KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus

Pharmacological Research

Volumn 64, Issue 4, 2011, Pages 397-409

  Ipavec, V ^a   Martire, M ^a   Barrese, V ^b   Taglialatela, M ^b,c   Curro D ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF MOLISE   (Italy)

Author keywords

KV7 channels; KCNQ channels; Nonadrenergic noncholinergic relaxation; Rat gastric fundus; Retigabine; XE 991

Indexed keywords

FLUPIRTINE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; PAPAVERINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL KCNQ4; POTASSIUM CHANNEL KCNQ5; POTASSIUM CHANNEL KV7; POTASSIUM CHANNEL KV7.1; POTASSIUM CHANNEL KV7.2; POTASSIUM CHANNEL KV7.3; RETIGABINE; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ANTICONVULSIVE AGENT; CARBAMIC ACID DERIVATIVE; PHENYLENEDIAMINE DERIVATIVE; POTASSIUM CHANNEL KCNQ;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ELECTROSTIMULATION; FEMALE; GENE EXPRESSION; GENE LOCATION; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; REPOLARIZATION; SIGNAL NOISE RATIO; SMOOTH MUSCLE FIBER; SMOOTH MUSCLE RELAXATION; SMOOTH MUSCLE TONE; STOMACH FUNDUS; STOMACH MOTILITY; TISSUE DISTRIBUTION; ANIMAL; DRUG ANTAGONISM; DRUG POTENTIATION; METABOLISM; MUSCLE RELAXATION; MUSCLE TONE; WISTAR RAT;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; ANTICONVULSANTS; CARBAMATES; FEMALE; GASTRIC FUNDUS; KCNQ POTASSIUM CHANNELS; MALE; MUSCLE RELAXATION; MUSCLE TONUS; PHENYLENEDIAMINES; RATS; RATS, WISTAR;

EID: 80052962380     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2011.06.016     Document Type: Article

References (55)

1. G.A. Gutman, K.G. Chandy, S. Grissmer, M. Lazdunsky, D. McKinnon, and L.A. Pardo International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels Pharmacol Rev 57 2005 473 508 (Pubitemid 43036437)
2. K.M. Sanders Regulation of smooth muscle excitation and contraction Neurogastroenterol Motil 20 Suppl 1 2008 39 53 (Pubitemid 351514537)
3. V7.1 (KCNQ1) properties and channelopathies J Physiol 586.7 2008 1785 1789
4. V7-modulating drugs Curr Opin Pharmacol 8 2008 65 74 (Pubitemid 351168693)
5. V7) channels Br J Pharmacol 156 2009 1185 1195
6. + channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway Proc Natl Acad Sci USA 97 2000 4333 4338 (Pubitemid 30226133)
7. V7 potassium channels in skeletal muscle proliferation, differentiation, and survival after myotoxic insults J Pharmacol Exp Ther 332 2010 811 820
8. I.A. Greenwood, and S. Ohya New tricks for old dogs: KCNQ expression and role in smooth muscle Br J Pharmacol 156 2009 1196 1203
9. + channel in murine gastrointestinal smooth muscles Am J Physiol Gastrointest Liver Physiol 297 2009 G107 G115
10. V7 channels in murine myometrium throughout oestrous cycle Pflugers Arch Eur J Physiol 457 2009 1111 1120
11. F. Rode, J. Svalø, M. Sheykhzade, and L.C.B. Rønn Functional effects of the KCNQ modulators retigabine and XE991 in the rat urinary bladder Eur J Pharmacol 638 2010 121 127
12. S.M. Sims, J.J. Singer, and J.V. Walsh Jr Cholinergic agonists suppress a potassium current in freshly dissociated smooth muscle cells of the toad J Physiol 367 1985 503 529 (Pubitemid 16195402)
13. E. Lammel, P. Deitmer, and T. Noack Suppression of steady membrane currents by acetylcholine in single smooth muscle cells of the guinea-pig gastric fundus J Physiol 432 1991 259 282
14. S. Ohya, K. Asakura, K. Muraki, M. Watanabe, and Y. Imaizumi Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle Am J Physiol Gastrointest Liver Physiol 282 2002 G277 G287
15. F. Azpiroz, and J.R. Malagelada Importance of vagal input in maintaining gastric tone in the dog J Physiol 384 1987 511 524 (Pubitemid 17026533)
16. D. Curr, V. Ipavec, and P. Preziosi Neurotransmitters of the non-adrenergic non-cholinergic relaxation of proximal stomach Eur Rev Med Pharmacol Sci 12 Suppl 1 2008 53 62
17. D. Curr, T. De Marco, and P. Preziosi Evidence for an apamin-sensitive, but not purinergic, component in the nonadrenergic noncholinergic relaxation of the rat gastric fundus Br J Pharmacol 143 2004 785 793 (Pubitemid 39611614)
18. J.R. Vane A sensitive method for the assay of 5-hydroxytryptamine Br J Pharmacol Chemother 12 1957 344 349
19. H.-S. Wang, Z. Pan, W. Shi, B.S. Brown, R.S. Wymore, and I.S. Cohen KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel Science 282 1998 1890 1893 (Pubitemid 28555268)
20. C. Rundfeldt, and R. Netzer Investigations into the mechanism of action of the new anticonvulsant retigabine. Interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels Arzneimittelforschung 50 2000 1063 1070 (Pubitemid 32002997)
21. D. Curr, A.R. Volpe, and P. Preziosi Nitric oxide synthase activity and non-adrenergic non-cholinergic relaxation in the rat gastric fundus Br J Pharmacol 117 1996 717 723 (Pubitemid 26070250)
22. D. Curr, T. De Marco, and P. Preziosi Involvement of peptide histidine isoleucine in non-adrenergic non-cholinergic relaxation of the rat gastric fundus induced by high-frequency neuronal firing Naunyn Schmiedebergs Arch Pharmacol 366 2002 578 586 (Pubitemid 35430448)
23. F. Vogalis Potassium channels in gastrointestinal smooth muscle J Auton Pharmacol 20 2000 207 219 (Pubitemid 34209003)
24. M. Martire, P. Castaldo, M. D'Amico, P. Preziosi, L. Annunziato, and M. Taglialatela M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals J Neurosci 21 2004 592 597 (Pubitemid 38166483)
25. 3H]dopamine release triggered by depolarization and pre-synaptic muscarinic receptor activation from rat striatal synaptosomes J Neurochem 102 2007 179 193 (Pubitemid 46906273)
26. V7 channels: interaction with dopaminergic and serotonergic neurotransmission in the CNS J Physiol 586 7 2008 1823 1832 (Pubitemid 351997511)
27. S. Ohya, G.P. Sergeant, I.A. Greenwood, and B. Horowitz Molecular variants of KCNQ channels expressed in murine portal vein myocytes: a role in delayed rectifier current Circ Res 92 2003 1016 1023 (Pubitemid 36588501)
28. V7 channels in murine vascular reactivity Br J Pharmacol 151 2007 758 770 (Pubitemid 47075320)
29. + channel KCNQ genes in human arteries Br J Pharmacol 162 2011 42 53
30. + currents Br J Pharmacol 155 2008 62 72
31. S. Joshi, V. Sedivy, D. Hodyc, J. Herget, and A.M. Gurney KCNQ modulators reveal a key role for KCNQ potassium channels in regulating the tone of rat pulmonary artery smooth muscle J Pharmacol Exp Ther 329 2009 368 376
32. V7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension Br J Pharmacol 157 2009 1241 1249
33. S.Y.M. Yeung, and I.A. Greenwood Electrophysiological and functional effects of the KCNQ channel blocker XE991 on murine portal vein SMC Br J Pharmacol 146 2005 585 595 (Pubitemid 41487075)
34. S. Joshi, P. Balan, and A.M. Gurney Pulmonary vasoconstrictor action of KCNQ potassium channel blockers Respir Res 7 2006 31 40
35. A.R. Mackie, L.I. Brueggemann, K.K. Henderson, A.J. Shiels, L.L. Cribbs, and K.E. Scrogin Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction by vasopressin, based on studies in single cells, pressurized arteries, and in vivo measurements of mesenteric vascular resistance J Pharmacol Exp Ther 325 2008 475 483 (Pubitemid 351574788)
36. X.Z. Zhong, M.I. Harhun, S.P. Olesen, S. Ohya, J.D. Moffatt, and W.C. Cole Participation of KCNQ (Kv7) potassium channels in myogenic control of cerebral arterial diameter J Physiol 588 2010 3277 3293
37. V7 channels to pregnant mouse and human myometrial contractility J Cell Mol Med 15 2011 577 586
38. U.A. Anderson, C. Carson, and K.D. McCloskey KCNQ currents and their contribution to resting membrane potential and the excitability of interstitial cells of Cajal from the guinea pig bladder J Urol 182 2009 330 336
39. C.L. Wladyka, and D.L. Kunze KCNQ/M-currents contribute to the resting membrane potential in rat visceral sensory neurons J Physiol 575 2006 175 189 (Pubitemid 44178136)
40. P. Elmedyb, K. Calloe, N. Schmitt, R. Schultz Hansen, M. Grunnet, and S.-P. Olesen Modulation of ERG Channels by XE991 Basic Clin Pharmacol Toxicol 100 2007 316 322 (Pubitemid 46633473)
41. R. Søgaard, T. Ljungstrøm, K.A. Pedersen, S.-P. Olesen, and B.S. Jensen KCNQ4 channels expressed in mammalian cells: functional characteristics and pharmacology Am J Physiol Cell Physiol 280 2001 859 866
42. B.C. Schroeder, M. Hechenberger, F. Weinreich, C. Kubisch, and T.J. Jentsch KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents J Biol Chem 275 2000 24089 24095 (Pubitemid 30624700)
43. S.Y.M. Yeung, W. Lange, M. Schwake1, and I.A. Greenwood Expression profile and characterisation of a truncated KCNQ5 splice variant Biochem Biophys Res Commun 371 2008 741 747
44. L. Tatulian, P. Delmas, F.C. Abogadie, and D.A. Brown Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine J Neurosci 21 2001 5535 5545 (Pubitemid 32692152)
45. A.D. Wickenden, W. Yu, A. Zou, T. Jegla, and P.K. Wagoner Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels Mol Pharmacol 58 2000 591 600
46. R.L. Schrøder, T. Jespersen, P. Christophersen, D. Strøbæk, B.S. Jensen, and S.-P. Olesen KCNQ4 channel activation by BMS-204352 and retigabine Neuropharmacology 40 2001 888 898 (Pubitemid 32510802)
47. H.S. Jensen, K. Callø, T. Jespersen, B.S. Jensen, and S.-P. Olesen The KCNQ5 potassium channel from mouse: a broadly expressed M-current like potassium channel modulated by zinc, pH, and volume changes Mol Brain Res 139 2005 52 62 (Pubitemid 41583589)
48. A.D. Wickenden, A. Zou, P.K. Wagoner, and T. Jegla Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells Br J Pharmacol 132 2001 381 384 (Pubitemid 32142349)
49. P. Robberecht, P. De Neef, and R.A. Lefebvre Influence of selective VIP receptor agonists in the rat gastric fundus Eur J Pharmacol 359 1998 77 80 (Pubitemid 28515725)
50. S.P.H. Alexander, A. Mathie, and J.A. Peters Guide to receptors and channels (GRAC), 4th ed Br J Pharmacol 158 Suppl 1 2009 S1 S254
51. S.M. Sims, J.J. Singer, and J.V. Walsh Jr Antagonistic adrenergic-muscarinic regulation of M current in smooth muscle cells Science 239 1988 190 193 (Pubitemid 18026683)
52. V7) potassium channels Nat Rev Neurosci 6 2005 850 862 (Pubitemid 41568727)
53. S. Dai, D.D. Hall, and J.W. Hell Supramolecular assemblies and localized regulation of voltage-gated ion channels Physiol Rev 89 2009 411 452
54. + channels Biochim Biophys Acta 1668 2005 223 233 (Pubitemid 40298926)
55. J.K. Hadley, G.M. Passmore, L. Tatulian, M. Al-Qatari, F. Ye, and A.D. Wickenden Stoichiometry of expressed KCNQ2/KCNQ3 potassium channels and subunit composition of native ganglionic M channels deduced from block by tetraethylammonium J Neurosci 23 2003 5012 5019 (Pubitemid 36793228)