Sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor ligand: Effects on dizocilpine and scopolamine-induced attentional impairments in female Sprague-Dawley rats

Psychopharmacology

Volumn 215, Issue 4, 2011, Pages 621-630

  Rezvani, Amir H ^a   Cauley, Marty ^a   Sexton, Hannah ^a   Xiao, Yingxian ^b   Brown, Milton L ^b   Paige, Mikell A ^b   McDowell, Brian E ^b   Kellar, Kenneth J ^b   Levin, Edward D ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

MK 801; Muscarinic cholinergic; Nicotinic receptors; NMDA glutaminergic; Sazetidine A; Sustained attention

Indexed keywords

DIZOCILPINE; NICOTINIC AGENT; NICOTINIC RECEPTOR ALPHA4BETA2; SAZETIDINE A; SCOPOLAMINE; SODIUM CHLORIDE; UNCLASSIFIED DRUG; AZETIDINE DERIVATIVE; DIZOCILPINE MALEATE; LIGAND; NICOTINIC RECEPTOR; PYRIDINE DERIVATIVE; SAZETIDINE-A;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENTION DISTURBANCE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; DRUG STRUCTURE; FEMALE; LATENT PERIOD; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RESPONSE TIME; SIGNAL DETECTION; TASK PERFORMANCE; VISUAL DISCRIMINATION; ANIMAL; ATTENTION; CHEMICAL STRUCTURE; CHEMISTRY; COGNITION; DRUG EFFECT; DRUG INTERACTION; METABOLISM; PHOTOSTIMULATION; PSYCHOMOTOR PERFORMANCE; SPRAGUE DAWLEY RAT;

ANIMALS; ATTENTION; AZETIDINES; BEHAVIOR, ANIMAL; COGNITION; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FEMALE; LIGANDS; MOLECULAR STRUCTURE; PHOTIC STIMULATION; PSYCHOMOTOR PERFORMANCE; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; SCOPOLAMINE;

EID: 80052959737     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-010-2161-8     Document Type: Article

References (65)

1. Bartus RT, Dean RL, Flicker C (1987) Cholinergic psychopharmacology: an integration of human and animal research on memory. In: Meltzer HY (ed) Psychopharmacology: the third generation of progress. Raven, New York, pp 219-232
2. Blondel A, Sanger D, Moser P (2000) Characterisation of the effects of nicotine in the five-choice serial reaction task in rats: antagonist studies. Psychopharmacology 149:293-305
3. Buccafusco JJ, Brach JW, Terry AV (2009) Desensitization of nicotinic acetylcholine receptors as a stategy for drug development. J Pharmacol Exp Ther 328:364-370
4. Bushnell P (1998) Behavioral approaches to the assessment of attention in animals. Psychopharmacology 138:231-259
5. Bushnell PJ, Oshiro WM, Padnos BK (1997) Detection of visual signals by rats: effects of chlordiazepoxide and cholinergic and adrenergic drugs on sustained attention. Psychopharmacology 134:230-241
6. Cannady R, Weir R, Wee B, Gotschlich E, Kolia N, Lau E, Brotherton J, Levin ED (2009) Nicotinic antagonist effects in the mediodorsal thalamic nucleus: regional heterogeneity of nicotinic receptor involvement in cognitive function. Biochem Pharmacol 78:788-794
7. Carbone AL, Moroni M, Groot-Kormelink PJ, Bermudez I (2009) Pentameric concatenated (a4)2(b2)3 and (a4)3(b2)2 nicotinic acetylcholine receptors: subunit arrangement determines functional expression. Br J Pharmacol 156:970-981
8. Collins AC, Romm E, Wehner JM (1988) Nicotine tolerance: an analysis of the time course of its development and loss in the rat. Psychopharmacology 96:7-14
9. Deiana S, Harrington CR, Wischik CM, Riedel G (2009) Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine. Psychopharmacology 202:53-65
10. Ellis JR, Ellis KA, Barthoolomeusz CF, Harrisn BJ, Wensens KA, Erskine FF, Vitetta L, Nathan PJ (2006) Muscarinic and nicotinic recptors synergistically modulate working memory and attention in humans. Int J Neuropsychopharmacol 9:175-189
11. Grilly DM (2000) A verification of psychostimulant-induced improvement in sustained attention in rats: effects of d-amphetamine, nicotine, and pemoline. Exp Clin Psychopharmacol 8:14-21
12. Grottick AJ, Higgins GA (2000) Effect of subtype selective nicotinic compounds on attention as assessed by the five-choice serial reaction time task. Behav Brain Res 117:197-208
13. Grottick AJ, Haman M, Wyler R, Higgins GA (2003) Reversal of a vigilance decrement in the aged rat by subtype-selective nicotinic ligands. Neuropsychopharmacology 28:880-887
14. Hahn B, Ross TJ, TYang Y, Kim I, Huestis MA, Stein EA (2007) Nicotine enhances visuospatial attention by deactivating areas of resting brain default network. J Neurosci 27:3477-3489
15. Hahn B, Ross TJ, Wolkenberg FA, Shakleya DM, Huestis MA, Stein EA (2009) Performace effects of nicotine during selective attention, divided attention, and simple stimulus detection: an fMRI study. Cereb Cortex 19:1990-2000
16. Hashimoto K, Koike K, Shimizu E, Iyo M (2005) Alpha7 nicotinic receptor agonists as potential therapeutic drugs for schizophrenia. Curr Med Chem Cent Nerv Syst Agents 5:171-184
17. Hasselmo ME, Sarter M (2011) Modes and models of forebrain cholinergic neuromodulation of cognition. Neuropsychopharmacol Rev 36:52-73
18. Howe WM, Ji J, Parikh V, Williams S, Mocaër E, Trocmé- Thiberge C, Sarter M (2010) Enhancement of attentional performance by selective stimulation os alpha4beta2* nAChRs: underlying cholinergic mechanisms. Neuropsychopharmacology 35:1391-1401
19. Hulihan-Giblin BA, Lumpkin MD, Kellar KJ (1990) Acute effects of nicotine on prolactin release in the rat: agonist and antagonist effects of a single injection of nicotine. J Pharmacol Exp Ther 252:15-20
20. Hulme EC, Lu ZL, Saldanha JW, Bee MS (2003) Structure and activation of muscarinic acetylcholine receptors. Biochem Soc Trans 31:29-34
21. Katz B, Thesleff S (1957) On the factors which determine the amplitude of the miniature end-plate potential. J Physiol 137:267-278
22. Koike K, Hashimoto K, Takai N, Shimizu E, Komatsu N, Watanabe H, Nakazato M, Okamura N, Stevens KE, Freedman R, Iyo M (2005) Tropisetron improves deficits in auditory P50 suppression in schizophrenia. Schizophr Res 76:67-72
23. Langley JH, Dickenson WL (1889) On the local paralysis of the peripheral ganglia and on the connexion of different classes of nerve fibres with them. Proc R Soc 46:423-431
24. Lawrence NS, Ross TJ, Stein EA (2002) Cognitive mechanisms of nicotine on visual attention. Neuron 36:539-548
25. Levin ED, Caldwell DP (2006) Low-dose mecamylamine improves learning of rats in the radial-arm maze repeated acquisition procedure. Neurobiol Learn Mem 86:117-122
26. Levin ED, Christopher NC (2002) Persistence of nicotinic agonist RJR 2403 induced working memory improvement in rats. Drug Dev Res 55:97-103
27. Levin ED, Briggs SJ, Christopher NC, Rose JE (1993) Chronic nicotinic stimulation and blockade effects on working memory. Behav Pharmacol 4:179-182
28. Levin ED, Kaplan S, Boardman A (1997) Acute nicotine interactions with nicotinic and muscarinic antagonists: working and reference memory effects in the 16-arm radial maze. Behav Pharmacol 8:236-242
29. Levin ED, Conners CK, Silva D, Hinton SC, Meck WH, March J, Rose JE (1998) Transdermal nicotine effects on attention. Psychopharmacology 140:135-141
30. Levin ED, Bettegowda C, Blosser J, Gordon J (1999) AR-R17779, an α7 nicotinic agonist, improves learning and memory in rats. Behav Pharmacol 10:675-680
31. Levin ED, McClernon FJ, Rezvani AH (2006) Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification and anatomic localization. Psychopharmacology 184:523-539
32. Levin ED, Rezvani AH, Slade S, Cauley M, Wells D, Hampton D, Petro A, Rose JE, Xiao Y, Brown ML, Paige MA, McDowell BE, Kellar K (2010) Sazetidine-A, a selective α4β2 nicotinic receptor desensitizing agent and partial agonist reduces nicotine self-administration in rats. J Pharmacol Exp Ther 332:933-939
33. Lippiello PM, Benchierif M, Gray JA, Peters S, Grigoryan G, Hodges H, Collins AC (1996) RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. J Pharmacol Exp Therap 279:1422-1429
34. Marks MJ, Meinerz NM, Brown RW, Collins AC (2010) 86Rb+efflux mediated by a4b2*-nicotinic acetylcholine receptors with high and low-sensitivity to stimulation by acetylcholine display similar agonist-induced desensitization. Biochem Pharmacol 80:1238-1251
35. Martin LF, Kem WR, Freedman R (2004) Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia. Psychopharmacology 174:54-64
36. McGaughy J, Decker MW, Sarter M (1999) Enhancement of sustained attention performance by the nicotinic acetylcholine receptor agonist ABT-418 in intact but not basal forebrain-lesioned rats. Psychopharmacology 144:175-182
37. Mirza NR, Bright JL (2001) Nicotine-induced enhancements in the five-choice serial reaction time task in rats are strain-dependent. Psychopharmacology 154:8-12
38. Mirza NR, Stolerman IP (1998) Nicotine enhances sustained attention in the rat under specific task conditions. Psychopharmacology 138:266-274
39. Mirza NR, Stolerman IP (2000) The role of nicotinic and muscarinic acetylcholine receptors in attention. Psychopharmacology 148:243-250
40. Molchen SE, Mellow AM, Lawlor BA, Weingartner HJ, Cohen RM, Cohen MR, Sunderland T (1990) TRH attenuates scopolamineinduced memory impairment in humans. Psychopharmacology 100:84-89
41. Muir JL, Everitt BJ, Robbins TW (1995) Reversal of visual attentional dysfunction following lesions of the cholinergic basal forebrain by physostigmine and nicotine but not by the 5-HT3 receptor antagonist, ondansetron. Psychopharmacology 118:82-92
42. Newhouse PA, Potter A, Singh A (2004) Effects of nicotinic stimulation on cognitive performance. Curr Opin Pharmacol 4:36-46
43. Olincy A, Harris JG, Johnson LL, Pender V, Kongs S, Allensworth D, Ellis J, Zerbe GO, Leonard S, Stevens KE, Stevens JO, Martin L, Adler LE, Soti F, Kem WR, Freedman R (2006) Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia. Arch Gen Psychiatry 63:630-638
44. Papke R, Webster J, Lippiello P, Bencherif M, Francis M (2000) The activation and inhibition of human nicotinic acetylcholine receptor by RJR-2403 indicate a selectivity for the alpha4beta2 receptor subtype. J Neurochem 75:204-216
45. Picciotto MR, Addy NA, Mineur YS, Brunzell DH (2008) It is not "either/or": activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood. Prog Neurobiol 84:329-342
46. Rezvani AH, Levin ED (2003) Nicotinic-glutamatergic interactions and attentional performance on an operant visual signal detection task in female rats. Eur J Pharmacol 465:83-90
47. Rezvani AH, Levin ED (2004) Nicotine-antipsychotic drug interactions and attentional performance in female rats. Eur J Pharmacol 486:175-182
48. Rezvani AH, Bushnell PJ, Levin ED (2002) Nicotine and mecamylamine effects on choice accuracy in an operant signal detection task. Psychopharmacology 164:369-375
49. Rezvani AH, Caldwell P, Levin ED (2005) Nicotinic-serotonergic drug interactions and attentional performance in rats. Psychopharmacology: 179:521-528
50. Rezvani AH, Caldwell DP, Levin ED (2006) Chronic nicotine interactions with clozapine and risperidone and attentional function in rats. Prog Neuro-Psychopharmacol Biol Psychiatry 30:190-197
51. Rezvani AH, Kholdebarin E, Dawson E, Levin ED (2008) Nicotine and clozapine effects on attentional performance impaired by the NMDA antagonist dizocilpine in female rats. Int J Neuropsychopharmacol 11:63-70
52. Rezvani AH, Kholdebarin E, Brucato FH, Callahan PM, Lowe DA, Levin ED (2009) Effect of R3487/MEM3454, a novel nicotinic alpha7 receptor partial agonist and 5-HT3 antagonist on sustained attention in rats. Prog Neuropsychopharmacol Biol Psychiatry 33:269-275
53. Rezvani AH, Slade S, Wells C, Petro A, Li TK, Lumeng L, Xiao Y, Brown ML, Paige MA, McDowell BE, Kellar KJ, Rose JE, Levin ED (2010) Sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor desensitizing agent and partial agonist reduces both alcohol and nicotine self-administration in selectively-bred alcohol preferring (P) rats. Psychopharmacology 211:161-174
54. Sarter M, Parikh V, Howe WM (2009) nAChR agonist-induced cognition enhancement: integration of cognitive and neuronal mechanisms. Biochem Pharmacol 78:658-667
55. Seo SW, Suh MK, Chin J, Na DL (2009) Mental confusion associated with scopolamine patch in elderly with mild cognitive impairment (MCI). Arch Gerontol Geriatr 49:204-207
56. Stolerman IP, Mirza NR, Hahn B, Shoaib M (2000) Nicotine in an animal model of attention. Eur J Pharmacol 393:147-154
57. Sydserff S, Sutton EJ, Song D, Quirk MC, Maciag C, Li C, Jonak G, Gurley D, Gordon JC, Christian EP, Doherty JJ, Hudzik T, Johnson E, Mrzljak L, Piser T, Smagin GN,Wang Y,Widzowski D, Smith JS (2009) Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes. Biochem Pharmacol 78:880-888
58. Terry AVJ, Risbrough VB, Buccafusco JJ, Menzaghi F (2002) Effects of (+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A), a selective ligand for nicotinic acetylcholine receptors, in tests of visual attention and distractibility in rats and monkeys. J Pharmacol Exp Ther 301:284-292
59. Turchi J, Holley LA, Sarter M (1995) Effects of nicotinic acetylcholine receptor ligands on behavioral vigilance in rats. Psychopharmacology 118:195-205
60. Warburton DM, Brown K (1971) Attenuation of stimulus sensitivity induced by scopolamine. Nature 230:126-127
61. Xiao Y, Fan H, Musachio JL, Wei ZL, Chellappan SK, Kozikowski AP, Kellar KJ (2006) Sazetidine-A, a novel ligand that desensitizes alpha4beta2 nicotinic acetylcholine receptors without activating them. Mol Pharmacol 70:1454-1460
62. Xiao Y, Yasuda RP, Sahibzada N, Horton L, DiPietro JR, Iwueze AF, Paige MA, McDowell B, Brown ML, Wolfe BB, Kellar KJ (2008) Pharmacological properties of sazetidine-A, a selective ligand of α4β2 nicotinic acetylcholine receptors. Proceedings of the 38th Annual Meeting of the Society for Neuroscience, Washington, DC
63. Xiao Y, Yasuda RP, Sahibzada N,Wolfe BB, Horton L, Paige M, Brown ML, Kellar KJ (2010) Sazetidine-A selectively induces a longlasting desensitization of α4β2 nAChRs. Proceedings of the 4oth Annual Meeting of the Society for Neurosciences, San Diego
64. Young J, Finlayson K, Spratt C, Marston H, Crawford N, Kelly J, Sharkey J (2004) Nicotine improves sustained attention in mice: evidence for involvement of the alpha 7 nicotinic acetylcholine receptor. Neuropsychopharmacology 29:891-900
65. Zwart R, Carbone AL, Moroni M, Bermudez I, Mogg AJ, Folly EA, Broad LM, Williams AC, Zhang D, Ding C, Heinz BA, Sher E (2008) Sazetidine-A is a potent and selective agonist at native and recombinant alpha 4 beta 2 nicotinic acetylcholine receptors. Mol Pharmacol 73:1838-1843