Inhibitory effects of Bangladeshi medicinal plant extracts on interactions between transcription factors and target DNA sequences

Evidence-based Complementary and Alternative Medicine

Volumn 5, Issue 3, 2008, Pages 303-312

  Lampronti, Ilaria ^a   Khan, Mahmud T H ^b   Borgatti, Monica ^a   Bianchi, Nicoletta ^a   Gambari, Roberto ^a,c  

^a UNIVERSITY OF FERRARA   (Italy)

^b University of Science and Technology of Chittagong   (Bangladesh)

^c Biothecnology Center   (Italy)

Author keywords

AP 1; CREB; GATA 1; Gene expression; Medicinal plants; NF kB; STAT 3; Transcription factors

Indexed keywords

AEGLE MARMELOS EXTRACT; APHANAMIXIS POLYSTACHYA EXTRACT; ARGEMONE OIL; CASSIA SOPHERA EXTRACT; CUSCUTA REFLEXA EXTRACT; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; EMBLICA OFFICINALIS EXTRACT; HEMIDESMUS INDICUS EXTRACT; HYGROPHILLA AURICULATA EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LAGERSTROEMIA SPECIOSA EXTRACT; MORINGA OLEIFERA EXTRACT; OCIMUM SANCTUM EXTRACT; OROXYLUM INDICUM EXTRACT; PAEDERIA FOETIDA EXTRACT; PLANT EXTRACT; POLYALTHIA LONGIFOLIA EXTRACT; RED SANDAL EXTRACT; RUMEX MARITIMUS EXTRACT; SARACA ASOKA EXTRACT; STAT3 PROTEIN; TERMINALIA ARJUNA EXTRACT; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR GATA 1; UNCLASSIFIED DRUG; VERNONIA ANTHELMINTICA EXTRACT;

AEGLE MARMELOS; APHANAMIXIS POLYSTACHYA; ARGEMONE MEXICANA; ARTICLE; B LYMPHOCYTE; BANGLADESH; CASSIA SOPHERA; CELL STRAIN K 562; CONTROLLED STUDY; CUSCUTA REFLEXA; DNA SEQUENCE; DRUG ACTIVITY; DRUG SCREENING; EMBLICA OFFICINALIS; ERYTHROLEUKEMIA CELL; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE TARGETING; HEMIDESMUS INDICUS; HUMAN; HUMAN CELL; HYGROPHILLA AURICULATA; LAGERSTROEMIA SPECIOSA; LEUKEMIA CELL LINE; MEDICINAL PLANT; MOLECULAR INTERACTION; MORINGA OLEIFERA; OCIMUM SANCTUM; OROXYLUM INDICUM; PAEDERIA FOETIDA; POLYALTHIA LONGIFOLIA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DNA INTERACTION; RAJI CELL; RED SANDAL; RUMEX MARITIMUS; SARACA ASOKA; TERMINALIA ARJUNA; VERNONIA ANTHELMINTICA;

EID: 51849085284     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1093/ecam/nem042     Document Type: Article

References (63)

1. Ji H, Wong WH. Computational biology: toward deciphering gene regulatory information in mammalian genomes. Biometrics 2006;62:645-63.
2. Penolazzi L, Magri E, Lambertini E, Calo G, Cozzani M, Siciliani G, et al. Local in vivo administration of a decoy oligonucleotide targeting NF-kappaB induces apoptosis of osteoclasts after application of orthodontic forces to rat teeth. Int J Mol Med 2006;18:807-11.
3. Penolazzi L, Magri E, Lambertini E, Bianchini E, Piva R, Gambari R. "In vivo" local transfection of a cis element decoy mimicking an estrogen receptor alpha gene promoter region induces apoptosis of osteoclasts following application of orthodontic forces to rat teeth. Apoptosis 2006;11:1653-6.
4. Chiarabelli C, Bianchi N, Borgatti M, Prus E, Fibach E, Gambari R. Induction of gamma-globin gene expression by tallimustine analogs in human erythroid cells. Haematologica 2003;88:826-7.
5. Fibach E, Bianchi N, Borgatti M, Prus E, Gambari R. Mithramycin induces fetal hemoglobin production in normal and thalassemic human erythroid precursor cells. Blood 2003;102:1276-81.
6. Mann MJ, Dzau VJ. Therapeutic applications of transcription factor decoy oligonucleotides. J Clin Invest 2000;106:1071-5.
7. Karkare S, Bhatnagar D. Promising nucleic acid analogs and mimics: characteristic features and applications of PNA, LNA, and morpholino. Appl Microbiol Biotechnol 2006;71:575-86.
8. Borgatti M, Finotti A, Romanelli A, Saviano M, Bianchi N, Lampronti I, et al. Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression. Curr Drug Targets 2004;5:735-44.
9. Sebban H, Courtois G. NF-kappaB and inflammation in genetic disease. Biochem Pharmacol 2006;72:1153-60.
10. Hayden MS, Ghosh S. Signaling to NF-kB. Genes Dev 2004;18:2195-224.
11. Chen F, Demers LM, Shi X. Upstream signal transduction of NF-kappaB activation. Curr Drug Targets Inflamm Allergy 2002;1:137-49.
12. Monteleone G, Mann J, Monteleone I, Vavassori P, Bremner R, Fantini M, et al. A failure of TGFbeta 1 negative regulation maintains sustained NF-KB activation in gut inflammation. J Biol Chem 2004;279:3925-32.
13. Liao CH, Sang S, Liang YC, Ho CT, Lin JK. Suppression of inducible nitric oxide synthase and cyclooxygenase-2 in down-regulating nuclear factor-kappaB pathway by Garcinol. Mol Carcinog 2004;41:140-9.
14. Loncar MB, Al-azzeh ED, Sommer PS, Marinovic M, Schmehl K, Kruschewski M, et al. Tumour necrosis factor alpha and nuclear factor kappaB inhibit transcription of human TFF3 encoding a gastrointestinal healing peptide. Gut 2003;52:1297-303.
15. Wagner EF, Eferl R. Fos/AP-1 proteins in bone and the immune system. Immunol Rev 2005;208:126-40.
16. Yoshimura A, Mori H, Ohishi M, Aki D, Hanada T. Negative regulation of cytokine signaling influences inflammation. Curr Opin Immunol 2003;15:704-8.
17. Hanada T, Yoshimura A. Regulation of cytokine signaling and inflammation. Cytokine Growth Factor Rev 2002;13:413-21.
18. Hodge DR, Hurt EM, Farrar WL. The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer 2005;41:2502-12.
19. Nakajima T, Aratani S, Nakazawa M, Hirose T, Fujita H, Nishioka K. Implications of transcriptional coactivator CREB binding protein complexes in rheumatoid arthritis. Mod Rheumatol 2004;14:6-11.
20. Masuda A, Yoshikai Y, Kume H, Matsuguchi T. The interaction between GATA proteins and activator protein-1 promotes the transcription of IL-13 in mast cells. J Immunol 2004;173:5564-73.
21. Hirasawa R, Shimizu R, Takahashi S, Osawa M, Takayanagi S, Kato Y, et al. Essential and instructive roles of GATA factors in eosinophil development. J Exp Med 2002;195:1379-86.
22. Sato K, Takayanagi H. Osteoclasts, rheumatoid arthritis, and osteoimmunology. Curr Opin Rheumatol 2006;18:419-26.
23. Nozaki K, Hikiami H, Goto H, Nakagawa T, Shibahara N, Shimada Y. Keishibukuryogan (Gui-Zhi-Fu-Ling-Wan), a Kampo Formula, Decreases Disease Activity and Soluble Vascular Adhesion Molecule-1 in Patients with Rheumatoid Arthritis. Evid Based Complement Alternat Med 2006;3:359-64.
24. Adcock IM, Ito K, Barnes PJ. Histone deacetylation: an important mechanism in inflammatory lung diseases. COPD 2005;2:445-55.
25. Blease K, Lewis A, Raymon HK. Emerging treatments for asthma. Expert Opin Emerg Drug 2003;8:71-81.
26. Gray SG, De Meyts P. Role of histone and transcription factor acetylation in diabetes pathogenesis. Diabetes Metab Res Rev 2005;21:416-33.
27. Stucchi A, Reed K, O'Brien M, Cerda S, Andrews C, Gower A, et al. A new transcription factor that regulates TNF-alpha gene expression, LITAF, is increased in intestinal tissues from patients with CD and UC. Inflamm Bowel Dis 2006;12:581-7.
28. Tohda C, Nakayama N, Hatanaka F, Komatsu K. Comparison of Anti-inflammatory Activities of Six Curcuma Rhizomes: a Possible Curcuminoid-independent Pathway Mediated by Curcuma phaeocaulis Extract. Evid Based Complement Alternat Med 2006;3:255-60.
29. Wu MJ, Wang L, Ding HY, Weng CY, Yen JH. Glossogyne tenuifolia acts to inhibit inflammatory mediator production in a macrophage cell line by downregulating LPS-induced NF-kappaB. J Biomed Sci 2004;11:186-99.
30. Ahmed S, Anuntiyo J, Malemud CJ, Haqqi TM. Biological basis for the use of botanicals in osteoarthritis and rheumatoid arthritis: a review. Evid Based Complement Alternat Med 2005;2:301-8.
31. Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol 2005;5:1749-70.
32. Fylaktakidou KC, Hadjipavlou-Litina DJ, Litinas KE, Nicolaides DN. Natural and synthetic coumarin derivatives with anti-inflammatory/antioxidant activities. Curr Pharm Des 2004;10:3813-33.
33. Nozaki K, Hikiami H, Goto H, Nakagawa T, Shibahara N, Shimada Y. Keishibukuryogan (gui-zhi-fu-ling-wan), a kampo formula, decreases disease activity and soluble vascular adhesion molecule-1 in patients with rheumatoid arthritis. Evid Based Complement Alternat Med 2006;3:359-64.
34. Saad B, Azaizeh H, Said O. Tradition and perspectives of arab herbal medicine: a review. Evid Based Complement Alternat Med 2005;2:475-9.
35. Khan MT, Lampronti I, Martello D, Bianchi N, Jabbar S, Choudhuri MS, et al. Identification of pyrogallol as an antiproliferative compound present in extracts from the medicinal plant Emblica officinalis: effects on in vitro cell growth of human tumor cell lines. Int J Oncol 2002;21:187-92.
36. Luo JZ, Luo L. American ginseng stimulates insulin production and prevents poptosis through egulation of uncoupling protein-2 in cultured beta Cells. Evid Based Complement Alternat Med 2006;3:365-72.
37. Lampronti I, Martello D, Bianchi N, Borgatti M, Lambertini E, Piva R, et al. In vitro antiproliferative effects on human tumor cell lines of extracts from the Bangladeshi medicinal plant Aegle marmelos Correa. Phytomedicine 2003;10:300-8.
38. Jagetia GC, Rao SK. Evaluation of cytotoxic effects of Dichloromethane extract of Guduchi (Tinospora cordifolia Miers ex Hook F & THOMS) on cultured HeLa cells. Evid Based Complement Alternat Med 2006;3:267-72.
39. Lambertini E, Piva R, Khan MT, Lampronti I, Bianchi N, Borgatti M, et al. Effects of extracts from Bangladeshi medicinal plants on in vitro proliferation of human breast cancer cell lines and expression of estrogen receptor alpha gene. Int J Oncol 2004;24:419-23.
40. Adams LS, Seeram NP, Hardy ML, Carpenter C, Heber D. Analysis of the interactions of botanical extract combinations against the viability of prostate cancer cell lines. Evid Based Complement Alternat Med 2006;3:117-24.
41. Chui CH, Lau FY, Tang JC, Kan KL, Cheng GY, Wong RS, et al. Activities of fresh juice of Scutellaria barbata and warmed water extract of Radix Sophorae Tonkinensis on anti-proliferation and apoptosis of human cancer cell lines. Int J Mol Med 2005;16:337-41.
42. Lau FY, Chui CH, Gambari R, Kok SH, Kan KL, Cheng GY, et al. Antiproliferative and apoptosis-inducing activity of Brucea javanica extract on human carcinoma cells. Int J Mol Med 2005;16:1157-62.
43. Xie F, Wu CF, Lai WP, Yang XJ, Cheung PY, Yao XS, et al. The osteoprotective effect of Herba epimedii (HEP) extract in vivo and in vitro. Evid Based Complement Alternat Med 2005;2:353-61.
44. Lampronti I, Saab AM, Gambari R. Antiproliferative activity of essential oils derived from plants belonging to the Magnoliophyta division. Int J Oncol 2006;29:989-95.
45. Lampronti I, Khan MTH, Bianchi N, Borgatti M, Gambari R. Inhibitory effects of medicinal plant extracts on interactions between DNA and trancription factors involved in inflammation. Minerva Biotecnologica 2004;16:93-9.
46. Lampronti I, Khan MTH, Bianchi N, Ather A, Borgatti M, Vizziello L, et al. Bangladeshi medicinal plant extracts inhibiting molecular interactions between nuclear factors and target DNA sequences mimicking NF-kappaB binding sites. Med Chem 2005;1:327-33.
47. Borgatti M, Lampronti I, Romanelli A, Pedone C, Saviano M, Bianchi N, et al. Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites. J Biol Chem 2003;278:7500-9.
48. Bianchi N, Chiarabelli C, Borgatti M, Mischiati C, Fibach E, Gambari R. Accumulation of gamma-globin mRNA and induction of erythroid differentiation after treatment of human leukaemic K562 cells with tallimustine. Br J Haematol 2001;113:951-61.
49. Drexler HG, Minowada J. History and classification of human-lymphoma cell lines. Leuk Lymphoma 1998;31:305-16.
50. Ganes S, Anel A, Lasierra P, Alava MA, Martinez-Lorenzo MJ, Piniero A, et al. Doxorubicin-induced apoptosis in human T-cell leukemia is mediated by caspase-3 activation in a Fas-independent way. FEBS Lett 1997;417:360-4.
51. Gambari R. New trends for the development of novel decoy molecules against nuclear factor kappa-B (NF-kB) transcription factor. Minerva Biotecnologica 2004;16:145-9.
52. Piva R, Penolazzi L, Lambertini E, Giordano S, Gambari R. Induction of apoptosis of human primary osteoclasts treated with a transcription factor decoy mimicking a promoter region of estrogen receptor alpha. Apoptosis 2005;10:1079-94.
53. Agarwal N, Gewirtz AM. Oligonucleotide therapeutics for hematologic disorders. Biochim Biophys Acta 1999;1489:85.
54. Praseuth D, Guieysse AL, Helene C. Triple helix formation and the antigene strategy for sequence-specific control of gene expression. Biochim Biophys Acta 1999;1489:181-206.
55. Gorman L, Glazer PM. Directed gene modification via triple helix formation. Curr Mol Med 2001;1:391-9.
56. Bianchi N, Chiarabelli C, Borgatti M, Mischiati C, Fibach E, Gambari R. Accumulation of gamma-globin mRNA and induction of erythroid differentiation after treatment of human leukaemic K562 cells with tallimustine. Br J Haematol 2001;113:951-61.
57. Heinrich M, Gibbons S. Ethnopharmacology in drug discovery: an analysis of its role and potential contribution. J Pharm Pharmacol 2001;53:425-32.
58. Wu MJ, Wang L, Ding HY, Weng CY, Yen JH. Glossogyne tenuifolia acts to inhibit inflammatory mediator production in a macrophage cell line by downregulating LPS-induced NF-kappaB. J Biomed Sci 2004;11:186-99.
59. Liao CH, Sang S, Liang YC, Ho CT, Lin JK. Suppression of inducible nitric oxide synthase and cyclooxygenase-2 in down-regulating nuclear factor-kappaB pathway by Garcinol. Mol Carcinog 2004;41:140-9.
60. Murakami A, Kitazono Y, Jiwajinda S, Koshimizu K, Ohigashi H. Niaziminin, a thiocarbamate from the leaves of Moringa oleifera, holds a strict structural requirement for inhibition of tumor-promoter-induced Epstein-Barr virus activation. Planta Med 1998;64:319-23.
61. Pawar RS, Bhutani KK. Effect of oleanane triterpenoids from Terminalia arjuna -a cardioprotective drug on the process of respiratory oxyburst. Phytomedicine 2005;12:391-3.
62. Tian G, Zhang U, Zhang T, Yang F, Ito Y. Separation of flavonoids from the seeds of Vernonia anthelmintica Willd by high-speed counter-current chromatography. J Chromatogr A 2004;1049:219-22.
63. Ragasa CY, Ngo HT, Rideout JA. Terpenoids and sterols from Lagerstroemia speciosa. J Asian Nat Prod Res 2005;7:7-12.