KCNQ Currents and Their Contribution to Resting Membrane Potential and the Excitability of Interstitial Cells of Cajal From the Guinea Pig Bladder

Journal of Urology

Volumn 182, Issue 1, 2009, Pages 330-336

  Anderson, Ursula A ^a   Carson, Christopher ^a   McCloskey, Karen D ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

electrophysiology; KCNQ potassium channels; membrane potentials; muscle, smooth; urinary bladder

Indexed keywords

10,10 BIS(4 PYRIDINYLMETHYL) 9(10H) ANTHRACENONE; ADENOSINE TRIPHOSPHATE; CALCIUM; CHROMANOL 293B; EGTAZIC ACID; FLUPIRTINE; LINOPIRDINE; MECLOFENAMIC ACID; POTASSIUM CHANNEL KCNQ;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL POLARITY; CONTROLLED STUDY; GUINEA PIG; HYPERPOLARIZATION; INTERSTITIAL CELL OF CAJAL; MEMBRANE STEADY POTENTIAL; NONHUMAN; PIPETTE; POTASSIUM CURRENT; PRIORITY JOURNAL; VOLTAGE CLAMP;

ACTION POTENTIALS; ANIMALS; CELLS, CULTURED; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIALS; FEMALE; GUINEA PIGS; KCNQ1 POTASSIUM CHANNEL; MALE; MEMBRANE POTENTIALS; MODELS, ANIMAL; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE; POTASSIUM CHANNEL BLOCKERS; PROBABILITY; RANDOM ALLOCATION; SENSITIVITY AND SPECIFICITY; URINARY BLADDER;

EID: 67349246072     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2009.02.108     Document Type: Article

References (20)

1. Wu C., Sui S.P., and Fry C.H. Purinergic regulation of guinea pig suburothelial myofibroblasts. J Physiol 559 (2004) 231
2. McCloskey K.D., and Gurney A.M. Kit positive cells in the guinea pig bladder. J Urol 168 (2002) 832
3. 2+ signaling in interstitial cells of Cajal from the guinea pig bladder. Am J Physiol Renal Physiol 294 (2008) F645
4. McCloskey K.D. Characterization of outward currents in interstitial cells from the guinea pig bladder. J Urol 173 (2005) 296
5. + channel (KCNQ) opener retigabine in freely moving, conscious rats. J Urol 172 (2004) 2054
6. Robbins J. KCNQ potassium channels: physiology, pathophysiology, and pharmacology. Pharmacol Ther 90 (2001) 1
7. Wang Q., Curran M.E., Splawski I., Burn T.C., Millholland J.M., VanRaay T.J., et al. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet 12 (1996) 17
8. Schroeder BC, Kubisch C, Stein V and Jentsch TJ: Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy. Nature 1008; 396: 687.
9. Kubisch C., Schroeder B.C., Friedrich T., Lütjohann B., El-Amraoui A., Marlin S., et al. KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness. Cell 96 (1999) 437
10. Yeung S.Y.M., and Greenwood I.A. Electrophysiological and functional effects of the KCNQ channel blocker XE991 on murine portal vein smooth muscle cells. Br J Pharmacol 146 (2005) 585
11. Zaczek R., Chorvat R.J., Saye J.A., Pierdomenico M.E., Maciag C.M., Logue A.R., et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther 285 (1998) 724
12. Aiken S.P., Lampe B.J., Murphy P.A., and Brown B.S. Reduction of spike frequency adaptation and blockade of M-current in rat CA1 pyramidal neurones by linopirdine (DuP 996), a neurotransmitter release enhancer. Br J Pharmacol 115 (1995) 1163
13. Lamas J.A., Selyanko A.A., and Brown D.A. Effects of a cognition-enhancer, linopirdine (DuP 996), on M-type potassium currents (IK(M)) and some other voltage- and ligand-gated membrane currents in rat sympathetic neurons. Eur J Neurosci 9 (1997) 605
14. + channel blocker chromanol 293B. Pflugers Arch 434 (1997) 499
15. Wladyka C.L., and Kunze D.L. KCNQ/M-currents contribute to the resting membrane potential in rat visceral sensory neurons. J Physiol 575 (2006) 175
16. Peretz A., Nachman R., Uziyel Y., Gibor G., Shabat D., and Attali B. Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties. Mol Pharmacol 67 (2005) 1053
17. Joshi S., Balan P., and Gurney A.M. Pulmonary vasoconstrictor action of KCNQ potassium channel blockers. Respir Res 7 (2006) 31
18. Ohya S., Sergeant G.P., Greenwood I.A., and Horowitz B. Molecular variants of KCNQ channels expressed in murine portal vein myocytes. Circ Res 92 (2003) 1016
19. Mackie A.R., Brueggemann L.I., Henderson K.K., Shiels A.J., Cribbs L.L., Scrogin K.E., et al. Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction by vasopressin. J Pharmacol Exp Ther 325 (2008) 475
20. 2+ signals in detrusor smooth muscles of the guinea pig urinary bladder. J Physiol 559 (2004) 567