Identification of a functional binding site for activin on the type I receptor ALK4

Journal of Biological Chemistry

Volumn 278, Issue 23, 2003, Pages 21129-21135

  Harrison, Craig A ^b   Gray, Peter C ^b   Koerber, Steven C ^b   Fischer, Wolfgang ^b   Vale, Wylie ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BONE; COMPLEXATION; PROTEINS;

RECEPTORS;

BIOCHEMISTRY;

ACTIVIN; BONE MORPHOGENETIC PROTEIN; DNA; IODINE 125; PROTEIN SERINE THREONINE KINASE; RECEPTOR SUBTYPE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ARTICLE; BINDING SITE; CELL CULTURE; COMPUTER MODEL; CONTROLLED STUDY; CROSS LINKING; EMBRYO; ENZYME ASSAY; HUMAN; HUMAN CELL; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN BINDING;

ACTIVIN RECEPTORS, TYPE I; ACTIVINS; AMINO ACIDS; ANIMALS; BINDING SITES; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE I; CELLS, CULTURED; EPITHELIAL CELLS; GENE EXPRESSION; HUMANS; KIDNEY; LUNG; MINK; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; RECEPTORS, GROWTH FACTOR; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0038418547     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302015200     Document Type: Article

References (43)

1. Massagué, J. (1998) Annu. Rev. Biochem. 67, 753-791
2. Wozney, J. M., Rosen, V., Celeste, A. J., Mitsock, L. M., Whitters, M. J., Kriz, R. W., Hewick, R. M., and Wang, E. A. (1988) Science 242, 1528-1534
3. Attisano, L., Wrana, J. L., Lopez-Casillas, F., and Massagué, J. (1994) Biochim. Biophys. Acta 1222, 71-80
4. Matzuk, M. M., Lu, N., Vogel, H., Sellheyer, K., Roop, D. R., and Bradley, A. (1995) Nature 374, 360-363
5. Hogan, B. L. (1996) Curr. Opin. Genet. Dev. 6, 432-438
6. Vale, W., Rivier, C., Hsueh, A., Campen, C., Meunier, H., Bicsak, T., Vaughan, J., Corrigan, A., Bardin, W., Sawchenko, P., Petraglia, F., Yu, J., Plotsky, P., Spiess, J., and Rivier, J. (1988) Recent Prog. Horm. Res. 44, 1-34
7. Bilezikjian, L. M., and Vale, W. W. (1992) Trends Endocrinol. Metab. 3, 218-223
8. Mather, J. P., Woodruff, T. K., and Krummen, L. A. (1992) Proc. Soc. Exp. Biol. Med. 201, 1-15
9. Matzuk, M. M., Kumar, T. R., Shou, W., Coerver, K. A., Lau, A. L., Behringer, R. R., and Finegold, M. J. (1996) Recent. Prog. Horm. Res. 51, 123-154
10. Brosh, N., Sternberg, D., Honigwachs-Sha'anani, J., Lee, B. C., Shav-Tal, Y., Tzehoval, E., Shulman, L. M., Toledo, J., Hacham, Y., Carmi, P., Jiang, W., Sasse, J., Horn, F., Burstein, Y., and Zipori, D. (1995) J. Biol. Chem. 270, 29594-29600
11. Phillips, D. J., Jones, K. L., Scheerlinck, J. Y., Hedger, M. P., and de Kretser, D. M. (2001) Mol. Cell. Endocrinol. 180, 155-162
12. Schwall, R. H., Robbins, K., Jardieu, P., Chang, L., Lai, C., and Terrell, T. G. (1993) Hepatology 18, 347-356
13. Matzuk, M. M., Finegold, M. J., Mather, J. P., Krummen, L., Lu, H., and Bradley, A. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 8817-8821
14. Schubert, D., Kimura, H., LaCorbiere, M., Vaughan, J., Karr, D., and Fischer, W. H. (1990) Nature 344, 868-870
15. Chen, Y. G., Lui, H. M., Lin, S. L., Lee, J. M., and Ying, S. Y. (2002) Exp. Biol. Med. (Maywood) 227, 75-87
16. Vale, W., Hsueh, A., Rivier, C., and Yu, J. (1990) in Peptide Growth Factors and Their Receptors, Handbook of Experimental Pharmacology (Sporn, M. A., and Roberts, A. B., eds) Vol. 95/Il, pp. 211-248, Springer-Verlag, Heidelberg, Germany
17. Isaacs, N. W. (1995) Curr. Opin. Struct. Biol. 5, 391-395
18. Mathews, L. S., and Vale, W. W. (1991) Cell 65, 973-982
19. Attisano, L., Carcamo, J., Ventura, F., Weis, F. M. B., Massagué, J., and Wrana, J. L. (1993) Cell 75, 671-680
20. Carcamo, J., Weis, F. M., Ventura, F., Wieser, R., Wrana, J. L., Attisano, L., and Massagué, J. (1994) Mol. Cell. Biol. 14, 3810-3821
21. Attisano, L., Wrana, J. L., Montalvo, E., and Massagué, J. (1996) Mol. Cell. Biol. 16, 1066-1073
22. Derynck, R., Zhang, Y., and Feng, X. H. (1998) Cell 95, 737-740
23. Greenwald, J., Groppe, J., Gray, P. C., Wiater, E., Kwiatkowski, W., Vale, W., and Choe, S. (2003) Mol. Cell 11, 605-617
24. Gray, P. C., Greenwald, J., Blount, A. L., Kunitake, K. S., Donaldson, C. J., Choe, S., and Vale, W. (2000) J. Biol. Chem. 275, 3206-3212
25. Wuytens, G., Verschueren, K., de Winter, J. P., Gajendran, N., Beck, L., Devos, K., Bosman, F., de Waele, P., Andries, M., van den Eijnden-van Raaij, A. J., Smith, J. C., and Huylebroeck, D. (1999) J. Biol. Chem. 274, 9821-9827
26. Fischer, W. H., Park, M., Donaldson, C., Wiater, E., Vaughan, J., Bilezikjian, L. M., and Vale, W. (2003) J. Endocrinol. 176, 61-68
27. Kirsch, T., Nickel, J., and Sebald, W. (2000) EMBO J. 19, 3314-3324
28. Kirsch, T., Sebald, W., and Dreyer, M. K. (2000) Nat. Struct. Biol. 7, 492-496
29. Bittencourt, J. C., Presse, F., Arias, C., Peto, C., Vaughan, J., Nahon, J.-L., Vale, W. W., and Sawchenko, P. E. (1992) J. Comp. Neurol. 319, 218-245
30. Liu, F., Pouponnot, C., and Massague, J. (1997) Genes Dev. 11, 3157-3167
31. Yan, Y. T., Liu, J. J., Luo, Y., E, C., Haltiwanger, R. S., Abate-Shen, C., and Shen, M. M. (2002) Mol. Cell. Biol. 22, 4439-4449
32. Tsuchida, K., Vaughan, J. M., Wiater, E. M., Gaddy-Kurten, D., and Vale, W. W. (1995) Endocrinol. 136, 5493-5503
33. Guimond, A., Sulea, T., Zwaagstra, J. C., Ekiel, I., and O'Connor-McCourt, M. D. (2002) FEBS Lett. 513, 147-152
34. Zhou, Y., Sun, H., Danila, D. C., Johnson, S. R., Sigai, D. P., Zhang, X., and Klibanski, A. (2000) Mol. Endocrinol. 14, 2066-2075
35. Su, G. H., Bansal, R., Murphy, K. M., Montgomery, E., Yeo, C. J., Hruban, R. H., and Kern, S. E. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 3254-3257
36. Gu, Z., Nomura, M., Simpson, B. B., Lei, H., Feijen, A., van den Eijnden-van Raaij, J., Donahoe, P. K., and Li, E. (1998) Genes Dev. 12, 844-857
37. Greenwald, J., Fischer, W. H., Vale, W. W., and Choe, S. (1999) Nat. Struct. Biol. 6, 18-22
38. Tendijke, P., Yamashita, H., Sampath, T. K., Reddi, A. H., Estevez, M., Riddle, D. L., Ichijo, H., Heldin, C. H., and Miyazono, K. (1994) J. Biol. Chem. 269, 16985-16988
39. Schier, A. F., and Shen, M. M. (2000) Nature 403, 385-389
40. Whitman, M. (2001) Dev. Cell 1, 605-617
41. Cheng, S. K., Olale, F., Bennett, J. T., Brivanlou, A. H., and Schier, A. F. (2003) Genes Dev. 17, 31-36
42. Gritsman, K., Zhang, J., Cheng, S., Heckscher, E., Talbot, W. S., and Schier, A. F. (1999) Cell 97, 121-132
43. Kessler, D. S., and Melton, D. A. (1994) Science 266, 596-604