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Volumn 10, Issue 4, 2010, Pages 575-586

NF-κB and STAT3 signaling in glioma: Targets for future therapies

Author keywords

cytokine; glioblastoma; intracellular signaling; JAK STAT; NF B

Indexed keywords

ANTINEOPLASTIC AGENT; AZD 1480; BORTEZOMIB; CEP 18770; GENISTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INCB 018424; JANUS KINASE; JANUS KINASE 2; LESTAURTINIB; OPB 31121; SALINOSPORAMIDE A; STAT3 DECOY; STAT3 PROTEIN; UNCLASSIFIED DRUG; XL 019;

EID: 77953633109     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/ern.10.21     Document Type: Review
Times cited : (118)

References (120)
  • 1
    • 0037161024 scopus 로고    scopus 로고
    • Chemotherapy in adult high-grade glioma: A systematic review and meta-analysis of individual patient data from 12 randomised trials
    • Stewart LA. Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials. Lancet 359(9311), 1011-1018 (2002).
    • (2002) Lancet , vol.359 , Issue.9311 , pp. 1011-1018
    • Stewart, L.A.1
  • 2
    • 35449003659 scopus 로고    scopus 로고
    • Racial/ethnic differences in survival among elderly patients with a primary glioblastoma
    • Barnholtz-Sloan JS, Maldonado JL, Williams VL et al. Racial/ethnic differences in survival among elderly patients with a primary glioblastoma. J. Neurooncol. 85(2), 171-180 (2007).
    • (2007) J. Neurooncol. , vol.85 , Issue.2 , pp. 171-180
    • Barnholtz-Sloan, J.S.1    Maldonado, J.L.2    Williams, V.L.3
  • 4
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • Excellent, comprehensive review of malignant glioma
    • Wen PY, Kesari S. Malignant gliomas in adults. N. Engl. J. Med. 359(5), 492-507 (2008). Excellent, comprehensive review of malignant glioma.
    • (2008) N. Engl. J. Med. , vol.359 , Issue.5 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2
  • 5
    • 0036192918 scopus 로고    scopus 로고
    • The WHO classification of tumors of the nervous system
    • discussion 226-219
    • Kleihues P, Louis DN, Scheithauer BW et al. The WHO classification of tumors of the nervous system. J. Neuropathol. Exp. Neurol. 61(3), 215-225; discussion 226-219 (2002).
    • (2002) J. Neuropathol. Exp. Neurol. , vol.61 , Issue.3 , pp. 215-225
    • Kleihues, P.1    Louis, D.N.2    Scheithauer, B.W.3
  • 8
    • 4944255253 scopus 로고    scopus 로고
    • Genetic pathways to glioblastoma: A population-based study
    • Ohgaki H, Dessen P, Jourde B et al. Genetic pathways to glioblastoma: a population-based study. Cancer Res. 64(19), 6892-6899 (2004).
    • (2004) Cancer Res. , vol.64 , Issue.19 , pp. 6892-6899
    • Ohgaki, H.1    Dessen, P.2    Jourde, B.3
  • 9
    • 65649121938 scopus 로고    scopus 로고
    • Glioblastoma multiforme oncogenomics and signaling pathways
    • Kanu OO, Hughes B, Di C et al. Glioblastoma multiforme oncogenomics and signaling pathways. Clin. Med. Oncol. 3, 39-52 (2009).
    • (2009) Clin. Med. Oncol. , vol.3 , pp. 39-52
    • Kanu, O.O.1    Hughes, B.2    Di, C.3
  • 11
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Breakthrough study describing the benefits of temozolomide in glioma treatment
    • Stupp R, Mason WP, van den Bent MJ et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. 352(10), 987-996 (2005). Breakthrough study describing the benefits of temozolomide in glioma treatment.
    • (2005) N. Engl. J. Med. , vol.352 , Issue.10 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    Van Den Bent, M.J.3
  • 12
    • 0031818983 scopus 로고    scopus 로고
    • Long-term glioblastoma multiforme survivors: A population-based study
    • Scott JN, Rewcastle NB, Brasher PM et al. Long-term glioblastoma multiforme survivors: a population-based study. Can. J. Neurol. Sci. 25(3), 197-201 (1998).
    • (1998) Can. J. Neurol. Sci. , vol.25 , Issue.3 , pp. 197-201
    • Scott, J.N.1    Rewcastle, N.B.2    Brasher, P.M.3
  • 13
    • 62549136102 scopus 로고    scopus 로고
    • Boron neutron capture therapy for newly diagnosed glioblastoma
    • Yamamoto T, Nakai K, Kageji T et al. Boron neutron capture therapy for newly diagnosed glioblastoma. Radiother. Oncol. 91(1), 80-84 (2009).
    • (2009) Radiother. Oncol. , vol.91 , Issue.1 , pp. 80-84
    • Yamamoto, T.1    Nakai, K.2    Kageji, T.3
  • 15
    • 47549101044 scopus 로고    scopus 로고
    • Molecular predictors in glioblastoma: Toward personalized therapy
    • Colman H, Aldape K. Molecular predictors in glioblastoma: toward personalized therapy. Arch. Neurol. 65(7), 877-883 (2008).
    • (2008) Arch. Neurol. , vol.65 , Issue.7 , pp. 877-883
    • Colman, H.1    Aldape, K.2
  • 16
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Network TTR. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455(7216), 1061-1068 (2008).
    • (2008) Nature , vol.455 , Issue.7216 , pp. 1061-1068
    • Network, T.T.R.1
  • 17
    • 70350449411 scopus 로고    scopus 로고
    • Advances in the genetics of glioblastoma: Are we reaching critical mass?
    • Purow B, Schiff D. Advances in the genetics of glioblastoma: are we reaching critical mass? Nat. Rev. Neurol. 5(8), 419-426 (2009).
    • (2009) Nat. Rev. Neurol. , vol.5 , Issue.8 , pp. 419-426
    • Purow, B.1    Schiff, D.2
  • 18
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons DW, Jones S, Zhang X et al. An integrated genomic analysis of human glioblastoma multiforme. Science 321(5897), 1807-1812 (2008).
    • (2008) Science , vol.321 , Issue.5897 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3
  • 19
    • 60849115270 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in gliomas
    • Yan H, Parsons DW, Jin G et al. IDH1 and IDH2 mutations in gliomas. N. Engl. J. Med. 360(8), 765-773 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , Issue.8 , pp. 765-773
    • Yan, H.1    Parsons, D.W.2    Jin, G.3
  • 20
    • 35949002429 scopus 로고    scopus 로고
    • Malignant astrocytic glioma: Genetics, biology, and paths to treatment
    • Furnari FB, Fenton T, Bachoo RM et al. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev. 21(21), 2683-2710 (2007).
    • (2007) Genes Dev. , vol.21 , Issue.21 , pp. 2683-2710
    • Furnari, F.B.1    Fenton, T.2    Bachoo, R.M.3
  • 21
    • 33644877965 scopus 로고    scopus 로고
    • Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells
    • Rao RD, Mladek AC, Lamont JD et al. Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells. Neoplasia 7(10), 921-929 (2005).
    • (2005) Neoplasia , vol.7 , Issue.10 , pp. 921-929
    • Rao, R.D.1    Mladek, A.C.2    Lamont, J.D.3
  • 22
  • 23
    • 70449517400 scopus 로고    scopus 로고
    • Antiangiogenic therapies for high-grade glioma
    • Norden AD, Drappatz J, Wen PY. Antiangiogenic therapies for high-grade glioma. Nat. Rev. Neurol. 5(11), 610-620 (2009).
    • (2009) Nat. Rev. Neurol. , vol.5 , Issue.11 , pp. 610-620
    • Norden, A.D.1    Drappatz, J.2    Wen, P.Y.3
  • 24
    • 77649237309 scopus 로고    scopus 로고
    • NF-κB and cancer: How intimate is this relationship
    • Prasad S, Ravindran J, Aggarwal BB. NF-κB and cancer: how intimate is this relationship. Mol. Cell. Biochem. 1336 (1-2), 25-37 (2010).
    • (2010) Mol. Cell. Biochem. , vol.1336 , Issue.1-2 , pp. 25-37
    • Prasad, S.1    Ravindran, J.2    Aggarwal, B.B.3
  • 25
    • 69149098253 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-3, inflammation, and cancer: How intimate is the relationship?
    • Aggarwal BB, Kunnumakkara AB, Harikumar KB et al. Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship? Ann. NY Acad. Sci. 1171, 59-76 (2009).
    • (2009) Ann. NY Acad. Sci. , vol.1171 , pp. 59-76
    • Aggarwal, B.B.1    Kunnumakkara, A.B.2    Harikumar, K.B.3
  • 26
    • 16644367311 scopus 로고    scopus 로고
    • IkBaM suppresses angiogenesis and tumorigenesis promoted by a constitutively active mutant EGFR in human glioma cells
    • Wu JL, Abe T, Inoue R, Fujiki M, Kobayashi H. IkBaM suppresses angiogenesis and tumorigenesis promoted by a constitutively active mutant EGFR in human glioma cells. Neurol. Res. 26(7), 785-791 (2004).
    • (2004) Neurol. Res. , vol.26 , Issue.7 , pp. 785-791
    • Wu, J.L.1    Abe, T.2    Inoue, R.3    Fujiki, M.4    Kobayashi, H.5
  • 27
    • 17844396959 scopus 로고    scopus 로고
    • Interleukin-6 induces transcriptional activation of vascular endothelial growth factor (VEGF) in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1
    • Loeffler S, Fayard B, Weis J, Weissenberger J. Interleukin-6 induces transcriptional activation of vascular endothelial growth factor (VEGF) in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1. Int. J. Cancer 115(2), 202-213 (2005).
    • (2005) Int. J. Cancer , vol.115 , Issue.2 , pp. 202-213
    • Loeffler, S.1    Fayard, B.2    Weis, J.3    Weissenberger, J.4
  • 28
  • 29
    • 33750466230 scopus 로고    scopus 로고
    • Introduction to NF-κB: Players, pathways, perspectives
    • Gilmore TD. Introduction to NF-κB: players, pathways, perspectives. Oncogene 25(51), 6680-6684 (2006).
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6680-6684
    • Gilmore, T.D.1
  • 30
    • 33750448661 scopus 로고    scopus 로고
    • Transcriptional regulation via the NF-κB signaling module
    • Hoffmann A, Natoli G, Ghosh G. Transcriptional regulation via the NF-κB signaling module. Oncogene 25(51), 6706-6716 (2006).
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6706-6716
    • Hoffmann, A.1    Natoli, G.2    Ghosh, G.3
  • 31
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-κB transcription factors
    • Pahl HL. Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18(49), 6853-6866 (1999).
    • (1999) Oncogene , vol.18 , Issue.49 , pp. 6853-6866
    • Pahl, H.L.1
  • 32
    • 17944378526 scopus 로고    scopus 로고
    • Activation by IKKa of a second, evolutionary conserved, NF-κB signaling pathway
    • Senftleben U, Cao Y, Xiao G et al. Activation by IKKa of a second, evolutionary conserved, NF-κB signaling pathway. Science 293(5534), 1495-1499 (2001).
    • (2001) Science , vol.293 , Issue.5534 , pp. 1495-1499
    • Senftleben, U.1    Cao, Y.2    Xiao, G.3
  • 33
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-κB signaling
    • Hayden MS, Ghosh S. Shared principles in NF-κB signaling. Cell 132(3), 344-362 (2008).
    • (2008) Cell. , vol.132 , Issue.3 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 34
    • 33750457370 scopus 로고    scopus 로고
    • Post-translational modifications regulating the activity and function of the nuclear factor kB pathway
    • Perkins ND. Post-translational modifications regulating the activity and function of the nuclear factor kB pathway. Oncogene 25(51), 6717-6730 (2006).
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6717-6730
    • Perkins, N.D.1
  • 35
    • 0032039076 scopus 로고    scopus 로고
    • Phosphorylation of NF-κB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300
    • Zhong H, Voll RE, Ghosh S. Phosphorylation of NF-κB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol. Cell 1(5), 661-671 (1998).
    • (1998) Mol. Cell. , vol.1 , Issue.5 , pp. 661-671
    • Zhong, H.1    Voll, R.E.2    Ghosh, S.3
  • 36
    • 0030570961 scopus 로고    scopus 로고
    • Transcription. A growing coactivator network
    • Janknecht R, Hunter T. Transcription. A growing coactivator network. Nature 383(6595), 22-23 (1996).
    • (1996) Nature , vol.383 , Issue.6595 , pp. 22-23
    • Janknecht, R.1    Hunter, T.2
  • 37
    • 0141703513 scopus 로고    scopus 로고
    • Tumor necrosis factor-α-induced IKK phosphorylation of NF-κB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway
    • Sakurai H, Suzuki S, Kawasaki N et al. Tumor necrosis factor-α-induced IKK phosphorylation of NF-κB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway. J. Biol. Chem. 278(38), 36916-36923 (2003).
    • (2003) J. Biol. Chem. , vol.278 , Issue.38 , pp. 36916-36923
    • Sakurai, H.1    Suzuki, S.2    Kawasaki, N.3
  • 38
    • 3543056884 scopus 로고    scopus 로고
    • Analysis of the activation status of Akt, NF-κB, and Stat3 in human diffuse gliomas
    • Wang H, Zhang W, Huang HJ, Liao WS, Fuller GN. Analysis of the activation status of Akt, NF-κB, and Stat3 in human diffuse gliomas. Lab. Invest. 84(8), 941-951 (2004).
    • (2004) Lab. Invest. , vol.84 , Issue.8 , pp. 941-951
    • Wang, H.1    Zhang, W.2    Huang, H.J.3    Liao, W.S.4    Fuller, G.N.5
  • 39
    • 55449102824 scopus 로고    scopus 로고
    • The ING4 tumor suppressor attenuates NF-κB activity at the promoter of target genes
    • Nozell S, Laver T, Moseley D et al. The ING4 tumor suppressor attenuates NF-κB activity at the promoter of target genes. Mol. Cell. Biol. 28(21), 6632-6645 (2008).
    • (2008) Mol. Cell. Biol. , vol.28 , Issue.21 , pp. 6632-6645
    • Nozell, S.1    Laver, T.2    Moseley, D.3
  • 40
    • 47549114245 scopus 로고    scopus 로고
    • Expression of nuclear factor-κB in human astrocytomas: Relation to pI κ Ba, vascular endothelial growth factor, Cox-2, microvascular characteristics, and survival
    • Korkolopoulou P, Levidou G, Saetta AA et al. Expression of nuclear factor-κB in human astrocytomas: relation to pI κ Ba, vascular endothelial growth factor, Cox-2, microvascular characteristics, and survival. Hum. Pathol. 39(8), 1143-1152 (2008).
    • (2008) Hum. Pathol. , vol.39 , Issue.8 , pp. 1143-1152
    • Korkolopoulou, P.1    Levidou, G.2    Saetta, A.A.3
  • 41
    • 43049109478 scopus 로고    scopus 로고
    • Nuclear factor-κB activation and differential expression of survivin and Bcl-2 in human grade 2-4 astrocytomas
    • Angileri FF, Aguennouz M, Conti A et al. Nuclear factor-κB activation and differential expression of survivin and Bcl-2 in human grade 2-4 astrocytomas. Cancer 112(10), 2258-2266 (2008).
    • (2008) Cancer , vol.112 , Issue.10 , pp. 2258-2266
    • Angileri, F.F.1    Aguennouz, M.2    Conti, A.3
  • 42
    • 55949104665 scopus 로고    scopus 로고
    • TNF signaling inhibition in the CNS: Implications for normal brain function and neurodegenerative disease
    • McCoy MK, Tansey MG. TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. J. Neuroinflammation 5, 45(2008).
    • (2008) J. Neuroinflammation , vol.5 , pp. 45
    • McCoy, M.K.1    Tansey, M.G.2
  • 43
    • 0033199867 scopus 로고    scopus 로고
    • Inhibition of nuclear factor-κB activation confers sensitivity to tumor necrosis factor-α by impairment of cell cycle progression in human glioma cells
    • Otsuka G, Nagaya T, Saito K, Mizuno M, Yoshida J, Seo H. Inhibition of nuclear factor-κB activation confers sensitivity to tumor necrosis factor-α by impairment of cell cycle progression in human glioma cells. Cancer Res. 59(17), 4446-4452 (1999).
    • (1999) Cancer Res. , vol.59 , Issue.17 , pp. 4446-4452
    • Otsuka, G.1    Nagaya, T.2    Saito, K.3    Mizuno, M.4    Yoshida, J.5    Seo, H.6
  • 44
    • 33749380913 scopus 로고    scopus 로고
    • PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-κB signaling pathway in human glioma cells
    • Koul D, Takada Y, Shen R, Aggarwal BB, Yung WK. PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-κB signaling pathway in human glioma cells. Biochem. Biophys. Res. Commun. 350(2), 463-471 (2006).
    • (2006) Biochem. Biophys. Res. Commun. , vol.350 , Issue.2 , pp. 463-471
    • Koul, D.1    Takada, Y.2    Shen, R.3    Aggarwal, B.B.4    Yung, W.K.5
  • 45
    • 0035004169 scopus 로고    scopus 로고
    • Expression of nuclear factor-κB, tumor necrosis factor receptor type 1, and c-Myc in human astrocytomas
    • Tokyo
    • Hayashi S, Yamamoto M, Ueno y et al. Expression of nuclear factor-κB, tumor necrosis factor receptor type 1, and c-Myc in human astrocytomas. Neurol. Med. Chir. (Tokyo) 41(4), 187-195 (2001).
    • (2001) Neurol. Med. Chir. , vol.41 , Issue.4 , pp. 187-195
    • Hayashi, S.1    Yamamoto, M.2    Ueno, Y.3
  • 46
    • 33751203592 scopus 로고    scopus 로고
    • Morphoproteomic demonstration of constitutive nuclear factor-κB activation in glioblastoma multiforme with genomic correlates and therapeutic implications
    • Brown RE, Law A. Morphoproteomic demonstration of constitutive nuclear factor-κB activation in glioblastoma multiforme with genomic correlates and therapeutic implications. Ann. Clin. Lab. Sci. 36(4), 421-426 (2006).
    • (2006) Ann. Clin. Lab. Sci. , vol.36 , Issue.4 , pp. 421-426
    • Brown, R.E.1    Law, A.2
  • 48
    • 0032053709 scopus 로고    scopus 로고
    • Mechanisms and consequences of activation of protein kinase B/Akt
    • Downward J. Mechanisms and consequences of activation of protein kinase B/Akt. Curr. Opin. Cell. Biol. 10(2), 262(1998).
    • (1998) Curr. Opin. Cell. Biol. , vol.10 , Issue.2 , pp. 262
    • Downward, J.1
  • 49
    • 0033517190 scopus 로고    scopus 로고
    • NF-κB is a target of AKT in anti-apoptotic PDGF signalling
    • Romashkova JA, Makarov SS. NF-κB is a target of AKT in anti-apoptotic PDGF signalling. Nature 401(6748), 86-90 (1999).
    • (1999) Nature , vol.401 , Issue.6748 , pp. 86-90
    • Romashkova, J.A.1    Makarov, S.S.2
  • 50
    • 0033038491 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-κB p65/RelA subunit
    • Sizemore N, Leung S, Stark GR. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-κB p65/RelA subunit. Mol. Cell. Biol. 19(7), 4798-4805 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , Issue.7 , pp. 4798-4805
    • Sizemore, N.1    Leung, S.2    Stark, G.R.3
  • 51
    • 0034987702 scopus 로고    scopus 로고
    • Malignant glioma: Genetics and biology of a grave matter
    • Maher EA, Furnari FB, Bachoo RM et al. Malignant glioma: genetics and biology of a grave matter. Genes Dev. 15(11), 1311-1333 (2001).
    • (2001) Genes Dev. , vol.15 , Issue.11 , pp. 1311-1333
    • Maher, E.A.1    Furnari, F.B.2    Bachoo, R.M.3
  • 52
    • 33644822862 scopus 로고    scopus 로고
    • Tumor necrosis factor-α-induced protein 3 as a putative regulator of nuclear factor-κB-mediated resistance to O6-alkylating agents in human glioblastomas
    • Bredel M, Bredel C, Juric D et al. Tumor necrosis factor-α-induced protein 3 as a putative regulator of nuclear factor-κB-mediated resistance to O6-alkylating agents in human glioblastomas. J. Clin. Oncol. 24(2), 274-287 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.2 , pp. 274-287
    • Bredel, M.1    Bredel, C.2    Juric, D.3
  • 53
    • 70350567644 scopus 로고    scopus 로고
    • The prolyl isomerase Pin1 regulates the NF-κB signaling pathway and interleukin-8 expression in glioblastoma
    • Atkinson GP, Nozell SE, Harrison DK, Stonecypher MS, Chen D, Benveniste EN. The prolyl isomerase Pin1 regulates the NF-κB signaling pathway and interleukin-8 expression in glioblastoma. Oncogene 28(42), 3735-3745 (2009).
    • (2009) Oncogene , vol.28 , Issue.42 , pp. 3735-3745
    • Atkinson, G.P.1    Nozell, S.E.2    Harrison, D.K.3    Stonecypher, M.S.4    Chen, D.5    Benveniste, E.N.6
  • 54
    • 51049106423 scopus 로고    scopus 로고
    • Aberrant NF-κB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor
    • Xie TX, Aldape KD, Gong W et al. Aberrant NF-κB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor. Int. J. Oncol. 33(1), 5-15 (2008).
    • (2008) Int. J. Oncol. , vol.33 , Issue.1 , pp. 5-15
    • Xie, T.X.1    Aldape, K.D.2    Gong, W.3
  • 55
    • 4143071413 scopus 로고    scopus 로고
    • In vitro and in vivo activity of the nuclear factor-κB inhibitor sulfasalazine in human glioblastomas
    • Robe PA, Bentires-Alj M, Bonif M et al. In vitro and in vivo activity of the nuclear factor-κB inhibitor sulfasalazine in human glioblastomas. Clin. Cancer Res. 10(16), 5595-5603 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , Issue.16 , pp. 5595-5603
    • Robe, P.A.1    Bentires-Alj, M.2    Bonif, M.3
  • 57
    • 67449143460 scopus 로고    scopus 로고
    • Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-κB
    • Chung WJ, Sontheimer H. Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-κB. J. Neurochem. 110(1), 182-193 (2009).
    • (2009) J. Neurochem. , vol.110 , Issue.1 , pp. 182-193
    • Chung, W.J.1    Sontheimer, H.2
  • 58
    • 70450228522 scopus 로고    scopus 로고
    • Early termination of ISRCTN45828668, a Phase 1/2 prospective, randomized study of sulfasalazine for the treatment of progressing malignant gliomas in adults
    • Robe PA, Martin DH, Nguyen-Khac MT et al. Early termination of ISRCTN45828668, a Phase 1/2 prospective, randomized study of sulfasalazine for the treatment of progressing malignant gliomas in adults. BMC Cancer 9, 372(2009).
    • (2009) BMC Cancer , vol.9 , pp. 372
    • Robe, P.A.1    Martin, D.H.2    Nguyen-Khac, M.T.3
  • 59
    • 0037204953 scopus 로고    scopus 로고
    • A road map for those who don't know JAK-STAT
    • Aaronson DS, Horvath CM. A road map for those who don't know JAK-STAT. Science 296(5573), 1653-1655 (2002).
    • (2002) Science , vol.296 , Issue.5573 , pp. 1653-1655
    • Aaronson, D.S.1    Horvath, C.M.2
  • 60
    • 0036731485 scopus 로고    scopus 로고
    • Stats: Transcriptional control and biological impact
    • Levy DE, Darnell JE Jr. Stats: transcriptional control and biological impact. Nat. Rev. Mol. Cell Biol. 3(9), 651-662 (2002).
    • (2002) Nat. Rev. Mol. Cell. Biol. , vol.3 , Issue.9 , pp. 651-662
    • Levy, D.E.1    Darnell Jr., J.E.2
  • 61
    • 4344596581 scopus 로고    scopus 로고
    • Oncostatin M: A pleiotropic cytokine in the central nervous system
    • Chen SH, Benveniste EN. Oncostatin M: a pleiotropic cytokine in the central nervous system. Cytokine Growth Factor Rev. 15(5), 379-391 (2004).
    • (2004) Cytokine Growth Factor Rev. , vol.15 , Issue.5 , pp. 379-391
    • Chen, S.H.1    Benveniste, E.N.2
  • 62
    • 35548944961 scopus 로고    scopus 로고
    • SnapShot: Jak-STAT signaling
    • Mertens C, Darnell JE Jr. SnapShot: JAK-STAT signaling. Cell 131(3), 612(2007).
    • (2007) Cell. , vol.131 , Issue.3 , pp. 612
    • Mertens, C.1    Darnell Jr., J.E.2
  • 63
    • 68149147407 scopus 로고    scopus 로고
    • SOCS1 and SOCS3 in the control of CNS immunity
    • Baker BJ, Akhtar LN, Benveniste EN. SOCS1 and SOCS3 in the control of CNS immunity. Trends Immunol. 30(8), 392-400 (2009).
    • (2009) Trends Immunol. , vol.30 , Issue.8 , pp. 392-400
    • Baker, B.J.1    Akhtar, L.N.2    Benveniste, E.N.3
  • 64
    • 38849199799 scopus 로고    scopus 로고
    • STAT3 as a target for inducing apoptosis in solid and hematological tumors
    • Al Zaid Siddiquee K, Turkson J. STAT3 as a target for inducing apoptosis in solid and hematological tumors. Cell Res. 18(2), 254-267 (2008).
    • (2008) Cell. Res. , vol.18 , Issue.2 , pp. 254-267
    • Al Zaid Siddiquee, K.1    Turkson, J.2
  • 65
    • 33746092509 scopus 로고    scopus 로고
    • Touched and moved by STAT3
    • 2006
    • Gao SP, Bromberg JF. Touched and moved by STAT3. Sci. STKE 2006(343), pe30 (2006).
    • (2006) Sci. STKE , Issue.343
    • Gao, S.P.1    Bromberg, J.F.2
  • 66
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat. Rev. Cancer 9(11), 798-809 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , Issue.11 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 67
    • 34547897027 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 (STAT3) in epithelial carcinogenesis
    • Kim DJ, Chan KS, Sano S, Digiovanni J. Signal transducer and activator of transcription 3 (STAT3) in epithelial carcinogenesis. Mol. Carcinog. 46(8), 725-731 (2007).
    • (2007) Mol. Carcinog , vol.46 , Issue.8 , pp. 725-731
    • Kim, D.J.1    Chan, K.S.2    Sano, S.3    Digiovanni, J.4
  • 68
    • 0036251154 scopus 로고    scopus 로고
    • Stat proteins and oncogenesis
    • Bromberg J. Stat proteins and oncogenesis. J. Clin. Invest. 109(9), 1139-1142 (2002).
    • (2002) J. Clin. Invest. , vol.109 , Issue.9 , pp. 1139-1142
    • Bromberg, J.1
  • 69
    • 0037028249 scopus 로고    scopus 로고
    • Inhibition of constitutively active STAT3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells
    • Rahaman SO, Harbor PC, Chernova O, Barnett GH, Vogelbaum MA, Haque SJ. Inhibition of constitutively active STAT3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene 21(55), 8404-8413 (2002).
    • (2002) Oncogene , vol.21 , Issue.55 , pp. 8404-8413
    • Rahaman, S.O.1    Harbor, P.C.2    Chernova, O.3    Barnett, G.H.4    Vogelbaum, M.A.5    Haque, S.J.6
  • 70
    • 58149144782 scopus 로고    scopus 로고
    • Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators
    • Lo HW, Cao X, Zhu H, Ali-Osman F. Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators. Clin. Cancer Res. 14(19), 6042-6054 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.19 , pp. 6042-6054
    • Lo, H.W.1    Cao, X.2    Zhu, H.3    Ali-Osman, F.4
  • 71
    • 85047699589 scopus 로고    scopus 로고
    • Constitutive activation of STAT3a in brain tumors: Localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2)
    • Schaefer LK, Ren Z, Fuller GN, Schaefer TS. Constitutive activation of STAT3a in brain tumors: localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2). Oncogene 21(13), 2058-2065 (2002).
    • (2002) Oncogene , vol.21 , Issue.13 , pp. 2058-2065
    • Schaefer, L.K.1    Ren, Z.2    Fuller, G.N.3    Schaefer, T.S.4
  • 72
    • 58149340584 scopus 로고    scopus 로고
    • The incidence, correlation with tumorinfltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas
    • Abou-Ghazal M, Yang DS, Qiao W et al. The incidence, correlation with tumorinfltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas. Clin. Cancer Res. 14(24), 8228-8235 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.24 , pp. 8228-8235
    • Abou-Ghazal, M.1    Yang, D.S.2    Qiao, W.3
  • 73
    • 51049089073 scopus 로고    scopus 로고
    • Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: Implications for STAT-3 activation and gene expression
    • Brantley EC, Nabors LB, Gillespie GY et al. Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: implications for STAT-3 activation and gene expression. Clin. Cancer Res. 14(15), 4694-4704 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.15 , pp. 4694-4704
    • Brantley, E.C.1    Nabors, L.B.2    Gillespie, G.Y.3
  • 74
    • 75149195336 scopus 로고    scopus 로고
    • The transcriptional network for mesenchymal transformation of brain tumours
    • Carro MS, Lim WK, Alvarez MJ et al. The transcriptional network for mesenchymal transformation of brain tumours. Nature 463(7279), 318-325 (2010).
    • (2010) Nature , vol.463 , Issue.7279 , pp. 318-325
    • Carro, M.S.1    Lim, W.K.2    Alvarez, M.J.3
  • 75
    • 2442657786 scopus 로고    scopus 로고
    • IL-6 is required for glioma development in a mouse model
    • Weissenberger J, Loeffler S, Kappeler A et al. IL-6 is required for glioma development in a mouse model. Oncogene 23(19), 3308-3316 (2004).
    • (2004) Oncogene , vol.23 , Issue.19 , pp. 3308-3316
    • Weissenberger, J.1    Loeffler, S.2    Kappeler, A.3
  • 76
    • 35648995976 scopus 로고    scopus 로고
    • Interleukin-6 and its receptor in cancer: Implications for translational therapeutics
    • Hong DS, Angelo LS, Kurzrock R. Interleukin-6 and its receptor in cancer: implications for translational therapeutics. Cancer 110(9), 1911-1928 (2007).
    • (2007) Cancer , vol.110 , Issue.9 , pp. 1911-1928
    • Hong, D.S.1    Angelo, L.S.2    Kurzrock, R.3
  • 77
    • 0344393467 scopus 로고    scopus 로고
    • Oncostatin-M induction of vascular endothelial growth factor expression in astroglioma cells
    • Repovic P, Fears CY, Gladson CL, Benveniste EN. Oncostatin-M induction of vascular endothelial growth factor expression in astroglioma cells. Oncogene 22(50), 8117-8124 (2003).
    • (2003) Oncogene , vol.22 , Issue.50 , pp. 8117-8124
    • Repovic, P.1    Fears, C.Y.2    Gladson, C.L.3    Benveniste, E.N.4
  • 78
    • 0033168292 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) production by astrocytes: Autocrine regulation by IL-6 and the soluble IL-6 receptor
    • Van Wagoner NJ, Oh JW, Repovic P, Benveniste EN. Interleukin-6 (IL-6) production by astrocytes: autocrine regulation by IL-6 and the soluble IL-6 receptor. J. Neurosci. 19(13), 5236-5244 (1999).
    • (1999) J. Neurosci. , vol.19 , Issue.13 , pp. 5236-5244
    • Van Wagoner, N.J.1    Oh, J.W.2    Repovic, P.3    Benveniste, E.N.4
  • 79
    • 33846804009 scopus 로고    scopus 로고
    • Interleukin-6 gene amplification and shortened survival in glioblastoma patients
    • Tchirkov A, Khalil T, Chautard e et al Interleukin-6 gene amplification and shortened survival in glioblastoma patients. Br. J. Cancer 96(3), 474-476 (2007).
    • (2007) Br. J. Cancer , vol.96 , Issue.3 , pp. 474-476
    • Tchirkov, A.1    Khalil, T.2    Chautard, E.3
  • 80
    • 33748532939 scopus 로고    scopus 로고
    • The role of human glioma-infltrating microglia/macrophages in mediating antitumor immune responses
    • Hussain SF, Yang D, Suki D, Aldape K, Grimm E, Heimberger AB. The role of human glioma-infltrating microglia/macrophages in mediating antitumor immune responses. Neuro. Oncol. 8(3), 261-279 (2006).
    • (2006) Neuro. Oncol. , vol.8 , Issue.3 , pp. 261-279
    • Hussain, S.F.1    Yang, D.2    Suki, D.3    Aldape, K.4    Grimm, E.5    Heimberger, A.B.6
  • 81
    • 35448979864 scopus 로고    scopus 로고
    • A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients
    • vivo study of the glio blas tomaassociated immune response and the role of STAT3
    • Hussain SF, Kong LY, Jordan J et al. A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients. Cancer Res. 67(20), 9630-9636 (2007). In vivo study of the glio blas tomaassociated immune response and the role of STAT3.
    • (2007) Cancer Res. , vol.67 , Issue.20 , pp. 9630-9636
    • Hussain, S.F.1    Kong, L.Y.2    Jordan, J.3
  • 82
    • 23844483446 scopus 로고    scopus 로고
    • STAT3 in resident macrophages as a repressor protein of infammatory response
    • Matsukawa A, Kudo S, Maeda T et al. STAT3 in resident macrophages as a repressor protein of infammatory response. J. Immunol. 175(5), 3354-3359 (2005).
    • (2005) J. Immunol. , vol.175 , Issue.5 , pp. 3354-3359
    • Matsukawa, A.1    Kudo, S.2    Maeda, T.3
  • 83
    • 33746534417 scopus 로고    scopus 로고
    • IL-23 promotes tumour incidence and growth
    • Langowski JL, Zhang X, Wu L et al. IL-23 promotes tumour incidence and growth. Nature 442(7101), 461-465 (2006).
    • (2006) Nature , vol.442 , Issue.7101 , pp. 461-465
    • Langowski, J.L.1    Zhang, X.2    Wu, L.3
  • 84
    • 0037849915 scopus 로고    scopus 로고
    • Inter leu kin-17 promotes angiogenesis and tumor growth
    • Numasaki M, Fukushi J, Ono M et al Inter leu kin-17 promotes angiogenesis and tumor growth. Blood 101(7), 2620-2627 (2003).
    • (2003) Blood , vol.101 , Issue.7 , pp. 2620-2627
    • Numasaki, M.1    Fukushi, J.2    Ono, M.3
  • 85
    • 33645286546 scopus 로고    scopus 로고
    • Regulatory T cells, tumour immunity and immunotherapy
    • Zou W Regulatory T cells, tumour immunity and immunotherapy. Nat. Rev. Immunol. 6(4), 295-307 (2006).
    • (2006) Nat. Rev. Immunol. , vol.6 , Issue.4 , pp. 295-307
    • Zou, W.1
  • 86
    • 28644445445 scopus 로고    scopus 로고
    • Inhibiting STAT3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
    • Elegant study showing the importance of STAT3 in the immune response to tumors
    • Kortylewski M, Kujawski M, Wang T et al. Inhibiting STAT3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat. Med. 11(12), 1314-1321 (2005). Elegant study showing the importance of STAT3 in the immune response to tumors.
    • (2005) Nat. Med. , vol.11 , Issue.12 , pp. 1314-1321
    • Kortylewski, M.1    Kujawski, M.2    Wang, T.3
  • 87
    • 39449093328 scopus 로고    scopus 로고
    • Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway
    • Demonstrates a STAT3 contribution to the EGFRvIII oncopathway in gliomas
    • de la Iglesia N, Konopka G, Puram SV et al. Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes Dev. 22(4), 449-462 (2008). Demonstrates a STAT3 contribution to the EGFRvIII oncopathway in gliomas.
    • (2008) Genes Dev. , vol.22 , Issue.4 , pp. 449-462
    • De La Iglesia, N.1    Konopka, G.2    Puram, S.V.3
  • 88
    • 44949176222 scopus 로고    scopus 로고
    • Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness
    • de la Iglesia N, Konopka G, Lim KL et al. Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness. J. Neurosci. 28(23), 5870-5878 (2008).
    • (2008) J. Neurosci. , vol.28 , Issue.23 , pp. 5870-5878
    • De La Iglesia, N.1    Konopka, G.2    Lim, K.L.3
  • 89
    • 58149267888 scopus 로고    scopus 로고
    • LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model
    • Fuh B, Sobo M, Cen L et al. LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model. Br. J. Cancer 100(1), 106-112 (2009).
    • (2009) Br. J. Cancer , vol.100 , Issue.1 , pp. 106-112
    • Fuh, B.1    Sobo, M.2    Cen, L.3
  • 90
    • 60349107511 scopus 로고    scopus 로고
    • STAT3 activation is required for the growth of U87 cell-derived tumours in mice
    • Dasgupta A, Raychaudhuri B, Haqqi T et al. STAT3 activation is required for the growth of U87 cell-derived tumours in mice. Eur. J. Cancer 45(4), 677-684 (2009).
    • (2009) Eur. J. Cancer , vol.45 , Issue.4 , pp. 677-684
    • Dasgupta, A.1    Raychaudhuri, B.2    Haqqi, T.3
  • 91
    • 70349402169 scopus 로고    scopus 로고
    • Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): Evidence of safety and efficacy in a 5-year extension study
    • Nishimoto N, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Azuma J. Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study. Ann. Rheum. Dis. 68(10), 1580-1584 (2009).
    • (2009) Ann. Rheum. Dis. , vol.68 , Issue.10 , pp. 1580-1584
    • Nishimoto, N.1    Miyasaka, N.2    Yamamoto, K.3    Kawai, S.4    Takeuchi, T.5    Azuma, J.6
  • 92
    • 0141842674 scopus 로고    scopus 로고
    • Identification of a cancer stem cell in human brain tumors
    • Singh SK, Clarke ID, Terasaki M et al Identification of a cancer stem cell in human brain tumors. Cancer Res. 63(18), 5821-5828 (2003).
    • (2003) Cancer Res. , vol.63 , Issue.18 , pp. 5821-5828
    • Singh, S.K.1    Clarke, I.D.2    Terasaki, M.3
  • 93
    • 67649118749 scopus 로고    scopus 로고
    • Turning cancer stem cells inside out: An exploration of glioma stem cell signaling pathways
    • Li Z, Wang H, Eyler CE, Hjelmeland AB, Rich JN. Turning cancer stem cells inside out: an exploration of glioma stem cell signaling pathways. J. Biol. Chem. 284(25), 16705-16709 (2009).
    • (2009) J. Biol. Chem. , vol.284 , Issue.25 , pp. 16705-16709
    • Li, Z.1    Wang, H.2    Eyler, C.E.3    Hjelmeland, A.B.4    Rich, J.N.5
  • 94
    • 70349100257 scopus 로고    scopus 로고
    • Wu PY CD133 as a marker for cancer stem cells: Progresses and concerns
    • Wu Y, Wu PY CD133 as a marker for cancer stem cells: progresses and concerns. Stem Cells Dev. 18(8), 1127-1134 (2009).
    • (2009) Stem Cells Dev. , vol.18 , Issue.8 , pp. 1127-1134
    • Wu, Y.1
  • 95
    • 75049083501 scopus 로고    scopus 로고
    • Stem cell associated gene expression in glioblastoma multiforme: Relationship to survival and the subventricular zone
    • Kappadakunnel M, Eskin A, Dong J et al Stem cell associated gene expression in glioblastoma multiforme: relationship to survival and the subventricular zone. J. Neurooncol. 96(3), 359-367 (2010).
    • (2010) J. Neurooncol. , vol.96 , Issue.3 , pp. 359-367
    • Kappadakunnel, M.1    Eskin, A.2    Dong, J.3
  • 96
    • 53449085011 scopus 로고    scopus 로고
    • Glioblastoma and stem cells
    • Altaner C. Glioblastoma and stem cells. Neoplasma 55(5), 369-374 (2008).
    • (2008) Neoplasma , vol.55 , Issue.5 , pp. 369-374
    • Altaner, C.1
  • 97
    • 11244293572 scopus 로고    scopus 로고
    • Isolation of cancer stem cells from adult glioblastoma multiforme
    • Yuan X, Curtin J, Xiong y et al. Isolation of cancer stem cells from adult glioblastoma multiforme. Oncogene 23(58), 9392-9400 (2004).
    • (2004) Oncogene , vol.23 , Issue.58 , pp. 9392-9400
    • Yuan, X.1    Curtin, J.2    Xiong, Y.3
  • 99
    • 58149340463 scopus 로고    scopus 로고
    • Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme
    • Pallini R, Ricci-Vitiani L, Banna GL et al Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme. Clin. Cancer Res. 14(24), 8205-8212 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.24 , pp. 8205-8212
    • Pallini, R.1    Ricci-Vitiani, L.2    Banna, G.L.3
  • 100
    • 70350212976 scopus 로고    scopus 로고
    • STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells
    • Sherry MM, Reeves A, Wu JK, Cochran BH. STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem Cells 27(10), 2383-2392 (2009).
    • (2009) Stem Cells , vol.27 , Issue.10 , pp. 2383-2392
    • Sherry, M.M.1    Reeves, A.2    Wu, J.K.3    Cochran, B.H.4
  • 101
    • 70350223977 scopus 로고    scopus 로고
    • Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth
    • Wang H, Lathia JD, Wu Q et al. Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. Stem Cells 27(10), 2393-2404 (2009).
    • (2009) Stem Cells , vol.27 , Issue.10 , pp. 2393-2404
    • Wang, H.1    Lathia, J.D.2    Wu, Q.3
  • 102
    • 37349067098 scopus 로고    scopus 로고
    • Epigeneticmediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells
    • Lee J, Son MJ, Woolard K et al. Epigeneticmediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell 13(1), 69-80 (2008).
    • (2008) Cancer Cell. , vol.13 , Issue.1 , pp. 69-80
    • Lee, J.1    Son, M.J.2    Woolard, K.3
  • 104
    • 19044397160 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and Ink4a/Arf: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis
    • Bachoo RM, Maher EA, Ligon KL et al Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell 1(3), 269-277 (2002).
    • (2002) Cancer Cell. , vol.1 , Issue.3 , pp. 269-277
    • Bachoo, R.M.1    Maher, E.A.2    Ligon, K.L.3
  • 106
    • 51049123447 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-3: A molecular hub for signaling pathways in gliomas
    • Brantley EC, Benveniste EN. Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas. Mol. Cancer Res. 6(5), 675-684 (2008).
    • (2008) Mol. Cancer Res. , vol.6 , Issue.5 , pp. 675-684
    • Brantley, E.C.1    Benveniste, E.N.2
  • 107
    • 63249092765 scopus 로고    scopus 로고
    • Persistently activated STAT3 maintains constitutive NF-κB activity in tumors
    • Great paper describing a role for STAT3 in maintaining active NF-κB in the nucleus of transformed cells
    • Lee H, Herrmann A, Deng JH et al. Persistently activated STAT3 maintains constitutive NF-κB activity in tumors. Cancer Cell 15(4), 283-293 (2009). Great paper describing a role for STAT3 in maintaining active NF-κB in the nucleus of transformed cells.
    • (2009) Cancer Cell. , vol.15 , Issue.4 , pp. 283-293
    • Lee, H.1    Herrmann, A.2    Deng, J.H.3
  • 108
    • 58649108302 scopus 로고    scopus 로고
    • IL-6 and STAT3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
    • Grivennikov S, Karin E, Terzic J et al. IL-6 and STAT3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 15(2), 103-113 (2009).
    • (2009) Cancer Cell. , vol.15 , Issue.2 , pp. 103-113
    • Grivennikov, S.1    Karin, E.2    Terzic, J.3
  • 109
    • 33646591224 scopus 로고    scopus 로고
    • STAT3 activation of NF-κB p100 processing involves CBP/p300-mediated acetylation
    • Nadiminty N, Lou W, Lee SO, Lin X, Trump DL, Gao AC. STAT3 activation of NF-κB p100 processing involves CBP/p300-mediated acetylation. Proc. Natl Acad. Sci. USA 103(19), 7264-7269 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , Issue.19 , pp. 7264-7269
    • Nadiminty, N.1    Lou, W.2    Lee, S.O.3    Lin, X.4    Trump, D.L.5    Gao, A.C.6
  • 110
    • 34249868449 scopus 로고    scopus 로고
    • Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkB
    • Yang J, Liao X, Agarwal MK, Barnes L, Auron PE, Stark GR. Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkB. Genes Dev. 21(11), 1396-1408 (2007).
    • (2007) Genes Dev. , vol.21 , Issue.11 , pp. 1396-1408
    • Yang, J.1    Liao, X.2    Agarwal, M.K.3    Barnes, L.4    Auron, P.E.5    Stark, G.R.6
  • 111
    • 43549097394 scopus 로고    scopus 로고
    • Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-κB pathways in subtypes of diffuse large B-cell lymphoma
    • Lam LT, Wright G, Davis RE et al. Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-κB pathways in subtypes of diffuse large B-cell lymphoma. Blood 111(7), 3701-3713 (2008).
    • (2008) Blood , vol.111 , Issue.7 , pp. 3701-3713
    • Lam, L.T.1    Wright, G.2    Davis, R.E.3
  • 112
    • 33845444046 scopus 로고    scopus 로고
    • Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    • Druker BJ, Guilhot F, O'Brien SG et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N. Engl. J. Med. 355(23), 2408-2417 (2006).
    • (2006) N. Engl. J. Med. , vol.355 , Issue.23 , pp. 2408-2417
    • Druker, B.J.1    Guilhot, F.2    O'Brien, S.G.3
  • 113
    • 57449104947 scopus 로고    scopus 로고
    • PI3K signaling in glioma - Animal models and therapeutic challenges
    • Cheng CK, Fan QW, Weiss WA. PI3K signaling in glioma - animal models and therapeutic challenges. Brain Pathol. 19(1), 112-120 (2009).
    • (2009) Brain Pathol. , vol.19 , Issue.1 , pp. 112-120
    • Cheng, C.K.1    Fan, Q.W.2    Weiss, W.A.3
  • 114
    • 39749169093 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibitors in neuro-oncology: Hopes and disappointments
    • Brandes AA, Franceschi E, Tosoni A, Hegi ME, Stupp R. Epidermal growth factor receptor inhibitors in neuro-oncology: hopes and disappointments. Clin. Cancer Res. 14(4), 957-960 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.4 , pp. 957-960
    • Brandes, A.A.1    Franceschi, E.2    Tosoni, A.3    Hegi, M.E.4    Stupp, R.5
  • 115
    • 58149204044 scopus 로고    scopus 로고
    • Exploratory analysis of the copy number alterations in glioblastoma multiforme
    • Freire P, Vilela M, Deus H et al. Exploratory analysis of the copy number alterations in glioblastoma multiforme. PLoS One 3(12), E4076 (2008).
    • (2008) PLoS One , vol.3 , Issue.12
    • Freire, P.1    Vilela, M.2    Deus, H.3
  • 116
    • 68049095262 scopus 로고    scopus 로고
    • MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance
    • Yip S, Miao J, Cahill DP et al. MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance. Clin. Cancer Res. 15(14), 4622-4629 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.14 , pp. 4622-4629
    • Yip, S.1    Miao, J.2    Cahill, D.P.3
  • 117
    • 68149180891 scopus 로고    scopus 로고
    • Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility
    • Wrensch M, Jenkins RB, Chang JS et al Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility. Nat. Genet. 41(8), 905-908 (2009).
    • (2009) Nat. Genet. , vol.41 , Issue.8 , pp. 905-908
    • Wrensch, M.1    Jenkins, R.B.2    Chang, J.S.3
  • 118
    • 67651039919 scopus 로고    scopus 로고
    • A network model of a cooperative genetic landscape in brain tumors
    • Uses a systems biology approach to determine the network of mutations that drive the malignant glioma phenotype
    • Bredel M, Scholtens DM, Harsh GR et al. A network model of a cooperative genetic landscape in brain tumors. JAMA 302(3), 261-275 (2009). Uses a systems biology approach to determine the network of mutations that drive the malignant glioma phenotype.
    • (2009) JAMA , vol.302 , Issue.3 , pp. 261-275
    • Bredel, M.1    Scholtens, D.M.2    Harsh, G.R.3
  • 119
    • 20044372154 scopus 로고    scopus 로고
    • MGMT gene silencing and benefit from temozolomide in glioblastoma
    • First study to show the importance of MGMT silencing in glioma patient outcome
    • Hegi ME, Diserens AC, Gorlia T et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N. Engl. J. Med. 352(10), 997-1003 (2005). First study to show the importance of MGMT silencing in glioma patient outcome.
    • (2005) N. Engl. J. Med. , vol.352 , Issue.10 , pp. 997-1003
    • Hegi, M.E.1    Diserens, A.C.2    Gorlia, T.3
  • 120
    • 68149182696 scopus 로고    scopus 로고
    • Temozolomide concomitant and adjuvant to radiotherapy in elderly patients with glioblastoma: Correlation with MGMT promoter methylation status
    • Brandes AA, Franceschi E, Tosoni A et al Temozolomide concomitant and adjuvant to radiotherapy in elderly patients with glioblastoma: correlation with MGMT promoter methylation status. Cancer 115(15), 3512-3518 (2009).
    • (2009) Cancer , vol.115 , Issue.15 , pp. 3512-3518
    • Brandes, A.A.1    Franceschi, E.2    Tosoni, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.