The TβR-I pre-helix extension is structurally ordered in the unbound form and its flanking prolines are essential for binding

Journal of Molecular Biology

Volumn 412, Issue 4, 2011, Pages 601-618

  Zuniga, Jorge E ^a,b   Ilangovan, Udayar ^a   Mahlawat, Pardeep ^a   Hinck, Cynthia S ^a   Huang, Tao ^a   Groppe, Jay C ^a,c   McEwen, Donald G ^a   Hinck, Andrew P ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b STANFORD UNIVERSITY   (United States)

^c TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

cis proline; cooperative binding; specificity; TGF ; type I receptor

Indexed keywords

BONE MORPHOGENETIC PROTEIN; PROLINE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1;

ARTICLE; DNA FLANKING REGION; EPITHELIUM CELL; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; RECEPTOR BINDING; REPORTER GENE; SIGNAL TRANSDUCTION;

EID: 80052970306     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.07.046     Document Type: Article

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