Importin β interacts with the endoplasmic reticulum-associated degradation machinery and promotes ubiquitination and degradation of mutant α1-antitrypsin

Journal of Biological Chemistry

Volumn 286, Issue 39, 2011, Pages 33921-33930

  Zhong, Yongwang ^a   Wang, Yang ^a   Yang, Hui ^a   Ballar, Petek ^a   Lee, Jin Gu ^b   Ye, Yihong ^b   Monteiro, Mervyn J ^a   Fang, Shengyun ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MACHINERY; PROTEINS;

ALPHA 1-ANTITRYPSIN; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATIONS; MISFOLDED PROTEINS; NUCLEOCYTOPLASMIC TRANSPORT; PROTEASOMAL DEGRADATION; PROTEIN QUALITY CONTROL; RECONSTITUTION ASSAY;

SUBSTRATES;

ALPHA 1 ANTITRYPSIN; GUANOSINE TRIPHOSPHATASE; KARYOPHERIN BETA; MUTANT PROTEIN; RAN PROTEIN;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN MISFOLDING; UBIQUITINATION;

EID: 80053176398     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.272906     Document Type: Article

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