Synthesis, biochemical and molecular modelling studies of antiproliferative azetidinones causing microtubule disruption and mitotic catastrophe

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 4595-4607

  O'Boyle, Niamh M ^a   Carr, Miriam ^a   Greene, Lisa M ^a   Keely, Niall O ^a   Knox, Andrew J S ^a   McCabe, Thomas ^a   Lloyd, David G ^a   Zisterer, Daniela M ^a   Meegan, Mary J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

lactam; Antiproliferative; Azetidinone; Combretastatin; Mitotic catastrophe; Tubulin

Indexed keywords

3 PHENYL 1,4 BIS(3,4,5 TRIMETHOXYPHENYL)AZETIDIN 12 ONE; 3 PHENYL 4 (2,3,4 TRIMETHOXYPHENYL) 1 (3,4,5 TRIMETHOXYPHENYL)AZETIDIN 2 ONE; 3 PHENYL 4 (2,4,5 TRIMETHOXYPHENYL) 1 (3,4,5 TRIMETHOXYPHENYL) AZETIDIN 2 ONE; 3,4,4 TRIPHENYL 1 (3,4,5 TRIMETHOXYPHENYL)AZETIDIN 2 ONE; 3,4,5 TRIMETHOXY N (2,4,6 TRIMETHOXYBENZYLIDENE)ANILINE; 3,4,5 TRIMETHOXY N (NAPHTHALEN 2 YLMETHYLENE)ANILINE; 3,4,5 TRIMETHOXY N [3 (4 METHOXYPHENYL)ALLYLIDENE]ANILINE; 4 (3 BROMO 4 METHOXYPHENYL) 3 PHENYL 1 (3,4,5 TRIMETHOXYPHENYL) AZETIDIN 2 ONE; 4 (3,4 DIMETHOXYPHENYL) 3 PHENYL 1 (3,4,5 TRIMETHOXYPHENYL) AZETIDIN 2 ONE; 4 (4 ETHOXYPHENYL) 3 PHENYL 1 (3,4,5 TRIMETHOXYPHENYL)AZETIDIN 2 ONE; 4 (4 FLUOROPHENYL) 3 PHENYL 1 (3,4,5 TRIMETHOXYPHENYL)AZETIDIN 2 ONE; 4 (4 METHOXYPHENYL) 3 PHENYL 1 (3,4,5 TRIMETHOXYBENZYL)AZETIDIN 2 ONE; 4 (4 METHOXYPHENYL) 3,4 DIPHENYL 1 (3,4,5 TRIMETHOXYPHENYL) AZETIDIN 2 ONE; 4 (4 METHOXYSTYRYL) 3 PHENYL 1 (3,4,5 TRIMETHOXYPHENYL)AZETIDIN 2 ONE; 4 (NAPHTHALEN 2 YL) 3 PHENYL 1 (3,4,5 TRIMETHOXYPHENYL)AZETIDIN 2 ONE; 4 [4 (DIMETHYLAMINO)PHENYL] 3 PHENYL 1 (3,4,5 TRIMETHOXYPHENYL)AZETIDIN 2 ONE; 4,4 BIS (4 METHOXYPHENYL) 3 PHENYL 1 (3,4,5 TRIMETHOXYPHENYL)AZETIDIN 2 ONE; AZETIDINONE DERIVATIVE; BETA LACTAM; COMBRETASTATIN A4; N (3 BROMO 4 METHOXYBENZYLIDENE) 3,4,5 TRIMETHOXYANILINE; N (4 ETHOXYBENZYLIDENE) 3,4,5 TRIMETHOXYANILINE; N (4 METHOXYBENZYLIDENE) 1 (3,4,5 TRIMETHOXYPHENYL)METHANAMINE; N [4 (DIMETHYLAMINO)BENZYLIDENE] 3,4,5 TRIMETHOXYANILINE; TUBULIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MITOSIS; MITOTIC CATASTROPHE; MOLECULAR MODEL; POLYMERIZATION; PROTEIN MODIFICATION; REFORMATSKY REACTION; STAUDINGER REACTION;

AZETIDINES; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; FLOW CYTOMETRY; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MICROTUBULES; MITOSIS; MODELS, MOLECULAR; SPECTROPHOTOMETRY, INFRARED;

EID: 80052949837     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.07.039     Document Type: Article

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