NF-κB fans the flames of lung carcinogenesis

Cancer Prevention Research

Volumn 3, Issue 4, 2010, Pages 403-405

  Wong, Kwok Kin ^a,b   Jacks, Tyler ^c,d   Dranoff, Glenn ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR C TYPE 5A; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SHORT HAIRPIN RNA; STAT3 PROTEIN; UNCLASSIFIED DRUG;

CANCER MODEL; CD8+ T LYMPHOCYTE; CYTOKINE PRODUCTION; CYTOTOXICITY; GENETIC ENGINEERING; HISTOPATHOLOGY; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; LUNG CANCER; LUNG CARCINOGENESIS; NONHUMAN; ONCOGENE K RAS; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; ANIMAL; CELL TRANSFORMATION; GENETICS; LUNG TUMOR; METABOLISM; MOUSE; NOTE; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; LUNG NEOPLASMS; MICE; NF-KAPPA B; SIGNAL TRANSDUCTION;

EID: 77950799529     PISSN: 19406207     EISSN: None     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-10-0042     Document Type: Review

References (33)

1. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100: 57-70.
2. Dougan M, Dranof f G. The immune response to tumors. Curr Protoc Immunol 2009;Chapter 20:Unit 20 11.
3. Dougan M, Dranof f G. Immune therapy for cancer. Annu Rev Immunol 2009;27:83-117.
4. Ahn GO, Brown JM. Role of endothelial progenitors and other bone marrow-derived cells in the development of the tumor vasculature. Angiogenesis 2009;12:159-164
5. Alison MR, Lim S, Houghton JM. Bone marrow-derived cells and epithelial tumours: more than just an inflammatory relationship. Curr Opin Oncol 2009;21:77-82.
6. Gao Q, Qiu SJ, Fan J, et al. Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. J Clin Oncol 2007;25:2586-2593
7. Coussens LM, Werb Z. Inflammation and cancer. Nature 2002;420: 860-867
8. Hiraoka N, Onozato K, Kosuge T, Hirohashi S. Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions. Clin Cancer Res 2006;12:5423-5434
9. Pages F, Berger A, Camus M, et al. Effector memory T cells, early metastasis, and survival in colorectal cancer. N Engl J Med 2005; 353:2654-2666 (Pubitemid 41817714)
10. Zhang L, Conejo-Garcia JR, Katsaros D, et al. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med 2003;348:203-213 (Pubitemid 36077915)
11. Dunn GP, Ikeda H, Bruce AT, et al. Interferon-γ and cancer immunoediting. Immunol Res 2005;32:231-245
12. Dunn GP, Koebel CM, Schreiber RD. Interferons, immunity and cancer immunoediting. Nat Rev Immunol 2006;6:836-848
13. Koebel CM, Vermi W, Swann JB, et al. Adaptive immunity maintains occult cancer in an equilibrium state. Nature 2007;450: 903-907 (Pubitemid 350231320)
14. Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet 2001;357:539-545 (Pubitemid 32173595)
15. Karin M. NF-κB and cancer: mechanisms and targets. Mol Carcinog 2006;45:355-361
16. Langowski JL, Kastelein RA, Oft M. Swords into plowshares: IL-23 repurposes tumor immune surveillance. Trends Immunol 2007;28: 207-212 (Pubitemid 46654872)
17. Langowski JL, Zhang X, Wu L, et al. IL-23 promotes tumour incidence and growth. Nature 2006;442:461-465 (Pubitemid 44264796)
18. Ochsenbein AF, Sierro S, Odermatt B, et al. Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction. Nature 2001;411:1058-1064 (Pubitemid 32612331)
19. Dranoff G. Cytokines in cancer pathogenesis and cancer therapy. Nat Rev Cancer 2004;4:11-22. (Pubitemid 38111131)
20. Dunn GP, Bruce AT, Sheehan KC, et al. A critical function for type I interferons in cancer immunoediting. Nat Immunol 2005;6:722-729
21. Dvorak HF. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 1986; 315:1650-1659
22. Karin M, Greten FR. NF-κB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005;5: 749-759
23. Hecht SS. Cigarette smoking and lung cancer: chemical mechanisms and approaches to prevention. Lancet Oncol 2002;3:461-469
24. Vlahos R, Bozinovski S, Jones JE, et al. Differential protease, innate immunity, and NF-κB induction profiles during lung inflammation induced by subchronic cigarette smoke exposure in mice. Am J Physiol Lung Cell Mol Physiol 2006;290:L931-45. (Pubitemid 43725055)
25. Schreinemachers DM, Everson RB. Aspirin use and lung, colon, and breast cancer incidence in a prospective study. Epidemiology 1994; 5:138-146
26. Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 2009;9:798-809.
27. Greten FR, Eckmann L, Greten TF, et al. IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 2004;118:285-296 (Pubitemid 39061110)
28. Deng J, Fujimoto J, Ye X-F, et al. Knockout of the tumor suppressor gene Gprc5a in mice leads to NF-κB activation in airway epithelium and promotes lung inflammation and tumorigenesis. Cancer Prev Res 2010;3:424-437
29. Barbie DA, Tamayo P, Boehm JS, et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature 2009;462:108-112
30. Houghton AM, Rzymkiewicz DM, Ji H, et al. Neutrophil elastasemediated degradation of IRS-1 accelerates lung tumor growth. Nat Med 2010;16:219-223
31. Meylan E, Dooley AL, Feldser DM, et al. Requirement for NF-κB signaling in a mouse model of lung adenocarcinoma. Nature 2009;462: 104-107
32. Takahashi H, Ogata H, Nishigaki R, Broide D, Karin M. Tobacco smoke promotes lung tumorigenesis by triggering IKKβ- and JNK1-dependent inflammation. Cancer Cell 2010;17:89-97.
33. Ji H, Houghton AM, Mariani TJ, et al. K-ras activation generates an inflammatory response in lung tumors. Oncogene 2006;25:2105-2112