Neurol. Res. 26(7), 785-791 (2004).
-
(2004)
Neurol. Res.
, vol.26
, Issue.7
, pp. 785-791
-
-
Wu, J.L.1
Abe, T.2
Inoue, R.3
Fujiki, M.4
Kobayashi, H.5
-
27
-
-
17844396959
-
Interleukin-6 induces transcriptional activation of vascular endothelial growth factor (VEGF) in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1
-
Loeffler S, Fayard B, Weis J, Weissenberger J. Interleukin-6 induces transcriptional activation of vascular endothelial growth factor (VEGF) in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1. Int. J. Cancer 115(2), 202-213 (2005).
-
(2005)
Int. J. Cancer
, vol.115
, Issue.2
, pp. 202-213
-
-
Loeffler, S.1
Fayard, B.2
Weis, J.3
Weissenberger, J.4
-
29
-
-
33750466230
-
Introduction to NF-κB: Players, pathways, perspectives
-
Gilmore TD. Introduction to NF-κB: players, pathways, perspectives. Oncogene 25(51), 6680-6684 (2006).
-
(2006)
Oncogene
, vol.25
, Issue.51
, pp. 6680-6684
-
-
Gilmore, T.D.1
-
30
-
-
33750448661
-
Transcriptional regulation via the NF-κB signaling module
-
Hoffmann A, Natoli G, Ghosh G. Transcriptional regulation via the NF-κB signaling module. Oncogene 25(51), 6706-6716 (2006).
-
(2006)
Oncogene
, vol.25
, Issue.51
, pp. 6706-6716
-
-
Hoffmann, A.1
Natoli, G.2
Ghosh, G.3
-
31
-
-
0033596121
-
Activators and target genes of Rel/NF-κB transcription factors
-
Pahl HL. Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18(49), 6853-6866 (1999).
-
(1999)
Oncogene
, vol.18
, Issue.49
, pp. 6853-6866
-
-
Pahl, H.L.1
-
32
-
-
17944378526
-
Activation by IKKa of a second, evolutionary conserved, NF-κB signaling pathway
-
Senftleben U, Cao Y, Xiao G et al. Activation by IKKa of a second, evolutionary conserved, NF-κB signaling pathway. Science 293(5534), 1495-1499 (2001).
-
(2001)
Science
, vol.293
, Issue.5534
, pp. 1495-1499
-
-
Senftleben, U.1
Cao, Y.2
Xiao, G.3
-
33
-
-
38849199203
-
Shared principles in NF-κB signaling
-
Hayden MS, Ghosh S. Shared principles in NF-κB signaling. Cell 132(3), 344-362 (2008).
-
(2008)
Cell.
, vol.132
, Issue.3
, pp. 344-362
-
-
Hayden, M.S.1
Ghosh, S.2
-
34
-
-
33750457370
-
Post-translational modifications regulating the activity and function of the nuclear factor kB pathway
-
Perkins ND. Post-translational modifications regulating the activity and function of the nuclear factor kB pathway. Oncogene 25(51), 6717-6730 (2006).
-
(2006)
Oncogene
, vol.25
, Issue.51
, pp. 6717-6730
-
-
Perkins, N.D.1
-
35
-
-
0032039076
-
Phosphorylation of NF-κB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300
-
Zhong H, Voll RE, Ghosh S. Phosphorylation of NF-κB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol. Cell 1(5), 661-671 (1998).
-
(1998)
Mol. Cell.
, vol.1
, Issue.5
, pp. 661-671
-
-
Zhong, H.1
Voll, R.E.2
Ghosh, S.3
-
36
-
-
0030570961
-
Transcription. A growing coactivator network
-
Janknecht R, Hunter T. Transcription. A growing coactivator network. Nature 383(6595), 22-23 (1996).
-
(1996)
Nature
, vol.383
, Issue.6595
, pp. 22-23
-
-
Janknecht, R.1
Hunter, T.2
-
37
-
-
0141703513
-
Tumor necrosis factor-α-induced IKK phosphorylation of NF-κB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway
-
Sakurai H, Suzuki S, Kawasaki N et al. Tumor necrosis factor-α-induced IKK phosphorylation of NF-κB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway. J. Biol. Chem. 278(38), 36916-36923 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, Issue.38
, pp. 36916-36923
-
-
Sakurai, H.1
Suzuki, S.2
Kawasaki, N.3
-
38
-
-
3543056884
-
Analysis of the activation status of Akt, NF-κB, and Stat3 in human diffuse gliomas
-
Wang H, Zhang W, Huang HJ, Liao WS, Fuller GN. Analysis of the activation status of Akt, NF-κB, and Stat3 in human diffuse gliomas. Lab. Invest. 84(8), 941-951 (2004).
-
(2004)
Lab. Invest.
, vol.84
, Issue.8
, pp. 941-951
-
-
Wang, H.1
Zhang, W.2
Huang, H.J.3
Liao, W.S.4
Fuller, G.N.5
-
39
-
-
55449102824
-
The ING4 tumor suppressor attenuates NF-κB activity at the promoter of target genes
-
Nozell S, Laver T, Moseley D et al. The ING4 tumor suppressor attenuates NF-κB activity at the promoter of target genes. Mol. Cell. Biol. 28(21), 6632-6645 (2008).
-
(2008)
Mol. Cell. Biol.
, vol.28
, Issue.21
, pp. 6632-6645
-
-
Nozell, S.1
Laver, T.2
Moseley, D.3
-
40
-
-
47549114245
-
Expression of nuclear factor-κB in human astrocytomas: Relation to pI κ Ba, vascular endothelial growth factor, Cox-2, microvascular characteristics, and survival
-
Korkolopoulou P, Levidou G, Saetta AA et al. Expression of nuclear factor-κB in human astrocytomas: relation to pI κ Ba, vascular endothelial growth factor, Cox-2, microvascular characteristics, and survival. Hum. Pathol. 39(8), 1143-1152 (2008).
-
(2008)
Hum. Pathol.
, vol.39
, Issue.8
, pp. 1143-1152
-
-
Korkolopoulou, P.1
Levidou, G.2
Saetta, A.A.3
-
41
-
-
43049109478
-
Nuclear factor-κB activation and differential expression of survivin and Bcl-2 in human grade 2-4 astrocytomas
-
Angileri FF, Aguennouz M, Conti A et al. Nuclear factor-κB activation and differential expression of survivin and Bcl-2 in human grade 2-4 astrocytomas. Cancer 112(10), 2258-2266 (2008).
-
(2008)
Cancer
, vol.112
, Issue.10
, pp. 2258-2266
-
-
Angileri, F.F.1
Aguennouz, M.2
Conti, A.3
-
42
-
-
55949104665
-
TNF signaling inhibition in the CNS: Implications for normal brain function and neurodegenerative disease
-
McCoy MK, Tansey MG. TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. J. Neuroinflammation 5, 45(2008).
-
(2008)
J. Neuroinflammation
, vol.5
, pp. 45
-
-
McCoy, M.K.1
Tansey, M.G.2
-
43
-
-
0033199867
-
Inhibition of nuclear factor-κB activation confers sensitivity to tumor necrosis factor-α by impairment of cell cycle progression in human glioma cells
-
Otsuka G, Nagaya T, Saito K, Mizuno M, Yoshida J, Seo H. Inhibition of nuclear factor-κB activation confers sensitivity to tumor necrosis factor-α by impairment of cell cycle progression in human glioma cells. Cancer Res. 59(17), 4446-4452 (1999).
-
(1999)
Cancer Res.
, vol.59
, Issue.17
, pp. 4446-4452
-
-
Otsuka, G.1
Nagaya, T.2
Saito, K.3
Mizuno, M.4
Yoshida, J.5
Seo, H.6
-
44
-
-
33749380913
-
PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-κB signaling pathway in human glioma cells
-
Koul D, Takada Y, Shen R, Aggarwal BB, Yung WK. PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-κB signaling pathway in human glioma cells. Biochem. Biophys. Res. Commun. 350(2), 463-471 (2006).
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.350
, Issue.2
, pp. 463-471
-
-
Koul, D.1
Takada, Y.2
Shen, R.3
Aggarwal, B.B.4
Yung, W.K.5
-
45
-
-
0035004169
-
Expression of nuclear factor-κB, tumor necrosis factor receptor type 1, and c-Myc in human astrocytomas
-
Tokyo
-
Hayashi S, Yamamoto M, Ueno y et al. Expression of nuclear factor-κB, tumor necrosis factor receptor type 1, and c-Myc in human astrocytomas. Neurol. Med. Chir. (Tokyo) 41(4), 187-195 (2001).
-
(2001)
Neurol. Med. Chir.
, vol.41
, Issue.4
, pp. 187-195
-
-
Hayashi, S.1
Yamamoto, M.2
Ueno, Y.3
-
46
-
-
33751203592
-
Morphoproteomic demonstration of constitutive nuclear factor-κB activation in glioblastoma multiforme with genomic correlates and therapeutic implications
-
Brown RE, Law A. Morphoproteomic demonstration of constitutive nuclear factor-κB activation in glioblastoma multiforme with genomic correlates and therapeutic implications. Ann. Clin. Lab. Sci. 36(4), 421-426 (2006).
-
(2006)
Ann. Clin. Lab. Sci.
, vol.36
, Issue.4
, pp. 421-426
-
-
Brown, R.E.1
Law, A.2
-
47
-
-
36949000268
-
NF-κB controls growth of glioblastomas/astrocytomas
-
Smith D, Shimamura T, Barbera S, Bejcek BE. NF-κB controls growth of glioblastomas/astrocytomas. Mol. Cell. Biochem. 307 (1-2), 141(2007).
-
(2007)
Mol. Cell. Biochem.
, vol.307
, Issue.1-2
, pp. 141
-
-
Smith, D.1
Shimamura, T.2
Barbera, S.3
Bejcek, B.E.4
-
48
-
-
0032053709
-
Mechanisms and consequences of activation of protein kinase B/Akt
-
Downward J. Mechanisms and consequences of activation of protein kinase B/Akt. Curr. Opin. Cell. Biol. 10(2), 262(1998).
-
(1998)
Curr. Opin. Cell. Biol.
, vol.10
, Issue.2
, pp. 262
-
-
Downward, J.1
-
49
-
-
0033517190
-
NF-κB is a target of AKT in anti-apoptotic PDGF signalling
-
Romashkova JA, Makarov SS. NF-κB is a target of AKT in anti-apoptotic PDGF signalling. Nature 401(6748), 86-90 (1999).
-
(1999)
Nature
, vol.401
, Issue.6748
, pp. 86-90
-
-
Romashkova, J.A.1
Makarov, S.S.2
-
50
-
-
0033038491
-
Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-κB p65/RelA subunit
-
Sizemore N, Leung S, Stark GR. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-κB p65/RelA subunit. Mol. Cell. Biol. 19(7), 4798-4805 (1999).
-
(1999)
Mol. Cell. Biol.
, vol.19
, Issue.7
, pp. 4798-4805
-
-
Sizemore, N.1
Leung, S.2
Stark, G.R.3
-
51
-
-
0034987702
-
Malignant glioma: Genetics and biology of a grave matter
-
Maher EA, Furnari FB, Bachoo RM et al. Malignant glioma: genetics and biology of a grave matter. Genes Dev. 15(11), 1311-1333 (2001).
-
(2001)
Genes Dev.
, vol.15
, Issue.11
, pp. 1311-1333
-
-
Maher, E.A.1
Furnari, F.B.2
Bachoo, R.M.3
-
52
-
-
33644822862
-
Tumor necrosis factor-α-induced protein 3 as a putative regulator of nuclear factor-κB-mediated resistance to O6-alkylating agents in human glioblastomas
-
Bredel M, Bredel C, Juric D et al. Tumor necrosis factor-α-induced protein 3 as a putative regulator of nuclear factor-κB-mediated resistance to O6-alkylating agents in human glioblastomas. J. Clin. Oncol. 24(2), 274-287 (2006).
-
(2006)
J. Clin. Oncol.
, vol.24
, Issue.2
, pp. 274-287
-
-
Bredel, M.1
Bredel, C.2
Juric, D.3
-
53
-
-
70350567644
-
The prolyl isomerase Pin1 regulates the NF-κB signaling pathway and interleukin-8 expression in glioblastoma
-
Atkinson GP, Nozell SE, Harrison DK, Stonecypher MS, Chen D, Benveniste EN. The prolyl isomerase Pin1 regulates the NF-κB signaling pathway and interleukin-8 expression in glioblastoma. Oncogene 28(42), 3735-3745 (2009).
-
(2009)
Oncogene
, vol.28
, Issue.42
, pp. 3735-3745
-
-
Atkinson, G.P.1
Nozell, S.E.2
Harrison, D.K.3
Stonecypher, M.S.4
Chen, D.5
Benveniste, E.N.6
-
54
-
-
51049106423
-
Aberrant NF-κB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor
-
Xie TX, Aldape KD, Gong W et al. Aberrant NF-κB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor. Int. J. Oncol. 33(1), 5-15 (2008).
-
(2008)
Int. J. Oncol.
, vol.33
, Issue.1
, pp. 5-15
-
-
Xie, T.X.1
Aldape, K.D.2
Gong, W.3
-
55
-
-
4143071413
-
In vitro and in vivo activity of the nuclear factor-κB inhibitor sulfasalazine in human glioblastomas
-
Robe PA, Bentires-Alj M, Bonif M et al. In vitro and in vivo activity of the nuclear factor-κB inhibitor sulfasalazine in human glioblastomas. Clin. Cancer Res. 10(16), 5595-5603 (2004).
-
(2004)
Clin. Cancer Res.
, vol.10
, Issue.16
, pp. 5595-5603
-
-
Robe, P.A.1
Bentires-Alj, M.2
Bonif, M.3
-
56
-
-
35148854098
-
Autocrine glutamate signaling promotes glioma cell invasion
-
Lyons SA, Chung WJ, Weaver AK, Ogunrinu T, Sontheimer H. Autocrine glutamate signaling promotes glioma cell invasion. Cancer Res. 67(19), 9463-9471 (2007).
-
(2007)
Cancer Res.
, vol.67
, Issue.19
, pp. 9463-9471
-
-
Lyons, S.A.1
Chung, W.J.2
Weaver, A.K.3
Ogunrinu, T.4
Sontheimer, H.5
-
57
-
-
67449143460
-
Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-κB
-
Chung WJ, Sontheimer H. Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-κB. J. Neurochem. 110(1), 182-193 (2009).
-
(2009)
J. Neurochem.
, vol.110
, Issue.1
, pp. 182-193
-
-
Chung, W.J.1
Sontheimer, H.2
-
58
-
-
70450228522
-
Early termination of ISRCTN45828668, a Phase 1/2 prospective, randomized study of sulfasalazine for the treatment of progressing malignant gliomas in adults
-
Robe PA, Martin DH, Nguyen-Khac MT et al. Early termination of ISRCTN45828668, a Phase 1/2 prospective, randomized study of sulfasalazine for the treatment of progressing malignant gliomas in adults. BMC Cancer 9, 372(2009).
-
(2009)
BMC Cancer
, vol.9
, pp. 372
-
-
Robe, P.A.1
Martin, D.H.2
Nguyen-Khac, M.T.3
-
59
-
-
0037204953
-
A road map for those who don't know JAK-STAT
-
Aaronson DS, Horvath CM. A road map for those who don't know JAK-STAT. Science 296(5573), 1653-1655 (2002).
-
(2002)
Science
, vol.296
, Issue.5573
, pp. 1653-1655
-
-
Aaronson, D.S.1
Horvath, C.M.2
-
60
-
-
0036731485
-
Stats: Transcriptional control and biological impact
-
Levy DE, Darnell JE Jr. Stats: transcriptional control and biological impact. Nat. Rev. Mol. Cell Biol. 3(9), 651-662 (2002).
-
(2002)
Nat. Rev. Mol. Cell. Biol.
, vol.3
, Issue.9
, pp. 651-662
-
-
Levy, D.E.1
Darnell Jr., J.E.2
-
61
-
-
4344596581
-
Oncostatin M: A pleiotropic cytokine in the central nervous system
-
Chen SH, Benveniste EN. Oncostatin M: a pleiotropic cytokine in the central nervous system. Cytokine Growth Factor Rev. 15(5), 379-391 (2004).
-
(2004)
Cytokine Growth Factor Rev.
, vol.15
, Issue.5
, pp. 379-391
-
-
Chen, S.H.1
Benveniste, E.N.2
-
62
-
-
35548944961
-
SnapShot: Jak-STAT signaling
-
Mertens C, Darnell JE Jr. SnapShot: JAK-STAT signaling. Cell 131(3), 612(2007).
-
(2007)
Cell.
, vol.131
, Issue.3
, pp. 612
-
-
Mertens, C.1
Darnell Jr., J.E.2
-
64
-
-
38849199799
-
STAT3 as a target for inducing apoptosis in solid and hematological tumors
-
Al Zaid Siddiquee K, Turkson J. STAT3 as a target for inducing apoptosis in solid and hematological tumors. Cell Res. 18(2), 254-267 (2008).
-
(2008)
Cell. Res.
, vol.18
, Issue.2
, pp. 254-267
-
-
Al Zaid Siddiquee, K.1
Turkson, J.2
-
65
-
-
33746092509
-
Touched and moved by STAT3
-
2006
-
Gao SP, Bromberg JF. Touched and moved by STAT3. Sci. STKE 2006(343), pe30 (2006).
-
(2006)
Sci. STKE
, Issue.343
-
-
Gao, S.P.1
Bromberg, J.F.2
-
66
-
-
70350500225
-
STATs in cancer inflammation and immunity: A leading role for STAT3
-
Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat. Rev. Cancer 9(11), 798-809 (2009).
-
(2009)
Nat. Rev. Cancer
, vol.9
, Issue.11
, pp. 798-809
-
-
Yu, H.1
Pardoll, D.2
Jove, R.3
-
67
-
-
34547897027
-
Signal transducer and activator of transcription 3 (STAT3) in epithelial carcinogenesis
-
Kim DJ, Chan KS, Sano S, Digiovanni J. Signal transducer and activator of transcription 3 (STAT3) in epithelial carcinogenesis. Mol. Carcinog. 46(8), 725-731 (2007).
-
(2007)
Mol. Carcinog
, vol.46
, Issue.8
, pp. 725-731
-
-
Kim, D.J.1
Chan, K.S.2
Sano, S.3
Digiovanni, J.4
-
68
-
-
0036251154
-
Stat proteins and oncogenesis
-
Bromberg J. Stat proteins and oncogenesis. J. Clin. Invest. 109(9), 1139-1142 (2002).
-
(2002)
J. Clin. Invest.
, vol.109
, Issue.9
, pp. 1139-1142
-
-
Bromberg, J.1
-
69
-
-
0037028249
-
Inhibition of constitutively active STAT3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells
-
Rahaman SO, Harbor PC, Chernova O, Barnett GH, Vogelbaum MA, Haque SJ. Inhibition of constitutively active STAT3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene 21(55), 8404-8413 (2002).
-
(2002)
Oncogene
, vol.21
, Issue.55
, pp. 8404-8413
-
-
Rahaman, S.O.1
Harbor, P.C.2
Chernova, O.3
Barnett, G.H.4
Vogelbaum, M.A.5
Haque, S.J.6
-
70
-
-
58149144782
-
Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators
-
Lo HW, Cao X, Zhu H, Ali-Osman F. Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators. Clin. Cancer Res. 14(19), 6042-6054 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.19
, pp. 6042-6054
-
-
Lo, H.W.1
Cao, X.2
Zhu, H.3
Ali-Osman, F.4
-
71
-
-
85047699589
-
Constitutive activation of STAT3a in brain tumors: Localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2)
-
Schaefer LK, Ren Z, Fuller GN, Schaefer TS. Constitutive activation of STAT3a in brain tumors: localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2). Oncogene 21(13), 2058-2065 (2002).
-
(2002)
Oncogene
, vol.21
, Issue.13
, pp. 2058-2065
-
-
Schaefer, L.K.1
Ren, Z.2
Fuller, G.N.3
Schaefer, T.S.4
-
72
-
-
58149340584
-
The incidence, correlation with tumorinfltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas
-
Abou-Ghazal M, Yang DS, Qiao W et al. The incidence, correlation with tumorinfltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas. Clin. Cancer Res. 14(24), 8228-8235 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.24
, pp. 8228-8235
-
-
Abou-Ghazal, M.1
Yang, D.S.2
Qiao, W.3
-
73
-
-
51049089073
-
Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: Implications for STAT-3 activation and gene expression
-
Brantley EC, Nabors LB, Gillespie GY et al. Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: implications for STAT-3 activation and gene expression. Clin. Cancer Res. 14(15), 4694-4704 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.15
, pp. 4694-4704
-
-
Brantley, E.C.1
Nabors, L.B.2
Gillespie, G.Y.3
-
74
-
-
75149195336
-
The transcriptional network for mesenchymal transformation of brain tumours
-
Carro MS, Lim WK, Alvarez MJ et al. The transcriptional network for mesenchymal transformation of brain tumours. Nature 463(7279), 318-325 (2010).
-
(2010)
Nature
, vol.463
, Issue.7279
, pp. 318-325
-
-
Carro, M.S.1
Lim, W.K.2
Alvarez, M.J.3
-
75
-
-
2442657786
-
IL-6 is required for glioma development in a mouse model
-
Weissenberger J, Loeffler S, Kappeler A et al. IL-6 is required for glioma development in a mouse model. Oncogene 23(19), 3308-3316 (2004).
-
(2004)
Oncogene
, vol.23
, Issue.19
, pp. 3308-3316
-
-
Weissenberger, J.1
Loeffler, S.2
Kappeler, A.3
-
76
-
-
35648995976
-
Interleukin-6 and its receptor in cancer: Implications for translational therapeutics
-
Hong DS, Angelo LS, Kurzrock R. Interleukin-6 and its receptor in cancer: implications for translational therapeutics. Cancer 110(9), 1911-1928 (2007).
-
(2007)
Cancer
, vol.110
, Issue.9
, pp. 1911-1928
-
-
Hong, D.S.1
Angelo, L.S.2
Kurzrock, R.3
-
77
-
-
0344393467
-
Oncostatin-M induction of vascular endothelial growth factor expression in astroglioma cells
-
Repovic P, Fears CY, Gladson CL, Benveniste EN. Oncostatin-M induction of vascular endothelial growth factor expression in astroglioma cells. Oncogene 22(50), 8117-8124 (2003).
-
(2003)
Oncogene
, vol.22
, Issue.50
, pp. 8117-8124
-
-
Repovic, P.1
Fears, C.Y.2
Gladson, C.L.3
Benveniste, E.N.4
-
78
-
-
0033168292
-
Interleukin-6 (IL-6) production by astrocytes: Autocrine regulation by IL-6 and the soluble IL-6 receptor
-
Van Wagoner NJ, Oh JW, Repovic P, Benveniste EN. Interleukin-6 (IL-6) production by astrocytes: autocrine regulation by IL-6 and the soluble IL-6 receptor. J. Neurosci. 19(13), 5236-5244 (1999).
-
(1999)
J. Neurosci.
, vol.19
, Issue.13
, pp. 5236-5244
-
-
Van Wagoner, N.J.1
Oh, J.W.2
Repovic, P.3
Benveniste, E.N.4
-
79
-
-
33846804009
-
Interleukin-6 gene amplification and shortened survival in glioblastoma patients
-
Tchirkov A, Khalil T, Chautard e et al Interleukin-6 gene amplification and shortened survival in glioblastoma patients. Br. J. Cancer 96(3), 474-476 (2007).
-
(2007)
Br. J. Cancer
, vol.96
, Issue.3
, pp. 474-476
-
-
Tchirkov, A.1
Khalil, T.2
Chautard, E.3
-
80
-
-
33748532939
-
The role of human glioma-infltrating microglia/macrophages in mediating antitumor immune responses
-
Hussain SF, Yang D, Suki D, Aldape K, Grimm E, Heimberger AB. The role of human glioma-infltrating microglia/macrophages in mediating antitumor immune responses. Neuro. Oncol. 8(3), 261-279 (2006).
-
(2006)
Neuro. Oncol.
, vol.8
, Issue.3
, pp. 261-279
-
-
Hussain, S.F.1
Yang, D.2
Suki, D.3
Aldape, K.4
Grimm, E.5
Heimberger, A.B.6
-
81
-
-
35448979864
-
A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients
-
vivo study of the glio blas tomaassociated immune response and the role of STAT3
-
Hussain SF, Kong LY, Jordan J et al. A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients. Cancer Res. 67(20), 9630-9636 (2007). In vivo study of the glio blas tomaassociated immune response and the role of STAT3.
-
(2007)
Cancer Res.
, vol.67
, Issue.20
, pp. 9630-9636
-
-
Hussain, S.F.1
Kong, L.Y.2
Jordan, J.3
-
82
-
-
23844483446
-
STAT3 in resident macrophages as a repressor protein of infammatory response
-
Matsukawa A, Kudo S, Maeda T et al. STAT3 in resident macrophages as a repressor protein of infammatory response. J. Immunol. 175(5), 3354-3359 (2005).
-
(2005)
J. Immunol.
, vol.175
, Issue.5
, pp. 3354-3359
-
-
Matsukawa, A.1
Kudo, S.2
Maeda, T.3
-
83
-
-
33746534417
-
IL-23 promotes tumour incidence and growth
-
Langowski JL, Zhang X, Wu L et al. IL-23 promotes tumour incidence and growth. Nature 442(7101), 461-465 (2006).
-
(2006)
Nature
, vol.442
, Issue.7101
, pp. 461-465
-
-
Langowski, J.L.1
Zhang, X.2
Wu, L.3
-
84
-
-
0037849915
-
Inter leu kin-17 promotes angiogenesis and tumor growth
-
Numasaki M, Fukushi J, Ono M et al Inter leu kin-17 promotes angiogenesis and tumor growth. Blood 101(7), 2620-2627 (2003).
-
(2003)
Blood
, vol.101
, Issue.7
, pp. 2620-2627
-
-
Numasaki, M.1
Fukushi, J.2
Ono, M.3
-
85
-
-
33645286546
-
Regulatory T cells, tumour immunity and immunotherapy
-
Zou W Regulatory T cells, tumour immunity and immunotherapy. Nat. Rev. Immunol. 6(4), 295-307 (2006).
-
(2006)
Nat. Rev. Immunol.
, vol.6
, Issue.4
, pp. 295-307
-
-
Zou, W.1
-
86
-
-
28644445445
-
Inhibiting STAT3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
-
Elegant study showing the importance of STAT3 in the immune response to tumors
-
Kortylewski M, Kujawski M, Wang T et al. Inhibiting STAT3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat. Med. 11(12), 1314-1321 (2005). Elegant study showing the importance of STAT3 in the immune response to tumors.
-
(2005)
Nat. Med.
, vol.11
, Issue.12
, pp. 1314-1321
-
-
Kortylewski, M.1
Kujawski, M.2
Wang, T.3
-
87
-
-
39449093328
-
Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway
-
Demonstrates a STAT3 contribution to the EGFRvIII oncopathway in gliomas
-
de la Iglesia N, Konopka G, Puram SV et al. Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes Dev. 22(4), 449-462 (2008). Demonstrates a STAT3 contribution to the EGFRvIII oncopathway in gliomas.
-
(2008)
Genes Dev.
, vol.22
, Issue.4
, pp. 449-462
-
-
De La Iglesia, N.1
Konopka, G.2
Puram, S.V.3
-
88
-
-
44949176222
-
Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness
-
de la Iglesia N, Konopka G, Lim KL et al. Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness. J. Neurosci. 28(23), 5870-5878 (2008).
-
(2008)
J. Neurosci.
, vol.28
, Issue.23
, pp. 5870-5878
-
-
De La Iglesia, N.1
Konopka, G.2
Lim, K.L.3
-
89
-
-
58149267888
-
LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model
-
Fuh B, Sobo M, Cen L et al. LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model. Br. J. Cancer 100(1), 106-112 (2009).
-
(2009)
Br. J. Cancer
, vol.100
, Issue.1
, pp. 106-112
-
-
Fuh, B.1
Sobo, M.2
Cen, L.3
-
90
-
-
60349107511
-
STAT3 activation is required for the growth of U87 cell-derived tumours in mice
-
Dasgupta A, Raychaudhuri B, Haqqi T et al. STAT3 activation is required for the growth of U87 cell-derived tumours in mice. Eur. J. Cancer 45(4), 677-684 (2009).
-
(2009)
Eur. J. Cancer
, vol.45
, Issue.4
, pp. 677-684
-
-
Dasgupta, A.1
Raychaudhuri, B.2
Haqqi, T.3
-
91
-
-
70349402169
-
Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): Evidence of safety and efficacy in a 5-year extension study
-
Nishimoto N, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Azuma J. Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study. Ann. Rheum. Dis. 68(10), 1580-1584 (2009).
-
(2009)
Ann. Rheum. Dis.
, vol.68
, Issue.10
, pp. 1580-1584
-
-
Nishimoto, N.1
Miyasaka, N.2
Yamamoto, K.3
Kawai, S.4
Takeuchi, T.5
Azuma, J.6
-
92
-
-
0141842674
-
Identification of a cancer stem cell in human brain tumors
-
Singh SK, Clarke ID, Terasaki M et al Identification of a cancer stem cell in human brain tumors. Cancer Res. 63(18), 5821-5828 (2003).
-
(2003)
Cancer Res.
, vol.63
, Issue.18
, pp. 5821-5828
-
-
Singh, S.K.1
Clarke, I.D.2
Terasaki, M.3
-
93
-
-
67649118749
-
Turning cancer stem cells inside out: An exploration of glioma stem cell signaling pathways
-
Li Z, Wang H, Eyler CE, Hjelmeland AB, Rich JN. Turning cancer stem cells inside out: an exploration of glioma stem cell signaling pathways. J. Biol. Chem. 284(25), 16705-16709 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, Issue.25
, pp. 16705-16709
-
-
Li, Z.1
Wang, H.2
Eyler, C.E.3
Hjelmeland, A.B.4
Rich, J.N.5
-
94
-
-
70349100257
-
Wu PY CD133 as a marker for cancer stem cells: Progresses and concerns
-
Wu Y, Wu PY CD133 as a marker for cancer stem cells: progresses and concerns. Stem Cells Dev. 18(8), 1127-1134 (2009).
-
(2009)
Stem Cells Dev.
, vol.18
, Issue.8
, pp. 1127-1134
-
-
Wu, Y.1
-
95
-
-
75049083501
-
Stem cell associated gene expression in glioblastoma multiforme: Relationship to survival and the subventricular zone
-
Kappadakunnel M, Eskin A, Dong J et al Stem cell associated gene expression in glioblastoma multiforme: relationship to survival and the subventricular zone. J. Neurooncol. 96(3), 359-367 (2010).
-
(2010)
J. Neurooncol.
, vol.96
, Issue.3
, pp. 359-367
-
-
Kappadakunnel, M.1
Eskin, A.2
Dong, J.3
-
96
-
-
53449085011
-
Glioblastoma and stem cells
-
Altaner C. Glioblastoma and stem cells. Neoplasma 55(5), 369-374 (2008).
-
(2008)
Neoplasma
, vol.55
, Issue.5
, pp. 369-374
-
-
Altaner, C.1
-
97
-
-
11244293572
-
Isolation of cancer stem cells from adult glioblastoma multiforme
-
Yuan X, Curtin J, Xiong y et al. Isolation of cancer stem cells from adult glioblastoma multiforme. Oncogene 23(58), 9392-9400 (2004).
-
(2004)
Oncogene
, vol.23
, Issue.58
, pp. 9392-9400
-
-
Yuan, X.1
Curtin, J.2
Xiong, Y.3
-
99
-
-
58149340463
-
Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme
-
Pallini R, Ricci-Vitiani L, Banna GL et al Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme. Clin. Cancer Res. 14(24), 8205-8212 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.24
, pp. 8205-8212
-
-
Pallini, R.1
Ricci-Vitiani, L.2
Banna, G.L.3
-
100
-
-
70350212976
-
STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells
-
Sherry MM, Reeves A, Wu JK, Cochran BH. STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem Cells 27(10), 2383-2392 (2009).
-
(2009)
Stem Cells
, vol.27
, Issue.10
, pp. 2383-2392
-
-
Sherry, M.M.1
Reeves, A.2
Wu, J.K.3
Cochran, B.H.4
-
101
-
-
70350223977
-
Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth
-
Wang H, Lathia JD, Wu Q et al. Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. Stem Cells 27(10), 2393-2404 (2009).
-
(2009)
Stem Cells
, vol.27
, Issue.10
, pp. 2393-2404
-
-
Wang, H.1
Lathia, J.D.2
Wu, Q.3
-
102
-
-
37349067098
-
Epigeneticmediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells
-
Lee J, Son MJ, Woolard K et al. Epigeneticmediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell 13(1), 69-80 (2008).
-
(2008)
Cancer Cell.
, vol.13
, Issue.1
, pp. 69-80
-
-
Lee, J.1
Son, M.J.2
Woolard, K.3
-
104
-
-
19044397160
-
Epidermal growth factor receptor and Ink4a/Arf: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis
-
Bachoo RM, Maher EA, Ligon KL et al Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell 1(3), 269-277 (2002).
-
(2002)
Cancer Cell.
, vol.1
, Issue.3
, pp. 269-277
-
-
Bachoo, R.M.1
Maher, E.A.2
Ligon, K.L.3
-
105
-
-
58049198191
-
Brain cancer stem cells display preferential sensitivity to Akt inhibition
-
Eyler CE, Foo WC, LaFiura KM, McLendon RE, Hjelmeland AB, Rich JN. Brain cancer stem cells display preferential sensitivity to Akt inhibition. Stem Cells 26(12), 3027-3036 (2008).
-
(2008)
Stem Cells
, vol.26
, Issue.12
, pp. 3027-3036
-
-
Eyler, C.E.1
Foo, W.C.2
LaFiura, K.M.3
McLendon, R.E.4
Hjelmeland, A.B.5
Rich, J.N.6
-
106
-
-
51049123447
-
Signal transducer and activator of transcription-3: A molecular hub for signaling pathways in gliomas
-
Brantley EC, Benveniste EN. Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas. Mol. Cancer Res. 6(5), 675-684 (2008).
-
(2008)
Mol. Cancer Res.
, vol.6
, Issue.5
, pp. 675-684
-
-
Brantley, E.C.1
Benveniste, E.N.2
-
107
-
-
63249092765
-
Persistently activated STAT3 maintains constitutive NF-κB activity in tumors
-
Great paper describing a role for STAT3 in maintaining active NF-κB in the nucleus of transformed cells
-
Lee H, Herrmann A, Deng JH et al. Persistently activated STAT3 maintains constitutive NF-κB activity in tumors. Cancer Cell 15(4), 283-293 (2009). Great paper describing a role for STAT3 in maintaining active NF-κB in the nucleus of transformed cells.
-
(2009)
Cancer Cell.
, vol.15
, Issue.4
, pp. 283-293
-
-
Lee, H.1
Herrmann, A.2
Deng, J.H.3
-
108
-
-
58649108302
-
IL-6 and STAT3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
-
Grivennikov S, Karin E, Terzic J et al. IL-6 and STAT3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 15(2), 103-113 (2009).
-
(2009)
Cancer Cell.
, vol.15
, Issue.2
, pp. 103-113
-
-
Grivennikov, S.1
Karin, E.2
Terzic, J.3
-
109
-
-
33646591224
-
STAT3 activation of NF-κB p100 processing involves CBP/p300-mediated acetylation
-
Nadiminty N, Lou W, Lee SO, Lin X, Trump DL, Gao AC. STAT3 activation of NF-κB p100 processing involves CBP/p300-mediated acetylation. Proc. Natl Acad. Sci. USA 103(19), 7264-7269 (2006).
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, Issue.19
, pp. 7264-7269
-
-
Nadiminty, N.1
Lou, W.2
Lee, S.O.3
Lin, X.4
Trump, D.L.5
Gao, A.C.6
-
110
-
-
34249868449
-
Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkB
-
Yang J, Liao X, Agarwal MK, Barnes L, Auron PE, Stark GR. Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkB. Genes Dev. 21(11), 1396-1408 (2007).
-
(2007)
Genes Dev.
, vol.21
, Issue.11
, pp. 1396-1408
-
-
Yang, J.1
Liao, X.2
Agarwal, M.K.3
Barnes, L.4
Auron, P.E.5
Stark, G.R.6
-
111
-
-
43549097394
-
Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-κB pathways in subtypes of diffuse large B-cell lymphoma
-
Lam LT, Wright G, Davis RE et al. Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-κB pathways in subtypes of diffuse large B-cell lymphoma. Blood 111(7), 3701-3713 (2008).
-
(2008)
Blood
, vol.111
, Issue.7
, pp. 3701-3713
-
-
Lam, L.T.1
Wright, G.2
Davis, R.E.3
-
112
-
-
33845444046
-
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
-
Druker BJ, Guilhot F, O'Brien SG et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N. Engl. J. Med. 355(23), 2408-2417 (2006).
-
(2006)
N. Engl. J. Med.
, vol.355
, Issue.23
, pp. 2408-2417
-
-
Druker, B.J.1
Guilhot, F.2
O'Brien, S.G.3
-
113
-
-
57449104947
-
PI3K signaling in glioma - Animal models and therapeutic challenges
-
Cheng CK, Fan QW, Weiss WA. PI3K signaling in glioma - animal models and therapeutic challenges. Brain Pathol. 19(1), 112-120 (2009).
-
(2009)
Brain Pathol.
, vol.19
, Issue.1
, pp. 112-120
-
-
Cheng, C.K.1
Fan, Q.W.2
Weiss, W.A.3
-
114
-
-
39749169093
-
Epidermal growth factor receptor inhibitors in neuro-oncology: Hopes and disappointments
-
Brandes AA, Franceschi E, Tosoni A, Hegi ME, Stupp R. Epidermal growth factor receptor inhibitors in neuro-oncology: hopes and disappointments. Clin. Cancer Res. 14(4), 957-960 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.4
, pp. 957-960
-
-
Brandes, A.A.1
Franceschi, E.2
Tosoni, A.3
Hegi, M.E.4
Stupp, R.5
-
115
-
-
58149204044
-
Exploratory analysis of the copy number alterations in glioblastoma multiforme
-
Freire P, Vilela M, Deus H et al. Exploratory analysis of the copy number alterations in glioblastoma multiforme. PLoS One 3(12), E4076 (2008).
-
(2008)
PLoS One
, vol.3
, Issue.12
-
-
Freire, P.1
Vilela, M.2
Deus, H.3
-
116
-
-
68049095262
-
MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance
-
Yip S, Miao J, Cahill DP et al. MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance. Clin. Cancer Res. 15(14), 4622-4629 (2009).
-
(2009)
Clin. Cancer Res.
, vol.15
, Issue.14
, pp. 4622-4629
-
-
Yip, S.1
Miao, J.2
Cahill, D.P.3
-
117
-
-
68149180891
-
Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility
-
Wrensch M, Jenkins RB, Chang JS et al Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility. Nat. Genet. 41(8), 905-908 (2009).
-
(2009)
Nat. Genet.
, vol.41
, Issue.8
, pp. 905-908
-
-
Wrensch, M.1
Jenkins, R.B.2
Chang, J.S.3
-
118
-
-
67651039919
-
A network model of a cooperative genetic landscape in brain tumors
-
Uses a systems biology approach to determine the network of mutations that drive the malignant glioma phenotype
-
Bredel M, Scholtens DM, Harsh GR et al. A network model of a cooperative genetic landscape in brain tumors. JAMA 302(3), 261-275 (2009). Uses a systems biology approach to determine the network of mutations that drive the malignant glioma phenotype.
-
(2009)
JAMA
, vol.302
, Issue.3
, pp. 261-275
-
-
Bredel, M.1
Scholtens, D.M.2
Harsh, G.R.3
-
119
-
-
20044372154
-
MGMT gene silencing and benefit from temozolomide in glioblastoma
-
First study to show the importance of MGMT silencing in glioma patient outcome
-
Hegi ME, Diserens AC, Gorlia T et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N. Engl. J. Med. 352(10), 997-1003 (2005). First study to show the importance of MGMT silencing in glioma patient outcome.
-
(2005)
N. Engl. J. Med.
, vol.352
, Issue.10
, pp. 997-1003
-
-
Hegi, M.E.1
Diserens, A.C.2
Gorlia, T.3
-
120
-
-
68149182696
-
Temozolomide concomitant and adjuvant to radiotherapy in elderly patients with glioblastoma: Correlation with MGMT promoter methylation status
-
Brandes AA, Franceschi E, Tosoni A et al Temozolomide concomitant and adjuvant to radiotherapy in elderly patients with glioblastoma: correlation with MGMT promoter methylation status. Cancer 115(15), 3512-3518 (2009).
-
(2009)
Cancer
, vol.115
, Issue.15
, pp. 3512-3518
-
-
Brandes, A.A.1
Franceschi, E.2
Tosoni, A.3
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